Mon.Jul 29, 2024

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Study identifies 18 proteins linked to heart failure, frailty

Medical Xpress - Cardiology

An analysis of blood samples from thousands of study participants, led by researchers at UT Southwestern Medical Center, revealed 18 proteins associated with both heart failure and frailty, conditions that commonly develop in late life. Their findings, published in JAMA Cardiology, could lead to new strategies to jointly predict risk, administer preventive approaches, or treat these conditions, which often occur together.

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Top Gene Therapy News at ASRS 2024

HCPLive

A recap of the 5 most popular topics related to gene therapy in ophthalmology coming from the 42nd American Society of Retina Specialists meeting.

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Rapid and Accurate Prediction Model for Cardiac Arrest Treatment

DAIC

R-EDByUS score features variables using only prehospital resuscitation data. Image courtesy of Takenobu Shimada, Osaka Metropolitan University (CC BY 4.0, [link] mtaschetta-millane Mon, 07/29/2024 - 09:09 July 29, 2024 — When it comes to treating cardiac arrest, acting quickly can mean the difference between life and death. Researchers from Osaka Metropolitan University have developed a new scoring model, using only prehospital resuscitation data, that accurately predicts neurological outcomes o

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FDA Warns of Overdoses With Compounded Semaglutide

Med Page Today

(MedPage Today) -- Overdoses, some even requiring hospitalization, have occurred due to patient and physician confusion around compounded semaglutide, the FDA detailed in an alert. Adverse events reported to the agency have ranged from gastrointestinal.

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Researcher develops new score system to better screen and treat HFpEF heart failure patients

Medical Xpress - Cardiology

A novel study co-authored by a heart failure cardiologist at University Hospitals Harrington Heart & Vascular Institute demonstrates the effectiveness of a newly developed scoring system in identifying patients with Heart Failure with Preserved Ejection Fraction (HFpEF). The study, titled "An Evidence-Based Screening Tool for Heart Failure with Preserved Ejection Fraction: The HFpEF-ABA Score," was published in Nature Medicine.

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Alzheimer's Biomarkers Show Tantalizing Hint at Utility for Tracking Prevention

Med Page Today

(MedPage Today) -- PHILADELPHIA -- Blood tests for Alzheimer's disease biomarkers may not only be useful for clinical diagnosis but could also make it possible to test preventive therapies in people not yet showing any signs of the condition.

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People Aged > 30 Years Report Inadequate Knowledge Towards Gouty Arthritis

HCPLive

Although half of participants strongly agreed that gouty arthritis is painful and can cause anxiety, only 15.28% agreed on the importance of dietary intake as a means for prevention.

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Statin Candidate Pool Shrinks if PREVENT Risk Calculator Is Put to Current Practice

Med Page Today

(MedPage Today) -- The rules for statin and blood pressure (BP) medication initiation may be rewritten with a new and improved cardiovascular risk prediction tool, research suggested. Use of the PREVENT equations would reclassify 53% of U.S. adults.

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Vitamin D Deficiency Prevalent Among Patients with Rheumatic Disease

HCPLive

Vitamin D insufficiency was linked to reduced muscle strength, increased pain, higher disease activity, fatigue, and worsened disease outcomes.

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Edwards Lifesciences Expands Structural Heart Portfolio With Acquisitions of JenaValve and Endotronix

DAIC

mtaschetta-millane Mon, 07/29/2024 - 09:02 July 29, 2024 — Edwards Lifesciences announced investments that reflect the company’s deep commitment to advancing patient care through structural heart innovation, addressing large unmet patient needs and supporting sustainable long-term growth. Edwards has entered into an agreement to acquire JenaValve Technology , a pioneer in the transcatheter treatment of aortic regurgitation (AR), a deadly disease that impacts a significant and growing populatio

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Kim Jong Un's Health Problems; Seine Olympic Event Nixed Again; Vegan Diet and Aging

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Officials in North Korea are looking for drugs to treat Supreme Leader Kim Jong Un's obesity-related health problems, according to spy intelligence. (AP) A high.

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Major Predictors of Omalizumab Treatment Discontinuation for Chronic Urticaria

HCPLive

These data indicate the need for future analyses of possible chronic urticaria activity biomarkers, as well as other elements of patient response to omalizumab treatment.

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Everyday activities aren't enough to protect against stroke

Science Daily - Stroke

Research shows that the physical activities we do as we go about our lives, at work or in the home, aren't enough to protect us from having a stroke. However, exercising in our free time and using active modes of transport are associated with a decreased risk of stroke.

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Study reveals link between transthyretin levels and heart disease risk

Medical Xpress - Cardiology

Physician–scientists from the University of Alabama at Birmingham Marnix E. Heersink School of Medicine have uncovered significant findings regarding the impact of transthyretin, or TTR, protein levels on heart disease risk.

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What will the new cardiovascular risk calculator mean for patients?

Science Daily - Heart Disease

If current guidelines for cholesterol and high blood pressure treatment remain unchanged, a newly unveiled heart risk calculator would render 16 million people ineligible for preventive therapy. Loss of eligibility for cholesterol and blood pressure medicines could lead to 107,000 more heart attacks and strokes over 10 years but may reduce new diabetes cases by 57,000 over the same period.

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Analysis forecasts more heart attacks and strokes under the new cardiovascular risk calculator tool

Medical Xpress - Cardiology

A recently unveiled cardiovascular disease risk calculator that measures a patient's risk for heart attack and stroke is better calibrated and more precise than its previous version, but if current treatment guidelines for cholesterol and blood pressure therapy remain unchanged, the new calculator may have unintended consequences, according to research from Harvard Medical School.

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Study Finds Semaglutide Can Reduce Risk of Tobacco-Related Healthcare Use

HCPLive

New study finds semaglutide may reduce smoking urge in type 2 diabetes patients, decreasing tobacco use disorder medical encounters by up to 32%.

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New score system to better screen and treat HFpEF heart failure patients

Science Daily - Heart Disease

A novel study co-authored by a heart failure cardiologist demonstrates the effectiveness of a newly developed scoring system in identifying patients with Heart Failure with Preserved Ejection Fraction (HFpEF).

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An ECG that changed paradigms about sudden death

HeartRhythm

After a long journey through different journals with the same reviewers rejecting our paper, Mel Scheinman, by then Associate Editor of the Journal of the American College of Cardiology, took personal care of our report.1 We were all convinced that we were dealing with just a clinical-electrocardiographic curiosity (Figure 1), but 3 decades later, it is clear that our human guesses were wrong.

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Study reveals link between transthyretin levels and heart disease risk

Science Daily - Heart Disease

Researchers reveal the impact of transthyretin protein levels on heart disease risk.

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Crisis Point: Improving Diversity in Dermatology

HCPLive

In this episode of Crisis Point, 3 experts in dermatology discuss ways in which those in the field are working to improve visibility of diverse skin types within dermatology education.

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Evaluation of the Cardiac and Metabolic Effects of Dapagliflozin in Heart Failure With Preserved Ejection Fraction

American College of Cardiology

The goal of the CAMEO-DAPA trial was to assess whether dapagliflozin, a sodium-glucose cotransporter-2 inhibitor (SGLT2i), affects rest and exercise pulmonary capillary wedge pressure (PCWP) in patients with heart failure with preserved ejection fraction (HFpEF).

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FDA Approves First Blood Test for Primary Colorectal Cancer Screening

HCPLive

The approval of Guardant Health’s Shield test makes it the first blood test to be approved as a primary screening option for CRC and the first to meet Medicare coverage requirements.

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Stuart J. Connolly, MD, April 9, 1949–June 2, 2024

HeartRhythm

Stuart Connolly brought the large clinical trial to arrhythmia medicine and changed the practice of medicine in the process.

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Wearable Heart Rate Tracking Linked to Increased Anxiety in AFib Patients

HCPLive

A study found wearable devices alerting irregular heart rhythms amplified anxiety in 1 in 5 participants with atrial fibrillation, which led people to be more likely to seek care.

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ACC CardiaCast: Elevated Lp(a): Actionable Strategies for Risk Assessment and Mitigation

American College of Cardiology

In this episode, Drs. Erin Michos and Gissette Reyes-Soffer discuss how clinicians can manage elevated Lp(a) by treating all modifiable factors in patients. The global risk assessment of patients and what can be done now to navigate and mitigate risk is also addressed.

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Roflumilast Cream 0.15% Launched by Arcutis for the Treatment of Eczema

HCPLive

This announcement follows roflumilast’s July 9 approval for the once-daily treatment of adults and children with mild to moderate atopic dermatitis.

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The Future of SAVR

Society of Thoracic Surgeons - Congenital

Webinar The Future of SAVR gmckinney Mon, 07/29/2024 - 15:07 August 8, 2024 With the emerging evidence, the use of SAVR in the era of TAVR expansion has been heavily debated. This webinar focuses on the latest science showing the benefit of SAVR over TAVR and will cover several key scenarios that could benefit from SAVR. Moderators Joanna Chikwe, MD, FRCS Cedars Sinai Los Angeles, CA George Arnaoutakis, MD University of Texas at Austin Dell Medical School Austin, TX Panelists Tsuyoshi Kaneko, MD

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Surgical management of native aortic valve leaflet avulsion during TAVR

Journal of Cardiothoracic Surgery

Transcatheter aortic valve replacement (TAVR) has increased in utilization since its approval for management of aortic stenosis patients across all risk strata. We report a rare case of aortic valve leaflet av.

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Targeting Disease Modification in Psoriasis and Psoriatic Arthritis

HCPLive

Dermatologic experts explore strategies to slow the progression of psoriasis to psoriatic arthritis, offering evidence-based insights to optimize patient outcomes and enhance long-term disease management.

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Left ventricular unloading with gentle chest compressions for patients on veno-arterial extracorporeal membrane oxygenation: two case reports

Frontiers in Cardiovascular Medicine

BackgroundInsufficient ventricular unloading is a serious complication during veno-arterial extracorporeal membrane oxygenation (VA-ECMO) that has a crucial impact on patient outcomes. The existing conservative treatment options are limited, while mechanical decompression techniques are challenging and restricted in terms of their adoption and application.

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Suboptimal Treatment of Inflammatory Bowel Disease in Clinical Practice

HCPLive

Silvio Danese, MD, PhD; Bruce Sands, MD, and Jean-Frederic Colombel, MD highlight the common practice in many community settings of treating inflammatory bowel disease with corticosteroids, with or without 5-aminosalicylic acid, and cycling patients through this regimen for prolonged periods, while emphasizing the significant impact and toxicities associated with this treatment approach.

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Wearable Defibrillator for Sudden Cardiac Arrest Risk

American College of Cardiology

What is the safety and clinical effectiveness of a novel patch–wearable cardioverter-defibrillator (P-WCD)?

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Unmet Needs and Starting Advanced Treatment in Inflammatory Bowel Disease

HCPLive

Silvio Danese, MD, PhD; Bruce Sands, MD, and Jean-Frederic Colombel, MD, highlight the common practice in many community settings of treating inflammatory bowel disease (IBD) with corticosteroids, with or without 5-aminosalicylic acid, and cycling patients through this regimen for prolonged periods, while emphasizing the significant impact and toxicities associated with this treatment approach.

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3D Echo for Prediction of LVOT Area Prior to TMVR

American College of Cardiology

What is the accuracy of three-dimensional (3D) transesophageal echocardiography (TEE) in predicting neo–left ventricular outflow tract (neo-LVOT) dimensions in patients undergoing transcatheter mitral valve replacement (TMVR), as compared with baseline computed tomography (CT)?

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Obicetrapib Hits Target in Phase 3 BROOKLYN Trial for HeFH

HCPLive

The phase 3 trial suggest obicetrapib offered significant reductions in LDL-C when added to maximally tolerated lipid-lowering therapy in HeFH.

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The sooner the better: Teaching healthy habits in elementary school can reduce abdominal fat

Medical Xpress - Cardiology

A study led by the Centro Nacional de Investigaciones Cardiovasculares (CNIC) and Fundación SHE, supported by "la Caixa" Foundation, demonstrates that teaching healthy habits through classroom activities helps to prevent the accumulation of abdominal fat during the first school years.

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