Thu.Jun 20, 2024

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Is Cholesterol Denialism Pseudoscience or Appropriate Medical Care?

Med Page Today

(MedPage Today) -- Recently, a cardiologist published a commentary in Medscape arguing that physicians and scientists who challenge the putative clinical benefit of statin medications are pseudoscientists. He claimed, ".somewhere along the way.

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Hot enough for ya? It may be too hot for your heart health!

American Heart News - Heart News

DALLAS, June 20, 2024 — It’s only the first day of summer and record high temperatures are already being reported across much of the U.S. That’s prompted the American Heart Association, celebrating a century of lifesaving service as the world’s leading.

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Lupus Complications Reduced With Common Diabetes Drug

Med Page Today

(MedPage Today) -- People with systemic lupus erythematosus (SLE) had lower rates of lupus nephritis, chronic kidney disease, and other complications when they were taking metformin, an analysis of medical records indicated. Among some 88,000.

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Microbot Medical Partners with Brigham and Women's Hospital for Its Pivotal Human Clinical Trial

DAIC

milla1cf Thu, 06/20/2024 - 19:42 June 20, 2024 — Microbot Medical Inc. announced its agreement with Brigham and Women’s Hospital ( BWH ), a leading academic medical center located in Boston, Massachusetts, to serve as one of the sites to perform the pivotal human clinical trial for its LIBERTY Endovascular Robotic Surgical System , as part of its Investigational Device Exemption (“IDE”) application.

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CYP2C19 Genetic Testing for Oral P2Y12 Inhibitor Therapy: A Scientific Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. There is significant variability in the efficacy and safety of oral P2Y12 inhibitors, which are used to prevent ischemic outcomes in common diseases such as coronary and peripheral arterial disease and stroke. Clopidogrel, a prodrug, is the most used oral P2Y12 inhibitor and is activated primarily after being metabolized by a highly polymorphic hepatic cytochrome CYP2C219 enzyme.

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Promising Long- and Short-term Clinical Data Show Potential of First ASD Occluder with a Bioresorbable, Metal-free Frame

DAIC

The reSept ASD Occluder has a bioresorbable, metal-free frame milla1cf Thu, 06/20/2024 - 19:39 June 20, 2024 — atHeart Medical , a medical device company establishing a new standard of care for atrial septal defects (ASDs) closure, announced promising long and short-term clinical outcomes of its reSept ASD occluder , to be presented at the medical conference CSI Frankfurt.

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Treatment of Asthma in Pediatric Patients

HCPLive

Robert Sporter, MD, explores the differences in treatment approaches between adult and pediatric populations, focusing on allergy-based asthma treatments such as allergen immunotherapy and biologics, and their specific applications in managing asthma in children.

More Trending

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Katie Ross-Driscoll, PhD, MPH: Disparities in Liver Transplant Referral, Evaluation

HCPLive

Ross-Driscoll explains how disparities in the liver transplant process begin prior to waitlisting and how findings from her research on referral and evaluation may inform interventions.

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HonorHealth Research Institute Study Uses New Programing for Pacemakers to Control High Blood Pressure Without Additional Drugs

DAIC

milla1cf Thu, 06/20/2024 - 19:40 June 20, 2024 — A programing algorithm, being tested by HonorHealth Research Institute for those patients with new or recently installed pacemakers, is designed so the device not only provides a steady heartbeat, but also controls high blood pressure. A recently opened clinical trial called BACKBEAT (BradycArdia paCemaKer for Blood prEssure treAtmenT) aims to use Medtronic’s Astra and Azure model pacemakers to not only treat slow heart rates but also delivers

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Zerlasiran Provides Significant Lp(a) Reductions at 48 Weeks, Phase 2 Data Shows

HCPLive

Zerlasiran, a siRNA agent, significantly reduced lipoprotein(a) levels by approximately 90% at 48 weeks in high-risk cardiovascular patients, per phase 2 data from Silence Therapeutics.

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Philips Showcases FDA-approved Zenition 90 Motorized at the 2024 Vascular Annual Meeting

DAIC

mtaschetta-millane Thu, 06/20/2024 - 08:32 June 19, 2024 — Royal Philips , a global leader in health technology, today announced the launch of Philips Image Guided Therapy Mobile C-arm System 9000 – Zenition 90 Motorized , designed to help clinicians deliver high-quality care to more patients. Philips is partnering with its customers to improve productivity.

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Early Data Shows CAR T Cell Therapy May Lead to Autoimmune Disease Remission

HCPLive

Two patients with autoimmune diseases from 2 phase ½ RESET trials had complete B cell depletion within 15 days post-infusion with CABA-201 and needed no additional medication.

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Which surrogate insulin resistance indices best predict coronary artery disease? A machine learning approach

Cardiovascular Diabetology

Various surrogate markers of insulin resistance have been developed, capable of predicting coronary artery disease (CAD) without the need to detect serum insulin. For accurate prediction, they depend only on g.

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Study Suggests Interferon-Beta Likely Not a Trigger for Psoriasis

HCPLive

These data do not support the idea that interferon-beta works as a trigger for psoriasis, though it may have a different influence on psoriasis among those with MS versus those without MS.

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Thirty-three-year follow-up of pseudoaneurysm of the mitral-aortic intervalvular fibrosa without surgical treatment: a case report and literature review

Journal of Cardiothoracic Surgery

Pseudoaneurysm of the mitral-aortic intervalvular fibrosa (PMAIF) is a rare complication of infective endocarditis or aortic valve surgery. Surgical treatment is suggested, but the long-term follow-up of conse.

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Household Air Pollution Linked to Anemia Risk in Pregnant Women

HCPLive

Exposure to carbon monoxide correlated with lower odds of anemia prevalence, whereas exposure to fine particulate matter had the opposite effect.

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Atherosclerosis Updates from the 92nd EAS Congress

Cardiometabolic Health Congress

The EAS 2024 Congress (May 26-29, 2024) has concluded, providing critical insights into atherosclerosis and related vascular disease. Here are some notable highlights: Prof. Giovanna Liuzzo (Italy) revealed that advancements in noninvasive imaging recently allow for direct visualization of coronary atherosclerotic plaques. This has major potential to refine risk stratification and enhance patient management.

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GRAVITI: Positive Topline Results for Guselkumab SC Induction in Crohn’s Disease

HCPLive

Positive topline results showed guselkumab (Tremfya) SC induction therapy met all primary and secondary endpoints, suggesting similar clinical benefit to IV induction seen in GALAXI.

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Atrium heart institute 1st in world to use new stent system

Becker's Hospital Review - Cardiology

Charlotte, N.C.-based Atrium Health Sanger Heart & Vascular Institute has become the first in the world to implant a new Duo venous stent system.

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Inflammatory Risk and CV Events in Patients Without Obstructive CAD

American College of Cardiology

Does coronary arterial inflammation drive cardiac mortality or major adverse cardiac events (MACE) in patients with or without coronary artery disease (CAD), and can an artificial intelligence (AI)-Risk prognostic algorithm be used as an alternative to traditional risk factor-based calculators to enhance clinical management?

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Study Reveals Gender Disparities in Long-Term Lipid Management After ACS for FH Patients

HCPLive

An analysis of patients with acute coronary syndrome shows women receive less lipid-lowering therapy and are less likely to meet LDL-C targets than men.

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Association between atherogenic index of plasma and new-onset stroke in individuals with different glucose metabolism status: insights from CHARLS

Cardiovascular Diabetology

Circulating atherogenic index of plasma (AIP) levels has been proposed as a novel biomarker for dyslipidemia and as a predictor of insulin resistance (IR) risk. However, the association between AIP and the inc.

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Aortic arch de-branching for suspected expanding perigraft haematoma after previous acute type-A dissection repair with AMDS stent: a technique for a potential future problem

Journal of Cardiothoracic Surgery

Acute Stanford type- A aortic dissections make up a large part of emergency cardiac surgery. They also carry a significant burden of morbidity. New techniques to aid aortic remodelling include the Ascyrus Medi.

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Impact of pretransplant T2DM on left ventricular deformation and myocardial perfusion in heart transplanted recipients: a 3.0 T cardiac magnetic resonance study

Cardiovascular Diabetology

Pretransplant type 2 diabetes mellitus (T2DM) is associated with increased cardiovascular and all-cause mortality after heart transplant (HT), but the underlying causes of this association remain unclear. The.

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Echocardiographic features of a giant aneurysm of membranous ventricular septum

Journal of Cardiothoracic Surgery

We describe the echocardiographic features of a 22-year-old female with a giant aneurysm of membranous ventricular septum (AMVS). Both transthoracic echocardiography (TTE) and transesophageal echocardiography.

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Atopic March in Pediatric Patients

HCPLive

Shahzad Mustafa, MD, examines the pediatric atopic march, a phenomenon characterized by the sequential development of wheezing, asthma, and food allergies in children, discussing the progression and interrelationship of these conditions. He also explores the potential benefits of early intervention with medications in managing these conditions in pediatric patients.

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Treatment of chronic mini-thoracotomy wound pain and lung herniation with intercostal cryoablation and surgical mesh repair: a case report

Journal of Cardiothoracic Surgery

The incidence of minimally invasive heart surgery via mini-thoracotomy (MT; right anterior thoracotomy) is on the rise, accompanied by an increase in post-MT intercostal nerve neuralgia and the risk of lung he.

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Biologic Discontinuation: Older Versus Younger Patients with Psoriasis

HCPLive

These data highlight rates of biologic treatment discontinuation in younger adult patients versus elderly patients, with comparisons drawn between IL-23 inhibitors and IL-17 inhibitors as well.

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The Surprising Way AI Is Reshaping Cardiac Ultrasound

Cassling

Artificial intelligence is evolving healthcare in innumerable ways. Though the public at large currently pictures consumer-focused tools like ChatGPT and the Dall-E image generator when they think of AI, a myriad of AI-based applications are being implemented in the background of healthcare systems around the country, improving patient outcomes and enhancing the workflows of providers everywhere.

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Filgotinib Demonstrates Early, Durable PRO Improvements in RA

HCPLive

A greater proportion of patients in the FIL 200 mg group achieved meaningful patient-reported response compared with placebo.

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Influence of ABC stroke score on late recurrence of paroxysmal atrial fibrillation following radiofrequency catheter ablation

Journal of Cardiothoracic Surgery

In this study we investigated the impact of ABC stroke score on the recurrence of paroxysmal atrial fibrillation (PAF) following radiofrequency catheter ablation (RFCA).

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Universal Newborn Screening Pivotal for Sickle Cell Disease Outcomes

HCPLive

Early detection from a universal newborn screening program in Canada significantly reduced disease-related burden in children with SCD.

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Intravascular Ultrasound Versus Angiography-Guided Drug-Coated Balloon Angioplasty

American College of Cardiology

The goal of the ULTIMATE III trial was to evaluate intravascular ultrasound (IVUS)-guided drug-coated balloon angioplasty compared with angiography-guided drug-coated balloon angioplasty among patients with de novo coronary lesions.

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8 out of 10 Patients with RA Achieve Sustained Remission at Month 12 with Upadacitinib

HCPLive

Among patients with RA who achieved remission at month 6, between 79.1% and 84.9% were able to sustain remission at month 12.

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FFR/iFR: Are the Published Cutoffs Applicable in Athletes?

American College of Cardiology

Invasive assessments of coronary physiology have revolutionized the approach to coronary revascularization in the cardiac catheterization laboratory.

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Pulsed-field is not inferior to thermal ablation regarding atrial remodeling in patients with paroxysmal atrial fibrillation

HeartRhythm

Atrial fibrillation (AF) is associated with left-atrial (LA) dilatation and reduced LA function and LA strain with further deterioration following the transition from paroxysmal to persistent AF.1 While influences of AF ablation with cryoballoon (CB) or radiofrequency (RF) have shown decreased LA volume index (LAVI) and improved LA strain after 3-months of follow-up (3Mo), data on pulsed-field ablation (PFA) is scarce.2,3 Cardiac magnetic resonance imaging studies demonstrated recovery of atrial

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Sacubitril/Valsartan vs. Valsartan and Symptomatic Hypotension

American College of Cardiology

Is there an association of sacubitril/valsartan versus valsartan, with symptomatic hypotension among patients who were enrolled in PARAGLIDE-HF trial?

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