Tue.Feb 13, 2024

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Denosumab Protective Against Diabetes?

Med Page Today

(MedPage Today) -- Continued treatment with the osteoporosis drug denosumab (Prolia) was tied to a lower risk of developing diabetes in a Taiwanese cohort study. In a propensity score-matched analysis, adherence to denosumab for osteoporosis was.

Diabetes 116
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Big systems have a responsibility to reach rural patients, pediatric heart leader says

Becker's Hospital Review - Cardiology

For Shelley Miyamoto, MD, there were two reasons to become a cardiologist: The mentors she encountered during residency who inspired her and the physiology of the heart.

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RapidAI Announces Late-Breaking Abstract Simultaneously Published in NEJM; Highlights Key Data Revealed at ISC 2024

DAIC

milla1cf Tue, 02/13/2024 - 17:52 February 13, 2024 — RapidAI , the global leader in developing Artificial Intelligence ( AI ) and clinical workflow solutions to combat life-threatening neurovascular, cardiac, and vascular diseases, today announced the publication of the TIMELESS trial in the New England Journal of Medicine (NEJM). Other select data from research studies unveiled last week at the American Heart Association ’s International Stroke Conference (ISC) underscore and reinforce the pi

Stroke 111
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ECG Cases 48 – ECG Interpretation in Cardiac Arrest

ECG Cases

In this month's ECG Cases blog Dr. Jesse McLaren reviews interpretation of the pre-arrest ECG: identifying high risk ECGs requiring empiric treatment like calcium for hyperkalemia, magnesium for long QT, or reperfusion for Occlusion MI; the intra-arrest ECG: identifying pseudo-PEA; and post-arrest ECG: the importance of serial ECGs to reduce false positive STEMI, role of POCUS to help with the differential of diffuse ST depression with reciprocal ST elevation in aVR, and identifying signs of Occ

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I Never Expected to Run a Code While Running the NYC Marathon

Med Page Today

(MedPage Today) -- I'd seen a 78-year-old in cardiac arrest before. In fact, I've resuscitated thousands, and run countless codes in 30-plus years as an emergency medicine nurse and doctor. I'm trained to take charge, make the most of staffing.

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Butterfly Network Launches Next-Generation Butterfly iQ3 in the United States

DAIC

The Butterfly iQ3 device featuring a new user-centric ergonomic design that is smaller, lighter and better weight distributed. milla1cf Tue, 02/13/2024 - 12:11 February 13, 2024 — Butterfly Network, Inc. , a digital health company transforming care through the power of portable, semiconductor-based ultrasound technology and intuitive software, announced today the commercial launch of its third-generation handheld point-of-care ultrasound (POCUS) system, Butterfly iQ3 , which received FDA c

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Large-Core Strokes Do Better Long-Term With Thrombectomy

Med Page Today

(MedPage Today) -- PHOENIX -- Endovascular thrombectomy for large-core acute ischemic stroke improved long-term outcomes, the SELECT2 trial affirmed. The intervention shifted the 1-year modified Rankin Scale (mRS) score distribution toward less.

Stroke 104

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Acupuncture may curb heightened risk of stroke associated with rheumatoid arthritis

Medical Xpress - Cardiology

A course of acupuncture may curb the heightened risk of stroke associated with rheumatoid arthritis, finds a comparative study published in the open access journal BMJ Open.

Stroke 104
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Acupuncture Reduces Incidence of Ischemic Stroke in RA

HCPLive

Patients with rheumatoid arthritis who received acupuncture had a lower cumulative incidence of ischemic stroke compared to those who did not.

Stroke 111
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A new solution for energy transfer to heart pumps mitigates infection

Medical Xpress - Cardiology

Roughly 1 in 2 wearers of ventricular assist devices are diagnosed with an infection. The reason for this is the thick cable for the power supply. ETH Zurich researchers have now developed a solution to mitigate this problem.

Research 102
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Anabolic steroid use can increase heart disease risk, study finds

Science Daily - Heart Disease

People using anabolic steroids could be increasing their underlying risk of a heart condition called atrial fibrillation, according to a new study.

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Updating allocation algorithms could help donor hearts reach the transplant patients who need them most

Medical Xpress - Cardiology

Receiving a heart transplant is a matter of life and death for many patients. Every time a heart becomes available, a "match run" is created to generate a list of transplant candidates ranked by an algorithm based on medical urgency, geography and pediatric status. Unfortunately, deceased donor organs are very scarce in the United States—so much so that some patients aren't even placed on waitlists because it's too unlikely that a heart will become available to them.

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Ep 191 The Future of EM – Systems Thinking

ECG Cases

In order fix EM, each of us needs to understand systems issues and systems thinking, and advocate for a better system based on sound systems principles and specific solutions. In this main episode EM Cases podcast Anton is joined by Dr. Alecs Chochinov and Dr. Davie Petrie, two systems thinkers and leaders in EM. They discuss solutions for how to fix EM in 5 spheres: having a coordinated mission, optimizing access points, accountability, disaster preparedness and adaptation/evolution.

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‘It’s Completely Changed My Practice’: Marla Dubinsky, MD, on Intestinal Ultrasound for Crohn’s Disease

HCPLive

Marla Dubinsky, MD, discusses the use of segmental intestinal ultrasound to address screen failure associated with the SES-CD in clinical trials and for detecting transmural healing.

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Isometric exercise: Using body weight to lower blood pressure

Medical Xpress - Cardiology

When you think about exercise, sweating through a cycling class, adding up miles from a brisk walk or pumping iron in the weight room may come to mind. But there's a different form of exercise that uses something besides movement to give you a workout. It's isometric exercise, which is gaining attention for its role in helping lower and control your blood pressure.

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Carbonylation of Runx2 at K176 by 4-Hydroxynonenal Accelerates Vascular Calcification

Circulation

Circulation, Ahead of Print. BACKGROUND:Vascular calcification, which is characterized by calcium deposition in arterial walls and the osteochondrogenic differentiation of vascular smooth muscle cells, is an actively regulated process that involves complex mechanisms. Vascular calcification is associated with increased cardiovascular adverse events.

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Not too late to repair: Gene therapy improves advanced heart failure in animal model

Medical Xpress - Cardiology

Heart failure remains the leading cause of mortality in the U.S. During a heart attack blood stops flowing into the heart. Without oxygen, part of the heart muscle dies. The heart muscle does not regenerate; instead, it replaces dead tissue with a scar made of cells called fibroblasts that do not help the heart pump. If there is too much scarring, the heart progressively enlarges, or dilates, weakens and eventually stops working.

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Michelle Kittleson, MD, PhD: Need for Justice in Heart Transplant Allocation

HCPLive

Michelle Kittleson, MD, PhD, provides insight into the potential impact of a new risk score for heart transplant allocation as well as the need for more equitable cardiovascular care in the US.

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Age and Aspirin Dosing in Secondary Prevention of Atherosclerotic Cardiovascular Disease

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundIn patients with atherosclerotic cardiovascular disease, increasing age is concurrently associated with higher risks of ischemic and bleeding events. The objectives are to determine the impact of aspirin dose on clinical outcomes according to age in atherosclerotic cardiovascular disease.Methods and ResultsIn the ADAPTABLE (Aspirin Dosing: A Patient‐Centric Trial Assessing Benefits and Long‐Term Effectiveness) trial, patients w

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Case Report: Giant left atrial cystic tumor: myxoma or intracardiac blood cyst?

Frontiers in Cardiovascular Medicine

Background Primary cardiac tumors are uncommon, with the majority being benign myxomas. Cystic myxoma, a particularly rare type of benign cardiac tumor, demands cautious differential diagnosis from other cardiac tumors. Case summary A 43-year-old male patient presenting with intermittent dyspnea was referred to our department for surgical evaluation.

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Rising Cardiac Troponin: A Prognostic Biomarker for Mortality After Acute Ischemic Stroke

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundElevated cardiac troponin (cTn) is detected in 10% to 30% of patients with acute ischemic stroke (AIS) and correlates with poor functional outcomes. Serial cTn measurements differentiate a dynamic cTn pattern (rise/fall >20%), specific for acute myocardial injury, from elevated but stable cTn levels (nondynamic), typically attributed to chronic cardiac/noncardiac conditions.

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Ion channel trafficking implications in heart failure

Frontiers in Cardiovascular Medicine

Heart failure (HF) is recognized as an epidemic in the contemporary world, impacting around 1%–2% of the adult population and affecting around 6 million Americans. HF remains a major cause of mortality, morbidity, and poor quality of life. Several therapies are used to treat HF and improve the survival of patients; however, despite these substantial improvements in treating HF, the incidence of HF is increasing rapidly, posing a significant burden to human health.

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Qingpeng Ointment Improves Pain, Swelling in Gouty Arthritis

HCPLive

The group receiving Qingpeng ointment showed significant differences compared to the control group in VAS scores, joint mobility, and disappearance rate after treatment for acute gouty arthritis.

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A study of clinical and serological correlation of early myocardial injury in elderly patients infected with the Omicron variant

Frontiers in Cardiovascular Medicine

Introduction Myocardial injury in elderly Omicron variant patients is a leading cause of severe disease and death. This study focuses on elucidating the clinical characteristics and potential risk factors associated with myocardial injury in elderly patients infected with the Omicron variant. Methods Myocardial injury was defined based on elevated cardiac troponin concentrations exceeding the 99th percentile upper reference limit.

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Salt Subs in Normal BP; Stroke Thrombectomy Without $$; Walmart's CVD Blood Test

Med Page Today

(MedPage Today) -- Among commonly used glucose-lowering medications for type 2 diabetes, liraglutide (Victoza) was tied to a particularly robust reduction of cardiovascular events. (Circulation) Fewer than half of Americans know their blood pressure.

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Ticagrelor vs. Clopidogrel in Complex, Chronic Coronary Syndrome

American College of Cardiology

What are outcomes of complex percutaneous coronary intervention (PCI) and the efficacy of ticagrelor versus clopidogrel in stable patients randomized in the ALPHEUS trial?

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Risk Score Proposed to Anchor Forthcoming Donor Heart Allocation Rules

Med Page Today

(MedPage Today) -- To more fairly rank candidates for heart transplant, researchers developed the U.S. candidate risk score (US-CRS) and found it to better discriminate risk for people with advanced heart failure than the current six-status system.

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Lipoprotein(a), C-Reactive Protein, and Cardiovascular Risk in Primary and Secondary Prevention Populations

JAMA Cardiology

This cohort study uses data from 3 populations to assess whether lipoprotein(a) levels are associated with cardiovascular risk independent of high sensitivity C-reactive protein level.

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Combination Therapy for Diabetes and Albuminuria

American College of Cardiology

What are the lifetime gains in cardiorenal event-free and overall survival with a combination treatment of sodium glucose cotransporter 2 inhibitors (SGLT2i), glucagon-like peptide-1 receptor agonists (GLP-1 RA), and the nonsteroidal mineralocorticoid receptor antagonist (ns-MRA) finerenone compared with conventional care in patients with type 2 diabetes and albuminuria?

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Sleep Apnea Prevalence in Cardio-Oncology Patients Similar to Other Risk Factors

HCPLive

Sleep apnea prevalence in cardiology patients was similar to the rates in patients with heart failure., and sleep apnea prevalence in cardio-oncology patients was the same or greater than other traditional risk factors.

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Tower recruits top cardiothoracic surgeon from Jefferson

Becker's Hospital Review - Cardiology

Rohinton Morris, MD, chief of the cardiothoracic surgery division at Philadelphia-based Jefferson Health, will become Tower Health's cardiothoracic surgery chief on April 15.

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New Risk Score Outperforms Current Model, Could Improve Heart Transplant Allocation

HCPLive

A novel risk score developed by University of Chicago investigators outperformed conventional models in predicting death in heart transplant candidates, which could help bring the field closer to optimal and equitable allocation.

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ACCEL Lite: Top Takeaways from the ACC 2023 Guideline for Chronic CAD for the Practicing Clinician

American College of Cardiology

To improve our understanding of the basic principles in the treatment and management of patients with chronic heart disease, in this interview, Salim S. Virani, MD, PhD, FACC, and Roger S. Blumenthal, MD, FACC, discuss top takeaways from the ACC 2023 Guideline for Chronic CAD.

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Mitapivat Sustains Reduction in Iron Burden in Pyruvate Kinase Deficiency

HCPLive

Mitapivat treatment was linked to long-term improvements in key markers of iron homeostasis and erythropoiesis in an analysis of the phase 3 ACTIVATE trial.

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Factors associated with safe and successful postoperative day 1 discharge after lung operations: a systematic review and meta-analysis

Journal of Cardiothoracic Surgery

A shorter length of stay (LOS) is associated with fewer hospital-acquired adverse conditions and decreased utilization of hospital resources. While modern perioperative care protocols have enabled some ambitio.

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FDA Grants 510(k) Clearance to Liver Attenuation AI Software HealthFLD

HCPLive

HealthFLD, a fully automated AI software for liver attenuation analysis from CT scans, has received FDA 510(k) clearance for use in the general population.

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Improved early risk stratification of deep sternal wound infection risk after coronary artery bypass grafting

Journal of Cardiothoracic Surgery

Deep sternal wound infection (DSWI) following open heart surgery is associated with excessive morbidity and mortality. Contemporary DSWI risk prediction models aim at identifying high-risk patients with varyin.