Wed.May 08, 2024

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FDA Warns on Insulin Pump Problem

Med Page Today

(MedPage Today) -- A mobile app used with an insulin pump that led to 224 injuries was recalled by Tandem Diabetes Care, the FDA announced today. The recall is for the 2.7 version of the Apple iOS t:connect mobile app, used in conjunction with.

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America’s CKM Syndrome Problem

CardiacWire

A new JAMA study revealed that a shocking 90% of US adults are at risk of developing cardiovascular-kidney-metabolic (CKM) syndrome, underscoring the need for preventative action before we face a wave of CKM-related heart disease. Officially published by the AHA six months ago, CKM syndrome defines the connections and risks associated with obesity, type 2 diabetes, chronic kidney disease, and cardiovascular disease.

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Ultrasound Neuromodulation Shows Promise to Treat Pulmonary Hypertension, Feinstein Institutes Research

DAIC

Feinstein Institutes’ Dr. Stavros Zanos is the senior author on the new bioelectronic medicine ultrasound paper. (Credit: Feinstein Institutes) milla1cf Wed, 05/08/2024 - 10:57 May 8, 2024 — Ultrasound could one day complement or even replace drugs to treat diseases. Bioelectronic medicine scientists at The Feinstein Institutes for Medical Research used noninvasive, splenic focused ultrasound stimulation (sFUS) and found they can reduce inflammation and improve symptoms of pulmonary arter

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Hypertrophic Cardiomyopathy Guidelines Add Drug Class, Endorse More Exercise

Med Page Today

(MedPage Today) -- Updates to national guidelines for the management of hypertrophic cardiomyopathy (HCM) endorse cardiac myosin inhibitor use in certain cases, greenlight more intensive physical activity, and expand treatment options for young.

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HeartFlow Announces Revolutionary Five-Year Data Demonstrating a 63 Percent Mortality Reduction with FFRCT-Guided Care in PAD Patients

DAIC

63 Percent Mortality Reduction with FFRCT-Guided Care in PAD Patients milla1cf Wed, 05/08/2024 - 11:12 May 8, 2024 — In a groundbreaking development, a study published in the Journal of Vascular Surgery reveals for the first time that coronary CTA ( CCTA ) with fractional flow reserve (FFR CT ) care significantly reduces mortality by over 60 percent at five years in patients with PAD undergoing major vascular surgery, far surpassing the current standard of care. 1 Atherosclerosis is a systemic

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Thrombectomy Led to Fewer Deaths in Patients With Acute Stroke and a Large Infarct

Med Page Today

(MedPage Today) -- In patients with acute stroke and a large infarct of unrestricted size, thrombectomy and medical care led to better functional outcomes and lower mortality compared with medical care alone, the prospective randomized LASTE trial.

Stroke 107
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4C Medical's AltaValve System Secures Dual FDA Breakthrough Device Designations, Expediting Patient Access to Advanced Mitral Valve Therapies

DAIC

milla1cf Wed, 05/08/2024 - 11:02 May 8, 2024 — 4C Medical Technologies, Inc. ("4C Medical"), a medical device company dedicated to advancing minimally invasive therapies for structural heart disease, has been granted Breakthrough Device designation by the U.S. Food and Drug Administratio n ( FDA ) for the AltaValve System , a transcatheter mitral valve replacement (TMVR) device.

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FDA Notes Safety and Quality Concerns with Getinge/Maquet Cardiovascular Devices

DAIC

mtaschetta-millane Wed, 05/08/2024 - 15:21 May 8, 2024 — The US Food and Drug Administration ( FDA ) is alerting health care providers and facilities about our continued safety and quality concerns with the following Getinge/Maquet cardiovascular medical devices: Getinge/Maquet/Datascope Cardiosave Hybrid and Rescue Intra-Aortic Balloon Pump (IABP) devices and Getinge/Maquet Cardiohelp system and HLS Sets.

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Exercise, new drug class recommended for management of hypertrophic cardiomyopathy

Science Daily - Heart Disease

Experts released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM). The guideline reiterates the importance of collaborative decision-making with patients who have HCM and provides updated recommendations for the most effective treatment pathways for adult and pediatric patients.

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Effectiveness, utilisation and cost associated with implantable loop recorders versus external monitors after ischaemic or cryptogenic stroke

Open Heart

Objective Implantable loop recorders (ILRs) are increasingly used for long-term rhythm monitoring after ischaemic and cryptogenic stroke, with the goal of detecting atrial fibrillation (AF) and subsequent initiation of oral anticoagulation to reduce risk of adverse clinical outcomes. There is a need to determine the effectiveness of different rhythm monitoring strategies in this context.

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Exercise, New Drug Class Recommended for Management of Hypertrophic Cardiomyopathy

American Heart News - Heart News

WASHINGTON and DALLAS (May 8, 2024) – The American College of Cardiology (ACC) and the American Heart Association (AHA) today released a new clinical guideline for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM). The.

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New York hospital halts open-heart surgeries

Becker's Hospital Review - Cardiology

Utica, N.Y.-based Wynn Hospital is temporarily suspending open-heart surgeries to review and strengthen the service, NBC affiliate WKTV reported May 7.

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Aspirin Hypersensitivity Guide for Cardiologists: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on aspirin hypersensitivity. This guide offers a practical approach to distinguishing and managing different types of aspirin reactions and highlights the role of interdisciplinary collaboration.

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The Art of Healing: Elevating Medical Practice Through Hands-On Training

ADN Center of Excellence

As medical professionals dedicated to the pursuit of excellence in patient care and medical knowledge, the significance of continuous learning cannot be overstated. In the ever-evolving landscape of healthcare, staying abreast of the latest advancements, techniques, and technologies is not just beneficial but essential. One crucial aspect of this ongoing educational journey is hands-on training, a cornerstone in the development and refinement of clinical skills.

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New ACC/AHA Guideline Focuses on Evaluation and Management of People With HCM

American College of Cardiology

The newest clinical guideline, released May 8 by the ACC and the American Heart Association (AHA), provides the latest evidence-based recommendations for effectively managing individuals diagnosed with hypertrophic cardiomyopathy (HCM).

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Association between triglyceride glucose-body mass index and long-term adverse outcomes of heart failure patients with coronary heart disease

Cardiovascular Diabetology

The triglyceride glucose-body mass index (TyG-BMI) is recognized as a reliable surrogate for evaluating insulin resistance and an effective predictor of cardiovascular disease. However, the link between TyG-BM.

BMI 59
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Daniel Su, MD: Value of Oral APX3330 for Diabetic Retinopathy Progression

HCPLive

Daniel Su, MD describes the promise of APX3330 for delaying or preventing diabetic retinopathy progression in a post-hoc analysis of the ZETA-1 trial.

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The Art of Healing: Elevating Medical Practice Through Hands-On Training

ADN Center of Excellence

As medical professionals dedicated to the pursuit of excellence in patient care and medical knowledge, the significance of continuous learning cannot be overstated. In the ever-evolving landscape of healthcare, staying abreast of the latest advancements, techniques, and technologies is not just beneficial but essential. One crucial aspect of this ongoing educational journey is hands-on training, a cornerstone in the development and refinement of clinical skills.

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Patients Help Develop Digital Health App to Improve Fibromyalgia-like Symptoms in Long COVID

HCPLive

These findings can be used to enhance usability of the digital health app and improve outcomes and quality of life among patients with long COVID.

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Association between the stress hyperglycemia ratio and 28-day all-cause mortality in critically ill patients with sepsis: a retrospective cohort study and predictive model establishment based on machine learning

Cardiovascular Diabetology

Sepsis is a severe form of systemic inflammatory response syndrome that is caused by infection. Sepsis is characterized by a marked state of stress, which manifests as nonspecific physiological and metabolic c.

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Unstable Housing May Be a Barrier to HCV Treatment Among People Who Inject Drugs

HCPLive

Findings suggest unstable housing may inhibit direct-acting antiviral treatment initiation in PWID with unstable housing compared to those with stable housing.

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MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1

Cardiovascular Diabetology

Dynamin-related protein 1 (Drp1) is a crucial regulator of mitochondrial dynamics, the overactivation of which can lead to cardiovascular disease. Multiple distinct posttranscriptional modifications of Drp1 have been reported, among which S-nitrosylation was recently introduced. However, the detailed regulatory mechanism of S-nitrosylation of Drp1 (SNO-Drp1) in cardiac microvascular dysfunction in diabetes remains elusive.

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Long Term Lipoprotein Apheresis Can Reduce Cardiovascular Events for Patients with Elevated Lp(a)

HCPLive

A new study highlights the potential of lipoprotein apheresis for reducing cardiovascular events in patients with elevated Lp(a).

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Pulmonary arterial hypertension related to congenital heart disease with a left-to-right shunt: phenotypic spectrum and approach to management

Frontiers in Cardiovascular Medicine

Patients with pulmonary hypertension associated with a left-right shunt include a wide spectrum of pathophysiological substrates, ranging from those characterized by pulmonary over-circulation to those with advanced pulmonary vascular disease. The former group may benefit from shunt repair in carefully selected cases but, when advanced pulmonary vascular disease has developed, defect closure should be avoided, and pulmonary vasodilators may be used to improve effort tolerance and hemodynamics.

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Ongoing Lp(a) Trials and Clinical Approaches to Treatment

HCPLive

Panelists discuss ongoing clinical trials aimed at lowering Lipoprotein(a) levels, emphasizing the importance of proactive patient testing, and referring to new guidelines recommending that everyone be tested once in their lifetime.

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Case Report of snare-assisted coaxiality optimized technique during valve deployment in patient with pure aortic regurgitation

Frontiers in Cardiovascular Medicine

In high-risk patients with pure native aortic regurgitation (PNAR), transcatheter aortic valve replacement (TAVR) remains an off-label intervention. Due to anatomical variations in the aortic root and technical challenges unique to PNAR, the transfemoral approach (TF-TAVR) requires continued accumulation of experience and technological refinement. In this context, we successfully and safely performed a snare-assisted TF-TAVR procedure for a patient with PNAR, characterized by significant aortic

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Innovations in Small Interfering RNA (siRNA) Therapy

HCPLive

Leading experts highlight the established role of PCSK9 inhibitors, such as evolocumab and alirocumab, and introduce the promising second-generation PCSK9 inhibitors, known as small interfering RNA (siRNA), which represent an innovative therapeutic approach that selectively reduces the production of specific proteins through RNA interference.

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Effects of trimetazidine on heart failure with reduced ejection fraction and associated clinical outcomes: a systematic review and meta-analysis

Open Heart

Background Despite maximal treatment, heart failure (HF) remains a major clinical challenge. Besides neurohormonal overactivation, myocardial energy homoeostasis is also impaired in HF. Trimetazidine has the potential to restore myocardial energy status by inhibiting fatty acid oxidation, concomitantly enhancing glucose oxidation. Trimetazidine is an interesting adjunct treatment, for it is safe, easy to use and comes at a low cost.

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Study Highlights Different Views Between Japanese, North Americans on Sun Protection

HCPLive

This analysis covered the different types of attitudes as well as behaviors related to sun exposure and skin cancer risk in Japan, comparing it to individuals in Europe and North America.

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What to Know About Bradycardia

AMS Cardiology

As we age, our bodies naturally start to change. This can include our hearts, which may develop conditions like bradycardia or a slow heart rate. While a slow heart rhythm might not sound concerning, it can sometimes lead to alarming symptoms and even pose severe health risks. What Is Bradycardia ? Are you wondering “ What is bradycardia ?” Bradycardia is a condition in which the heart’s rhythm is too slow.

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How Do the New HIPAA Laws Impact My Cardiology Clinic?

GEMMS

HIPAA regulations ensure every healthcare provider is accountable for the confidentiality and protection of patient data. Cardiologists deal with some of the most intimate aspects of a person’s health, from heart conditions to life-saving interventions. Cardiologists have a responsibility to safeguard patient data with the utmost care and diligence.

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Study Lays Groundwork for Potential Vaccine Customized for Children with Recurrent Eczema Flares

HCPLive

These data from investigators at Trinity College Dublin highlighted the immune response mechanisms visible in children with atopic dermatitis.

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2024 AHA/ACC/Multisociety Hypertrophic Cardiomyopathy Guideline: Key Points

American College of Cardiology

The following are key points to remember from the 2024 AHA/ACC/multisociety guideline for the management of hypertrophic cardiomyopathy (HCM).

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Endotypes and Phenotypes in Asthma

HCPLive

S Shahzad Mustafa, MD, discusses various asthma endotypes and phenotypes, considering factors such as race, age of onset, gender, BMI, and lung function test results.

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Eagle’s Eye View: The New AHA/ACC Hypertrophic Cardiomyopathy Guideline, Smoking Cessation, Embolic Stroke

American College of Cardiology

In this week’s View, Dr. Eagle looks at the new AHA/ACC Hypertrophic Cardiomyopathy Guideline, then examines a randomized clinical trial that studied smoking cessation after initial treatment failure with varenicline or nicotine.

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Comorbidities Pose Higher Risk of Severe COVID-19 Outcomes Than IMIDs

HCPLive

An IMID diagnosis or use of immunomodulatory medications were not shown to be a significant risk factor of severe COVID-19 outcomes.

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Performance of Large Language Models as a Resource for Atrial Fibrillation Patients and Providers

HeartRhythm

Large language models (LLM) are deep learning algorithms capable of performing natural language processing tasks, with open-access LLMs increasing used by the general public.1 Despite the fact that LLMs were not designed for healthcare applications and have no disclaimers regarding their use for medical advice, patients and providers use them as resources for medical questions and assistance in decision-making.