Thu.Oct 17, 2024

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Lower your cholesterol early, and stick with it!

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 18 October 2024; doi:10.1038/s41569-024-01095-x Consumption of a high-fat diet leads to the progressive growth of atherosclerotic lesions. Two new studies document that, despite similar overall exposure to high-fat diet over a lifetime, an intermittent consumption of high-fat diet early in life accelerates atherosclerosis compared with continuous consumption of a high-fat diet.

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Patients with Genetic HS Susceptibility Predisposed to Coronary Artery Disease, Diabetes

HCPLive

This analysis was conducted to evaluate whether genetic risk of hidradenitis suppurativa was linked to greater risk of future cardiometabolic disease.

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Initial prescriptions of sedatives among older stroke survivors may include too many pills

American Heart News - Heart News

Research Highlights: Within 90 days after having an ischemic (clot-caused) stroke, about 5% of stroke survivors ages 65 and older were prescribed benzodiazepines (depressants that relieve anxiety, muscle spasms, produce sedation and reduce seizures).

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Cognitive Deficits in Schizophrenia: Which Antipsychotics Should Be Avoided?

HCPLive

A new study identifies antipsychotics to avoid for patients with schizophrenia who have cognitive deficits, including haloperidol, fluphenazine, and clozapine.

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Which clot-busting drug is tied to better recovery after stroke?

Science Daily - Heart Disease

For people with ischemic stroke, treatment with the clot-busting drug tenecteplase is associated with a slightly higher likelihood of an excellent recovery and reduced disability three months later than the drug alteplase, according to a meta-analysis. Researchers found that the likelihood of good recovery was similar between the two treatments.

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The Future of Lipoprotein Apheresis, with Laurence Sperling, MD, and Eugenia Gianos, MD

HCPLive

In part 3 of our Special Report on lipoprotein apheresis, Sperling and Gianos discuss future considerations for use and the evolving landscape of lipid management.

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Stroke Survivors Still Prescribed a 'Concerning' Amount of Benzos

Med Page Today

(MedPage Today) -- More vigilance may be needed regarding the amount of benzodiazepines being dispensed to older stroke survivors, though prescription patterns at the national level have improved in recent years. Medicare records showed that within.

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Study Identifies Gut Microbiome Makeup, Diversity Differences in People With Fibromyalgia

HCPLive

The study also identified a tendency for more prevalent human herpesvirus 6B in people with FM than in those without.

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Initial prescriptions of sedatives among older stroke survivors may include too many pills

Science Daily - Heart Disease

Initial prescriptions of benzodiazepines, a class of drugs used to treat anxiety and sleep problems after a stroke may include too many pills for adults ages 65 or older, finds new study.

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FDA Extends Review of Obeticholic Acid (Ocaliva) sNDA for Primary Biliary Cholangitis

HCPLive

The FDA has extended its review of the sNDA, delaying the previous October 15, 2024, PDUFA date, without providing a new anticipated action date.

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Johns Hopkins-designed tech diagnoses heart attack in minutes

Becker's Hospital Review - Cardiology

Baltimore-based Johns Hopkins University has designed a chip capable of diagnosing heart attacks within minutes, according to a study published Oct. 15 in Advanced Science.

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FDA Approves Sodium Oxybate for Cataplexy, Excessive Daytime Sleepiness in Pediatric Narcolepsy

HCPLive

Following the approval of sodium oxybate for cataplexy in adults with cataplexy, the FDA approves this indication for the pediatric population.

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Altered RBC deformability in diabetes: clinical characteristics and RBC pathophysiology

Cardiovascular Diabetology

Reduced red blood cell deformability (RBCD) is associated with diabetic vascular complications, but early pathophysiological RBC changes and predictive demographic and clinical factors in populations with diab.

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Exploring the Role, History of Lipoprotein Apheresis, with Laurence Sperling, MD, and Eugenia Gianos, MD

HCPLive

Laurence Sperling, MD, and Eugenia Gianos, MD, discuss the historical context and underutilization of lipoprotein apheresis in part 1 of a 3-part video series.

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Heart Failure Society of America issues cardio-oncology guidance: 5 things to know

Becker's Hospital Review - Cardiology

The Heart Failure Society of America has released a scientific statement outlining its insights on the link between heart failure and cancer, the two leading causes of mortality and morbidity in the U.S. The statement was published Oct. 15 in the Journal of Cardiac Failure.

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Optimizing Use and Clinical Considerations for Lipoprotein Apheresis, with Laurence Sperling, MD, and Eugenia Gianos, MD

HCPLive

In part 2 of this 3-part series, Sperling and Gianos highlight the role of lipoprotein apheresis in contemporary settings and the supporting evidence base.

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Researchers eye possible over-prescription of benzodiazepine after stroke: 5 things to know

Becker's Hospital Review - Cardiology

Despite evidence suggesting overuse of benzodiazepine in older adults can be associated with dependence, the drug is potentially being over-prescribed to older adult stroke survivors, according to a study published Oct. 17 in Stroke.

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50% of Patients with Sepsis Admitted to the Emergency Department Die Within 2 years

HCPLive

A new prospective study discovered predictors for mortality among patients with sepsis admitted to the emergency department, including age, history of cancer, and dementia.

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AHA's statement on COVID-19-associated arrhythmias: 8 takeaways

Becker's Hospital Review - Cardiology

The American Heart Association has released a scientific statement providing guidance on the management of patients with COVID-19-related cardiac arrhythmias and autonomic dysfunction. The statement was published Oct. 14 in Circulation.

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Risankizumab (Skyrizi) Dose Optimization Effective, Safe for Patients with Psoriasis

HCPLive

This analysis aligns with previous research into dose optimization of biologics for psoriasis, affirming enhancement of outcomes without compromising patient safety.

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West Virginia system adds pediatric cardiology care

Becker's Hospital Review - Cardiology

Discover specialized pediatric cardiology services at Rivers Health in Point Pleasant, W.Va. with the addition of Dr.

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High Genetic Gout Risk Associated With Increased Risk of CVD

HCPLive

Adherence to a preventative, favorable lifestyle significantly reduced CVD risk in participants with high and low genetic risk.

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Calmodulin kinase II inhibition suppresses atrioventricular conduction by regulating intracellular Ca2+ homeostasis

HeartRhythm

Ca2+/calmodulin-dependent protein kinase II(CaMKII) inhibition decelerates atrioventricular node (AVN) conduction, providing a potential treatment for tachycardia. However, the effectiveness of CaMKII inhibition on tachycardia and its underlying mechanism remains unclear.

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Comorbid Fibromyalgia Does Not Impact Low FODMAP Diet Adherence, Outcomes for IBS

HCPLive

Adherence to an adapted low FODMAP diet and its impact on IBS symptoms were not affected based on the presence of fibromyalgia.

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Chronic Wireless Communication Between Dual-Chamber Leadless Pacemaker Devices

HeartRhythm

Aveirâ„¢ DR (Abbott) is a dual-chamber leadless pacemaker (LP) system with distinct atrial and ventricular LPs (ALP, VLP) that communicate wirelessly to deliver atrioventricular synchronous pacing. Success rates of these implant-to-implant (i2iâ„¢) transmissions have not been systematically evaluated.

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Root cause analysis of inappropriate Interventions in cardiology : The culprit is sitting pretty in front of us !

Dr. S. Venkatesan MD

Some two decades ago, we, the cardiology community started writing guidelines, recommendations, protocols, whatever you call it, in managing specific clinical problems in cardiology. In this model, there is a class of recommendation supported by different level of evidence. This concept looked perfectly scientific, futuristic, and grew so well.It has been considered the de facto standard of practice.

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Subepicardial adipose tissue as a modulator of arrhythmias

HeartRhythm

The subepicardial tissue is composed of myocardium, fatty tissue, neurons, inflammatory cells, arteries, veins and lymphatic vessels. These components are intimately related and not separated by a visceral layer. Myocardial function can be altered by invasion of adipose tissue into the myocardium creating structural changes, by electrotonic coupling between myocytes and adipocytes, and in response to epicardial adipose secretome signalling.

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Ablation Strategies for AF Recurrences

American College of Cardiology

What is the comparative efficacy of two contemporary ablation strategies for patients with atrial fibrillation (AF) recurrences despite durably isolated pulmonary veins?

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Use of artificial intelligence algorithms to reduce transmissions in implantable loop recorders

HeartRhythm

Over the last decade implantable loop recorders (ILRs), have improved in size and ease of implantation, leading to their widespread use for the diagnosis and management of heart rhythm disorders. While their remote monitoring capabilities have led to the rapid growth in use, the subsequent workload due to excessive data has become a significant problem impacting clinics globally.

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Pacemaker Implantation Among Cross-Country Skiers

American College of Cardiology

Does prolonged, high-intensity endurance training increase the risk of bradycardia requiring pacemaker implantation and ultimately the long-term mortality risk?

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Poststroke Anxiety: The Other Poststroke Mood Disorder

Stroke Journal

Stroke, Ahead of Print.

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Effect of aortic valve phenotype and sex on aorta dilation in patients with aortic stenosis

Open Heart

Background Bicuspid aortic valve (BAV) is often associated with a concomitant aortopathy. However, few studies have evaluated the effect of the aortic valve (AV) phenotype on the rate of dilation of the aorta. This study aimed to compare the progression rate of aorta dimensions according to AV phenotype (BAV vs tricuspid AV (TAV)), fusion type and sex in patients with aortic stenosis (AS).