Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Heterozygous (HET) truncating variant mutations in the TTN gene (TTNtvs), encoding the giant titin protein, are the most common genetic cause of dilated cardiomyopathy (DCM). However, the molecular mechanisms by which TTNtv mutations induce DCM are controversial. Here, we studied 127 clinically identified DCM human cardiac samples with next-generation sequencing (NGS), high-resolution gel electrophoresis, Western blot analysis, and super-resolution microscopy in order to dissect the structural a

Cardiomyopathy 117

Cardiomyopathy 117

Med Page Today

JANUARY 16, 2024

(MedPage Today) -- Medical marijuana was associated with an elevated risk of new-onset arrhythmia in a Danish population with chronic pain. (European Heart Journal) Severe drug-induced QT prolongation was fairly common in patients taking one of.

Arrhythmia 111

Arrhythmia 111

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Recent studies using cell type–specific knockout mouse models have improved our understanding of the pathophysiological relevance of suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) endoplasmic reticulum–associated (ER-associated) degradation (ERAD); however, its importance in humans remains unclear, as no disease variant has been identified.

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111

DAIC

JANUARY 16, 2024

Getty Images milla1cf Tue, 01/16/2024 - 14:11 January 16, 2024 — Artificial intelligence (AI) has the potential to detect rheumatic heart disease (RHD) with the same accuracy as a cardiologist, according to new research demonstrating how sophisticated deep learning technology can be applied to this disease of inequity. The work could prevent hundreds of thousands of unnecessary deaths around the world annually.

Heart Disease 105

Heart Disease Ultrasound Technology Echocardiogram 105

HCPLive

JANUARY 16, 2024

Compared to individuals without OSA and regular sleep, individuals with OSA combined with severely irregular sleep had the highest odds of hypertension, according to a new study.

Hypertension 100

Hypertension 100

DAIC

JANUARY 16, 2024

milla1cf Tue, 01/16/2024 - 13:57 January 16, 2024 — Penumbra, Inc. , a thrombectomy company, has recently secured CE Mark (Conformité Européenne) for its Indigo System CAT RX designed to address the limitations of traditional management strategies in acute coronary syndrome (ACS). Traditional modalities utilizing syringe aspiration suffer from diminished vacuum once fluid enters the system.

Blood Clot 105

Blood Clot Anatomy Plaque Outcomes 105

Becker's Hospital Review - Cardiology

JANUARY 16, 2024

Remembering the life and legacy of pioneering cardiologist Dr. Bruce Wilkoff, who passed away at 69 after a battle with pancreatic cancer.

Cancer 116

Cancer 116

Science Daily - Stroke

JANUARY 16, 2024

This month, a group of stroke survivors in British Columbia will test a new technology designed to aid their recovery, and ultimately restore use of their limbs and hands. Participants will wear a new groundbreaking 'smart glove' capable of tracking their hand and finger movements during rehabilitation exercises.

Stroke 100

Stroke Strokes Exercise Technology 100

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Mutations in ATP-binding cassette A3 (ABCA3), a phospholipid transporter critical for surfactant homeostasis in pulmonary alveolar type II epithelial cells (AEC2s), are the most common genetic causes of childhood interstitial lung disease (chILD). Treatments for patients with pathological variants of ABCA3 mutations are limited, in part due to a lack of understanding of disease pathogenesis resulting from an inability to access primary AEC2s from affected children.

Pulmonary 104

Pulmonary 104

American Heart News - Heart News

JANUARY 16, 2024

Highlights: Research teams share findings and progress on projects aimed at harnessing digital solutions — including text messaging, smartphone apps, wearable devices and artificial intelligence — to improve health, reduce health care disparities,

Research 96

Research Technology 96

HCPLive

JANUARY 16, 2024

Findings suggest serum C3 may be a viable biomarker for the occurrence and prognosis of IgAN, highlighting the role of the complement system in the disease’s pathogenesis.

Biomarkers 98

Biomarkers 98

Medical Xpress - Cardiology

JANUARY 16, 2024

A driving simulation study has shown we are one step closer to monitoring our heart health in real time via a tiny device worn in the ear.

Research 111

Research 111

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

The combination of targeted therapy with immune checkpoint inhibition (ICI) is an area of intense interest. We studied the interaction of fibroblast growth factor receptor (FGFR) inhibition with ICI in urothelial carcinoma (UC) of the bladder, in which FGFR3 is altered in 50% of cases. Using an FGFR3-driven, Trp53-mutant genetically engineered murine model (UPFL), we demonstrate that UPFL tumors recapitulate the histology and molecular subtype of their FGFR3-altered human counterparts.

Cancer 96

Cancer 96

JAMA Cardiology

JANUARY 16, 2024

This prespecified analysis of the Cholesterol Lowering via Bempedoic Acid, an ATP Citrate Lyase (ACL)–Inhibiting Regimen (CLEAR) Outcomes trial investigates if bempedoic acid is associated with a reduction in the total burden of cardiovascular events in patients at high risk for cardiovascular disease.

Cholesterol 99

Cholesterol Cardiovascular Disease Outcomes 99

HCPLive

JANUARY 16, 2024

The updated labeling for dupilumab’s use resulted from the first phase 3 trial assessing a biologic within this subgroup of eczema patients.

105

105

Medical Xpress - Cardiology

JANUARY 16, 2024

Researchers at Oregon Health & Science University have found that quality of care for pediatric patients who experience cardiac arrest outside of the hospital is lower compared with adults, prompting an urgent call to action to improve care delivery for the potentially deadly event.

Cardiac Arrest 91

Cardiac Arrest Hospital Pediatrics Research 91

HCPLive

JANUARY 16, 2024

During this segment of his interview, Eingun James Song, MD, spoke about upcoming treatments for psoriasis and personalizing care for patients.

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98

Medical Xpress - Cardiology

JANUARY 16, 2024

Obesity-induced heart disease, which affects up to 10% of the population in certain age ranges, is considered an untreatable condition and 75% of people don't survive more than five years beyond diagnosis.

Obesity 91

Obesity Heart Disease Research 91

American Heart News - Heart News

JANUARY 16, 2024

DALLAS, 16 DE ENERO DE 2024 - La salud bucal de un paciente puede ser un indicador de su salud y bienestar general. Las investigaciones demuestran que la inflamación crónica de las encías puede estar asociada con otras enfermedades crónicas, como.

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82

Medical Xpress - Cardiology

JANUARY 16, 2024

In a collaboration between the Fralin Biomedical Research Institute at VTC and Carilion Clinic, researchers have learned that by preserving large superficial leg veins intended for coronary bypass grafting in a mixture of the anticoagulant heparin and blood, rather than heparin and saline, the veins were better protected from cell and tissue damage.

Research 88

Research 88

American Heart News - Heart News

JANUARY 16, 2024

DALLAS, JANUARY 16, 2024 — A patient’s oral health can be an indicator of overall health and well-being. Research shows that chronic gum inflammation may be associated with other chronic diseases including coronary artery disease and diabetes.[1] In.

Coronary Artery Disease 84

Coronary Artery Disease Chronic Disease Heart Disease Diabetes 84

ECG Guru

JANUARY 16, 2024

For a better overview, the leads aVF and V2-V4 are not shown in this ECG. The basic rhythm is atrial fibrillation (no P waves or flutter waves visible, but fibrillation waves). When the conduction rate drops, the QRS complexes are narrow. Faster conduction results in wide QRS complexes with LBBB morphology. This is an example of phase 3 (acceleration dependant) LBBB.

Atrial Fibrillation 75

Atrial Fibrillation 75

The British Journal of Cardiology

JANUARY 16, 2024

We aimed to describe the safety and tolerability of initiation of sodium-glucose cotransporter 2 inhibitors (SGLT2i) during hospitalisation with heart failure, and the frequency of, and reasons for, subsequent discontinuation. In total, 934 patients who were not already prescribed a SGLT2i were hospitalised with heart failure, 77 (8%) were initiated on a SGLT2i a median of five (3–8.5) days after admission and two (0.5–5) days prior to discharge.

Inpatient 75

Inpatient Blood Pressure Heart Failure Article 75

Medical Xpress - Cardiology

JANUARY 16, 2024

Artificial intelligence (AI) has the potential to detect rheumatic heart disease (RHD) with the same accuracy as a cardiologist, according to new research demonstrating how sophisticated deep learning technology can be applied to this disease of inequity. The work could prevent hundreds of thousands of unnecessary deaths around the world annually.

Heart Disease 80

Heart Disease Technology Research 80

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Cancer remains a leading cause of mortality on a global scale. Lung cancer, specifically non–small cell lung cancer (NSCLC), is a prominent contributor to this burden. The management of NSCLC has advanced substantially in recent years, with immunotherapeutic agents, such as immune checkpoint inhibitors (ICIs), leading to improved patient outcomes. Although generally well tolerated, the administration of ICIs can result in unique side effects known as immune-related adverse events (irAEs).

Pulmonary 79

Pulmonary Cancer Outcomes 79

Dr. Paddy Barrett

JANUARY 16, 2024

Life is a game of odds. We would all love to have guarantees that we will not get sick, that those we love will not die, and that by simply doing ‘all the right things’, we will avoid any health issues. But that’s just not how life works. But you can tilt the odds in our favour. To an enormous degree. Firstly, you have to know your foe.

Cancer 73

Cancer Dementia Diabetes Cardiovascular Disease 73

Circulation

JANUARY 16, 2024

Circulation, Ahead of Print. During the COVID-19 pandemic, the American Heart Association created a new 2024 Impact Goal with health equity at its core, in recognition of the increasing health disparities in our country and the overwhelming evidence of the damaging effect of structural racism on cardiovascular and stroke health. Concurrent with the announcement of the new Impact Goal was the release of an American Heart Association presidential advisory on structural racism, recognizing racism a

Health Disparities 78

Health Disparities COVID-19 Circulation Stroke 78

Frontiers in Cardiovascular Medicine

JANUARY 16, 2024

Introduction Catheter ablation is an effective and safe strategy for treating atrial fibrillation patients. Nevertheless, studies on the long-term outcomes of catheter ablation in patients with dilated cardiomyopathy are limited. This study aimed to assess the electrophysiological characteristics of atrial fibrillation patients with dilated cardiomyopathy and compare the long-term clinical outcomes between patients undergoing catheter ablation and medical therapy.

Atrial Fibrillation 64

Atrial Fibrillation Cardiomyopathy Ablation Heart Failure 64

Journal of the American Heart Association

JANUARY 16, 2024

Journal of the American Heart Association, Volume 13, Issue 2 , January 16, 2024. BackgroundIdentification of children with latent rheumatic heart disease (RHD) by echocardiography, before onset of symptoms, provides an opportunity to initiate secondary prophylaxis and prevent disease progression. There have been limited artificial intelligence studies published assessing the potential of machine learning to detect and analyze mitral regurgitation or to detect the presence of RHD on standard por

Bicuspid/Mitral 68

Bicuspid/Mitral Heart Disease Echocardiogram Innovation 68

Journal of Clinical Investigation - Cardiology

JANUARY 16, 2024

Suppressor of lin-12-like–HMG-CoA reductase degradation 1 (SEL1L-HRD1) ER-associated degradation (ERAD) plays a critical role in many physiological processes in mice, including immunity, water homeostasis, and energy metabolism; however, its relevance and importance in humans remain unclear, as no disease variant has been identified. Here, we report a biallelic SEL1L variant (p.

Physiology 66

Physiology 66

Journal of the American Heart Association

JANUARY 16, 2024

Journal of the American Heart Association, Volume 13, Issue 2 , January 16, 2024. BackgroundSmartphone applications and wearable devices are promising mobile health interventions for hypertension self‐management. However, most mobile health interventions fail to use contextual data, potentially diminishing their impact. The myBPmyLife Study is a just‐in‐time adaptive intervention designed to promote personalized self‐management for patients with hypertension.Methods and ResultsThe study is a 6‐m

Blood Pressure 67

Blood Pressure Diet Innovation Hypertension 67

Medical Xpress - Cardiology

JANUARY 16, 2024

A spider venom molecule being investigated by a University of Queensland team has met critical benchmarks towards becoming a treatment for heart attack and stroke.

Heart Attack 69

Heart Attack Heart attacks Stroke Strokes 69

ADN Center of Excellence

JANUARY 16, 2024

At Biruni University Hospital, our committed fellows, led by Prof. Dr. Şevket Görgülü, completed their journey with a successful fellowship completion ceremony. This wonderful occasion, full of sincere feelings and shared triumphs, exemplifies the unwavering dedication and skill made inside the walls of this prestigious institution. As the sun set on their fellowship programs, the accomplished fellows came together to reflect on the transforming events that marked their time in the Interventiona

Hospital 59

Hospital Interventional Cardiology Certification Academic 59

DAIC

JANUARY 16, 2024

Satya Shreenivas, MD, MBA milla1cf Tue, 01/16/2024 - 14:26 January 16, 2024 — Cardiac Dimensions , a leader in the development of innovative and minimally invasive treatment modalities to address patients suffering from heart failure with functional mitral regurgitation (FMR), announced that renowned interventional cardiologist Satya Shreenivas, MD, MBA has joined the company as Chief Medical Officer.

Bicuspid/Mitral 59

Bicuspid/Mitral Heart Failure Catheterization Laboratory Innovation 59

HCPLive

JANUARY 16, 2024

In this interview, Del Rosso spoke on takeaways from his conference talk ‘What's New in the Medicine Chest? Acne, Rosacea, Actinic Keratoses, Psoriasis, Urticaria and Other Common Dermatoses.

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59

American College of Cardiology

JANUARY 16, 2024

What are the bleeding and thrombotic events associated with direct oral anticoagulants (DOACs) or vitamin K antagonists (VKAs) in a prospective cohort of patients who underwent transcatheter mitral valve replacement (TMVR)?

Bicuspid/Mitral 65

Bicuspid/Mitral Article 65

HCPLive

JANUARY 16, 2024

The FDA grants the company agreement under a Special Protocol Assessment to evaluate TRS01 ophthalmic solution for the treatment of non-infectious uveitis, including uveitic glaucoma.

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