Thu.Dec 21, 2023

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Research offers new insights into how breakdown of omega-6 fatty acids influences metabolism

Medical Xpress - Cardiology

What role do omega-6 fatty acids play in cardiovascular disease and diabetes? Scientists from Mannheim, together with researchers from Heidelberg, Frankfurt, and Hangzhou in China, have investigated the breakdown of omega-6 fatty acids and gained new insights into how their oxidation products influence the metabolism.

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Therapeutic Hypothermia May Not Benefit Cardiac Arrest Patients

Med Page Today

(MedPage Today) -- Therapeutic hypothermia did not improve survival or functional outcomes in unconscious patients after out-of-hospital cardiac arrest with initial nonshockable rhythm, a meta-analysis of patient-level data found. The primary.

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Artery calcification more common in night owls, shows study

Medical Xpress - Cardiology

Artery calcification is almost twice as common in night owls compared to early birds, according to a study from the University of Gothenburg, Sweden. Circadian rhythm appears to be particularly important for the heart and blood vessels during the early stages of the disease.

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Vaccine Hesitancy Differs for COVID-19, Flu Shots

HCPLive

Data from a nationally representative survey show that, despite most US adults agree the COVID-19 and flu vaccines are safe and effective, there is discrepancy in why some may not want one or the other.

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Statins found to reduce risk of blood clots associated with menopausal hormone therapy

Medical Xpress - Cardiology

Researchers at the University of Texas Medical Branch, Galveston, have provided substantial evidence supporting the potential role of statins in mitigating venous thromboembolism (VTE) risk associated with hormone therapy in postmenopausal women, possibly reshaping the risk-benefit considerations for this population.

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Colchicine Not the Answer for Recurring Arrhythmias After Ablation

Med Page Today

(MedPage Today) -- For patients undergoing catheter ablation for atrial fibrillation (Afib), there was no signal that a brief course of colchicine reduced atrial arrhythmia recurrence or improved clinical outcomes when taken for 10 days starting.

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MDMA-Assisted Therapy for PTSD Awaits FDA Decision

HCPLive

Jennifer Mitchell, PhD, discusses MAPS Public Benefit Corporations’ recent New Drug Application submission for MDMA-Assisted Therapy for PTSD and what the treatment’s potential approval could mean for people with PTSD.

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More Trending

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Structural Racism Linked to Increased Prevalence of Kidney Disease, Diabetes, & Cardiovascular Disease

HCPLive

A new study is raising awareness around the effects of structural racism on the prevalence of chronic health conditions.

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Ago2 Protects Against Diabetic Cardiomyopathy by Activating Mitochondrial Gene Translation

Circulation

Circulation, Ahead of Print. BACKGROUND:Diabetes is associated with cardiovascular complications. microRNAs translocate into subcellular organelles to modify genes involved in diabetic cardiomyopathy. However, functional properties of subcellular Ago2 (Argonaute2), a core member of miRNA machinery, remain elusive.METHODS:We elucidated the function and mechanism of subcellular localized Ago2 on mouse models for diabetes and diabetic cardiomyopathy.

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Micki Hultquist, MS: Long-term Anifrolumab-fnia Data Demonstrate Safety, Efficacy in SLE

HCPLive

Data from the phase 3 TULIP long-term extension trial support the favorable benefit-risk profile of anifrolumab-fnia demonstrated in previous trials.

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Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183?291 Participants From 29 Prospective Studies

Stroke Journal

Stroke, Volume 55, Issue 1 , Page 50-58, January 1, 2024. BACKGROUND:The effect of marine omega-3 PUFAs on risk of stroke remains unclear.METHODS:We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts. Each site conducted a de novo individual-level analysis using a prespecified analytical protocol with defined exposures, covariates, analytical methods, and outcomes; the har

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Jonathan Sadeh, MD, MSc: Afimetoran Improves Disease Activity, Severity in Lupus

HCPLive

Results provide the first clinical evidence to suggest that afimetoran may offer a benefit to patients with cutaneous lupus erythematosus.

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Association between hyponatremia and adverse clinical outcomes of heart failure: current evidence based on a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

Background Heart failure (HF) is a global health challenge. The perturbations in fluid and electrolyte equilibrium, particularly the compromised sodium balance associated with HF lead to high mortality rates. Hence, elucidating the correlation between serum sodium levels and the prognosis of HF is of paramount importance. This study aimed to conduct a comprehensive meta-analysis to thoroughly investigate the interplay between hyponatremia and the prognostic outlook of individuals with HF.

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Future Developments in Fibromyalgia Treatment

HCPLive

Philip J. Mease, MD, highlights the potential of blood biomarkers to assist with diagnosing fibromyalgia, as well as other imaging modalities.

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Spatiotemporal distribution characteristics and influencing factors of the rate of cardiovascular hospitalization in Ganzhou city of China

Frontiers in Cardiovascular Medicine

Aims The objective of this study was to analyze hospitalization rates for cardiovascular diseases (CVD) in Ganzhou City, Jiangxi Province of China from 2015 to 2020 and to uncover the spatiotemporal distribution characteristics and influencing factors, and thus to provide reference for the prevention and control of CVD and public health resources planning.

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Combination Therapy in LDL Lowering

HCPLive

Expert cardiologists describe the importance of combination therapy for hyperlipidemia in high risk patients

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In-stent restenosis in acute coronary syndrome—a classic and a machine learning approach

Frontiers in Cardiovascular Medicine

Background In acute coronary syndrome (ACS), a number of previous studies tried to identify the risk factors that are most likely to influence the rate of in-stent restenosis (ISR), but the contribution of these factors to ISR is not clearly defined. Thus, the need for a better way of identifying the independent predictors of ISR, which comes in the form of Machine Learning (ML).

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2023 AHA Focused Update on Adult ACLS: Key Points

American College of Cardiology

The following are key points to remember about a 2023 American Heart Association (AHA) focused update on adult advanced cardiovascular life support (ACLS).

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Expression of secreted frizzled-related proteins in acute aortic dissection patients and the effects on prognosis

Frontiers in Cardiovascular Medicine

Background Secreted frizzled-related proteins (SFRPs) were reported to be involved in cardiovascular diseases. This study aimed to observe plasma SFRP levels in acute aortic dissection (AD) patients and the effects of SFRP expression on AD prognosis. Methods Plasma levels of SFRP1, SFRP2, SFRP3, SFRP4, and SFRP5 were measured in AD patients and non-AD (NAD) patients.

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The Future and Resources in HCV Care

HCPLive

Expert hepatologists discuss future developments in HCV that they are excited about and provide resources for new providers to get started on delivering HCV care.

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Genetic Susceptibility Modifies Relationships Between Air Pollutants and Stroke Risk: A Large Cohort Study

Stroke Journal

Stroke, Volume 55, Issue 1 , Page 113-121, January 1, 2024. BACKGROUND:The extent to which genetic susceptibility modifies the associations between air pollutants and the risk of incident stroke is still unclear. This study was designed to investigate the separate and joint associations of long-term exposure to air pollutants and genetic susceptibility on stroke risk.METHODS:The participants of this study were recruited by the UK Biobank between 2006 and 2010.

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Katie Falloon, MD: SEQUENCE and Treatment Positioning

HCPLive

Katie Falloon, MD, discusses findings from the SEQUENCE study, the importance of treatment positioning, and what direct data from head-to-head studies contributes to this understanding.

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Objective Randomized Blinded Investigation With Optimal Medical Therapy of Angioplasty in Stable Angina

American College of Cardiology

The goal of the ORBITA-2 trial was to assess the efficacy of percutaneous coronary intervention (PCI) compared with a sham placebo procedure for angina relief among patients with stable angina who were not on background antianginal medication.

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Outlook Therapeutics Submits ONS-5010 Special Protocol Assessment to FDA

HCPLive

Based on the special protocol assessment submission, the company expects to begin the non-inferiority trial for the ophthalmic bevacizumab in the first quarter of 2024.

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VENTRICULAR TACHYCARDIA WITH SUCCESSFUL ATP

ECG Guru

If ventricular tachycardia occurs in an Implantable Cardioverter Defibrillator (ICD) wearer, the ICD can combat this with 2 different forms of therapy, provided these are activated (which can be done using a programming device). First, the ICD attempts to override the tachycardia. The fastest pacemaker gets control of the heart. If this is not successful, the defibrillator function is used.

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Overcoming Access Barriers to Novel Non Statin Therapies

HCPLive

Dr. Taub describes effective strategies in overcoming access barriers to novel lipid lowering therapies.

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Blood pressure, cholesterol before age 55 years impact risk for heart disease

Medical Xpress - Cardiology

Genetically-predicted systolic blood pressure (SBP) and low-density lipoprotein cholesterol (LDL-C) increase the risk for coronary heart disease (CHD), independent of age, according to a study published online Dec. 20 in PLOS ONE.

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Dual-Orexin Receptor Antagonists for Treatment of Insomnia

HCPLive

In an upcoming Peer Exchange program entitled “Dual-Orexin Receptor Antagonists for Treatment of Insomnia” Dr Paul Doghramji will moderate a conversation with physicians about this class of agents for treatment of insomnia and discuss other therapeutic advancements in the field.

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Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia

American College of Cardiology

The goal of the trial was to evaluate simvastatin compared with control among patients with moderate to severe coronavirus disease 2019 (COVID-19) infection.

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Patients Report High Anti-VEGF Satisfaction Despite Treatment-Related Barriers

HCPLive

Patients with retinal diseases found intravitreal anti-VEGF therapy and disease management challenging, but most expressed high levels of satisfaction with their treatment.

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Pulmonary Valve Replacement in Tetralogy of Fallot

American College of Cardiology

What are the temporal trends in pulmonary valve replacement (PVR) procedural volume and durability of bioprosthetic pulmonary valves (BPV)?

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Study Identifies Factors Influencing Risk of Alcohol-Related Liver Disease, Cirrhosis

HCPLive

Specific interactions between binge drinking, genetic risk, and diabetes mellitus were found to significantly influence the risk of alcohol-related cirrhosis.

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ACCEL Lite: Top Takeaways from 2023: EP with DJ Lakkireddy, MD, MBA, FACC

American College of Cardiology

In this interview, Dhanunjaya “DJ” Lakkireddy, MBBS, FACC, and Alison L. Bailey, MD, FACC discuss the top takeaways from 2023 in cardiac electrophysiology including AF and the latest guidelines and ARTESIA and MONITOR-AF studies.

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Clinical Pearls for Clinicians Treating Fibromyalgia

HCPLive

Philip J. Mease, MD, discusses treatment selection in fibromyalgia, highlighting combination therapy as well as the importance of a holistic approach to care.

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Alternate Interpretation of Left Bundle Branch Potential – Response to a Research Letter

HeartRhythm

This reader disagrees with the conclusions stated in Research Letter “Electrophysiological characteristics of left bundle branch potential during implantation” by Ponnusamy et al.

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Alcohol Consumption Pattern May Be Better Predictor of Liver Disease Than Volume

HCPLive

Specific interactions between binge drinking, genetic risk, and diabetes mellitus were found to significantly influence the risk of alcohol-related cirrhosis.

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Increasing Activity After Stroke: A Randomized Controlled Trial of High-Intensity Walking and Step Activity Intervention

Stroke Journal

Stroke, Volume 55, Issue 1 , Page 5-13, January 1, 2024. BACKGROUND:Physical inactivity in people with chronic stroke profoundly affects daily function and increases recurrent stroke risk and mortality, making physical activity improvements an important target of intervention. We compared the effects of a high-intensity walking intervention (FAST), a step activity monitoring behavioral intervention (SAM), or a combined intervention (FAST+SAM) on physical activity (ie, steps/day).

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