Fri.Dec 13, 2024

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Sudden Palpitations in a Young Adult

Dr. Smith's ECG Blog

Written by Magnus Nossen and Ken Grauer ( with Comment by Smith ) The ECG in Figure-1 was electronically transmitted by the ambulance service for evaluation. The patient is a young adult male with acute onset of palpitations. He was hemodynamically stable at the time ECG #1 was recorded. QUESTIONS: How would you interpret this ECG? What entities to consider in your differential diagnosis?

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Dementia Incidence Linked to Inflammatory Foods

Med Page Today

(MedPage Today) -- Diets higher in inflammatory foods were tied to an increased incidence of dementia in older adults, longitudinal data from the Framingham Heart Study Offspring cohort showed. Over 13 years of follow-up, higher Dietary Inflammatory.

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IgAN, FSGS Linked to Greater Kidney Replacement Therapy Risk Than Common CKD Etiologies

HCPLive

Despite having a lower risk of hospitalization, cardiovascular events, and mortality, patients with IgAN and FSGS had a higher risk of CKD progression.

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Heart-related side effects of cancer treatment must be addressed as early as possible, experts say

Medical Xpress - Cardiology

The devastating news of a cancer diagnosis understandably makes doctors and patients focus on the cancer itself. However, experts in cardio-oncology from the European Society of Cardiology (ESC) emphasize that heart and cardiovascular health must be included as early as possible in the patient's cancer treatment plan to ensure the best possible outcomes.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Ralph A. DeFronzo, MD: Noxious Nine and Mifepristone for Hypercortisolism in T2D

HCPLive

Ralph A. DeFronzo, MD discusses the Noxious Nine and the impact of hypercortisolism on difficult-to-control type 2 diabetes.

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How Apob & Visceral Fat Increase Your Risk Of Heart Disease.

Dr. Paddy Barrett

When it comes to cardiovascular disease, two of the biggest risk factors we must consider are: ApoB concentration - A measure of the number of circulating lipid particles. Visceral Fat & Insulin Resistance - The amount of fat in your abdominal cavity and major organs and how it influences your risk of insulin resistance. It is easy to separate these two factors and attempt to address them independently, but recent studies suggest that there may be a close relationship that we need to be awar

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Exposure to remote wildfire smoke linked to increased medical visits for heart and lung problems

Medical Xpress - Cardiology

Wildfire smoke has long been known to exacerbate health problems like heart disease, lung conditions, and asthma, but now a new study finds that smoke from these fires can lead to poor health thousands of miles away.

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FDA Approves Crinecerfont for Congenital Adrenal Hyperplasia

HCPLive

Crinecerfont is indicated to be used with glucocorticoids to control androgen levels in adults and pediatric patients with classic congenital adrenal hyperplasia.

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Physiology Friday #248: Cold Exposure Improves Metabolic and Cellular Health—But You’ve Gotta Shiver for It

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. You can find more products I’m affiliated with on my website. Physiologically Speaking is a reader-supported publication.

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Automated oxygen administration versus manual control in acute cardiovascular care: a randomised controlled trial

Heart BMJ

Background Oxygen therapy is commonly administered to patients with acute cardiovascular conditions during hospitalisation. Both hypoxaemia and hyperoxia can cause harm, making it essential to maintain oxygen saturation (SpO 2 ) within a target range. Traditionally, oxygen administration is manually controlled by nursing staff, guided by intermittent pulse oximetry readings.

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Capstan’s Robotic MR/TR Frontier Funding

CardiacWire

Capstan Medical took a key step towards its vision of launching the first robotic cardiac valve surgery system, landing $110M in Series C funding. The new funding eclipses the $31M Series B round that Capstan raised in August 2023, bringing its total funding to over $150M. Capstan earmarked the funds for expanding its team to meet its upcoming development goals and execute its future pivotal trials.

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Unresponsive patient with bradycardia

Heart BMJ

Clinical introduction A patient in their 60s, with a background of asthma and seizures from alcohol withdrawal was brought in via ambulance to the emergency department. The patient was in a comatose state, the Glasgow Coma Scale Score was 8 (E2, V2, M4), with no localising neurological findings. The patient had last been seen well the previous day. The patient was grimacing and agitated, presented with bradycardia at 40 beats per minute, and was mottled and cold.

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Upadacitinib Sustained Efficacy, Safety Among Patients with Atopic Dermatitis Over 188 Weeks

HCPLive

This interim analysis highlights positive findings from the Measure Up 1 and 2 studies regarding upadacitinib for patients with atopic dermatitis.

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Effects of resveratrol on aortic growth in patients with Marfan syndrome: a single-arm open-label multicentre trial

Heart BMJ

Background Resveratrol, a dietary supplement that intervenes in cellular metabolism, has been shown to reduce aortic growth rate in a mouse model of Marfan syndrome (MFS), a condition associated in humans with life-threatening aortic complications, often preceded by aortic dilatation. The primary objective of this study was to investigate the effects of resveratrol on aortic growth rate in patients with MFS.

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Jennifer B. Green, MD: Implementation of Evidence-Based Therapies for T2D

HCPLive

Jennifer B. Green, MD highlights the successful implementation of evidence-based therapies for high-risk patients with type 2 diabetes.

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Diagnostic accuracy of non-invasive cardiac imaging modalities in patients with a history of coronary artery disease: a meta-analysis

Heart BMJ

Background The diagnostic performance of non-invasive imaging techniques for detecting obstructive coronary artery disease (CAD) in patients with a history of myocardial infarction or percutaneous coronary intervention has not been comprehensively evaluated. This meta-analysis assesses the diagnostic value of coronary CT angiography (CCTA), CCTA combined with CT perfusion (CCTA+CTP), cardiac MRI (CMR) and single-photon emission CT (SPECT) compared with invasive reference standards.

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Study Finds No Link Between Therapist CBT Skill and Patient Outcomes

HCPLive

A study finds that therapists deliver high-quality CBT in routine psychiatric care but found no evidence that therapist adherence and competence correlate to patient outcomes.

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Correction: The efficacy of extraembryonic stem cells in improving blood flow within animal models of lower limb ischaemia

Heart BMJ

Mohamed Omer S, Krishna SM, Li J, et al. The efficacy of extraembryonic stem cells in improving blood flow within animal models of lower limb ischaemia. Heart 2016;102:69-74. This article was amended after publication to correct an error in the assessment for publication bias.

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Global Experts Gather to Discuss the Latest in Cardiovascular Advances

Society of Thoracic Surgeons - Congenital

The 2024 Latin American Cardiovascular Conference, held in Buenos Aires, brought together leading experts from across the Americas and Europe and focused on key areas of cardiovascular medicine, such as coronary artery disease, congenital heart disease, atrial fibrillation, and heart failure.

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Optimising management of moderate secondary mitral regurgitation: insights into pharmacological and interventional approaches

Heart BMJ

Secondary mitral regurgitation (SMR) is a complex and evolving challenge in the landscape of heart failure (HF) management. Although significant secondary MR has been widely recognised for its adverse outcomes, moderate SMR has historically been considered a more benign entity. However, recent evidence, including the manuscript we are referring to, 1 suggests that moderate SMR may not be as innocent as previously thought.

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Immunodeficiency, Injection Drug Use Linked to Failed HCV Treatment in People with HIV

HCPLive

Lower CD4+ cell counts, HCV genotype 4, and recent injection drug use were linked to unsuccessful DAA treatment in people with HCV and HIV.

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Bally Ribbon Mills Offers Medical Textiles for Cardiovascular Applications

DAIC

tim.hodson Fri, 12/13/2024 - 08:41 Bally Ribbon Mills (BRM) offers abroad product line of medical textiles and fabrics ideal for use in cardiovascular, orthopedic and dental prosthetic applications. Tubular prosthesis of medical textiles can become one with the repaired vessel over time and can provide less invasive options than operations like open heart surgery.

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Three-dimensional printing-guided percutaneous transcatheter replacement in coarctation of the aorta: a retrospective study

Frontiers in Cardiovascular Medicine

BackgroundTo evaluate the feasibility, effectiveness and assistant effect of 3D printed aortic model in the treatment on congenital coarctation of the aorta (CoA) in adolescents and adults.MethodsFrom December 2018 to December 2023, a total of 10 patients with congenital coarctation of aorta underwent percutaneous balloon dilatation covered stent implantation in the department of cardiovascular surgery, Xijing Hospital.

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Study Highlights Reasons for Discontinuation of Systemic Treatments for Atopic Dermatitis

HCPLive

These data provide insight into characteristics of those who choose to discontinue systemic therapies for eczema.

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A bibliometric analysis of abdominal aortic aneurysm (2014–2024)

Frontiers in Cardiovascular Medicine

BackgroundAbdominal aortic aneurysm (AAA) is a localized bulge of the abdominal aorta, which mainly manifests as a pulsatile mass in the abdomen. Once an abdominal aortic aneurysm ruptures, the patient's life is seriously endangered. Surgery is the preferred treatment for abdominal aortic aneurysm. At present, there has been no comprehensive review of the current status of abdominal aortic aneurysm research.

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Changes in Restless Legs Syndrome Treatment Recommendations

HCPLive

The AASM has updated its RLS guidelines, now recommending against the standard use of dopamine agonists due to evidence of augmentation.

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Cardiology MCQ: Doppler Basics

All About Cardiovascular System and Disorders

The ultrasound reflected from red blood cells moving away from the transducer has: A. Higher frequency and is colour coded red B. Higher frequency and colour coded blue C. Lower frequency and colour coded red D. Lower frequency and colour coded blue Correct answer: D. Lower frequency and colour coded blue Ultrasound reflected from red blood cells moving towards the transducer will be perceived as having higher frequency.

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Unmet Needs in CSU Management

HCPLive

Panelists discuss the unmet needs in chronic spontaneous urticaria (CSU) management, highlighting the evolution of the field toward more personalized and effective treatment strategies to address refractory symptoms.

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Pediatric Brain Stem Cavernoma: A Therapeutic Conundrum

Stroke Journal

Stroke, Ahead of Print.

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Key Takeaways and Future Directions in CSU Care

HCPLive

Panelists discuss their advice for dermatologists managing chronic spontaneous urticaria (CSU), emphasizing the importance of individualized treatment plans, and staying updated on emerging therapies and clinical guidelines.

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Comparative assessment of inter-atrial conduction delay during Bachmann’s bundle pacing and right atrial appendage pacing using bi-atrial strain rate echocardiography

HeartRhythm

The P-wave morphology during right atrial appendage pacing (RAAp) is wider than that during sinus rhythm (SR). This increased inter-atrial conduction delay (IACD) correlates with an increased risk of developing atrial fibrillation (AF).1,2 Bachmann's bundle pacing (BBp), characterized by a P-wave morphology similar to that during SR and shortened P-wave duration (PWD), was reported to significantly reduce the incidence and permanence of AF compared with RAAp and non-specific atrial septal pacing

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Tadashi Matsushita, MD, PhD: Reducing Treatment Burden in Hemophilia A

HCPLive

Matsushita discussed findings from the OLE FRONTIER4 study of Mim8.

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Electrophysiological Signatures in Global Cerebral Ischemia: Neuroprotection Via Chemogenetic Inhibition of CA1 Pyramidal Neurons in Rats

Journal of the American Heart Association

Journal of the American Heart Association, Volume 13, Issue 24 , December 17, 2024. BackgroundAlthough there has been limited research into the perturbation of electrophysiological activity in the brain after ischemia, the activity signatures during ischemia and reperfusion remain to be fully elucidated. We aim to comprehensively describe these electrophysiological signatures and interrogate their correlation with ischemic damage during global cerebral ischemia and reperfusion.Methods and Result

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Exploring Bempedoic Acid: Clinical Indications, Efficacy, and Future Directions in Cardiovascular Risk Management

HCPLive

Panelists discuss how bempedoic acid offers a promising alternative for patients who are statin-intolerant, demonstrating efficacy in reducing major cardiovascular events and low-density lipoprotein cholesterol, while addressing its role in managing residual cardiovascular risk, particularly in high-risk populations.

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Evidence Gaps Contribute to Lack of Effective Use of Digital Health Technologies in Cardiometabolic Disease

American College of Cardiology

Key gaps preventing digital health technologies (DHTs) from meeting their full potential in assisting with the prevention, early detection and better management of cardiometabolic disease is the topic of a Special Communication article published Dec. 4 in JACC.

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The impact of atrial fibrillation and smoking history on brain deficits

The American Journal of Cardiology

Publication date: Available online 12 December 2024 Source: The American Journal of Cardiology Author(s): Ashwin Balu, Gregory Y H Lip