Wed.Oct 02, 2024

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1 in 4 Americans will develop heart failure: What healthcare leaders should know

Becker's Hospital Review - Cardiology

One in 4 Americans (24%) will develop heart failure in their lifetime, according to a new report published Sept. 24 in the Journal of Cardiac Failure.

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Metabolic Accelerator Shows Promise for Weight Loss Side of Obesity-HFpEF Equation

Med Page Today

(MedPage Today) -- The novel investigational weight loss agent HU6 had mixed results specifically targeting obesity-related heart failure with preserved ejection fraction (HFpEF), based on the small HuMain-HFpEF trial. After 19 weeks on daily.

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HBV Treatment Eligibility Greater in New WHO Guidelines Than Other International Guidelines

HCPLive

Compared with other international guidelines, the 2024 World Health Organization HBV guidelines had the highest treatment eligibility rates.

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New Study Highlights Life-Saving Impact of Guideline-Directed Medical Therapy in Heart Failure Patients

DAIC

tim.hodson Wed, 10/02/2024 - 11:54 Heart failure is a rapidly growing public health issue that can be difficult to manage on a global scale. But there are tools that exist that can improve outcomes, such as guideline-directed medical therapy (GDMT). New UCLA-led research highlights the important role that these guidelines can play in reducing mortality rates for individuals suffering from heart failure with reduced ejection fraction (HFrEF), a type of heart failure affecting an estimated 29 mill

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There Is A Better Way To Assess & Manage Heart Disease.

Dr. Paddy Barrett

When it comes to assessing and managing the risk of heart disease, we all know that as a healthcare system, we could do better. The main takeaway from Tuesday’s email was that patients want a proper risk assessment, advanced testing, and a plan. I attempt to meet these requirements for my patients and for those going through the Heart Health Formula.

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New cardiovascular disease risk marker discovered in older women

Medical Xpress - Cardiology

Researchers at Karolinska Institutet have identified a new potential risk marker for cardiovascular disease in women. A new study shows an association between low levels of an anti-inflammatory antibody and the risk of heart attack and coronary heart disease.

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Hematology Month in Review: September 2024

HCPLive

This month in review highlights vitamin D supplementation in anemia, the prevalence of iron deficiency in US adults, and the efficacy of rpFVIII in treating acquired hemophilia A.

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EMBARK-HFpEF Trial Flexes Mavacamten’s HF Potential

CardiacWire

A new HFpEF treatment might be on the horizon, after results from the EMBARK-HFpEF trial showed that BMS’ hypertrophic cardiomyopathy treatment, mavacamten (Camzyos), safely improved key HFpEF symptoms and biomarkers. Mavacamten is the only cardiac myosin inhibitor with FDA approval to treat obstructive HCM, and works by reducing heart muscle contraction and improving blood flow.

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Global study highlights the life-saving impact of guideline-directed medical therapy in heart failure patients

Medical Xpress - Cardiology

Heart failure is a rapidly growing public health issue that can be difficult to manage on a global scale. But there are tools that exist that can improve outcomes, such as guideline-directed medical therapy (GDMT).

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Falls Among Older Adults Pose a Greater Economic Burden Than Firearm Deaths

HCPLive

A recent study found that after 2019, the combined cost of fatal falls among people aged ≥ 45 exceeded firearm injury costs, highlighting the economic burden of senior falls.

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New cardiovascular disease risk marker discovered in older women

Science Daily - Heart Disease

Researchers have identified a new potential risk marker for cardiovascular disease in women. A new study shows an association between low levels of an anti-inflammatory antibody and the risk of heart attack and coronary heart disease.

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UMass taps international partner for AI, stroke care project

Becker's Hospital Review - Cardiology

Worcester, Mass.-based UMass Chan Medical School has partnered with South Korea-based Hallym University on an AI application to expand healthcare access for rural stroke patients.

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Sickle Cell Disease May Play Role in Childhood Lead Poisoning Cases

HCPLive

An analysis of NYC’s lead registry data from 2005 to 2019 revealed a potential association between sickle cell disease and childhood lead poisoning.

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Use of ultra-low contrast dose CT aortography for the management of aortic aneurysmal disease

Journal of Cardiothoracic Surgery

Computed tomography aortography (CTA) is used in the assessment of aortic pathologies and planning of surgical intervention. However, its dependence on iodinated contrast can result in development of contrast-.

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TCFA : The stylish caps of Atherosclerotic plaques are getting disproportionate attention.

Dr. S. Venkatesan MD

One of my colleagues was joking ,nowadays patients force us to read or even educate us. I completely concurred with him. Doctor, do you have any investigation to know how much the total plaque burden is in my coronary artery? Yes. Sure , we have many modalities, right from CT calcium to OCT, NIR, etc. How would I know , which one of them is high risk and vulnerable ?

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Association between inflammatory biomarkers and postoperative acute kidney injury after cardiac surgery in patients with preoperative renal dysfunction: a retrospective pilot analysis

Journal of Cardiothoracic Surgery

Acute kidney injury (AKI) represents a significant post-cardiac surgery complication, particularly prevalent among individuals with pre-existing renal dysfunction. Chronic kidney disease (CKD) is frequently ac.

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Deucravacitinib Effective Across All Endpoints at Week 16 for Scalp Psoriasis

HCPLive

The phase 3b/4 findings from PSORIATYK SCALP suggest that oral deucravacitinib led to significant improvements for patients with scalp psoriasis.

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Surgical repair of “Swiss Cheese” ventricular septal defects with two-patch and right ventricular apex-exclusion technique: mid-term follow-up results

Journal of Cardiothoracic Surgery

"Swiss Cheese" ventricular septal defects represent a serious congenital heart disease with suboptimal clinical outcomes and a lack of consensus regarding its management. This study presents mid-term follow-up.

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New Research Identifies Predictive Changes in Joint Microenviroment Prior to RA Onset

HCPLive

The data also support the validity of further research into targeting CD-40 signaling in patients with RA not responding to treatment.

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Analysis of the therapeutic effect of right mid-axillary approach in the surgical treatment of ASD and VSD in children

Journal of Cardiothoracic Surgery

To compare the therapeutic effects of right vertical infra-axillary thoracotomy (RVIAT) and Standard Median Sternotomy (SMS) in the repair of atrial septal defect (ASD) and ventricular septal defect (VSD), and.

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Ashfaq Marghoob, MD: Artificial Intelligence, Smartphone Use for Pigmented Lesion Classification

HCPLive

This segment of Marghoob’s interview featured a discussion of pigmented lesion identification and use of technology such as AI.

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Myocardial Scarring and SCD in Young HCM Patients

American College of Cardiology

What is the association between late gadolinium enhancement (LGE) on cardiac magnetic resonance imaging (cMRI) and sudden cardiac death (SCD) in pediatric patients with hypertrophic cardiomyopathy (HCM), and does it add to pediatric SCD risk models?

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Few Patients with Abnormal Urine Protein Dipstick Results Get Follow-Up Albuminuria Testing

HCPLive

Only 6.7% of patients with an abnormal protein dipstick test result had guideline-recommended follow-up albuminuria testing.

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Isoproterenol- and Pacing-Induced Changes of J Waves Unrelated to Idiopathic Ventricular Fibrillation.

HeartRhythm

Decades ago, an association of J waves with cardiac arrest (CA) or ventricular fibrillation (VF) was reported (1), whereas J waves have been observed in individuals in the general population. Mechanistically, J waves are thought to be mediated predominantly via increased transient outward currents (Ito) characterized by bradycardia-dependent augmentation (2-3).

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If Successful, Inclisiran Primary Prevention Trial Could Expand Patient Population by More than 22 Million

HCPLive

Rahul Aggarwal, MD, discusses how the VICTORION-1 PREVENT trial eligibility criteria apply to the general US population.

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Personal Genetic-Hypertension Odyssey From Phenotypes to Genotypes and Targets

Hypertension Journal

Hypertension, Ahead of Print. Hypertension requires increased systemic vascular resistance. Thus far, Mendelian hypertension–related genes are related to salt retention, an indirect regulatory effect. With the identification of mutated, overactive, PDE3A (phosphodiesterase 3A), we have uncovered a more direct vasoconstrictive mechanism. The autosomal-dominant syndrome features another specific phenotype, brachydactyly type E.

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Early Rheumatoid Arthritis Characteristics Have Changed Over Last 20 Years

HCPLive

More research is needed to investigate changing trends at presentation and help to inform current treatment strategies.

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Sacubitril/Valsartan in Pediatric HF (PANORAMA-HF Trial)

American College of Cardiology

What is the safety and efficacy of sacubitril/valsartan as compared with enalapril in children 1 month to

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Cardiology Month in Review: September 2024

HCPLive

The HCPLive Cardiology month in review for September 2024 spotlights ESC Congress 2024, Family Heart Global Summit, pipeline updates, and more!

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Patients undergoing emergent surgery for type A intramural hematomas or type A aortic dissections have similar outcomes

Journal of Cardiothoracic Surgery

Despite key differences in pathological processes, both Intramural Hematomas and Aortic Dissections are Acute Aortic Syndromes repaired with similar surgical technique. The objective of this study was to deter.

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Association of Anticoagulant Use With Hemorrhage Location and Etiology in Incident Spontaneous Intracerebral Hemorrhage

Stroke Journal

Stroke, Ahead of Print. BACKGROUND:It is unknown whether hypertensive microangiopathy or cerebral amyloid angiopathy (CAA) predisposes more to anticoagulant-associated intracerebral hemorrhage (AA-ICH). The purpose of our study was to determine whether AA-ICH is associated with lobar location and probable CAA.METHODS:This was a cross-sectional analysis of patients with first-ever spontaneous ICH admitted to a tertiary hospital in Boston, between 2008 and 2023.

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Family Screening in Hypertrophic Cardiomyopathy

American College of Cardiology

What is the diagnostic yield of screening relatives of hypertrophic cardiomyopathy (HCM) patients and predictive factors for HCM development during long-term follow-up in relatives from gene-elusive families?

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Additional Data From SEQUOIA-HCM Presented at HFSA Annual Scientific Meeting

DAIC

tim.hodson Wed, 10/02/2024 - 11:08 Sept. 30, 2024 — Cytokinetics, Inc. recently announced that additional analyses synthesizing data from SEQUOIA-HCM ( S afety, E fficacy, and Q uantitative U nderstanding of O bstruction I mpact of A ficamten in HCM ), the Phase 3 clinical trial of aficamten in patients with symptomatic obstructive hypertrophic cardiomyopathy (HCM), were presented virtually at the Heart Failure Society of America (HFSA) Annual Scientific Meeting by Martin Maron, M.D.,

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Research explores genetic treatment for rare arrhythmias

Medical Xpress - Cardiology

Variants in a gene that plays a key role in heart function can cause potentially life-threatening arrhythmia syndromes known as calmodulinopathy.

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Hospital Survival After AAA Repair, Myocardial Fibrosis and Aortic Stenosis, MRA Use in HF

American College of Cardiology

In this week’s View, Dr. Eagle looks at sex-specific differences in alive hospital discharge following abdominal aortic aneurysm (AAA) repair.

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Some Epilepsy Drugs Tied to Cardiovascular Events in Older People

Med Page Today

(MedPage Today) -- An association between epilepsy and cardiovascular events (CVEs) in older people was likely largely due to the use of enzyme-inducing antiseizure medications (EIASM), according to a prospective cohort study from Canada. Among.

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