Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Heterozygous (HET) truncating variant mutations in the TTN gene (TTNtvs), encoding the giant titin protein, are the most common genetic cause of dilated cardiomyopathy (DCM). However, the molecular mechanisms by which TTNtv mutations induce DCM are controversial. Here, we studied 127 clinically identified DCM human cardiac samples with next-generation sequencing (NGS), high-resolution gel electrophoresis, Western blot analysis, and super-resolution microscopy in order to dissect the structural a

Cardiomyopathy 122

Cardiomyopathy 122

American Heart News - Heart News

JANUARY 16, 2024

Highlights: Research teams share findings and progress on projects aimed at harnessing digital solutions — including text messaging, smartphone apps, wearable devices and artificial intelligence — to improve health, reduce health care disparities,

Research 122

Research Technology 122

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Vascular aging affects multiple organ systems, including the brain, where it can lead to vascular dementia. However, a concrete understanding of how aging specifically affects the brain vasculature, along with molecular readouts, remains vastly incomplete. Here, we demonstrate that aging is associated with a marked decline in Notch3 signaling in both murine and human brain vessels.

Dementia 122

Dementia 122

American Heart News - Heart News

JANUARY 16, 2024

DALLAS, 16 DE ENERO DE 2024 - La salud bucal de un paciente puede ser un indicador de su salud y bienestar general. Las investigaciones demuestran que la inflamación crónica de las encías puede estar asociada con otras enfermedades crónicas, como.

111

111

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Recent studies using cell type–specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum–associated (ER-associated) degradation (ERAD); however, its importance in humans remains unclear, as no disease variant has been identified.

115

115

DAIC

JANUARY 16, 2024

Getty Images milla1cf Tue, 01/16/2024 - 14:11 January 16, 2024 — Artificial intelligence (AI) has the potential to detect rheumatic heart disease (RHD) with the same accuracy as a cardiologist, according to new research demonstrating how sophisticated deep learning technology can be applied to this disease of inequity. The work could prevent hundreds of thousands of unnecessary deaths around the world annually.

Heart Disease 105

Heart Disease Ultrasound Technology Echocardiogram 105

Science Daily - Stroke

JANUARY 16, 2024

This month, a group of stroke survivors in British Columbia will test a new technology designed to aid their recovery, and ultimately restore use of their limbs and hands. Participants will wear a new groundbreaking 'smart glove' capable of tracking their hand and finger movements during rehabilitation exercises.

Stroke 106

Stroke Strokes Exercise Technology 106

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Adolescent idiopathic scoliosis (AIS) is the most common form of spinal deformity, affecting millions of adolescents worldwide, but it lacks a defined theory of etiopathogenesis. Because of this, treatment of AIS is limited to bracing and/or invasive surgery after onset. Preonset diagnosis or preventive treatment remains unavailable. Here, we performed a genetic analysis of a large multicenter AIS cohort and identified disease-causing and predisposing variants of SLC6A9 in multigeneration famili

103

103

Med Page Today

JANUARY 16, 2024

(MedPage Today) -- Medical marijuana was associated with an elevated risk of new-onset arrhythmia in a Danish population with chronic pain. (European Heart Journal) Severe drug-induced QT prolongation was fairly common in patients taking one of.

Arrhythmia 104

Arrhythmia 104

HCPLive

JANUARY 16, 2024

Compared to individuals without OSA and regular sleep, individuals with OSA combined with severely irregular sleep had the highest odds of hypertension, according to a new study.

Hypertension 100

Hypertension 100

Medical Xpress - Cardiology

JANUARY 16, 2024

A 30-minute walk at moderate intensity temporarily reduced blood pressure in women with rheumatoid arthritis, not only at rest but also under stress. This was the conclusion drawn from a study involving physical and cognitive tests conducted at the University of São Paulo (USP) in Brazil.

Blood Pressure 103

Blood Pressure Exercise 103

Becker's Hospital Review - Cardiology

JANUARY 16, 2024

Remembering the life and legacy of pioneering cardiologist Dr. Bruce Wilkoff, who passed away at 69 after a battle with pancreatic cancer.

Cancer 116

Cancer 116

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Mutations in ATP-binding cassette A3 (ABCA3), a phospholipid transporter critical for surfactant homeostasis in pulmonary alveolar type II epithelial cells (AEC2s), are the most common genetic causes of childhood interstitial lung disease (chILD). Treatments for patients with pathological variants of ABCA3 mutations are limited, in part due to a lack of understanding of disease pathogenesis resulting from an inability to access primary AEC2s from affected children.

Pulmonary 105

Pulmonary 105

JAMA Cardiology

JANUARY 16, 2024

This prespecified analysis of the Cholesterol Lowering via Bempedoic Acid, an ATP Citrate Lyase (ACL)–Inhibiting Regimen (CLEAR) Outcomes trial investigates if bempedoic acid is associated with a reduction in the total burden of cardiovascular events in patients at high risk for cardiovascular disease.

Cholesterol 104

Cholesterol Cardiovascular Disease Outcomes 104

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Glycogen storage disease type III (GSDIII) is a rare inborn error of metabolism affecting liver, skeletal muscle, and heart due to mutations of the AGL gene encoding for the glycogen debranching enzyme (GDE). No curative treatment exists for GSDIII. The 4.6 kb GDE cDNA represents the major technical challenge toward the development of a single recombinant adeno-associated virus–derived (rAAV-derived) vector gene therapy strategy.

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98

HCPLive

JANUARY 16, 2024

Findings suggest serum C3 may be a viable biomarker for the occurrence and prognosis of IgAN, highlighting the role of the complement system in the disease’s pathogenesis.

Biomarkers 98

Biomarkers 98

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) inhibition with ICI in urothelial carcinoma (UC) of the bladder, in which FGFR3 is altered in 50% of cases. Using an FGFR3-driven, Trp53-mutant genetically engineered murine model (UPFL), we demonstrate that UPFL tumors recapitulate the histology and molecular subtype of their FGFR3-altered human counterparts.

Cancer 96

Cancer 96

Medical Xpress - Cardiology

JANUARY 16, 2024

A driving simulation study has shown we are one step closer to monitoring our heart health in real time via a tiny device worn in the ear.

Research 109

Research 109

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Alzheimer’s disease is characterized by the accumulation of amyloid-β plaques, aggregation of hyperphosphorylated tau (pTau), and microglia activation. Galectin-3 (Gal3) is a β-galactoside–binding protein that has been implicated in amyloid pathology. Its role in tauopathy remains enigmatic. Here, we showed that Gal3 was upregulated in the microglia of humans and mice with tauopathy. pTau triggered the release of Gal3 from human induced pluripotent stem cell–derived microglia in both its free an

Plaque 96

Plaque 96

HCPLive

JANUARY 16, 2024

The updated labeling for dupilumab’s use resulted from the first phase 3 trial assessing a biologic within this subgroup of eczema patients.

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105

American Heart News - Heart News

JANUARY 16, 2024

DALLAS, JANUARY 16, 2024 — A patient’s oral health can be an indicator of overall health and well-being. Research shows that chronic gum inflammation may be associated with other chronic diseases including coronary artery disease and diabetes.[1] In.

Coronary Artery Disease 94

Coronary Artery Disease Chronic Disease Heart Disease Diabetes 94

HCPLive

JANUARY 16, 2024

During this segment of his interview, Eingun James Song, MD, spoke about upcoming treatments for psoriasis and personalizing care for patients.

98

98

Medical Xpress - Cardiology

JANUARY 16, 2024

Obesity-induced heart disease, which affects up to 10% of the population in certain age ranges, is considered an untreatable condition and 75% of people don't survive more than five years beyond diagnosis.

Obesity 85

Obesity Heart Disease Research 85

Dr. Paddy Barrett

JANUARY 16, 2024

Life is a game of odds. We would all love to have guarantees that we will not get sick, that those we love will not die, and that by simply doing ‘all the right things’, we will avoid any health issues. But that’s just not how life works. But you can tilt the odds in our favour. To an enormous degree. Firstly, you have to know your foe.

Cancer 81

Cancer Dementia Diabetes Cardiovascular Disease 81

Medical Xpress - Cardiology

JANUARY 16, 2024

In a collaboration between the Fralin Biomedical Research Institute at VTC and Carilion Clinic, researchers have learned that by preserving large superficial leg veins intended for coronary bypass grafting in a mixture of the anticoagulant heparin and blood, rather than heparin and saline, the veins were better protected from cell and tissue damage.

Research 82

Research 82

ECG Guru

JANUARY 16, 2024

For a better overview, the leads aVF and V2-V4 are not shown in this ECG. The basic rhythm is atrial fibrillation (no P waves or flutter waves visible, but fibrillation waves). When the conduction rate drops, the QRS complexes are narrow. Faster conduction results in wide QRS complexes with LBBB morphology. This is an example of phase 3 (acceleration dependant) LBBB.

Atrial Fibrillation 75

Atrial Fibrillation 75

Medical Xpress - Cardiology

JANUARY 16, 2024

Researchers at Oregon Health & Science University have found that quality of care for pediatric patients who experience cardiac arrest outside of the hospital is lower compared with adults, prompting an urgent call to action to improve care delivery for the potentially deadly event.

Cardiac Arrest 79

Cardiac Arrest Hospital Pediatrics Research 79

The British Journal of Cardiology

JANUARY 16, 2024

We aimed to describe the safety and tolerability of initiation of sodium-glucose cotransporter 2 inhibitors (SGLT2i) during hospitalisation with heart failure, and the frequency of, and reasons for, subsequent discontinuation. In total, 934 patients who were not already prescribed a SGLT2i were hospitalised with heart failure, 77 (8%) were initiated on a SGLT2i a median of five (3–8.5) days after admission and two (0.5–5) days prior to discharge.

Inpatient 75

Inpatient Blood Pressure Heart Failure Article 75

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Cancer remains a leading cause of mortality on a global scale. Lung cancer, specifically non–small cell lung cancer (NSCLC), is a prominent contributor to this burden. The management of NSCLC has advanced substantially in recent years, with immunotherapeutic agents, such as immune checkpoint inhibitors (ICIs), leading to improved patient outcomes. Although generally well tolerated, the administration of ICIs can result in unique side effects known as immune-related adverse events (irAEs).

Pulmonary 81

Pulmonary Cancer Outcomes 81

Circulation

JANUARY 16, 2024

Circulation, Ahead of Print. During the COVID-19 pandemic, the American Heart Association created a new 2024 Impact Goal with health equity at its core, in recognition of the increasing health disparities in our country and the overwhelming evidence of the damaging effect of structural racism on cardiovascular and stroke health. Concurrent with the announcement of the new Impact Goal was the release of an American Heart Association presidential advisory on structural racism, recognizing racism a

Health Disparities 78

Health Disparities COVID-19 Circulation Stroke 78

Medical Xpress - Cardiology

JANUARY 16, 2024

Artificial intelligence (AI) has the potential to detect rheumatic heart disease (RHD) with the same accuracy as a cardiologist, according to new research demonstrating how sophisticated deep learning technology can be applied to this disease of inequity. The work could prevent hundreds of thousands of unnecessary deaths around the world annually.

Heart Disease 73

Heart Disease Technology Research 73

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

BACKGROUND. Accurate detection of graft-versus-host disease (GVHD) is a major challenge in the management of patients undergoing hematopoietic stem cell transplantation (HCT). Here, we demonstrated the use of circulating cell-free DNA (cfDNA) for detection of tissue turnover and chronic GVHD (cGVHD) in specific organs. METHODS. We established a cocktail of tissue-specific DNA methylation markers and used it to determine the concentration of cfDNA molecules derived from the liver, skin, lungs, co

Biomarkers 69

Biomarkers Transplant Circulation Research 69

Frontiers in Cardiovascular Medicine

JANUARY 16, 2024

Introduction Catheter ablation is an effective and safe strategy for treating atrial fibrillation patients. Nevertheless, studies on the long-term outcomes of catheter ablation in patients with dilated cardiomyopathy are limited. This study aimed to assess the electrophysiological characteristics of atrial fibrillation patients with dilated cardiomyopathy and compare the long-term clinical outcomes between patients undergoing catheter ablation and medical therapy.

Atrial Fibrillation 64

Atrial Fibrillation Cardiomyopathy Ablation Electrophysiology 64

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) ER-associated degradation (ERAD) plays a critical role in many physiological processes in mice, including immunity, water homeostasis, and energy metabolism; however, its relevance and importance in humans remain unclear, as no disease variant has been identified. Here, we report a biallelic SEL1L variant (p.

Physiology 69

Physiology 69

Journal of the American Heart Association

JANUARY 16, 2024

Journal of the American Heart Association, Volume 13, Issue 2 , January 16, 2024. BackgroundIdentification of children with latent rheumatic heart disease (RHD) by echocardiography, before onset of symptoms, provides an opportunity to initiate secondary prophylaxis and prevent disease progression. There have been limited artificial intelligence studies published assessing the potential of machine learning to detect and analyze mitral regurgitation or to detect the presence of RHD on standard por

Bicuspid/Mitral 68

Bicuspid/Mitral Heart Disease Echocardiogram Innovation 68

ADN Center of Excellence

JANUARY 16, 2024

At Biruni University Hospital, our committed fellows, led by Prof. Dr. Şevket Görgülü, completed their journey with a successful fellowship completion ceremony. This wonderful occasion, full of sincere feelings and shared triumphs, exemplifies the unwavering dedication and skill made inside the walls of this prestigious institution. As the sun set on their fellowship programs, the accomplished fellows came together to reflect on the transforming events that marked their time in the Interventiona

Hospital 59

Hospital Interventional Cardiology Certification Academic 59

Journal of the American Heart Association

JANUARY 16, 2024

Journal of the American Heart Association, Volume 13, Issue 2 , January 16, 2024. BackgroundSmartphone applications and wearable devices are promising mobile health interventions for hypertension self‐management. However, most mobile health interventions fail to use contextual data, potentially diminishing their impact. The myBPmyLife Study is a just‐in‐time adaptive intervention designed to promote personalized self‐management for patients with hypertension.Methods and ResultsThe study is a 6‐m

Blood Pressure 67

Blood Pressure Diet Innovation Hypertension 67