Wed.Jan 08, 2025

article thumbnail

AI-ECG’s 2025 Kickoff

CardiacWire

The buzz around artificial intelligences impact on cardiology keeps growing louder, and thats proving to be particularly true in the AI-ECG segment, with 2025 already off to a strong start from ECG startups and researchers alike. AI and ECG pair well due to the strong pattern recognition that machine learning algorithms can achieve. This AI-ECG pairing is bringing the modality into a wider range of diseases and allowing integration with new device form factors.

article thumbnail

Mineralys Therapeutics Announces Phase 2 Clinical Trial of Lorundrostat

DAIC

tim.hodson Wed, 01/08/2025 - 14:11 Jan. 8, 2025 Mineralys Therapeutics, Inc., a clinical-stage biopharmaceutical company focused on developing medicines to target hypertension, chronic kidney disease (CKD) and other diseases, hasannounced that the U.S. Food and Drug Administration (FDA) has cleared the companys Investigational New Drug (IND) Application for a Phase 2 clinical trial to evaluate the effect of lorundrostat in the treatment of subjects with moderate-to-severe obstructive sleep apne

article thumbnail

Exposure to aircraft noise linked to worse heart function

Science Daily - Heart Disease

People who live close to airports and are exposed to high aircraft noise levels could be at greater risk of poor heart function, increasing the likelihood of heart attacks, life-threatening heart rhythms and strokes, according to a new study.

article thumbnail

Sleep Month in Review: December 2024

HCPLive

This Month in Review captures 7 sleep medicine news, including FDA updates, from December 2024.

105
105
article thumbnail

Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

article thumbnail

Varipulse Heart Device Procedures Paused After Safety Events

Med Page Today

(MedPage Today) -- Just months after FDA approval, Johnson & Johnson paused the rollout of its Varipulse pulsed field ablation (PFA) platform in the U.S. due to safety reasons. In a U.S. external evaluation cohort, four reported neurovascular.

Ablation 104
article thumbnail

Polypill Therapy Cost-Effective for CVD Risk in Underserved Populations

HCPLive

An economic analysis highlights a cardiovascular polypill's potential to lower healthcare costs and address income-based health disparities.

More Trending

article thumbnail

Chlorthalidone vs. Hydrochlorothiazide for Hypertension: Renal Outcomes

NEJM Journal Watch - Cardiology

In a secondary analysis from a randomized trial, no important differences were noted.

article thumbnail

Building digital twins and hearts: New technology could predict various health outcomes

Medical Xpress - Cardiology

Imagine having a digital carbon copy of yourself that physicians could use to predict long-term risks for disease, assess how your body may respond to treatment, and simulate surgeries in advance. A virtual twin may sound as far-fetched as robotic surgery and self-driving cars once did, but researchers are studying how to turn this vision into a reality.

article thumbnail

Left Ventricular Assist Device Therapy in Cold and Dry Patients

Circulation: Heart Failure

Circulation: Heart Failure, Ahead of Print. BACKGROUND:Patients with end-stage heart failure and low pulmonary capillary wedge pressure are referred to as cold and dry and represent an understudied minority in whom the benefit of left ventricular assist device (LVAD) therapy is unclear.METHODS:Adults receiving LVADs between 2006 and 2017 in the Interagency Registry for Mechanically Assisted Circulatory Support database were classified as cold and wet (pulmonary capillary wedge pressure >1

article thumbnail

Second pig heart transplant patient offers vital lessons

Medical Xpress - Cardiology

Continuing significant advancements in the field of xenotransplantation, surgeon-scientists from the University of Maryland School of Medicine provided an extensive analysis on the second patient in the world to receive a genetically-modified pig organ.

article thumbnail

Heart Failure with Preserved Ejection Fraction

The New England Journal of Medicine

Heart failure with preserved ejection fraction is noted for symptoms of heart failure, LVEF of at least 50%, and cardiac or structural abnormalities. Treatment includes diuretics and SGLT2 inhibitors.

article thumbnail

New treatment option shows promise for severe hypertrophic cardiomyopathy in children

Medical Xpress - Cardiology

Trametinib, a mitogen-activated protein kinase (MEK) inhibitor, reduces mortality and morbidity in children with severe hypertrophic cardiomyopathy (HCM) caused by pathogenic variants in the RAS/MAPK pathway, according to a study published in JACC: Basic to Translational Science.

article thumbnail

Transcatheter Valve Replacement in Severe Tricuspid Regurgitation

The New England Journal of Medicine

In a randomized trial involving patients with severe tricuspid regurgitation, transcatheter tricuspid-valve replacement was superior to medical therapy at 1 year.

article thumbnail

Late-gadolinium enhancement predicts appropriate device therapies in non-ischemic recipients of primary prevention implantable cardioverter-defibrillators

HeartRhythm

Better risk stratification is needed to evaluate patients with non-ischemic cardiomyopathy (NICM) for prophylactic implantable cardioverter-defibrillators (ICD). Growing evidence suggests cardiac magnetic resonance imaging (CMR) may be useful in this regard.

article thumbnail

Exposure to aircraft noise linked to worse heart function

Medical Xpress - Cardiology

People who live close to airports and are exposed to high aircraft noise levels could be at greater risk of poor heart function, increasing the likelihood of heart attacks, life-threatening heart rhythms and strokes, according to a study led by UCL (University College London) researchers.

article thumbnail

Evolution of Imaging Techniques in Ischemic Stroke

Stroke Journal

Stroke, Ahead of Print.

Stroke 75
article thumbnail

Calming chaotic waves with small electrical intervention: Researchers develop technique to stop irregular heartbeats

Medical Xpress - Cardiology

Researchers from Durham University have made an exciting discovery that could improve how doctors treat dangerous heart rhythms, like those seen in cardiac arrest.

article thumbnail

Epicardial Substrate Ablation in Symptomatic Brugada Syndrome Patients: An Updated Systematic Review and Single-arm Meta-analysis

HeartRhythm

Brugada syndrome (BrS) is a genetic heart disease that predisposes individuals to ventricular arrhythmias and sudden cardiac death. Although implantable cardioverter-defibrillators (ICDs) and quinidine are primary treatments, recurrent BrS-triggered ventricular arrhythmias can persist. In this setting, epicardial substrate ablation has emerged as a promising alternative for symptomatic patients.

article thumbnail

End-of-life care can be more aggressive for cancer patients with defibrillators

Medical Xpress - Cardiology

Patients with advanced cancer who also had cardiac defibrillators were more likely than those without these implants to receive aggressive end-of-life care, a team led by UT Southwestern Medical Center researchers found in a new study. The findings, published in Cancer, could help physicians guide patients in this growing population toward care that better matches their goals.

article thumbnail

A Comparison of Peripherally Inserted Central Catheter Materials

The New England Journal of Medicine

Chlorhexidine or hydrophobic PICCs were not superior to standard polyurethane PICCs for the prevention of device failure due to infectious or noninfectious complications.

71
article thumbnail

The Extravascular Implantable Cardioverter-Defibrillator: A Promising Novel Device

American College of Cardiology

Transvenous implantable cardioverter-defibrillators (ICDs) are the reference standard for preventing sudden cardiac death (SCD) but have risks associated with intravascular lead placement.

article thumbnail

Alcohol-Associated Liver Disease, MASLD Drive Growing Liver Cancer Burden in the US

HCPLive

From 2000 to 2021, primary liver cancer incidences and deaths in the US increased by more than 100%, driven by rapid growth in ALD and MASLD.

Cancer 64
article thumbnail

Key Updates in the 2025 American Diabetes Association (ADA) Diabetes Guidelines 

Cardiometabolic Health Congress

Last month, the 2025 American Diabetes Association (ADA) guidelines were introduced, providing updates for diagnosing and managing diabetes and prediabetes. These new guidelines offer actionable, evidence-based recommendations to improve care delivery. 1. ADA Updates: Continuous Glucose Monitoring (CGM) for Type 2 Diabetes on Glucose-Lowering Agents The ADA now recommends considering CGM for adults with type 2 diabetes who are using glucose-lowering agents other than insulin.

article thumbnail

Mortality and Comorbidities with COPD

HCPLive

Panelists discuss current statistics indicating that COPD is one of the top three leading causes of death worldwide, with high morbidity and mortality rates, particularly in individuals over 40 years of age, and a growing global burden due to risk factors like smoking and air pollution.

article thumbnail

Inside the expansion plans of Broward Health's 1st cardiology chief

Becker's Hospital Review - Cardiology

Jose Baez-Escudero, MD, in November stepped into his role as the first systemwide chief of cardiology at Fort Lauderdale, Fla.-based Broward Health, where he also now serves as chief of cardiac electrophysiology.

article thumbnail

C-Reactive Protein Effective as Biomarker for HS Treated with Adalimumab

HCPLive

Patients in this post-hoc analysis with elevated CRP were found to have a higher BMI and more severe hidradenitis suppurativa.

article thumbnail

Increased Risk of Surgical Aortic Valve Replacement After Prior Transcatheter vs. Surgical Aortic Valve Replacement with Concomitant Valve Disease

Society of Thoracic Surgeons - Congenital

News Increased Risk of Surgical Aortic Valve Replacement After Prior Transcatheter vs.

article thumbnail

Biosimilars Month in Review: December 2024

HCPLive

The biosimilars month in review highlights a newly approved ustekinumab biosimilar and a look into the field in 2024.

59
article thumbnail

American College of Cardiology to honor 21 industry leaders

Becker's Hospital Review - Cardiology

"Discover the 21 industry leaders being honored by the American College of Cardiology for their contributions to global cardiovascular care and outcomes.

article thumbnail

FDA Grants Orphan Drug Designation to CNP-104 for Primary Biliary Cholangitis

HCPLive

The designation follows positive topline data from the phase 2a trial of CNP-104 in PBC, which were presented at AASLDs The Liver Meeting

59
article thumbnail

Associations of Accelerometer-Derived Moderate-to-Vigorous Physical Activity and Atrioventricular Block in a Healthy Elderly Population

HeartRhythm

There is limited information on protective factors related to atrioventricular (AV) block.

45
article thumbnail

Global Atopic Dermatitis Among Children Projected to Rise Over 50 Years

HCPLive

This analysis using worldwide data from GBD 2021 indicates that the global burden of eczema in children has gradually risen and has been projected to continue increasing.

59
article thumbnail

Action Steps Following CCTA Coding Change From 2025 OPPS Final Rule

American College of Cardiology

The Centers for Medicare and Medicaid Services (CMS) has temporarily reassigned coronary CT angiography (CCTA) codes 75572-75574 from ambulatory payment classification (APC) 5571 to APC 5572 in the 2025 Outpatient Prospective Payment System (OPPS) final rule. This change will raise reimbursement for these services from a national rate of $175.06 in 2024 to $357.13 in 2025.

article thumbnail

LB-102 Shows Promise in Reducing Acute Schizophrenia Symptoms: New Phase 2 Data

HCPLive

Phase 2 data demonstrates the effectiveness of LB-102, developed with the potential to be the first-in-class benzamide antipsychotic, for adults with acute schizophrenia.

59
article thumbnail

NPA7: A Dual Receptor Activating Peptide That Inhibits Cardiac Oxidative Stress

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Cardiomyocyte oxidative stress significantly contributes to the progression of hypertension-induced heart failure, highlighting the need for targeted therapies. We developed a novel peptide, NPA7, that coactivates the GC-A (guanylyl cyclase A)/cGMP and MasR (Mas receptor)/cAMP pathway. This study aimed to test NPA7s ability to inhibit oxidative stress by modulating the p62-KEAP1 (Kelch-like ECH-associated protein 1)-NRF2 (nuclear factor erythroid 2-relate

article thumbnail

Pediatric Lipid Treatment Recommendations

HCPLive

Panelists discuss how statin therapy can be initiated in children with familial hypercholesterolemia as early as 8 to 10 years old, following careful evaluation and lifestyle interventions.