Mon.Jul 08, 2024

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In Parkinson's Disease, Cognitive Symptoms Often Emerge Soon After Diagnosis

Med Page Today

(MedPage Today) -- About a third of people with Parkinson's disease reported cognitive symptoms early in the disease course, a large cross-sectional study showed. Of 25,000 Fox Insight study participants who had a Parkinson's diagnosis for a median.

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Combining popular diabetes drugs offers complementary heart and kidney benefits

Science Daily - Heart Disease

New research shows combined use of sodium glucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP1-RAs) is likely to offer additional protection against heart and kidney disease in patients with diabetes.

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Which Anticoagulant Is Safest for Afib Patients With Cirrhosis?

Med Page Today

(MedPage Today) -- Apixaban (Eliquis) was associated with lower serious bleeding rates than rivaroxaban (Xarelto) or warfarin in patients with cirrhosis and atrial fibrillation (AF, Afib) in a nationwide cohort study. Among more than 12,000 such.

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Ep 196 Pediatric Meningitis Recognition, Workup and Management

ECG Cases

In this episode: recognition, risk stratification, decision tools, indications for lumbar puncture in the febrile pediatric patient, tips and trick on performing LPs in children, and ED management of pediatric meningitis. We answer such questions as: what are the test characteristics of the various clinical features of meningitis across various ages?

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Tirzepatide Bests Semaglutide for Real-World Weight Loss

Med Page Today

(MedPage Today) -- In formulations indicated for type 2 diabetes, tirzepatide (Mounjaro) yielded more weight loss than semaglutide (Ozempic) in people with overweight or obesity, according to real-world data. In the first 3 months on treatment.

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How A New Cardiovascular Suite is Strengthening the Heart of Community Healthcare in Iowa

Cassling

Time is muscle. This common phrase is well-known to healthcare providers in the ED who have been called upon to treat a heart attack. The longer you take to stabilize the heart, the higher the risk of long-term damage to the patient’s heart. "Time is muscle” was the impetus for the new $6 million cardiovascular suite at Methodist Jennie Edmundson Hospital in Council Bluffs, Iowa.

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Differences in Binding Affinity Between Integrase Inhibitors in HIV

HCPLive

An infectious disease specialist discusses the differences in binding affinity between dolutegravir and bictegravir and how it informs treatment selection.

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Half of US counties lack a cardiologist: New study

Becker's Hospital Review - Cardiology

Nearly 50% of all U.S. counties do not have a single practicing cardiologist, most of which are in rural counties where residents are most in need of higher levels of care, according to research published July 8 in the Journal of the American College of Cardiology.

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Delayed Fibromyalgia Diagnosis Linked to Worse Disease Severity

HCPLive

Fibromyalgia severity is correlated to how long the condition takes to get diagnosed, a new study showed.

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Pulsed field ablation procedures found safe and effective for atrial fibrillation patients

Medical Xpress - Cardiology

Pulsed field ablation (PFA) is safe for treating patients with common types of atrial fibrillation (AF), according to the largest study of its kind on this new technology, led by the Icahn School of Medicine at Mount Sinai.

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Updates to Guidelines Announced for Management of Atopic Dermatitis

HCPLive

These updated guidelines by the AAAAI and ACAAI Joint Task Force incorporate additional research regarding treatment options for eczema.

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Expert Panel Outlines Strategies Integrating Shared Decision-Making Into Team-Based Care

American College of Cardiology

An Expert Panel Perspective published in JACC: Advances proposes best practice recommendations for integrating shared decision-making (SDM) as part of multidisciplinary team-based care delivery.

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Brain organ plays key role in adult neurogenesis

Science Daily - Stroke

Research found the choroid plexus and cerebrospinal fluid play a key role in maintaining a pool of newly born neurons to repair the adult brain after injury.

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Prospective Comparison of ARNI With ACEI to Determine Impact on Global Mortality and Morbidity in Heart Failure

American College of Cardiology

The goal of the PARADIGM-HF trial was to evaluate treatment with the combined neprilysin inhibitor (sacubitril)/angiotensin-receptor blocker (valsartan) (LCZ696) compared with enalapril among participants with heart failure due to reduced ejection fraction (EF).

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Tirzepatide Bests Semaglutide in Real-World Weight Loss Analysis

HCPLive

A study of 18,000 patients showed tirzepatide (Mounjaro) led to more significant weight loss than semaglutide (Ozempic) in adults with overweight or obesity.

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No Practicing Cardiologist in Nearly Half of US Counties, Despite Higher CV, Mortality Risk

American College of Cardiology

A new analysis helps to define the geographic disparities in access to cardiovascular care, finding that 46.3% (1,454) of all U.S. counties, comprising 22 million residents, do not have a practicing cardiologist.

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Mirna Chehade, MD, MPH: “Exciting” Phase 3 Data for Dupilumab in Pediatric Eosinophilic Esophagitis

HCPLive

Chehade reviews key findings from the phase 3 EoE kids trial and how they inform dupilumab’s use in children 1-11 years of age with eosinophilic esophagitis.

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Pulsed field ablation procedures found safe and effective for atrial fibrillation patients

Science Daily - Heart Disease

Pulsed field ablation (PFA) is safe for treating patients with common types of atrial fibrillation (AF), according to a new study.

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Active Disease at 3 Months Predicts Poorer Long-Term Outcomes in JIA

HCPLive

Older children (aged >5 years) with JIA exhibited a 40% to 45% higher point prevalence of active disease at month 12 when compared with younger patients.

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Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias

Frontiers in Cardiovascular Medicine

BackgroundHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI models, representing a major hurdle to translation. Our group previously reported that these arrhythmias arise from a focal mechanism whereby graft tissue functions as an ectopic pacemaker; therefore, we hypothesized that hPSC-CMs engineered w

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Treatment Guidelines and Regimens for Managing Patients with HIV

HCPLive

Sorana Segal-Maurer, MD, provides an overview of treatment guidelines for the management of patients with HIV and provides insights on currently available therapeutic regimens.

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A Patient’s Journey Through Sudden Heart Failure to a Life-Saving Heart Transplant

CTVS

One of the most common health issues facing men is heart disease. A precursor to heart attacks and heart failure, heart disease continues to be the leading cause of death in men over recent years. Unfortunately, even if you are presumably healthy, with no history or obvious symptoms of heart disease, it still may be there. If you think it can’t happen to you, think again.

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Managing Adverse Effects in HE Treatment

HCPLive

Medical experts discuss the management of patients with hepatic encephalopathy (HE) receiving lactulose and rifaximin therapy and develop diarrhea or a urinary tract infection (UTI) in the outpatient setting.

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CTVS Celebrates Physician Recognition

CTVS

Nothing makes us prouder at CTVS than when our physicians are recognized by fellow peers in the medical community and professional achievement. This year we are pleased to share that not one, but two of our specialists have been named as Texas Monthly Super Doctors Rising Stars, cardiothoracic surgeon Dr. Brendan P. Dewan and vascular surgeon Dr. Nicolas Zea.

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Intravascular Lithotripsy Outcomes in Contemporary PCI

American College of Cardiology

What are the trends and outcomes of coronary intravascular lithotripsy (IVL), rotational/orbital atherectomy, or both among patients who underwent percutaneous coronary intervention (PCI) in Michigan?

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Patient Support Program May Decrease Rates of Adalimumab Discontinuation Among Patients with IMIDs

HCPLive

Discontinuation was less likely in the prospective Patient Support Program (PSP) group compared with the retrospective non-PSP group.

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Prospective Comparison of ARNI With ARB Global Outcomes in HF With Preserved Ejection Fraction

American College of Cardiology

The goal of the PARAGON-HF trial was to evaluate the neprilysin-angiotension receptor inhibitor sacubitril/valsartan among patients with heart failure with preserved ejection fraction (HFpEF).

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Overview of Outpatient Strategies for Optimizing Patient Outcomes in HE

HCPLive

The expert panel on hepatic encephalopathy (HE) presents clinical recommendations for managing patients with recurrent or episodic HE in the outpatient setting.

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Study Calls For Targeted Strategies For Managing Diabetic Cardiomyopathy Across Racial, Ethnic Groups

American College of Cardiology

Distinct racial and ethnic variations in baseline characteristics among patients with diabetic cardiomyopathy (DbCM), underscore the need for personalized and targeted strategies for managing overall care and outcomes.

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M. Safwan Badr, MD: Novel Treatments for Central Sleep Apnea in Last 10 Years

HCPLive

Emerging treatments for CSA include hypochlorite phrenic nerve stimulation and pharmacological intervention, Badr told HCPLive.

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What families need to know about inherited high cholesterol in children

Medical Xpress - Cardiology

Many parents think of high cholesterol as a health concern that only affects adults. But did you know that around one in 250 children have elevated cholesterol levels that aren't related to diet, exercise or lifestyle?

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Study Highlights Efficacy of Dupilumab for Atopic Dermatitis in Head, Neck Regions

HCPLive

These findings confirm the ways in which patient responses in the head and neck areas contribute to modifications in life quality among those with eczema.

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Analysis finds almost half of US counties have no cardiologists despite higher prevalence of CV risk factors, mortality

Medical Xpress - Cardiology

Disparities in cardiovascular disease outcomes between urban and rural areas continue to widen, yet nearly half of U.S. counties do not have a practicing cardiologist. According to an analysis published in the Journal of the American College of Cardiology (JACC), these counties tend to be more rural and socioeconomically disadvantaged, with a greater burden of cardiovascular disease, thus highlighting deep geographic disparity in access to cardiovascular care.

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PI*SS Genotype Linked to Decreased Risk of AATD-Related Lung Disease

HCPLive

Compared to individuals with the PI*ZZ genotype, those with PI*SS had a lower risk of lung disease, increased lung function, and better quality of life.

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PET scans can offer faster, clearer images for diagnosing heart disease

Medical Xpress - Cardiology

When it comes to diagnostic imaging of your heart—such as MRI, CT, SPECT, PET—it can be overwhelming to know what kind of scan is right for you. What is your doctor looking for, and what exactly does the imaging show?

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Genentech Announces Reintroduction of Susvimo for Wet AMD

HCPLive

Marking the end of a voluntary recall, the FDA approved updates to Susvimo regarding the ocular implant and refill needle.

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What Are the Long-Term Effects of Dual vs. Single Antiplatelet Therapy After Coronary-Artery Bypass Grafting?

NEJM Journal Watch - Cardiology

Long-term follow-up of a clinical trial from China suggests a lower risk for major adverse cardiovascular events with dual antiplatelet therapy.