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Laurence Sperling, MD, and Eugenia Gianos, MD, discuss the historical context and underutilization of lipoprotein apheresis in part 1 of a 3-part video series.
Research Highlights: Within 90 days after having an ischemic (clot-caused) stroke, about 5% of stroke survivors ages 65 and older were prescribed benzodiazepines (depressants that relieve anxiety, muscle spasms, produce sedation and reduce seizures).
Nature Reviews Cardiology, Published online: 18 October 2024; doi:10.1038/s41569-024-01095-x Consumption of a high-fat diet leads to the progressive growth of atherosclerotic lesions. Two new studies document that, despite similar overall exposure to high-fat diet over a lifetime, an intermittent consumption of high-fat diet early in life accelerates atherosclerosis compared with continuous consumption of a high-fat diet.
In part 2 of this 3-part series, Sperling and Gianos highlight the role of lipoprotein apheresis in contemporary settings and the supporting evidence base.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Initial prescriptions of benzodiazepines, a class of drugs used to treat anxiety and sleep problems after a stroke may include too many pills for adults ages 65 or older, finds new study.
For people with ischemic stroke, treatment with the clot-busting drug tenecteplase is associated with a slightly higher likelihood of an excellent recovery and reduced disability three months later than the drug alteplase, according to a meta-analysis. Researchers found that the likelihood of good recovery was similar between the two treatments.
For people with ischemic stroke, treatment with the clot-busting drug tenecteplase is associated with a slightly higher likelihood of an excellent recovery and reduced disability three months later than the drug alteplase, according to a meta-analysis. Researchers found that the likelihood of good recovery was similar between the two treatments.
(MedPage Today) -- More vigilance may be needed regarding the amount of benzodiazepines being dispensed to older stroke survivors, though prescription patterns at the national level have improved in recent years. Medicare records showed that within.
Despite evidence suggesting overuse of benzodiazepine in older adults can be associated with dependence, the drug is potentially being over-prescribed to older adult stroke survivors, according to a study published Oct. 17 in Stroke.
A new study identifies antipsychotics to avoid for patients with schizophrenia who have cognitive deficits, including haloperidol, fluphenazine, and clozapine.
Written by Jesse McLaren Two patients in their 70s presented to the ED with chest pain and RBBB. Do either, both, or neither have occlusion MI? Patient 1 : a 75 year old called paramedics with one day of left shoulder pain which migrated to the central chest, which was worse with deep breaths. Past medical history included RBBB without other cardiac history, but old ECG was not available.
In part 3 of our Special Report on lipoprotein apheresis, Sperling and Gianos discuss future considerations for use and the evolving landscape of lipid management.
Does prolonged, high-intensity endurance training increase the risk of bradycardia requiring pacemaker implantation and ultimately the long-term mortality risk?
Baltimore-based Johns Hopkins University has designed a chip capable of diagnosing heart attacks within minutes, according to a study published Oct. 15 in Advanced Science.
What is the comparative efficacy of two contemporary ablation strategies for patients with atrial fibrillation (AF) recurrences despite durably isolated pulmonary veins?
A new prospective study discovered predictors for mortality among patients with sepsis admitted to the emergency department, including age, history of cancer, and dementia.
Background Despite tremendous therapeutic advancements, a significant proportion of coronary artery disease patients suffer from refractory angina pectoris, that is, quality-of-life-compromising angina that is non-manageable with established pharmacological and interventional treatment options. Adenoviral vascular endothelial growth factor-D NC (AdVEGF-D)-encoding gene therapy (GT) holds promise for the treatment of refractory angina.
Reduced red blood cell deformability (RBCD) is associated with diabetic vascular complications, but early pathophysiological RBC changes and predictive demographic and clinical factors in populations with diab.
This analysis aligns with previous research into dose optimization of biologics for psoriasis, affirming enhancement of outcomes without compromising patient safety.
The Heart Failure Society of America has released a scientific statement outlining its insights on the link between heart failure and cancer, the two leading causes of mortality and morbidity in the U.S. The statement was published Oct. 15 in the Journal of Cardiac Failure.
The American Heart Association has released a scientific statement providing guidance on the management of patients with COVID-19-related cardiac arrhythmias and autonomic dysfunction. The statement was published Oct. 14 in Circulation.
Some two decades ago, we, the cardiology community started writing guidelines, recommendations, protocols, whatever you call it, in managing specific clinical problems in cardiology. In this model, there is a class of recommendation supported by different level of evidence. This concept looked perfectly scientific, futuristic, and grew so well.It has been considered the de facto standard of practice.
Atrial fibrillation (AF) and premature ventricular complexes (PVCs) are common arrhythmias associated with significant morbidity and mortality.1,2 The presence and burden of PVCs are associated with increased incidence of AF.3 Catheter ablation is recommended for AF and PVCs in symptomatic, drug-refractory patients, but evidence for combined ablation is lacking.
The HeartLogic algorithm (Boston Scientific, St Paul, MN) integrates data from implantable cardioverter-defibrillator (ICD) sensors to predict heart failure (HF) decompensation: first (S1) and third (S3) heart sounds, intrathoracic impedance, respiration rate, ratio of respiration rate to tidal volume (RSBI), and night heart rate.
Ca2+/calmodulin-dependent protein kinase II(CaMKII) inhibition decelerates atrioventricular node (AVN) conduction, providing a potential treatment for tachycardia. However, the effectiveness of CaMKII inhibition on tachycardia and its underlying mechanism remains unclear.
Aveir™ DR (Abbott) is a dual-chamber leadless pacemaker (LP) system with distinct atrial and ventricular LPs (ALP, VLP) that communicate wirelessly to deliver atrioventricular synchronous pacing. Success rates of these implant-to-implant (i2i™) transmissions have not been systematically evaluated.
Background Bicuspid aortic valve (BAV) is often associated with a concomitant aortopathy. However, few studies have evaluated the effect of the aortic valve (AV) phenotype on the rate of dilation of the aorta. This study aimed to compare the progression rate of aorta dimensions according to AV phenotype (BAV vs tricuspid AV (TAV)), fusion type and sex in patients with aortic stenosis (AS).
The subepicardial tissue is composed of myocardium, fatty tissue, neurons, inflammatory cells, arteries, veins and lymphatic vessels. These components are intimately related and not separated by a visceral layer. Myocardial function can be altered by invasion of adipose tissue into the myocardium creating structural changes, by electrotonic coupling between myocytes and adipocytes, and in response to epicardial adipose secretome signalling.
Over the last decade implantable loop recorders (ILRs), have improved in size and ease of implantation, leading to their widespread use for the diagnosis and management of heart rhythm disorders. While their remote monitoring capabilities have led to the rapid growth in use, the subsequent workload due to excessive data has become a significant problem impacting clinics globally.
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