CardiacWire

JANUARY 21, 2024

A pair of JACC studies laid what might be a new scientific foundation for all that research showing that people with high lipoprotein(a) have elevated cardiovascular risks. The first study analyzed 502k UK Biobank participants , identifying two clusters of genetic variants that either raise apoB by increasing Lp(a) or LDL, showing that the Lp(a) cluster faced far greater cardiovascular risks: Each 50 nmol/L higher Lp(a)-apoB brought a 28% greater risk for coronary heart disease, versus 4% with L

Heart Disease 111

Heart Disease Research Cardiovascular Disease Outcomes 111

Heart Sisters

JANUARY 21, 2024

"We all want the words we use publicly to be heard, understood and maybe even remembered."~ Carrie Fox :3 ways my public speaking skills evolved after my heart attack.

Heart Attack 100

Heart Attack Heart attacks Heart Disease 100

Cardiovascular Diabetology

JANUARY 21, 2024

It is well-known that systemic inflammation plays a crucial role in the pathogenesis and prognosis of acute myocardial infarction (AMI). The systemic immune-inflammation index (SII, platelet × neutrophil/lymph.

Myocardial Infarction 72

Myocardial Infarction Diabetes Research 72

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 311-323, February 1, 2024. Intracranial atherosclerotic disease (ICAD) is one of the most common causes of stroke worldwide. Among people with stroke, those of East Asia descent and non-White populations in the United States have a higher burden of ICAD-related stroke compared with Whites of European descent. Disparities in the prevalence of asymptomatic ICAD are less marked than with symptomatic ICAD.

Stenosis 74

Stenosis Thrombosis Dementia Stroke 74

Frontiers in Cardiovascular Medicine

JANUARY 21, 2024

Background Segmentation of cardiac structures is an important step in evaluation of the heart on imaging. There has been growing interest in how artificial intelligence (AI) methods—particularly deep learning (DL)—can be used to automate this process. Existing AI approaches to cardiac segmentation have mostly focused on cardiac MRI. This systematic review aimed to appraise the performance and quality of supervised DL tools for the segmentation of cardiac structures on CT.

Pulmonary 59

Pulmonary Research 59

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 355-365, February 1, 2024. This comprehensive literature review focuses on acute stroke related to intracranial atherosclerotic stenosis (ICAS), with an emphasis on ICAS-large vessel occlusion. ICAS is the leading cause of stroke globally, with high recurrence risk, especially in Asian, Black, and Hispanic populations.

Stenosis 66

Stenosis Stents Stent Risk Factors 66

Frontiers in Cardiovascular Medicine

JANUARY 21, 2024

Introduction Totum-070 is a combination of five plant extracts enriched in polyphenols to target hypercholesterolemia, one of the main risk factors for cardiovascular diseases. The aim of this study was to investigate the effects of Totum-070 on cholesterol levels in an animal model of diet-induced hypercholesterolemia. Methods C57BL/6JOlaHsd male mice were fed a Western diet and received Totum-070, or not, by daily gavage (1g/kg and 3g/kg body weight) for 6 weeks.

Diet 59

Diet Cholesterol Obesity Risk Factors 59

Journal of Cardiothoracic Surgery

JANUARY 21, 2024

Acute type A aortic dissection is treated with an emergency procedure that uses ascending aortic replacement (AAR). However, to avoid a residual dissected aorta with a false lumen, total arch replacement (TAR).

Aortic 52

Aortic Research 52

Dr. S. Venkatesan MD

JANUARY 21, 2024

High-density lipoproteins (HDLs) represent a class of lipids, very heterogeneous in structure, composition, and biological functions.The density is between 1.063 to 1.210. It has at least 5 sub-types. Normal HDL level in blood should be above 35mg (50-60mg Ideal). When it goes beyond 60 there is not much benefit to accrue and also some surprise findings are there.

Cholesterol 52

Cholesterol Cardiovascular Disease Article Diabetes 52

Journal of Cardiothoracic Surgery

JANUARY 21, 2024

Delirium is a common postoperative complication among patients who undergo Stanford Type A aortic dissection (TAAD). It is associated with increased mortality, as well as other serious surgical outcomes. This.

Aortic 52

Aortic Risk Factors Outcomes 52

The American Journal of Cardiology

JANUARY 21, 2024

Publication date: Available online 20 January 2024 Source: The American Journal of Cardiology Author(s): William R. Miranda, Alexander C. Egbe, Alexander Van De Bruaene, Heidi M. Connolly, Luke J. Burchill, C.

Exercise 52

Exercise 52

HCPLive

JANUARY 21, 2024

Patients with uveitis switched from adalimumab originator to SB5 did not experience clinically significant differences in treatment efficacy and safety.

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Circulation

JANUARY 21, 2024

Circulation, Volume 149, Issue 4 , Page 332-334, January 23, 2024.

Circulation 78

Circulation 78

HCPLive

JANUARY 21, 2024

These data suggest the promise of morphine for cough among those with idiopathic pulmonary fibrosis, though longer term research may be necessary.

Pulmonary 52

Pulmonary Research 52

HeartRhythm

JANUARY 21, 2024

The optimal technique for venous access (VA) in cardiac implantable electronic device (CIED) implant procedures is unclear1. Ultrasound guided (US) axillary VA has been established as a safe, effective, and efficient technique for CIED implantation2. Optimal technique for US guided axillary VA requires imaging and puncture of the “extrathoracic portion” of the axillary vein2.

Ultrasound 45

Ultrasound 45

HCPLive

JANUARY 21, 2024

Roger A Levy, MD, PhD, discusses the recent guideline updates regarding the treatment and management of lupus nephritis.

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Frontiers in Cardiovascular Medicine

JANUARY 21, 2024

Background and aims Epidemiology of atherosclerotic cardiovascular disease might be different in patients with polygenic hypercholesterolemia plus high levels (≥30 mg/dl) of Lp(a) (H-Lpa) than in those with polygenic hypercholesterolemia alone (H-LDL). We compared the incidence of peripheral artery disease (PAD), coronary artery disease (CAD), and cerebrovascular disease (CVD) in patients with H-Lpa and in those with H-LDL.

Cardiovascular Disease 45

Cardiovascular Disease Peripheral Arterial Disease Cerebrovascular Disease Coronary Artery Disease 45

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 344-354, February 1, 2024. Intracranial atherosclerotic disease and resultant intracranial stenosis is a global leading cause of stroke, and poses an ongoing treatment challenge. Among patients with intracranial stenosis, those with hemodynamic compromise are at high risk for recurrent stroke despite medical therapy and risk factor modification.

Stenosis 40

Stenosis Risk Factors Technology Stroke 40

European Journal of Heart Failure

JANUARY 21, 2024

Summary of study findings. HFrEF, heart failure with reduced ejection fraction; NT-proBNP, N-terminal pro-brain natriuretic peptide. Aims Sodium restriction was not associated with improved outcomes in heart failure patients in recent trials. The skin might act as a sodium buffer, potentially explaining tolerance to fluctuations in sodium intake without volume overload, but this is insufficiently understood.

Heart Failure 40

Heart Failure Blood Pressure Outcomes Research 40

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 335-343, February 1, 2024. Reducing the high risk of recurrent stroke in patients with symptomatic intracranial atherosclerotic stenosis (sICAS) has proven to be challenging, but aggressive medical management, with intensive risk factor control and antithrombotic therapy, has been shown to be beneficial. High-intensity statins are recommended for patients with atherosclerotic stroke, including sICAS.

Stenosis 40

Stenosis Blood Pressure Diet Risk Factors 40

European Journal of Heart Failure

JANUARY 21, 2024

Early changes in estimated glomerular filtration rate (eGFR) post-initiation of empagliflozin in patients with heart failure with preserved ejection fraction (HFpEF). CI, confidence interval; CV, cardiovascular; HHF, hospitalization for heart failure; HR, hazard ratio; LVEF, left ventricular ejection fraction. Aims Renal function (estimated glomerular filtration rate [eGFR]) changes early after the introduction of empagliflozin have not been described in heart failure with preserved ejection fra

Preserved Ejection Fraction 40

Preserved Ejection Fraction Heart Failure Outcomes Hospital 40

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 324-334, February 1, 2024. Intracranial atherosclerotic stenosis is a prevalent cause of ischemic stroke worldwide. Its association with silent cerebral infarcts and its contribution to cognitive impairment and dementia emphasize the critical need for disease prevention and effective management strategies. Despite extensive research on secondary stroke prevention treatment over the past several decades, intracranial atherosclerotic stenosis continues to exhibit

Stenosis 40

Stenosis Dementia Stroke Strokes 40

European Journal of Heart Failure

JANUARY 21, 2024

Myocardial perfusion in cardiac amyloidosis. Images on the left panel show an example of coronary angiography, first-pass perfusion maps and stress and rest myocardial perfusion maps of a patient with cardiac amyloidosis. The coronary angiogram is unobstructed and visual analysis of first-pass perfusion shows a global reduction in myocardial blood flow.

Coronary Angiogram 40

Coronary Angiogram Biomarkers Outcomes Research 40

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 413-422, February 1, 2024. BACKGROUND:Frail people with atrial fibrillation are often undertreated with oral anticoagulants (OACs), and evidence for the net clinical benefit (NCB) of OAC is sparse. We, therefore, examined the risk of thromboembolic events, major bleeding, and NCB of anticoagulation treatment.METHODS:This was a nationwide cohort study including frail patients aged with incident atrial fibrillation between 2013 and 2018.

Atrial Fibrillation 40

Atrial Fibrillation Stroke Strokes 40

European Journal of Heart Failure

JANUARY 21, 2024

Abstract Despite remarkable improvements in the management of heart failure (HF), HF remains one of the most rapidly growing cardiovascular condition resulting in a substantial burden on healthcare systems worldwide. In clinical practice, however, a relevant proportion of patients are treated with suboptimal combinations and doses lower than those recommended in the current guidelines.

Heart Failure 40

Heart Failure Pharmacology Physiology Article 40

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 432-442, February 1, 2024. BACKGROUND:While most European Regions perform well in global comparisons, large discrepancies within stroke epidemiological parameters exist across Europe. The objective of this analysis was to evaluate the stroke burden across European regions and countries in 2019 and its difference to 2010.METHODS:The GBD 2019 analytical tools were used to evaluate regional and country-specific estimates of incidence, prevalence, deaths, and disabi

Stroke 40

Stroke Strokes 40

European Journal of Heart Failure

JANUARY 21, 2024

Main findings of the study. Bar plots: in red, patients with low flow-low gradient (LF-LG) aortic stenosis; in blue, patients with normal flow-high gradient (HG) aortic stenosis; in black: controls. AS, aortic stenosis; AVR, aortic valve replacement; AU, arbitrary units; GDF-15, growth differentiation factor-15; GLUT, glucose transporter; IL, interleukin; MR-proADM, mid-regional pro-adrenomedullin; NF-κB, nuclear factor-κB; NHE, sodium–hydrogen exchanger, PICP, procollagen type I carboxy-termina

Stenosis 40

Stenosis Aortic Aortic valve Coronary Artery Disease 40

Circulation

JANUARY 21, 2024

Circulation, Volume 149, Issue 4 , Page 290-292, January 23, 2024.

Atrial Fibrillation 49

Atrial Fibrillation Circulation 49

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 259-259, February 1, 2024.

Stroke 40

Stroke Strokes 40

Circulation

JANUARY 21, 2024

Circulation, Volume 149, Issue 4 , Page 277-278, January 23, 2024.

Circulation 49

Circulation 49

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 452-453, February 1, 2024.

Stroke 40

Stroke Strokes 40

Circulation

JANUARY 21, 2024

Circulation, Volume 149, Issue 4 , Page 330-331, January 23, 2024.

Circulation 45

Circulation 45

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page e42-e42, February 1, 2024.

Stroke 40

Stroke Strokes 40

Circulation

JANUARY 21, 2024

Circulation, Volume 149, Issue 4 , Page 335-338, January 23, 2024.

Myocardial Infarction 45

Myocardial Infarction Pulmonary Circulation 45

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 305-310, February 1, 2024.

Atherosclerosis 40

Atherosclerosis Stroke Strokes 40

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page e33-e34, February 1, 2024.

Stroke 40

Stroke Strokes 40

Stroke Journal

JANUARY 21, 2024

Stroke, Volume 55, Issue 2 , Page 506-518, February 1, 2024. Emerging clinical and preclinical data have demonstrated that the pathophysiology of arterial ischemic stroke in the adult, neonates, and children share similar mechanisms that regulate brain damage but also have distinct molecular signatures and involved cellular pathways due to the maturational stage of the central nervous system and the immune system at the time of the insult.

Stroke 40

Stroke Strokes Outcomes 40