Physiologically Speaking

NOVEMBER 22, 2024

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post. Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

Physiology 111

Physiology Dementia Genetic predisposition Exercise 111

Med Page Today

NOVEMBER 22, 2024

(MedPage Today) -- Uptake of continuous glucose monitoring (CGM) was relatively low among vulnerable diabetes patients in the largest national system of safety-net primary care clinics, a retrospective cross-sectional study found. In patients.

Diabetes 122

Diabetes 122

HCPLive

NOVEMBER 22, 2024

Kugelmas reviews findings from a secondary analysis of the phase 3 ELATIVE trial suggesting elafibranor is associated with stable kidney function.

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Medical Xpress - Cardiology

NOVEMBER 22, 2024

Researchers at Penn State are using machine learning and existing electrocardiogram (ECG) data to help doctors make more accurate predictions. A team of artificial intelligence engineers, in collaboration with a team of physicians from Penn State Heart and Vascular Institute, is working to develop novel algorithms for point-of-care, in-house use and for technology licensing.

AFIB 105

AFIB Electrocardiogram Technology Strokes 105

HCPLive

NOVEMBER 22, 2024

In part 1 of this 2-part discussion, hosts explore the ethical foundation and background of euthanasia and medically-assisted suicide.

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Science Daily - Heart Disease

NOVEMBER 22, 2024

A new study found that prolonged standing at work had a negative impact on the research participants' 24-hour blood pressure. In contrast, spending more time sitting at work was associated with better blood pressure. The study suggests that activity behavior during working hours may be more relevant to 24-hour blood pressure than recreational physical activity.

Blood Pressure 100

Blood Pressure Research 100

HCPLive

NOVEMBER 22, 2024

A study identified homelessness and minority status as factors that impact clozapine prescription patterns.

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HCPLive

NOVEMBER 22, 2024

Following the publication of the new RLS recommendations, HCPLive spoke with John Winkelman, MD, PhD, chair of the AASM committee that revised the guidelines.

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Journal of the American Heart Association

NOVEMBER 22, 2024

Journal of the American Heart Association, Ahead of Print. BackgroundThe cardiovascular impact of cannabis use is incompletely understood. Although evidence links chronic use to an increased risk of disease and adverse cardiovascular events, few studies have investigated the acute effects of cannabis inhalation on subclinical dysfunction. Furthermore, it remains unknown how method of inhalation and cannabinoid profile modify risk.

Cardiac Function 81

Cardiac Function Blood Pressure 81

HCPLive

NOVEMBER 22, 2024

This meta-analysis showed that both secondary closure techniques substantially reduce the risk of hidradenitis suppurativa recurrence compared to primary direct closure.

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Cardiometabolic Health Congress

NOVEMBER 22, 2024

This year, the cardiometabolic health community has witnessed remarkable advancements. From breakthrough medications to innovative technologies, there is a lot for cardiometabolic clinicians professionals to celebrate. Let’s explore some key developments in 2024 that are offering hope to clinicians and patients. Innovative Therapies and Medications for Cardiometabolic Clinicians Lipid Management and Cardiovascular Therapies : Olezarsen , a new triglyceride-lowering agent, showcased impressive re

Blood Pressure 59

Blood Pressure Obesity Preserved Ejection Fraction Coronary Artery Disease 59

HCPLive

NOVEMBER 22, 2024

With approval, acoramaidis becomes the first agent with a label specifying near-complete stabilization of TTR.

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American College of Cardiology

NOVEMBER 22, 2024

An expert panel report, one of three in a special series published in JACC: CardioOncology, provides a review of the current evidence for the cardiovascular care of patients before cardiotoxic cancer therapy and highlights gaps in the evidence.

Cancer 61

Cancer Article 61

HCPLive

NOVEMBER 22, 2024

In this analysis, the investigators systematically assessed links between the macronutrient profiles of common allergenic foods and corresponding prevalence of food allergy.

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Medical Xpress - Cardiology

NOVEMBER 22, 2024

A Finnish study found that prolonged standing at work had a negative impact on the research participants' 24-hour blood pressure. In contrast, spending more time sitting at work was associated with better blood pressure.

Blood Pressure 56

Blood Pressure Research 56

HCPLive

NOVEMBER 22, 2024

FDA grants Rare Pediatric Disease, Fast Track designations to gildeuretinol, aiming to accelerate treatment for Stargardt disease.

Pediatrics 59

Pediatrics 59

American College of Cardiology

NOVEMBER 22, 2024

What is the bleeding risk of nonsteroidal anti-inflammatory drug (NSAID) use in addition to oral anticoagulants (OACs) for the treatment of venous thromboembolism (VTE)?

Article 53

Article 53

HCPLive

NOVEMBER 22, 2024

The supplemental Biologics License Application is supported by the phase 3 ASTRO study of guselkumab SC induction therapy in ulcerative colitis.

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Dr. S. Venkatesan MD

NOVEMBER 22, 2024

Atrial fibrillation: Think locally act globally It is clear, except in specific situations like HT, LVH, HFpEF, and other left (or right )sided structural heart diseases, the bulk of the AF is part of systemic destabilization of neuro-metabolic homeostasis. Atria become a poor, jittery victim to a complex interaction of multitude of factors like obesity, systemic inflammation, fatty infiltration, anxiety, abnormal neuro-cardiac modulation, chronic oxygen deprivation. etc.

Atrial Fibrillation 52

Atrial Fibrillation Arrhythmia Risk Factors Bradycardia 52

HCPLive

NOVEMBER 22, 2024

The sNDA was intended to include positive two-year data in the US Prescribing Information for avacincaptad pegol based on the GATHER2 clinical trial.

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Journal of the American Heart Association

NOVEMBER 22, 2024

Journal of the American Heart Association, Ahead of Print.

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HCPLive

NOVEMBER 22, 2024

Tesser discussed the background of the phase 3 RESET-RA trial and efficacy findings.

Outcomes 59

Outcomes 59

Journal of the American Heart Association

NOVEMBER 22, 2024

Journal of the American Heart Association, Ahead of Print.

Cardiovascular Disease 45

Cardiovascular Disease 45

HCPLive

NOVEMBER 22, 2024

Findings from PsABIOnd can help reassure clinicians of similar efficacy between treatment choices.

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NEJM Journal Watch - Cardiology

NOVEMBER 22, 2024

Closure of the atrial appendage was superior to oral anticoagulation in safety and noninferior in effectiveness.

Atrial Fibrillation 45

Atrial Fibrillation Ablation Strokes Stroke 45

HCPLive

NOVEMBER 22, 2024

In part 2 of this 2-part discussion, hosts discuss ethical considerations and the growing evidence base around euthanasia and medical assistance in dying.

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American College of Cardiology

NOVEMBER 22, 2024

The following are key points to remember from an international consensus on cardiopulmonary resuscitation (CPR) and emergency cardiovascular care science with treatment recommendations.

Article 45

Article 45

HCPLive

NOVEMBER 22, 2024

Panelists discuss the challenges associated with using biologics for chronic spontaneous urticaria (CSU), including issues related to accessibility and cost, while also explaining why Burton tyrosine kinase (BTK) is considered an ideal target for CSU treatment due to its role in mediating mast cell degranulation.

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American College of Cardiology

NOVEMBER 22, 2024

Preventing, detecting and managing cancer therapy-related cardiovascular toxicity (CTR-CVT) is a clear objective during cancer treatment. An expert panel report published in JACC: CardioOncology provides practical recommendations during cancer therapy supported by high-quality evidence that can be applied across diverse settings, and highlights the significant gaps in knowledge in cardio-oncology.

Cardio Oncology 40

Cardio Oncology Cancer Article 40

HCPLive

NOVEMBER 22, 2024

Panelists discuss how the treatment goals for chronic spontaneous urticaria (CSU) focus on achieving symptom control and improving quality of life for patients, while also aiming for effective management strategies and adherence to treatment plans for physicians.

Quality of Life 52

Quality of Life 52

Journal of Cardiovascular Electrophysiology

NOVEMBER 22, 2024

ABSTRACT Introduction Substernal extravascular defibrillators (EV ICDs) have been shown to be effective and safe for patients at risk of sudden cardiac death, however, there is little evidence around the safety of extracting chronic devices. Methods and Results We present a 50-year-old patient in whom a Medtronic EV ICD system was successfully removed without specialist extraction tools, 186 weeks after implantation, by an operator experienced in transvenous lead extraction but without formal tr

Defibrillator 40

Defibrillator Sudden Cardiac Death 40

HCPLive

NOVEMBER 22, 2024

Panelists discuss the current and future roles of advanced treatments, including biologics and Bruton tyrosine kinase (BTK) inhibitors, in the management of chronic spontaneous urticaria (CSU), highlighting their potential to improve patient outcomes and the evolving landscape of treatment options.

Outcomes 52

Outcomes 52

Stroke Journal

NOVEMBER 22, 2024

Stroke, Ahead of Print. BACKGROUND:Stroke triggers are factors that may precipitate a stroke within a given time interval and can predict the timing of a stroke. While hypoglycemia has been established as a risk factor for cardiovascular events such as acute ischemic stroke (AIS), there is limited research demonstrating hypoglycemic events as stroke triggers.

Diabetes 40

Diabetes Strokes Stroke Medicare 40

HCPLive

NOVEMBER 22, 2024

Panelists discuss how steroids can play a role in the management of chronic spontaneous urticaria (CSU), while emphasizing that practitioners should exercise caution due to potential adverse effects and the need for careful monitoring when using systemic steroids.

Exercise 52

Exercise 52

Journal of the American Heart Association

NOVEMBER 22, 2024

Journal of the American Heart Association, Ahead of Print.

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The American Journal of Cardiology

NOVEMBER 22, 2024

Publication date: Available online 22 November 2024 Source: The American Journal of Cardiology Author(s): Rahul Chaudhary, Matthew E.

Thrombosis 40

Thrombosis 40

Journal of the American Heart Association

NOVEMBER 22, 2024

Journal of the American Heart Association, Ahead of Print. Atrial fibrillation (AF) and coronary artery disease are frequently associated and, when so, lead to a grim prognosis. Recent studies suggest the presence of interconnected pathophysiological pathways between the 2 conditions that can promote and aggravate each other, igniting a vicious cycle.

Coronary Artery Disease 40

Coronary Artery Disease Atrial Fibrillation Stenosis Physiology 40