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When they become fathers, men who have an unhealthy, high-cholesterol diet can cause increased risk of cardiovascular disease, or CVD, in their daughters, a mouse study has found.
(MedPage Today) -- Liraglutide (Saxenda) added to lifestyle intervention helped reduce BMI in young children with obesity, the phase IIIa SCALE Kids trial found. By week 56, kids, ages 6 to <12 years, on once-daily 3-mg liraglutide lost 5.8.
A scientific team has created a preclinical blood test to identify adults most likely to develop severe respiratory conditions, including chronic obstructive pulmonary disease (COPD). The blood test analyzes 32 proteins that scientists determined accurately predicted an adult with an increased likelihood for requiring medical care for or dying from severe respiratory illness.
On this month's EM Quick Hits podcast: Ian Chernoff on the often elusive diagnosis of traumatic coronary artery dissection, Anand Swaminathan on proper use of insulin in DKA and in hyperkalemia, Brit Long and Hans Rosenberg on mesenteric ischemia pearls and pitfalls in diagnosis and management, Dave Jerome on recognition and management exercise-associated hyponatremia and heat illness and Jesse McLaren on the Queen of Hearts AI model in helping identify occlusion MI on ECG.
Findings highlight disease burden and ongoing unmet needs in patients with IBS-C and IBS-D, suggesting the benefit of prescription medications on rates of satisfaction and symptom control.
(MedPage Today) -- An investigational once-weekly insulin was noninferior to a daily option for patients with type 2 diabetes, but proved risky for those with type 1 diabetes, the phase III QWINT-2 and -5 trials showed. In insulin-naive patients.
Nature Reviews Cardiology, Published online: 11 September 2024; doi:10.1038/s41569-024-01075-1 The immune response is not unlike a game of chess, with white and black pieces playing opposing roles and orchestrating an opening, a middle and an endgame of innate immunity, adaptive immunity and resolution, respectively. After decades of research, the study of atheroimmunology has brought the first therapeutics to the clinic.
tim.hodson Tue, 09/10/2024 - 13:18 Sept. 10, 2024 — Royal Philips and the World Stroke Organization (WSO) have published a policy paper calling for a revolution in stroke care to make a real difference to the lives of millions and bring significant economic benefits worldwide. Strokes affect an estimated 12 million people globally every year, including an increasing number of young people.
tim.hodson Tue, 09/10/2024 - 13:18 Sept. 10, 2024 — Royal Philips and the World Stroke Organization (WSO) have published a policy paper calling for a revolution in stroke care to make a real difference to the lives of millions and bring significant economic benefits worldwide. Strokes affect an estimated 12 million people globally every year, including an increasing number of young people.
Circulation, Ahead of Print. Early identification of kidney dysfunction in patients with advanced heart failure is crucial for timely interventions. In addition to elevations in serum creatinine, kidney dysfunction encompasses inadequate maintenance of sodium and volume homeostasis, retention of uremic solutes, and disrupted endocrine functions. Hemodynamic derangements and maladaptive neurohormonal upregulations contribute to fluctuations in kidney indices and electrolytes that may recover with
Is early cardiac magnetic resonance (CMR) prior to an invasive coronary angiogram (ICA) in patients with suspected non–ST-segment elevation myocardial infarction (NSTEMI) useful?
Triglyceride-glucose (TyG) index, a dependable indicator of insulin resistance, has been identified as a valid marker regarding multiple cardiovascular diseases. Nevertheless, the correlation of TyG index with.
Deepak Bhatt, MD, MPH, MBA, discusses the results of a prespecified analysis of the EMPACT-MI trial examining the effect across the spectrum of baseline kidney function.
In this episode, Dr. Jim Januzzi interviews guideline author Dr. Lynne Stevenson on the importance of understanding the optimal evaluation and management of patients with heart failure.
Fragility fractures occur every minute in France, totaling 500,000 annually. A report calls for expanding fracture liaison services to address the growing osteoporosis burden.
Although the “obesity paradox” is comprehensively elucidated in heart failure (HF) with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF), the role of body composition in left v.
Findings underscore the importance of alcohol cessation in patients with steatotic liver disease, suggesting a synergistic effect between steatosis and alcohol on disease progression.
Observational studies have revealed associations between maternal lipid metabolites and gestational diabetes mellitus (GDM). However, whether these associations are causal remain uncertain.
ATSN-101 was well tolerated 12 months after treatment and demonstrated on average, a 100-fold improvement in vision, with some improved by 10,000-fold.
Although insulin resistance (IR) is among the most frequent and pathogenically relevant complications accompanying childhood obesity, its role in modulating and exacerbating obesity pathophysiology has not yet.
Acute myocardial infarction (AMI) is a serious, deadly disease with a high incidence. However, it remains unclear how necroptosis affects the pathophysiology of AMI. Using bioinformatic analyses, this study in.
Bentall surgery is the main method for treating aortic root lesions, but traditional Bentall method is very difficult for patients with mild aortic sinus dilation to directly anastomose the coronary artery ori.
(MedPage Today) -- Not all defibrillator pad positions may work equally well for patients with shockable out-of-hospital cardiac arrest. (JAMA Network Open) Medical therapy for aortic stenosis? Early clinical data on evogliptin were disappointing.
Recombinant human soluble thrombomodulin (rTM) has recently been used as a promising therapeutic natural anti-coagulant drug for disseminated intravascular coagulation (DIC). Here we investigated the safety an.
tim.hodson Tue, 09/10/2024 - 13:34 Sept. 5,2024 - Prolocor, Inc. and Slingshot Biosciences recently announced the publication in Bioanalysis of the results from their analytic validation testing titled: "Assessing Prognosis by Quantifying FcγRIIa on Fixed Platelets." “Prolocor is excited to advance this new prognostic tool to guide clinical decision making.
A phase 3 trial found mirtazapine ineffective in reducing breathlessness in respiratory disease patients, urging caution with off-label antidepressant use.
"Discover the latest guidelines from the European Society of Cardiology for managing chronic coronary syndromes, including the strong recommendation for using u
Isolation line placed at the pulmonary vein antrum (PVA) area is superior to ostium level in atrial fibrillation (AF) control. However, less is known about the electrophysiological characteristics of PVA.
Lifetime statin treatment increased quality-of-life-adjusted survival in men and women aged ≥70 years with and without previous CVD in the United Kingdom.
The goal of the MOST trial was to evaluate argatroban vs. eptifibatide vs. placebo among patients with acute ischemic stroke treated with intravenous thrombolytic therapy.
The endocrinology month in review for August 2024 spotlights 6 pieces of major pipeline news or regulatory announcements as well as multiple episodes of Diabetes Dialogue.
These findings resulted from a systematic literature review highlighting the impact of stigma and lack of support on self-image for patients with eczema, psoriasis, HS, and other conditions.
The SAHELI randomized clinical trial among South Asian adults compares the effectiveness of a culturally adapted, group-based counseling intervention with written health education materials for reducing cardiovascular disease risk factors.
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