Thu.Oct 05, 2023

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Explore TAVI: Join Us Next Month for an Exclusive Cardiologist Session!

ADN Center of Excellence

Are you a dedicated cardiologist who's eager to discover the latest insights on the #TAVI procedure? Look no further! Our upcoming session is just around the corner, and we've gathered all the crucial information you need to stay at the forefront of this game-changing technology. Demystifying the #TAVIProcedure: Let's get straight to the heart of the matter.

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Increased deep sleep benefits your heart

Science Daily - Heart Disease

Researchers play ultra-brief tones to stimulate the brain during deep sleep. This stimulation improves cardiac output and relaxation of the left ventricle. Such technology to improve cardiovascular function could be relevant both in disease treatment and competitive sports.

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Characteristics of tissue temperature during ablation with THERMOCOOL SMARTTOUCH SF versus TactiCath versus QDOT MICRO catheters (Qmode and Qmode+): An in vivo porcine study

Journal of Cardiovascular Electrophysiology

We aimed to investigate differences in tissue temperature characteristics during radiofrequency ablation using three catheters, commonly employed in the 50 W high-power short-duration (HPSD) setting and a 90 W/4 s very HPSD setting catheter. We identified temperature variations across the four ablation settings and their association with collateral damage, including injuries to the esophagus and phrenic nerve.

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Prenatal Nicotine Exposure Raises Male Blood Pressure via FTO-Mediated NOX2/ROS Signaling

Hypertension Journal

Hypertension, Ahead of Print. Background:Cigarette smoking/nicotine exposure in pregnancy shows an increased risk of hypertension in offspring, but the mechanisms are unclear. This study tested the hypothesis that m6A RNA hypomethylation epigenetically regulates vascular NOX (NADPH oxidase) and reactive oxygen species production, contributing to the fetal programming of a hypertensive phenotype in nicotine-exposed offspring.Methods:Pregnant rats were exposed to episodic chronic intermittent nico

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Left ventricular lead placement in cardiac resynchronization therapy: current data and potential explanations for lack of benefit

HeartRhythm

This paper reviews the literature on image-guided cardiac resynchronization therapy (CRT) studies. Improved outcome to CRT has been associated with the placement of an LV lead in the latest activated segment free from scar. The majority of randomized clinical trials investigating a guided LV lead implantation did not show superiority over conventional implantation approaches.

Anatomy 40
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Glycolysis Promotes Angiotensin II–Induced Aortic Remodeling Through Regulating Endothelial-to-Mesenchymal Transition via the Corepressor C-Terminal Binding Protein 1

Hypertension Journal

Hypertension, Volume 80, Issue 12 , Page 2627-2640, December 1, 2023. BACKGROUND:Endothelial dysfunction plays a crucial role in aortic remodeling. Aerobic glycolysis and endothelial-to-mesenchymal transition (EndoMT) have, respectively, been suggested to contribute to endothelial dysfunction in many cardiovascular diseases. Here, we tested the hypothesis that glycolytic reprogramming is critical for EndoMT induction in aortic remodeling through an epigenetic mechanism mediated by a transcriptio

Aortic 40
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Assessing the association between genetic and phenotypic features of dilated cardiomyopathy and outcome in patients with coronary artery disease

European Journal of Heart Failure

In this study, two independent cohorts were used to investigate for cardiovascular magnetic resonance (CMR) and genetic features of dilated cardiomyopathy (DCM) in individuals with coronary artery disease (CAD). First, the UK Biobank was used to assess for the association between rare variants in DCM-associated genes, phenotype and outcomes in participants with CAD.

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Calcium channel blocker use and outcomes in patients with heart failure and mildly reduced and preserved ejection fraction

European Journal of Heart Failure

Abstract Aims Patients with heart failure (HF) and mildly reduced ejection fraction (HFmrEF) and preserved ejection fraction (HFpEF) are often treated with calcium channel blockers (CCBs), although the safety of CCBs in these patients is uncertain. We aimed to investigate the association between CCB use and clinical outcomes in patients with HFmrEF/HFpEF; CCBs were examined overall, as well as by subtype (dihydropyridine and non-dihydropyridine).

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Acute Basilar Artery Occlusion Induced by Rapidly Progressive Thrombosis in Vertebrobasilar Dolichoectasia

Stroke Journal

Stroke, Volume 54, Issue 12 , Page e494-e495, December 1, 2023.

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Potential Diagnostic Role for a Combined Postmortem DNA and RNA Sequencing for Brugada Syndrome

Circulation: Genomic and Precision Medicine

Circulation: Genomic and Precision Medicine, Ahead of Print.

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Randomized Clinical Outcome Trials in Hypertension

Hypertension Journal

Hypertension, Ahead of Print.

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Gardner Treadmill Protocol

All About Cardiovascular System and Disorders

Gardner Treadmill Protocol Gardner Treadmill Protocol, also known as Gardner-Skinner Protocol was described in 1991 [1]. It is used mainly in the evaluation of peripheral arterial disease. The seminal article evaluated the effect of handrail support on claudication distance. Handrail support reduces energy cost of treadmill walking, and can affect claudication distance and hemodynamic responses in persons with peripheral vascular disease.