Tue.Oct 08, 2024

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Certain Arm Positions Can Lead to Inaccurate Blood Pressure Readings

Med Page Today

(MedPage Today) -- Certain arm positions -- supported on a lap or hanging by the side of the body -- led to significant overestimation of blood pressure readings compared with standardized positioning, a randomized trial in JAMA Internal Medicine.

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Caffeine intake linked to better vascular health in study

Medical Xpress - Cardiology

Consuming more caffeine may improve heart health, according to a study published in the Rheumatology journal.

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How terrible can it be to fail to recognize OMI? To whom is OMI Obvious or Not Obvious?

Dr. Smith's ECG Blog

This was sent to me by a reader who wishes to remain anonymous. A lady in her 60s came to the ER with chest discomfort and shortness of breath. She had a history of previous anterior MI treated by primary PCI to the proximal LAD. The first EKG is from 2:30 PM on the day of presentation to the ER. Smith : To me this is a blatantly obvious acute anterior OMI.

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Time-Restricted Eating Shows Promise for Metabolic Syndrome in 3-Month Trial

HCPLive

Time-restricted eating, even without calorie restriction, improved glycemic control and cardiometabolic health in patients with metabolic syndrome.

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Checkpoint Inhibitors for Lung Cancer Linked to Pulmonary Embolism

Med Page Today

(MedPage Today) -- BOSTON -- Patients with metastatic lung cancer who were treated with immune checkpoint inhibitors (ICIs) had higher odds of developing a pulmonary embolism, according to a retrospective cohort study. Among propensity-matched.

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Dual-Antiplatelet Therapy After Drug-Eluting Stenting in ACS

JAMA Cardiology

This systematic review and network meta-analysis investigates the optimal duration of dual antiplatelet therapy in patients with acute coronary syndromes (ACS) undergoing percutaneous coronary intervention with drug-eluting stents.

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Social Determinants of Health Shape Pain Outcomes in Sickle Cell Disease

HCPLive

Education and employment, social and emotional functioning, and healthcare access are notable factors influencing pain in sickle cell disease.

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Unmet Needs, Future Research in Schizophrenia and Muscarinic Agonists

HCPLive

In part 5 of 5, experts discuss ongoing unmet needs and future research priorities in schizophrenia management.

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UMass hospital cuts heart failure readmissions in half

Becker's Hospital Review - Cardiology

Southbridge, Mass.-based UMass Memorial Health-Harrington Hospital reduced the all-cause 30-day readmission for heart failure patients by 50% as part of a remote patient monitoring program with digital health company Brook Health.

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FDA Grants Breakthrough Therapy Designation to Survodutide for Noncirrhotic MASH

HCPLive

In addition to the Breakthrough Therapy Designation, Boehringer Ingelheim announced the initiation of 2 phase 3 trials in adults with MASH and fibrosis and compensated MASH cirrhosis.

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Renuka Jain, MD, FACC, Named Next BOG Chair-Elect

American College of Cardiology

The ACC has named Renuka Jain, MD, FACC, as the incoming chair-elect of its Board of Governors, beginning April 2025 following ACC.25 in Chicago, IL. She will replace David E. Winchester, MD, MS, FACC, as BOG Chair for 2026 to 2027.

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Embracing New Therapies in Schizophrenia Management: Introductions

HCPLive

In part 1 of 5, panel moderator gives an overview of the Special Report focusing on the approval of Xanomeline and tropism chloride capsules for schizophrenia.

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Team-Based Care of Women With CVD From the Preconception Through Postpartum Periods: Optimizing Preconception Cardiometabolic Conditions

American College of Cardiology

Cardiovascular disease (CVD) has been the leading cause of maternal death in the United States, with increasing rates over the past decades due to factors such as advancing age and increased CVD risk factors.

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Trial finds metabolic risk contributes to diabetes onset in people with HIV

Medical Xpress - Cardiology

For people with HIV (PWH) with low-to-moderate atherosclerotic cardiovascular disease (ASCVD) risk, metabolic risk factors contribute to new-onset diabetes mellitus (DM) among those treated with pitavastatin or placebo, according to a study published online Oct. 8 in the Annals of Internal Medicine.

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CHEST 2024: Ensifentrine Improves Lung Function, Quality of Life Regardless of COPD Severity

HCPLive

New research presented at CHEST 2024 highlights ensifentrine’s effectiveness in improving lung function, symptoms, and quality of life for COPD patients, regardless of disease severity.

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Prime Locations for AEDs; Fluctuating Lp(a); Formalized Telestroke Training?

Med Page Today

(MedPage Today) -- A study in Taiwan suggested that public automated external defibrillators (AEDs) are optimally located near bus stops and convenience stores. (Journal of the American Heart Association) Many people experienced clinically significant.

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WVU Medicine opens '1-stop-shop' cardiometabolic clinic

Becker's Hospital Review - Cardiology

Morgantown, W.Va.-based WVU Medicine has opened the first cardiometabolic clinic in West Virginia to provide more streamlined care for patients with heart disease and metabolic conditions.

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Balancing the Benefits and Risks of Xanomeline and Trospium Chloride Capsules

HCPLive

In part 4 of 5, experts discuss medication adherence to schizophrenia treatments, particularly of xanomeline and trospium choloride capsules for schizophrenia.

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The relationship between repeated measurements of HbA1c and risk of coronary events among the common haptoglobin phenotype groups: the Action for Health in Diabetes (Look AHEAD) study

Cardiovascular Diabetology

In the ACCORD study, participants with the haptoglobin (Hp) 2–2 phenotype and glycated hemoglobin (HbA1c) ≥ 8.0% had a higher risk of coronary artery disease (CAD) compared to those with HbA1c 7.0–7.9%.

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New Research Supports Universal HCV Screening Over Risk-Based Testing

HCPLive

Findings highlight HCV infection burden among people without injection drug use, a known risk factor for HCV, and call for universal testing to better capture these individuals.

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External validation and calibration of risk equations for prediction of diabetic kidney diseases among patients with type 2 diabetes in Taiwan

Cardiovascular Diabetology

Most existing risk equations for predicting/stratifying individual diabetic kidney disease (DKD) risks were developed using relatively dated data from selective and homogeneous trial populations comprising pre.

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Allergy Month in Review: September 2024

HCPLive

In the allergy news space, this Month in Review highlights some of the most significant stories covered by the editorial team.

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Report of a giant invasive, wall-penetrating cardiac lipoma

Journal of Cardiothoracic Surgery

Cardiac lipoma, a seldom-encountered benign tumor positioned beneath the endocardium, has the potential to impair electrophysiological functions. Diagnosis is principally based on imaging modalities. The uniqu.

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Early diaphragm dysfunction assessed by ultrasonography after cardiac surgery: a retrospective cohort study

Frontiers in Cardiovascular Medicine

ObjectiveApproximately 10%–70% of patients may develop diaphragmatic dysfunction after cardiac surgery, which may lead to delayed weaning from mechanical ventilation, increased ICU stays, postoperative hospitalization stays, and respiratory complications. However, its impact on prognosis and risk factors remain controversy. Therefore, we conducted a retrospective cohort study in which we evaluated diaphragmatic dysfunction in patients who underwent cardiac surgery via bedside diaphragm ultrasoun

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Expert consensus on management of STEMI: 5 things to know

Becker's Hospital Review - Cardiology

The Society of Cardiovascular Angiography and Interventions has published an expert consensus statement on the management of patients with ST-elevation myocardial infarction.

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Case Report: Multimodality imaging of a bronchogenic cyst in the interatrial septum

Frontiers in Cardiovascular Medicine

Intracardiac bronchogenic cysts (IBCs) are very rare. To date, only a few cases of IBC have been reported in the literature. We report a case of a bronchogenic cyst that arose from the interatrial septum in a 42-year-old man who presented with symptoms of palpitation. A unilocular cystic lesion of the heart was found initially on echocardiography and subsequently on computed tomography and magnetic resonance imaging.

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Chronic Use of Amiodarone Against Implantable Cardioverter-Defibrillator Therapy for Primary Prevention of Death in Patients With Chagas Cardiomyopathy Study

American College of Cardiology

The goal of the CHAGASICS trial was to evaluate implantable cardioverter-defibrillators (ICDs) compared with amiodarone among patients with chronic Chagas cardiomyopathy.

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Amlexanox reduces new-onset atrial fibrillation risk in sepsis by downregulating S100A12: a Mendelian randomization study

Frontiers in Cardiovascular Medicine

BackgroundSepsis is characterized by high morbidity and mortality rates, alongside limited therapeutic efficacy. Atrial fibrillation (AF), the most common arrhythmia, has been closely linked to sepsis in prior research. However, the specific mechanisms through which sepsis leads to new-onset AF remain poorly understood. This study focuses on identifying critical genes that are dysregulated in the development of new-onset AF within the context of sepsis, with the goal of uncovering new potential

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FDA Issues Second CRL for Dasiglucagon (Zegalogue) in Congenital Hyperinsulinism

HCPLive

The FDA's decision to issue a CRL was announced on October 08, 2024 and cites issues with the timing of the facility inspection.

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Impact of admission glucose and 30-day major adverse cardiovascular events on patients with chest pain in an emergency setting: insights from the China EMPACT registry

Frontiers in Cardiovascular Medicine

ObjectiveAlthough the association between admission glucose (AG) and major adverse cardiac events (MACE) is well-documented, its relationship with 30-day MACE in patients presenting with cardiac chest pain remains unclarified. In light of this, this study aims to examine the correlation between AG levels and the incidence of MACE in patients with chest pain in an emergency setting.Materials and methodsWe consecutively enrolled patients who presented to the emergency department for chest pain sym

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Ixekizumab as Effective, if not More Effective as TNFi, JAKi, IL-12/23i for PsA Treatment

HCPLive

An interim analysis of the PRO-SPIRIT study compared outcomes at 3 months after starting new treatments for psoriatic arthritis.

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Plasma metabolome mediates the causal relationship between immune cells and heart failure: a two-step bidirectional Mendelian randomization study

Frontiers in Cardiovascular Medicine

BackgroundPrior research has established a correlation between immune cell activity and heart failure (HF), but the causal nature of this relationship remains unclear. Furthermore, the potential influence of metabolite levels on this interaction has not been comprehensively explored. To address these gaps, we employed a bidirectional Mendelian randomization (MR) approach in two stages to examine whether metabolite levels can mediate the causal relationship between immune cells and HF.MethodsGene

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Ophthalmology Month in Review: September 2024

HCPLive

This September 2024 month in review highlights recent advances in gene therapies and therapies demonstrating the potential for improved vision outcomes.

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Older Patients With NSTEMI Randomized Interventional Treatment: SENIOR-RITA Trial

American College of Cardiology

In this interview, Drs. Nanette Kass Wenger and Vijay Kunadian discuss the SENIOR RITA trial results and the importance of individualizing routine invasive therapy in individuals ≥75 years of age.

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Gerald Maguire, MD: The Future of Acetylcholine and Muscarinic Receptors

HCPLive

HCPLive spoke with Maguire about the benefits of acetylcholine and muscarinic receptors for the treatment of schizophrenia.

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Delta QRS and outcomes post CRT in the Resynchronization-Defibrillation for Ambulatory Heart Failure Trial

HeartRhythm

Amongst patients with left ventricular systolic dysfunction and prolonged QRS duration, cardiac resynchronization therapy (CRT) can improve cardiac electromechanical synchrony, and prevent adverse clinical outcomes.

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Mechanism of Action of Xanomeline and Trospium Chloride Capsules in Schizophrenia

HCPLive

In part 2 of 5, experts discuss the unique mechanism of xanomeline and trospium choloride capsules for the treatment of schizozphrenia.

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