Ken Grauer, MD

OCTOBER 10, 2024

I was sent the ECG shown in Figure-1 — told only that the patient was a middle-aged man with septicemia. QUESTIONS: Is this rhythm too fast to be sinus tachycardia? Are flutter waves hidden within the QRS and T waves? Are we seeing the retrograde P waves of AVNRT? Is this ATach ( A trial T achycardia )? Figure-1: The initial ECG in today's case. MY Thoughts on Today’s CASE: In my opinion — none of the above answers are optimal to describe the rhythm in Figure-1.

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Blog Tachycardia Atrial Flutter 146

American Heart News - Heart News

OCTOBER 10, 2024

Statement Highlights: Previous studies have found that 14-81% of patients with heart failure experience some degree of cognitive impairment affecting language, memory or executive function. Evidence also indicates that people with atrial fibrillation.

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Atrial Fibrillation Heart Failure Heart Disease 121

HCPLive

OCTOBER 10, 2024

Based on the regulatory feedback provided by the FDA, Nanoscope announced plans to initiate Biologics License Application submission in Q1 2025.

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Med Page Today

OCTOBER 10, 2024

(MedPage Today) -- While it's true that becoming a doctor means a guaranteed six-figure salary, these salaries vary dramatically between specialties. The good news is in 2024, the Physician Compensation Report from Doximity listed 12 medical.

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HCPLive

OCTOBER 10, 2024

A short-term rise in air pollution levels between neighboring days was significantly linked to an increased risk of schizophrenia hospitalizations in China.

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Hospital 111

Dr. Smith's ECG Blog

OCTOBER 10, 2024

Written by Pendell Meyers A man in his early sixties with no significant medical history (including a "negative cardiac workup a few years ago" for unclear indication) called 911 for acute chest pain constantly for the past 5 hours. EMS arrived and recorded vital signs within normal limits and the following ECG during active pain: EMS1 @ 0157: What do you think?

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Chest Pain STEMI Blog Stenosis 90

HCPLive

OCTOBER 10, 2024

Xanomeline trospium chloride offers a new pathway in schizophrenia treatment, improving cognitive symptoms without D2 receptor-related side effects like tardive dyskinesia.

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HCPLive

OCTOBER 10, 2024

The designation was granted to Mirum Pharmaceuticals based on a positive interim analysis of the phase 2b VANTAGE study of volixibat.

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American Heart News - Heart News

OCTOBER 10, 2024

Aspectos destacados de la declaración: En estudios anteriores se ha descubierto que entre el 14 y el 81% de los pacientes con insuficiencia cardíaca presentan algún grado de deterioro cognitivo que afecta el lenguaje, la memoria o la función.

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HCPLive

OCTOBER 10, 2024

Second-generation long-acting injectables were particularly underutilized, and especially among older patients.

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Stroke Journal

OCTOBER 10, 2024

Stroke, Ahead of Print. The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Thus, achieving optimal brain health has been identified as a public health priority and a major challenge. Cardiovascular diseases are the leading cause of death and disability in the United States and around the world.

Public Health 75

Public Health Atrial Fibrillation Dementia Heart Failure 75

HCPLive

OCTOBER 10, 2024

Being female and having bipolar II disorder were independent risk factors for serious AEs in a new study.

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Risk Factors 104

Science Daily - Heart Disease

OCTOBER 10, 2024

Inflammation of the arteries is a primary precursor and driver of cardiovascular disease -- the No. 1 killer of people in the United States. This inflammation is associated with the buildup of dangerous plaque inside the arteries. Advanced treatments are needed to target this inflammation in patients. Researchers have tested a new nanoparticle nanotherapy infusion that precisely targets inflammation and activates the immune system to help clear out arterial plaque.

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Research Plaque Cardiovascular Disease 67

HCPLive

OCTOBER 10, 2024

While this analysis found social anhedonia may be a potential intervention for some, nonsocial cognition may have a significant role in social disconnection for those with schizophrenia.

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Science Daily - Heart Disease

OCTOBER 10, 2024

A new American Heart Association scientific statement suggests addressing cardiovascular health earlier in life may reduce the risk of stroke and help preserve thinking and memory later in life.

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Atrial Fibrillation Heart Failure Heart Disease Strokes 66

HCPLive

OCTOBER 10, 2024

These data suggest that relapse among those with schizophrenia may be common 6 months after ECT, with more than half of patients likely to experience relapse within 2 years.

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Becker's Hospital Review - Cardiology

OCTOBER 10, 2024

"Oklahoma Children's Hospital OU Health performs first pediatric heart transplant in decades, reviving program and becoming only center in state.

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Heart Transplant Transplant Pediatrics Hospital 59

HCPLive

OCTOBER 10, 2024

A study of more than 130k with schizophrenia revealed significant variability in relapse and treatment failure rates across different antipsychotics.

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Nature Reviews - Cardiology

OCTOBER 10, 2024

Nature Reviews Cardiology, Published online: 11 October 2024; doi:10.1038/s41569-024-01074-2 In this Review, Mestroni and colleagues provide an overview of the pathophysiological mechanisms underlying dilated cardiomyopathy, including both genetic and non-genetic causes, and discuss the development of novel therapies, such as small molecules and gene therapy.

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Cardiomyopathy 52

Frontiers in Cardiovascular Medicine

OCTOBER 10, 2024

Despite significant advances in diagnosis and treatment over recent decades, cardiovascular disease (CVD) remains one of the leading causes of morbidity and mortality in Western countries. This persistent burden is partly due to the incomplete understanding of fundamental pathogenic mechanisms, which limits the effectiveness of current therapeutic interventions.

Atherosclerosis 52

Atherosclerosis Heart Failure Cardiomyopathy Cardiovascular Disease 52

Becker's Hospital Review - Cardiology

OCTOBER 10, 2024

A group of women in cardiology have called for increased awareness of the risks pregnant people encounter during cardiology training. The group voiced their concerns in an editorial published Aug. 7 in JAMA Cardiology , where group members also serve as editors.

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Frontiers in Cardiovascular Medicine

OCTOBER 10, 2024

BackgroundPulmonary vein isolation (PVI) is successful in approximately 50% of patients with persistent atrial fibrillation (PsAF) at one year. Identifying pre-procedurally the patients who respond favorably to a PVI alone strategy could improve their management. The present study aims to assess the predictive value of clinical response to pre-ablation electrical cardioversion (ECV) to identify the responders to PVI.MethodsConsecutive patients undergoing catheter ablation for PsAF were retrospec

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Atrial Fibrillation Ablation Pulmonary 52

Cardiometabolic Health Congress

OCTOBER 10, 2024

As artificial intelligence (AI) continues revolutionizing healthcare, a new generation of startups is emerging in the cardiometabolic space. These innovative companies leverage AI to develop cutting-edge diagnostic tools, predictive analytics, and personalized medicine approaches. By harnessing the power of machine learning and big data, these startups are transforming the landscape of cardiovascular, renal, and metabolic care.

Innovation 52

Innovation Technology Kidney Disease Chronic Disease 52

Frontiers in Cardiovascular Medicine

OCTOBER 10, 2024

BackgroundManaging pulmonary embolism (PE) at extremely high altitudes poses unique challenges due to harsh environmental conditions and limited healthcare resources.MethodThis study retrospectively analyzed Tibetan PE patients in the Tibet Autonomous Region of China to evaluate the effectiveness and safety of combined endovascular interventional therapy in high-altitude areas.ResultsThe average altitude of long-term residence for Tibetan patients was 3,863.4 ± 317.4 m, with an average age of 62

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Embolism Pulmonary Chest Pain 52

Heart BMJ

OCTOBER 10, 2024

Background Cardiovascular disease (CVD) risk increases with age. Statins reduce cardiovascular risk but their effects are less certain at older ages. We assessed the long-term effects and cost-effectiveness of statin therapy for older people in the contemporary UK population using a recent meta-analysis of randomised evidence of statin effects in older people and a new validated CVD model.

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Cholesterol Cardiovascular Disease Diabetes Outcomes 52

Frontiers in Cardiovascular Medicine

OCTOBER 10, 2024

BackgroundWe conducted a large-scale epidemiological analysis to investigate the associations between systemic inflammation markers and heart failure (HF). Our aim is to identify potential biomarkers for early detection of HF.MethodsA cross-sectional study was conducted using data from the National Health and Nutrition Examination Survey. We investigated the associations between five systemic inflammation markers (neutrophil to lymphocyte ratio [NLR], platelet to lymphocyte ratio [PLR], systemic

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Heart Failure Biomarkers 52

Heart BMJ

OCTOBER 10, 2024

Background Proteomic biomarkers have shown promise in predicting various cardiovascular conditions, but their utility in assessing the risk of atrial fibrillation (AF) remains unclear. This study aimed to develop and validate a protein-based risk score for predicting incident AF and to compare its predictive performance with traditional clinical risk factors and polygenic risk scores in a large cohort from the UK Biobank.

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Atrial Fibrillation Biomarkers Risk Factors 52

Frontiers in Cardiovascular Medicine

OCTOBER 10, 2024

BackgroundThe association between education and atherosclerotic cardiovascular disease (ASCVD) has been well described for decades. Nevertheless, most cardiovascular risk models, including SCORE2, still do not take educational status into account even if this factor is easily assessed and costs nothing to acquire. Using carotid plaques as a proxy for ASCVD, we analysed educational status as associated with carotid plaque development, to determine if the relationship remains, how it relates to tr

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Education Plaque Risk Factors Cardiovascular Disease 52

Heart BMJ

OCTOBER 10, 2024

Clinical introduction A patient in their 70s with a history of schizophrenia, hypothyroidism and poor compliance to medication was brought in by ambulance with confusion, agitation and hypothermia. Glasgow Coma Scale (GCS) was 7 (E1V2M4). Neurological examination, imaging and toxicology were normal. There was extensive periorbital swelling. Observations found heart rate 38 bpm, blood pressure 140/63, temperature 35.1°C and 22 respirations/min saturating 97% on room air.

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Blood Pressure Echocardiogram 52

Frontiers in Cardiovascular Medicine

OCTOBER 10, 2024

BackgroundInflammation is an important driver of hypertension with numerous components, and there is a paucity of research on the specific inflammatory factors that induce hypertension; therefore, we wanted to investigate the relationship between specific inflammatory factors and hypertension.PurposeA two-sample Mendelian randomization (MR) study was conducted to assess the causal relationship between systemic inflammatory regulators and hypertension (primary or secondary types).Methoda large-sc

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Hypertension Research 52

Heart BMJ

OCTOBER 10, 2024

The frequent concurrence of elevated blood pressure (BP) and type 2 diabetes markedly elevates the risk of cardiovascular disease and mortality. In this review, we discuss the evidence supporting the role of BP-lowering therapies in preventing cardiovascular events in people with type 2 diabetes and the most appropriate BP treatment target in these individuals.

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Blood Pressure Diabetes Pharmacology Cardiovascular Disease 52

Dr. S. Venkatesan MD

OCTOBER 10, 2024

“ In one sense, meta-analysis will come closer to a milder form of glorified academic plagiarism” Can meta-analysis really be called as original scientific research ? No it is not, but some may say yes. It is very difficult to dispute either. But, the fact of the matter is, meta-analyses are not a true science of innovation. It is using some others’ work( sort of intellectual steal ?

Research 52

Research Academic Innovation Exercise 52

Heart BMJ

OCTOBER 10, 2024

Background Preventing high heart rates in patients with atrial fibrillation (AF) is a key objective of AF management. Data regarding heart rates in patients with paroxysmal AF (PAF) is lacking. This analysis aimed to provide insight into heart rates during PAF episodes measured with continuous implantable loop monitoring. Methods In present analysis of the Interaction between hyperCoagulability, Electrical remodeling, and Vascular Destabilization in the Progression of AF study, we included 349 p

Atrial Fibrillation 52

Atrial Fibrillation 52

HCPLive

OCTOBER 10, 2024

HCPLive spoke with Monroe regarding muscarinic modulators, both the ones in development and xanomeline trospium chloride capsules (Cobenfy).

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Heart BMJ

OCTOBER 10, 2024

Introduction ST-segment elevation myocardial infarction (STEMI) diagnosis is based on a clinical presentation and ST-segment elevation (STE) in at least two consecutive leads. Despite being deeply rooted in both the literature and in current medical knowledge and having been pivotal in advancing reperfusion therapy for patients with acute myocardial infarction (MI), the diagnosis of STEMI presents a significant issue: What we, the authors, call the ‘no false negative paradox’ This pa

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STEMI Myocardial Infarction 52

American College of Cardiology

OCTOBER 10, 2024

A new multisocietal statement details the ACC and American Heart Association (AHA's) work over the last several years to optimize clinical practice guidelines, and outlines the continued work and vision for guideline optimization.

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Article 51

Heart BMJ

OCTOBER 10, 2024

The term ‘epidemic’ is increasingly used to describe the rising global prevalence of atrial fibrillation (AF). Recent estimates suggest that AF accounts for between 0.9% and 1.6% of total healthcare expenditure in the UK, forecast to rise to 4% over the next two decades. 1 This trend—which is also anticipated internationally—underpins efforts to identify individuals at high risk of future AF, in addition to those with AF without manifest symptoms, in the hope of targeted

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Atrial Fibrillation Risk Factors Kidney Disease Heart Failure 52