American Heart News - Heart News
JANUARY 16, 2024
Highlights: Research teams share findings and progress on projects aimed at harnessing digital solutions — including text messaging, smartphone apps, wearable devices and artificial intelligence — to improve health, reduce health care disparities,
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Heterozygous (HET) truncating variant mutations in the TTN gene (TTNtvs), encoding the giant titin protein, are the most common genetic cause of dilated cardiomyopathy (DCM). However, the molecular mechanisms by which TTNtv mutations induce DCM are controversial. Here, we studied 127 clinically identified DCM human cardiac samples with next-generation sequencing (NGS), high-resolution gel electrophoresis, Western blot analysis, and super-resolution microscopy in order to dissect the structural a
American Heart News - Heart News
JANUARY 16, 2024
DALLAS, 16 DE ENERO DE 2024 - La salud bucal de un paciente puede ser un indicador de su salud y bienestar general. Las investigaciones demuestran que la inflamación crónica de las encías puede estar asociada con otras enfermedades crónicas, como.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Vascular aging affects multiple organ systems, including the brain, where it can lead to vascular dementia. However, a concrete understanding of how aging specifically affects the brain vasculature, along with molecular readouts, remains vastly incomplete. Here, we demonstrate that aging is associated with a marked decline in Notch3 signaling in both murine and human brain vessels.
Science Daily - Stroke
JANUARY 16, 2024
This month, a group of stroke survivors in British Columbia will test a new technology designed to aid their recovery, and ultimately restore use of their limbs and hands. Participants will wear a new groundbreaking 'smart glove' capable of tracking their hand and finger movements during rehabilitation exercises.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Recent studies using cell type–specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum–associated (ER-associated) degradation (ERAD); however, its importance in humans remains unclear, as no disease variant has been identified.
DAIC
JANUARY 16, 2024
Getty Images milla1cf Tue, 01/16/2024 - 14:11 January 16, 2024 — Artificial intelligence (AI) has the potential to detect rheumatic heart disease (RHD) with the same accuracy as a cardiologist, according to new research demonstrating how sophisticated deep learning technology can be applied to this disease of inequity. The work could prevent hundreds of thousands of unnecessary deaths around the world annually.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
DAIC
JANUARY 16, 2024
milla1cf Tue, 01/16/2024 - 13:57 January 16, 2024 — Penumbra, Inc. , a thrombectomy company, has recently secured CE Mark (Conformité Européenne) for its Indigo System CAT RX designed to address the limitations of traditional management strategies in acute coronary syndrome (ACS). Traditional modalities utilizing syringe aspiration suffer from diminished vacuum once fluid enters the system.
JAMA Cardiology
JANUARY 16, 2024
This prespecified analysis of the Cholesterol Lowering via Bempedoic Acid, an ATP Citrate Lyase (ACL)–Inhibiting Regimen (CLEAR) Outcomes trial investigates if bempedoic acid is associated with a reduction in the total burden of cardiovascular events in patients at high risk for cardiovascular disease.
HCPLive
JANUARY 16, 2024
Compared to individuals without OSA and regular sleep, individuals with OSA combined with severely irregular sleep had the highest odds of hypertension, according to a new study.
Medical Xpress - Cardiology
JANUARY 16, 2024
A 30-minute walk at moderate intensity temporarily reduced blood pressure in women with rheumatoid arthritis, not only at rest but also under stress. This was the conclusion drawn from a study involving physical and cognitive tests conducted at the University of São Paulo (USP) in Brazil.
Becker's Hospital Review - Cardiology
JANUARY 16, 2024
Remembering the life and legacy of pioneering cardiologist Dr. Bruce Wilkoff, who passed away at 69 after a battle with pancreatic cancer.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity, affecting millions of adolescents worldwide, but it lacks a defined theory of etiopathogenesis. Because of this, treatment of AIS is limited to bracing and/or invasive surgery after onset. Preonset diagnosis or preventive treatment remains unavailable. Here, we performed a genetic analysis of a large multicenter AIS cohort and identified disease-causing and predisposing variants of SLC6A9 in multigeneration famili
HCPLive
JANUARY 16, 2024
Findings suggest serum C3 may be a viable biomarker for the occurrence and prognosis of IgAN, highlighting the role of the complement system in the disease’s pathogenesis.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Mutations in ATP-binding cassette A3 (ABCA3), a phospholipid transporter critical for surfactant homeostasis in pulmonary alveolar type II epithelial cells (AEC2s), are the most common genetic causes of childhood interstitial lung disease (chILD). Treatments for patients with pathological variants of ABCA3 mutations are limited, in part due to a lack of understanding of disease pathogenesis resulting from an inability to access primary AEC2s from affected children.
Medical Xpress - Cardiology
JANUARY 16, 2024
A driving simulation study has shown we are one step closer to monitoring our heart health in real time via a tiny device worn in the ear.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Glycogen storage disease type III (GSDIII) is a rare inborn error of metabolism affecting liver, skeletal muscle, and heart due to mutations of the AGL gene encoding for the glycogen debranching enzyme (GDE). No curative treatment exists for GSDIII. The 4.6 kb GDE cDNA represents the major technical challenge toward the development of a single recombinant adeno-associated virus–derived (rAAV-derived) vector gene therapy strategy.
HCPLive
JANUARY 16, 2024
The updated labeling for dupilumab’s use resulted from the first phase 3 trial assessing a biologic within this subgroup of eczema patients.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Alzheimer’s disease is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (pTau), and microglia activation. Galectin-3 (Gal3) is a β-galactoside–binding protein that has been implicated in amyloid pathology. Its role in tauopathy remains enigmatic. Here, we showed that Gal3 was upregulated in the microglia of humans and mice with tauopathy. pTau triggered the release of Gal3 from human induced pluripotent stem cell–derived microglia in both its free an
American Heart News - Heart News
JANUARY 16, 2024
DALLAS, JANUARY 16, 2024 — A patient’s oral health can be an indicator of overall health and well-being. Research shows that chronic gum inflammation may be associated with other chronic diseases including coronary artery disease and diabetes.[1] In.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) inhibition with ICI in urothelial carcinoma (UC) of the bladder, in which FGFR3 is altered in 50% of cases. Using an FGFR3-driven, Trp53-mutant genetically engineered murine model (UPFL), we demonstrate that UPFL tumors recapitulate the histology and molecular subtype of their FGFR3-altered human counterparts.
HCPLive
JANUARY 16, 2024
During this segment of his interview, Eingun James Song, MD, spoke about upcoming treatments for psoriasis and personalizing care for patients.
Medical Xpress - Cardiology
JANUARY 16, 2024
Obesity-induced heart disease, which affects up to 10% of the population in certain age ranges, is considered an untreatable condition and 75% of people don't survive more than five years beyond diagnosis.
Dr. Paddy Barrett
JANUARY 16, 2024
Life is a game of odds. We would all love to have guarantees that we will not get sick, that those we love will not die, and that by simply doing ‘all the right things’, we will avoid any health issues. But that’s just not how life works. But you can tilt the odds in our favour. To an enormous degree. Firstly, you have to know your foe.
Medical Xpress - Cardiology
JANUARY 16, 2024
In a collaboration between the Fralin Biomedical Research Institute at VTC and Carilion Clinic, researchers have learned that by preserving large superficial leg veins intended for coronary bypass grafting in a mixture of the anticoagulant heparin and blood, rather than heparin and saline, the veins were better protected from cell and tissue damage.
ECG Guru
JANUARY 16, 2024
For a better overview, the leads aVF and V2-V4 are not shown in this ECG. The basic rhythm is atrial fibrillation (no P waves or flutter waves visible, but fibrillation waves). When the conduction rate drops, the QRS complexes are narrow. Faster conduction results in wide QRS complexes with LBBB morphology. This is an example of phase 3 (acceleration dependant) LBBB.
Medical Xpress - Cardiology
JANUARY 16, 2024
Researchers at Oregon Health & Science University have found that quality of care for pediatric patients who experience cardiac arrest outside of the hospital is lower compared with adults, prompting an urgent call to action to improve care delivery for the potentially deadly event.
The British Journal of Cardiology
JANUARY 16, 2024
We aimed to describe the safety and tolerability of initiation of sodium-glucose cotransporter 2 inhibitors (SGLT2i) during hospitalisation with heart failure, and the frequency of, and reasons for, subsequent discontinuation. In total, 934 patients who were not already prescribed a SGLT2i were hospitalised with heart failure, 77 (8%) were initiated on a SGLT2i a median of five (3–8.5) days after admission and two (0.5–5) days prior to discharge.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Cancer remains a leading cause of mortality on a global scale. Lung cancer, specifically non–small cell lung cancer (NSCLC), is a prominent contributor to this burden. The management of NSCLC has advanced substantially in recent years, with immunotherapeutic agents, such as immune checkpoint inhibitors (ICIs), leading to improved patient outcomes. Although generally well tolerated, the administration of ICIs can result in unique side effects known as immune-related adverse events (irAEs).
Circulation
JANUARY 16, 2024
Circulation, Ahead of Print. During the COVID-19 pandemic, the American Heart Association created a new 2024 Impact Goal with health equity at its core, in recognition of the increasing health disparities in our country and the overwhelming evidence of the damaging effect of structural racism on cardiovascular and stroke health. Concurrent with the announcement of the new Impact Goal was the release of an American Heart Association presidential advisory on structural racism, recognizing racism a
Medical Xpress - Cardiology
JANUARY 16, 2024
Artificial intelligence (AI) has the potential to detect rheumatic heart disease (RHD) with the same accuracy as a cardiologist, according to new research demonstrating how sophisticated deep learning technology can be applied to this disease of inequity. The work could prevent hundreds of thousands of unnecessary deaths around the world annually.
Frontiers in Cardiovascular Medicine
JANUARY 16, 2024
Introduction Catheter ablation is an effective and safe strategy for treating atrial fibrillation patients. Nevertheless, studies on the long-term outcomes of catheter ablation in patients with dilated cardiomyopathy are limited. This study aimed to assess the electrophysiological characteristics of atrial fibrillation patients with dilated cardiomyopathy and compare the long-term clinical outcomes between patients undergoing catheter ablation and medical therapy.
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
BACKGROUND. Accurate detection of graft-versus-host disease (GVHD) is a major challenge in the management of patients undergoing hematopoietic stem cell transplantation (HCT). Here, we demonstrated the use of circulating cell-free DNA (cfDNA) for detection of tissue turnover and chronic GVHD (cGVHD) in specific organs. METHODS. We established a cocktail of tissue-specific DNA methylation markers and used it to determine the concentration of cfDNA molecules derived from the liver, skin, lungs, co
Journal of the American Heart Association
JANUARY 16, 2024
Journal of the American Heart Association, Volume 13, Issue 2 , January 16, 2024. BackgroundIdentification of children with latent rheumatic heart disease (RHD) by echocardiography, before onset of symptoms, provides an opportunity to initiate secondary prophylaxis and prevent disease progression. There have been limited artificial intelligence studies published assessing the potential of machine learning to detect and analyze mitral regurgitation or to detect the presence of RHD on standard por
Journal of Clinical Investigation - Cardiology
JANUARY 16, 2024
Suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) ER-associated degradation (ERAD) plays a critical role in many physiological processes in mice, including immunity, water homeostasis, and energy metabolism; however, its relevance and importance in humans remain unclear, as no disease variant has been identified. Here, we report a biallelic SEL1L variant (p.
Journal of the American Heart Association
JANUARY 16, 2024
Journal of the American Heart Association, Volume 13, Issue 2 , January 16, 2024. BackgroundSmartphone applications and wearable devices are promising mobile health interventions for hypertension self‐management. However, most mobile health interventions fail to use contextual data, potentially diminishing their impact. The myBPmyLife Study is a just‐in‐time adaptive intervention designed to promote personalized self‐management for patients with hypertension.Methods and ResultsThe study is a 6‐m
ADN Center of Excellence
JANUARY 16, 2024
At Biruni University Hospital, our committed fellows, led by Prof. Dr. Şevket Görgülü, completed their journey with a successful fellowship completion ceremony. This wonderful occasion, full of sincere feelings and shared triumphs, exemplifies the unwavering dedication and skill made inside the walls of this prestigious institution. As the sun set on their fellowship programs, the accomplished fellows came together to reflect on the transforming events that marked their time in the Interventiona
Expert insights. Personalized for you.
122 
Let's personalize your content