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Researchers from Mass General Brigham and collaborating institutions have developed a non-invasive approach to manipulate cardiac tissue activity by using light to stimulate an innovative ink incorporated into bioprinted tissue. Their goal is to develop a technique that can be used to repair the heart. Their findings in preclinical models, published in Science Advances, show the transformative potential of non-invasive therapeutic methods to control electrically active tissues.
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.
Panelists discuss how dysbiosis of the lung microbiome can exacerbate chronic obstructive pulmonary disease (COPD) through increased inflammation and altered immune responses. In contrast, chest CT imaging is indicated for patients with severe COPD, suspected comorbidities, surgical planning, or unexplained symptoms despite standard treatment. These factors highlight the complexity of COPD management.
tim.hodson Fri, 01/24/2025 - 11:51 Jan. 24, 2025 In-patients undergoing coronary artery bypass grafting (CABG), a novel analysis evaluating surgeon preference for multi- versus single-arterial grafting may help explain the differing results between prior retrospective analyses and randomized controlled trials regarding long-term survival. A study presented at The Society of Thoracic Surgeons 61st Annual Meeting explores findings in more than a million U.S.
Fully published results from Athos Therapeutics AZALEA-TIMI 71 trial for its novel Factor XI inhibitor abelacimab, confirming the drugs lower bleeding risks, but leaving researchers uncertain about its ability to prevent stroke in AFib patients. Current guidelines recommend direct-acting oral anticoagulants (DOACs) for AF because they reduce ischemic stroke with a lower risk of brain hemorrhage.
tim.hodson Fri, 01/24/2025 - 11:03 Jan. 22, 2025 Anthos Therapeutics, Inc., aclinical-stage biopharmaceutical company developing therapies to treatcardiovascular metabolic diseases, founded by Blackstone Life Sciences, has published the results of the landmark AZALEA-TIMI 71 study in the January 23 issue of the New England Journal of Medicine (NEJM).
Wars and scientific debates do not end that easily. Parallel to the Vietnam war days of 1970s to the current Ukraine-Russia conflict of 2025, one silent academic war is going on, in the conflict-ridden corridors of cardiology and cardiac surgery. (The CASS study of 1970s to the ORBITA era of 2025) Any amount of scientific literature, debates, guidelines, failed to tick the right choice of revascularisation in chronic CAD.
A specially designed drug prevented laboratory mice from developing heart failure after heart attacks, according to new research from Cedars-Sinai. This discovery could lead to new treatments to prevent heart failure, a serious cardiac condition that develops in up to 30% of heart attack survivors within one year.
A specially designed drug prevented laboratory mice from developing heart failure after heart attacks, according to new research from Cedars-Sinai. This discovery could lead to new treatments to prevent heart failure, a serious cardiac condition that develops in up to 30% of heart attack survivors within one year.
GLP-1 RA initiation boosted new thyroid cancer diagnoses, compared with other anti-diabetic drugs, but enhanced early detection may have played a role.
With a recent surge in influenza, COVID-19, norovirus, respiratory syncytial virus (RSV), and other respiratory viruses, it's critical to pay close attention to your heart and symptomsespecially if you have heart disease or the risk factors for it. That's the message from experts at Mount Sinai Fuster Heart Hospital during American Heart Month.
This class 2 recall by FDA officials of almost 3000 First Aid Beauty brand face moisturizers resulted from deviation from Current Good Manufacturing Practice regulations.
Women who experienced any of five major adverse pregnancy outcomes have increased risk of heart failure (HF) up to 46 years later and need early preventive actions and long-term clinical care to reduce that risk.
A new study sheds light on one of the most severe consequences of stroke: damage to the brain's 'cables'-- the so-called nerve fibers -- which leads to permanent impairments.
The Supreme Court recently agreed to hear a case about adolescent e-cigarette use and the FDAs role in addressing it. A ruling against the FDA could have implications for its authority and for public health.
Assessment of vessel lesions using optical ultrasonic flow ratio (OUFR) based on hybrid intravascular ultrasound-optical coherence tomography (IVUS-OCT) is safe and effective and provided better diagnostic performance vs. fractional flow reserve (FFR) than OUFR based on either IVUS or OCT alone.
Short-term exposure to ozone (O3) pollution may reduce oxygen availability, prompting compensatory increases in red blood cell count (RBC) and hemoglobin (HGB), which exacerbate arterial stiffness, according to a study published Jan. 22 in JACC.
Abnormal changes in P-wave parameters indicative of atrial electrical remodeling often manifest earlier than changes in other indicators reflecting atrial structural remodeling in paroxysmal atrial fibrillation.
I am a fan of using low-carb diets for both weight loss and improving metabolic health. Low-carb diets have consistently shown benefits in improving these parameters 1. Over the last few years, it seems, according to most social media, that if you are not going ‘Low Carb, ’ you are seriously risking your health. But Let Me Tell You A Story.
The updated clinical practice guideline addresses new research and clinical developments since the first iteration of the guideline was released in 2014.
Factors associated with 30-day readmission were shorter hospital stays after transplant, insurance status, and patient history of diabetes and malignancy.
In this weeks View, Dr. Eagle looks at left atrial appendage occlusion for stroke prevention in patients with AFib. He then discusses a new treatment for severe hypertrophic cardiomyopathy in children. Finally, Dr. Eagle explores anticoagulation for patients who are hospitalized with COVID-19.
This class 2 recall of almost 3000 First Aid Beauty brand face moisturizers resulted from deviation from Current Good Manufacturing Practice regulations.
Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:Intravascular imaging (IVI) is widely recognized to improve outcomes after percutaneous coronary intervention (PCI). However, IVI is underutilized and is not yet established as a performance measure for quality PCI.METHODS:We examined temporal trends of IVI use for all PCIs performed at Veterans Affairs hospitals in the United States from 2010 to 2022 using retrospective observational cohorts.
ABSTRACT Introduction A leadless pacemaker (LLPM) was recommended for a patient with intermittent complete heart block and near-syncope. Methods and Results Delivery of LLPM is through a large sheath that has limited deflection and steerability. This report describes the successful deployment of a ventricular LLPM in a patient with prior surgical correction of AV septal defect with subsequent significant right atrial enlargement.
Stroke, Ahead of Print. Cardiovascular diseases such as stroke are a major cause of morbidity and mortality for patients with chronic kidney disease (CKD). The underlying mechanisms connecting CKD and cardiovascular disease are yet to be fully elucidated, but inflammation is proposed to play an important role based on genetic association studies, studies of inflammatory biomarkers, and clinical trials of anti-inflammatory drug targets.
ABSTRACT Background Pulsed-field ablation (PFA) is an innovative non-thermal method for arrhythmia treatment. The efficacy of various PFA configurations in relation to contact force (CF) has not been well-studied in vivo. Objectives This study evaluated the effect of CF on acute bipolar PFA lesions in both a vegetal and an in vivo porcine heart model.
ABSTRACT Introduction Permanent implantation of a DF-4 implantable cardiac defibrillator (ICD) lead in the left bundle branch area (LBBA-ICD) is the next paradigm in amalgamating cardiac resynchronization therapy (CRT) and defibrillation. We systematically investigated feasibility/success rate, procedural caveats, and complications associated with a permanent DF-4 LBBA ICD implant and pertinent data at short-term follow-up.
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