Tue.Sep 10, 2024

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Like father, like daughter

Science Daily - Heart Disease

When they become fathers, men who have an unhealthy, high-cholesterol diet can cause increased risk of cardiovascular disease, or CVD, in their daughters, a mouse study has found.

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Patients with IBS Report Treatment Dissatisfaction, Lack of Symptom Control

HCPLive

Findings highlight disease burden and ongoing unmet needs in patients with IBS-C and IBS-D, suggesting the benefit of prescription medications on rates of satisfaction and symptom control.

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Experimental blood test predicts risk for developing COPD, other severe respiratory diseases

Science Daily - Heart Disease

A scientific team has created a preclinical blood test to identify adults most likely to develop severe respiratory conditions, including chronic obstructive pulmonary disease (COPD). The blood test analyzes 32 proteins that scientists determined accurately predicted an adult with an increased likelihood for requiring medical care for or dying from severe respiratory illness.

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EM Quick Hits 59 Traumatic Coronary Artery Dissection, Proper Use of Insulin, Mesenteric Ischemia, Exercise Associated Hyponatremia, AI for OMI

ECG Cases

On this month's EM Quick Hits podcast: Ian Chernoff on the often elusive diagnosis of traumatic coronary artery dissection, Anand Swaminathan on proper use of insulin in DKA and in hyperkalemia, Brit Long and Hans Rosenberg on mesenteric ischemia pearls and pitfalls in diagnosis and management, Dave Jerome on recognition and management exercise-associated hyponatremia and heat illness and Jesse McLaren on the Queen of Hearts AI model in helping identify occlusion MI on ECG.

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Atheroimmunology: keeping the immune system in atherosclerosis in check

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 11 September 2024; doi:10.1038/s41569-024-01075-1 The immune response is not unlike a game of chess, with white and black pieces playing opposing roles and orchestrating an opening, a middle and an endgame of innate immunity, adaptive immunity and resolution, respectively. After decades of research, the study of atheroimmunology has brought the first therapeutics to the clinic.

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World Stroke Organization, Philips Release Paper on Expanding Access to Stroke Care

DAIC

tim.hodson Tue, 09/10/2024 - 13:18 Sept. 10, 2024 — Royal Philips and the World Stroke Organization (WSO) have published a policy paper calling for a revolution in stroke care to make a real difference to the lives of millions and bring significant economic benefits worldwide. Strokes affect an estimated 12 million people globally every year, including an increasing number of young people.

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Liraglutide Helped Cut BMI in Kids With Obesity as Young as 6

Med Page Today

(MedPage Today) -- Liraglutide (Saxenda) added to lifestyle intervention helped reduce BMI in young children with obesity, the phase IIIa SCALE Kids trial found. By week 56, kids, ages 6 to <12 years, on once-daily 3-mg liraglutide lost 5.8.

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Weekly Insulin Efsitora Noninferior to Daily Degludec in Type 1, Type 2 Diabetes

Med Page Today

(MedPage Today) -- An investigational once-weekly insulin was noninferior to a daily option for patients with type 2 diabetes, but proved risky for those with type 1 diabetes, the phase III QWINT-2 and -5 trials showed. In insulin-naive patients.

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CMR Before Invasive Coronary Angiography in Suspected NSTEMI

American College of Cardiology

Is early cardiac magnetic resonance (CMR) prior to an invasive coronary angiogram (ICA) in patients with suspected non–ST-segment elevation myocardial infarction (NSTEMI) useful?

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Triglyceride-glucose index correlates with the occurrence and prognosis of acute myocardial infarction complicated by cardiogenic shock: data from two large cohorts

Cardiovascular Diabetology

Triglyceride-glucose (TyG) index, a dependable indicator of insulin resistance, has been identified as a valid marker regarding multiple cardiovascular diseases. Nevertheless, the correlation of TyG index with.

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New Report Reveals 1 Fracture Occurs Every Minute in France’s Population

HCPLive

Fragility fractures occur every minute in France, totaling 500,000 annually. A report calls for expanding fracture liaison services to address the growing osteoporosis burden.

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The role of body composition in left ventricular remodeling, reverse remodeling, and clinical outcomes for heart failure with mildly reduced ejection fraction: more knowledge to the “obesity paradox”

Cardiovascular Diabetology

Although the “obesity paradox” is comprehensively elucidated in heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), the role of body composition in left v.

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MetALD Associated with 30% Greater Risk of Cancer-Related Mortality than MASLD

HCPLive

Findings underscore the importance of alcohol cessation in patients with steatotic liver disease, suggesting a synergistic effect between steatosis and alcohol on disease progression.

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Mendelian randomization analysis reveals causal effects of blood lipidome on gestational diabetes mellitus

Cardiovascular Diabetology

Observational studies have revealed associations between maternal lipid metabolites and gestational diabetes mellitus (GDM). However, whether these associations are causal remain uncertain.

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Deepak Bhatt, MD, MPH, MBA: SGLT2 Offers Kidney Protective Benefit in Post-MI Population

HCPLive

Deepak Bhatt, MD, MPH, MBA, discusses the results of a prespecified analysis of the EMPACT-MI trial examining the effect across the spectrum of baseline kidney function.

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Probing erythrocytes as sensitive and reliable sensors of metabolic disturbances in the crosstalk between childhood obesity and insulin resistance: findings from an observational study, in vivo challenge tests, and ex vivo incubation assays

Cardiovascular Diabetology

Although insulin resistance (IR) is among the most frequent and pathogenically relevant complications accompanying childhood obesity, its role in modulating and exacerbating obesity pathophysiology has not yet.

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ATSN-101 Gene Therapy Reports Positive Data in Phase 1/2 Trial

HCPLive

ATSN-101 was well tolerated 12 months after treatment and demonstrated on average, a 100-fold improvement in vision, with some improved by 10,000-fold.

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Identification of potential therapeutic targets from bioinformatics analysis of necroptosis and immune infiltration in acute myocardial infarction

Journal of Cardiothoracic Surgery

Acute myocardial infarction (AMI) is a serious, deadly disease with a high incidence. However, it remains unclear how necroptosis affects the pathophysiology of AMI. Using bioinformatic analyses, this study in.

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Defibrillator Positioning; PFA for PVC Ablation; Harvey Weinstein's Heart Surgery

Med Page Today

(MedPage Today) -- Not all defibrillator pad positions may work equally well for patients with shockable out-of-hospital cardiac arrest. (JAMA Network Open) Medical therapy for aortic stenosis? Early clinical data on evogliptin were disappointing.

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Application of preset coronary artery orifice patch in Bentall surgery

Journal of Cardiothoracic Surgery

Bentall surgery is the main method for treating aortic root lesions, but traditional Bentall method is very difficult for patients with mild aortic sinus dilation to directly anastomose the coronary artery ori.

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Prolocor, Slingshot Bioscience Publish Paper on Prognostic Tool to Help Assess Thrombosis Risk

DAIC

tim.hodson Tue, 09/10/2024 - 13:34 Sept. 5,2024 - Prolocor, Inc. and Slingshot Biosciences recently announced the publication in Bioanalysis of the results from their analytic validation testing titled: "Assessing Prognosis by Quantifying FcγRIIa on Fixed Platelets." “Prolocor is excited to advance this new prognostic tool to guide clinical decision making.

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A retrospective study on safety and efficacy of recombinant human soluble thrombomodulin to acute aortic dissection with disseminated intravascular coagulation

Journal of Cardiothoracic Surgery

Recombinant human soluble thrombomodulin (rTM) has recently been used as a promising therapeutic natural anti-coagulant drug for disseminated intravascular coagulation (DIC). Here we investigated the safety an.

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Coping Methods, Lack of Support Are Predictors of Self-Stigma for Patients with Skin Disease

HCPLive

These findings resulted from a systematic literature review highlighting the impact of stigma and lack of support on self-image for patients with eczema, psoriasis, HS, and other conditions.

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Latest echocardiogram guidelines recommend ultrasound contrast agent

Becker's Hospital Review - Cardiology

"Discover the latest guidelines from the European Society of Cardiology for managing chronic coronary syndromes, including the strong recommendation for using u

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Endocrinology Month in Review: August 2024

HCPLive

The endocrinology month in review for August 2024 spotlights 6 pieces of major pipeline news or regulatory announcements as well as multiple episodes of Diabetes Dialogue.

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Understanding the Optimal Evaluation and Management of Patients With HF: An Interview with Drs. Januzzi and Stevenson

American College of Cardiology

In this episode, Dr. Jim Januzzi interviews guideline author Dr. Lynne Stevenson on the importance of understanding the optimal evaluation and management of patients with heart failure.

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Mirtazapine Fails to Ease Breathlessness in New Study Despite Previous Hopes

HCPLive

A phase 3 trial found mirtazapine ineffective in reducing breathlessness in respiratory disease patients, urging caution with off-label antidepressant use.

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Sotagliflozin and Health Status in Worsening HF

American College of Cardiology

What are the effects of sotagliflozin versus placebo on heart failure (HF)-related health status?

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Lifetime Statin Therapy Cost-Effective, Improves Senior Health Outcomes

HCPLive

Lifetime statin treatment increased quality-of-life-adjusted survival in men and women aged ≥70 years with and without previous CVD in the United Kingdom.

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Understanding electrical pulmonary vein antrum for paroxysmal atrial fibrillation: Further look into super high-density electroanatomic mapping of the left atrium

HeartRhythm

Isolation line placed at the pulmonary vein antrum (PVA) area is superior to ostium level in atrial fibrillation (AF) control. However, less is known about the electrophysiological characteristics of PVA.

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Small Subset of Patients With Fibromyalgia Improved After Septoplasty

HCPLive

Although only 9 patients with FM and nasal septum deviation were included in the study, none met the criteria for fibromyalgia after surgery.

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Multi-arm Optimization of Stroke Thrombolysis

American College of Cardiology

The goal of the MOST trial was to evaluate argatroban vs. eptifibatide vs. placebo among patients with acute ischemic stroke treated with intravenous thrombolytic therapy.

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Alvin Wells, MD, PhD: Informing Treatment Strategy for Rheumatic Disease With PrismRA

HCPLive

Wells discussed the PrismRA blood test, which may benefit planning treatment regimens for patients with rheumatic disease.

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Culturally Adapted Lifestyle Intervention for South Asian Adults With Cardiovascular Risk Factors

JAMA Cardiology

The SAHELI randomized clinical trial among South Asian adults compares the effectiveness of a culturally adapted, group-based counseling intervention with written health education materials for reducing cardiovascular disease risk factors.

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Study Reaffirms Efficacy of Baricitinib Treatment for Patients with Alopecia Areata

HCPLive

These findings also highlight that an early response to alopecia areata treatment can be identified with trichoscopy.

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From Gadolinium to Generative AI: The Quest for Contrast-Free Cardiac Imaging

Circulation: Cardiovascular Imaging

Circulation: Cardiovascular Imaging, Ahead of Print.

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Weinstein's Emergency Condition; Georgia Doctor Killed in Crash; Cantaloupe Recalled

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Former film producer Harvey Weinstein was rushed to emergency heart surgery from Rikers Island, where he was imprisoned for sex crimes. (ABC News) James Earl Jones.

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