Mon.May 27, 2024

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Chest pain: Are these really "Nonspecific ST-T wave abnormalities", as the cardiologist interpretation states?

Dr. Smith's ECG Blog

Written by Jesse McLaren, with a very few edits by Smith A 60-year-old presented with chest pain. The ECG did not meet STEMI criteria, and the final cardiology interpretation was “ST and T wave abnormality, consider anterior ischemia”. But are there any other signs of Occlusion MI? There’s only minimal ST elevation in III, which does not meet STEMI criteria of 1mm in two contiguous leads.

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Anemia Increases Risk of End-Stage Kidney Disease in IgA Nephropathy

HCPLive

An analysis of more than 800 IgAN patients treated from 2002-2021 provides an overview of factors associated with anmeia as well as its impact on pgronosis.

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EuroPCR 2024 Highlights

Cardiology Update

EuroPCR is the annual official congress of the European Association of Percutaneous Cardiovascular Interventions (EACPI). EuroPCR 2024 was held 14-17 May in Paris, France. In this episode Dr. Chadi Alraies discusses the top 10 sessions from EuroPCR 2024. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram.

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Jonathan Barratt, MD: Matching-Adjusted Indirect Comparisons of eGFR slopes for IgAN Treatments

HCPLive

Jonathan Barratt, MD, discusses a matching-adjusted indirect comparison of sparsentan and irbesartan against standard of care plus optimized RASI.

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Aficamten reduces symptoms in obstructive hypertrophic cardiomyopathy

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 May 2024; doi:10.1038/s41569-024-01044-8 Data from the SEQUOIA-HCM trial show that aficamten, a cardiac myosin inhibitor, increases exercise capacity and improves quality of life in patients with symptomatic obstructive hypertrophic cardiomyopathy.

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Fadi Fakhouri, MD, PhD: Pegcetacoplan in Post-Transplant C3 Glomerulopathy and IC-MPGN

HCPLive

Fadi Fakhouri, MD, PhD, discusses the 1-year results of the NOBLE trial examining use of pegcetacoplan in patients with post-transplant C3G or IC-MPGN.

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Plozasiran, an RNA Interference Agent Targeting APOC3, for Mixed Hyperlipidemia

The New England Journal of Medicine

This phase 2b trial of a short interfering RNA that targets APOC3 showed substantive dose-dependent lowering of triglyceride levels.

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Homemade pericardial bifurcated graft for Q fever-infected abdominal aortic aneurysm open repair: a case report

Frontiers in Cardiovascular Medicine

Q fever is a zoonotic infection caused by Coxiella burnetii. In rare cases, it can lead to vascular complications, including infected aneurysms. Successful treatment involves surgery and antibiotics, but there is no established consensus or clear recommendation for the choice of material graft. We report a case of abdominal aortic aneurysm infected by C. burnetii treated by open surgery with complete resection of the aneurysm and homemade bovine pericardial bifurcated graft reconstruction and lo

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Zigakibart 52-Week Data Demonstrate Potential in IgA Nephropathy

HCPLive

Jonathan Barratt, MD, discusses the 52-week data from the phase 1/2 trial of zigakibart, which was presented at the 61st European Renal Association Congress.

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Short- and long-term performance of risk calculation tools for mortality in patients with acute coronary syndrome

Frontiers in Cardiovascular Medicine

BackgroundThe mortality rate of acute coronary syndrome (ACS) remains high. Therefore, patients with ACS should undergo early risk stratification, for which various risk calculation tools are available. However, it remains uncertain whether the predictive performance varies over time between risk calculation tools for different target periods. This study aimed to compare the predictive performance of risk calculation tools in estimating short- and long-term mortality risks in patients with ACS,

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Bariatric metabolic surgery more effective than GLP1R agonists in preventing congestive HF

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 28 May 2024; doi:10.1038/s41569-024-01042-w In patients with type 2 diabetes mellitus and obesity, bariatric metabolic surgery is associated with a lower risk of the incidence of first-ever congestive heart failure than treatment with glucagon-like peptide 1 receptor agonists, according to a new study.

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Fistula of the mitral-aortic intervalvular fibrosa in a patient with bacterial endocarditis: a case report and systematic literature review

Journal of Cardiothoracic Surgery

A fistulous tract in the mitro-aortic intervalvular fibrosa (MAIVF) is a rare entity, which presents as a complication of endocarditis or surgical trauma. Generally, it is associated to a pseudoaneurysm of the.

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Low Remnant Cholesterol and Subsequent Risk of New-Onset Atrial Fibrillation: A Prospective Cohort Study

HeartRhythm

Atrial fibrillation (AF) is a common arrhythmia with high morbidity and mortality implications. Several studies have described a paradoxical inverse relationship between serum cholesterol and the risk of AF, but it remains unknown whether remnant cholesterol (RC) is associated with AF incidence.

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Evolving Cardiac Safety in Drug Discovery: Time for Immunology Integration

Circulation

Circulation, Volume 149, Issue 22 , Page 1704-1707, May 28, 2024.

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Non–chest pain symptoms and likelihood of coronary occlusion in emergency department patients with ST segment elevation undergoing emergent coronary angiography

Coronary Artery Disease Journal

Objectives Patients presenting with suspected ST segment elevation myocardial infarction frequently have symptoms in addition to chest pain, including dyspnea, nausea or vomiting, diaphoresis, and lightheadedness or syncope. These symptoms are often regarded as supporting the diagnosis of infarction. We sought to determine the prevalence of the non–chest pain symptoms among patients who were confirmed as having a critically diseased coronary vessel as opposed to those with no angiographic culpri

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Double Whammy Complicating Management of Pulmonary Hypertension

Circulation

Circulation, Volume 149, Issue 22 , Page 1770-1774, May 28, 2024.