Wed.Feb 07, 2024

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Blood thinners added to clot-busting medication did not improve stroke outcomes

American Heart News - Stroke News

Research Highlights: Although giving blood thinners along with clot-busting medication may help in treating heart attacks, it did not improve 90-day outcomes in people with clot-caused strokes. Enrollment in a large clinical trial, which had been.

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CTA and ACC Collaborate to Tackle Cardiovascular Disease with Technology

DAIC

milla1cf Wed, 02/07/2024 - 18:05 February 7, 2024 — The Consumer Technology Association ( CTA ) and the American College of Cardiology ( ACC ) are announcing the release of their second industry framework for the use of consumer cardiovascular technology solutions in the screening and diagnosis for cardiovascular conditions. This new document builds off of the previously published Best Practices for Consumer Cardiovascular Technology Solutions in January 2022.

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Una nueva investigación científica probará la calculadora de riesgo PREVENT entre diversos grupos

American Heart News - Heart News

DALLAS, 7 de febrero de 2024 — Equipos de investigación de Northwestern University Feinberg School of Medicine, New York University y Duke University trabajarán juntos para evaluar la precisión de la nueva calculadora de riesgo PREVENTTM de la American.

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Can a Common Diabetes Drug Turn Patients' Urine Into Alcohol?

Med Page Today

(MedPage Today) -- One patient had multiple false positive toxicology tests after taking a popular diabetes drug. Despite not ingesting alcohol for over 10 months, a man in his early 60s tested positive for ethanol in his urine on the last four.

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‘Vision Loss in Later Life is not Normal’: Vision Loss Projected to Rise in Older Adults

HCPLive

Since the Baby Boomers are transitioning into older age by 2040 and 2050, the dramatic rise in the global aging population will increase demands for ophthalmic care.

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High-Risk HPV in Women Heightens Risk of Heart Disease Death

Med Page Today

(MedPage Today) -- Women with high-risk strains of human papillomavirus (HPV) had a far higher risk of death from certain types of cardiovascular disease (CVD), a prospective cohort study from Korea found. Compared to women without high-risk strains.

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Inflammation Has Little to No Effect on Safety, Effectiveness of Roxadustat for Anemia in CKD

HCPLive

According to a new systematic review and meta-analysis, roxadustat's efficacy remains consistent across varying inflammation levels in patients with chronic kidney disease.

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Clinical, Pathological Distinctions Provide Basis for Differentiating IgAN, IgAVN

HCPLive

Findings from this retrospective study help address challenges in distinguishing immunoglobulin A nephropathy from immunoglobulin A vasculitis-associated nephritis, overcoming their shared pathogenetic features.

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Anticoagulant Falls Short for Secondary Stroke Prevention in Atrial Cardiopathy

Med Page Today

(MedPage Today) -- Oral anticoagulation (OAC) was no better than low-dose aspirin for secondary stroke prevention in people with left atrial cardiopathy absent evidence of atrial fibrillation (Afib or AF), the ARCADIA trial showed. Recurrent strokes.

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ISC 2024 Late-breaking Science Finding from ZODIAC Study: Position of Head Before Surgery May Improve Stroke Patient’s Neurological Function

DAIC

Late-breaking science from a multi-center U.S. trial presented during the International Stroke Conference found that while hospital beds for stroke patients are typically elevated at the head, a flat head position before surgical removal of a blood clot in the brain (thrombectomy) may lead to better outcomes. Results of the ZODIAC trial were shared by researchers on the first day of the American Stroke Association’s ISA 2024 conference which runs through Feb. 9 in Phoenix, AZ.

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Tirzepatide Significantly Reduces HbA1c, Body Weight in Type 1 Diabetes

HCPLive

A new proof-of-concept observation study reports the dual GLP-1/GIP agonist's positive efficacy and safety for adults with T1D.

Diabetes 116
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Findings from MOST Trial Presented at ISC24: Blood thinners added to clot-busting medication did not improve stroke outcomes

DAIC

Findings from the highly-anticipated MOST (Multi-Arm Optimization of Stroke Thrombolysis) trial were presented on the first day of the American Stroke Association’s International Stroke Conference, ISC 2024, being held through Feb. 9 Phoenix, AZ. Opeolu M. Adeoye, M.D., M.S., shown here, is lead author of the study and BJC HealthCare Distinguished Professor of Emergency Medicine and chair of the department of emergency medicine at Washington University School of Medicine in St.

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Position of stroke patient’s head before surgery may improve neurological function

American Heart News - Stroke News

Research Highlights: Hospital beds for stroke patients are typically elevated at the head, however, a flat head position before surgical removal of a blood clot in the brain (thrombectomy) may lead to better outcomes. Results from a multicenter trial.

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Nerve Stimulation Plus Intense Rehab May Improve Arm and Hand Function After Stroke

DAIC

The brain has about 100 billion cells called neurons. It’s made up of distinct parts, that developed though human evolution. Copyright American Heart Association milla1cf Wed, 02/07/2024 - 18:19 February 7, 2024 — Combining brain stimulation with intense physical rehabilitation helped stroke survivors recover movement in their arms and hands and maintain these improvements for one year, according to a study to be presented at the American Stroke Association’s International Stroke Conference 2

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New research uncovers biological drivers of heart disease risk

Science Daily - Heart Disease

Over the past 15 years, researchers have identified hundreds of regions in the human genome associated with heart attack risk. However, researchers lack efficient ways to explore how these genetic variants are molecularly connected to cardiovascular disease, limiting efforts to develop therapeutics. To streamline analysis of hundreds of genetic variants associated with coronary artery disease (CAD), a team of researchers combined multiple sequencing and experimental techniques to map the relatio

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New scientific research will test PREVENT risk calculator among diverse groups

American Heart News - Heart News

DALLAS, Feb. 7, 2024 — Research teams from Northwestern University Feinberg School of Medicine, New York University and Duke University will work together to assess the accuracy of the American Heart Association’s new PREVENTTM risk calculator with.

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Convergent approach to persistent atrial fibrillation ablation: long-term single-centre safety and efficacy

Frontiers in Cardiovascular Medicine

Background Efforts to maintain sinus rhythm in patients with persistent atrial fibrillation (PsAF) remain challenging, with suboptimal long-term outcomes. Methods All patients undergoing convergent PsAF ablation at our centre were retrospectively analysed. The Atricure Epi-Sense® system was used to perform surgical radiofrequency ablation of the LA posterior wall followed by endocardial ablation.

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SGLT2 Inhibitors and False Positive Toxicology Tests

The New England Journal of Medicine

A patient with diabetes who was taking empagliflozin, an SGLT2 inhibitor, had false positive urine screening tests for ethanol in a room-temperature sample, owing to bacterial fermentation of glucose that yielded ethanol.

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Pulsed Field Ablation for Atrial Fibrillation in real-life settings: Efficacy, Safety and Lesion Durability in Patients with Recurrences

HeartRhythm

Initial findings from feasibility studies on pulsed field ablation (PFA) in the treatment of atrial fibrillation (AF) indicated high rates of efficacy and pulmonary vein (PV) isolation (PVI) durability upon systematic remapping. Nonetheless, there remains a shortage of data regarding effectiveness, lesion durability and safety of the procedure beyond the scope of feasibility studies.

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B-lines by lung ultrasound as a predictor of re-intubation in mechanically ventilated patients with heart failure

Frontiers in Cardiovascular Medicine

Introduction There have been few studies on predictors of weaning failure from MV in patients with heart failure (HF). We sought to investigate the predictive value of B-lines measured by lung ultrasound (LUS) on the risk of weaning failure from mechanical ventilation (MV) and in-hospital outcomes. Methods This was a single-center, prospective observational study that included HF patients who were on invasive MV.

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Meta-Analysis of Implantable Hemodynamic Monitors for HFrEF

American College of Cardiology

Does using implantable hemodynamic monitors (IHMs) reduce mortality and heart failure hospitalizations (HFHs) in patients with heart failure and reduced ejection fraction (HFrEF)?

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A nomogram for predicting left atrial thrombus or spontaneous echo contrast in non-valvular atrial fibrillation patients using hemodynamic parameters from transthoracic echocardiography

Frontiers in Cardiovascular Medicine

Background Atrial fibrillation (AF) is the most common cardiac arrhythmia and is associated with a high risk of stroke. This study was designed to investigate the relationship between hemodynamic parameters and left atrial thrombus/spontaneous echo contrast (LAT/SEC) in non-valvular atrial fibrillation (NVAF) patients and establish a predictive nomogram that integrates hemodynamic parameters with clinical predictors to predict the risk of LAT/SEC.

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Stephen Harrison, MD: Promising Phase 3 Data for Resmetirom in NASH, Fibrosis

HCPLive

Stephen Harrison, MD, discusses results from the phase 3 MAESTRO-NASH trial, highlighting resmetirom’s safety and efficacy for NASH resolution and fibrosis improvement.

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Dynamic arterial elastance as a predictor of arterial pressure response to norepinephrine weaning in mechanically ventilated patients with vasoplegic syndrome—a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

Introduction During the de-escalation phase of circulatory shock, norepinephrine weaning may induce diverse arterial pressure responses in patients with different vasomotor tones. Dynamic arterial elastance (Ea dyn ) has been extensively studied to predict the arterial pressure response to interventions. We conducted this meta-analysis to systematically assess the predictive performance of Ea dyn for the mean arterial pressure (MAP) response to norepinephrine weaning in mechanically ventilated p

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Predictive Model Detects Hyperuricemia Risk in Patients Treated with Aspirin

HCPLive

According to the analysis, eGFR, BMI, and waist circumference were the most important factors for hyperuricemia in individuals taking aspirin.

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Relationship between peri-coronary inflammation and coronary vascular function in patients with suspected coronary artery disease

Frontiers in Cardiovascular Medicine

Background In this study, we aim to investigate the relationship between the attenuation of peri-coronary adipose tissue (PCAT) in patients with suspected coronary artery disease (CAD) and the assessment of coronary vascular functions using coronary flow reserve (CFR). Methods We included 364 patients who underwent 13 N-NH 3 positron emission tomography/computed tomography and coronary computed tomography angiography (CCTA).

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Arrhythmic Risk in Biventricular vs. Left Bundle Branch Area Pacing

American College of Cardiology

Is there a difference in the occurrence of sustained ventricular tachycardia (VT) or ventricular fibrillation (VF) and new-onset atrial fibrillation (AF) between patients undergoing biventricular pacing (BVP) versus left bundle branch area pacing (LBBAP)?

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Spontaneous coronary artery dissection in women in the generative period: clinical characteristics, treatment, and outcome—a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

Introduction Spontaneous coronary artery dissection (SCAD) is a non-traumatic and non-iatrogenic separation of the coronary arterial wall. Materials and methods This systematic review and meta-analysis is reported following the PRISMA guidelines and is registered in the PROSPERO database. A literature search was focused on female patients in generative period (16–55 of age) with acute coronary syndrome (ACS) caused by SCAD, and comparison from that database NP-SCAD (spontaneous coronary artery d

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Cardiorenal effectiveness of empagliflozin vs. glucagon-like peptide-1 receptor agonists: final-year results from the EMPRISE study

Cardiovascular Diabetology

No randomized clinical trials have directly compared the cardiorenal effectiveness of empagliflozin and GLP-1RA agents with demonstrated cardioprotective effects in patients with a broad spectrum of cardiovasc.

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Sarcopenia, sarcopenic obesity, and arterial stiffness among older adults

Frontiers in Cardiovascular Medicine

Background Aging is associated with a higher prevalence of sarcopenia, sarcopenic obesity (SO), and increased arterial stiffening, with possible detrimental effects on morbidity and mortality. The aim of this study was to assess the relationships between sarcopenia, SO, and different indexes of arterial stiffness in older adults. Methods A total of 77 hospitalized patients (mean age 78.68 ± 9.65 years) were evaluated, obtaining anthropometric variables, biochemical samples, handgrip test, and bo

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Simple and secure thrombectomy without circulatory arrest for acute pulmonary embolism

Journal of Cardiothoracic Surgery

Surgical pulmonary artery thrombectomy is a well-established emergency treatment for massive pulmonary embolism (PE) in which fibrinolysis or thrombolysis are not effective. However, surgery for massive PE tha.

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Metabolomic profiling reveals key metabolites associated with hypertension progression

Frontiers in Cardiovascular Medicine

Introduction Pre-hypertension is a prevalent condition among the adult population worldwide. It is characterized by asymptomatic elevations in blood pressure beyond normal levels but not yet reaching the threshold for hypertension. If left uncontrolled, pre-hypertension can progress to hypertension, thereby increasing the risk of serious complications such as heart disease, stroke, kidney damage, and others.

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Association between atherogenic index of plasma control level and incident cardiovascular disease in middle-aged and elderly Chinese individuals with abnormal glucose metabolism

Cardiovascular Diabetology

The atherogenic index of plasma (AIP) and cardiovascular disease (CVD) in participants with abnormal glucose metabolism have been linked in previous studies. However, it was unclear whether AIP control level a.

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Modified blade: an interventional option in rigid bronchoscopy for non-resectable benign tracheal stenosis

Journal of Cardiothoracic Surgery

Benign tracheobronchial stenosis is a abnormal tracheal lumen narrowing that may incur progressive dyspnea and life-threatening hypoxemia. There is no consensus on which patients should be treated with endosco.

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Medtronic LINQ Insertable Cardiac Monitors Prove Cost-effective Compared to Standard of Care in Ischemic Stroke Patients with Suspected Atrial Fibrillation

DAIC

milla1cf Wed, 02/07/2024 - 18:26 February 7, 2024 — Medtronic announced new cost-effectiveness data from the STROKE AF clinical study, which showed that continuous monitoring with the Medtronic Reveal LINQ insertable cardiac monitor (ICM) is significantly more cost-effective than the standard of care in ischemic stroke patients with large artery and small vessel disease.

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Prognostic value of right ventricular free-wall longitudinal strain in patients with pulmonary hypertension: systematic review and meta-analyses

Open Heart

Background Right ventricular (RV) dysfunction is associated with adverse outcomes in patients with pulmonary hypertension (PH). This systematic review and meta-analysis evaluated the prognostic value of RV free-wall longitudinal strain (RVfwLS), compared with other RV parameters in PH. Methods We searched for articles presenting the HR of two-dimensional RVfwLS in PH.

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MOST: Blood Thinners Lack Improvement in Ischemic Stroke Outcomes

HCPLive

Blood thinners added to clot-busting medication did not improve 90-day stroke outcomes, leading to early discontinuation of the MOST trial.

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