Thu.Sep 12, 2024

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A new app to 'uncuff' blood pressure monitoring

Science Daily - Heart Disease

Researchers have developed a groundbreaking smartphone app that measures blood pressure using a smartphone's built-in sensors, eliminating the need for traditional cuffs. This technology can make blood pressure monitoring more accessible and convenient, especially for underserved populations. By allowing users to measure their blood pressure anytime and anywhere, the app could revolutionize cardiovascular care and improve early detection of hypertension.

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Acute chest pain, right bundle branch block, no STEMI criteria, and negative initial troponin.

Dr. Smith's ECG Blog

Written by Pendell Meyers A man in his 40s called EMS for acute chest pain that awoke him from sleep, along with nausea and shortness of breath. His history included known heart failure with prior EF 18%, insulin dependent diabetes, and polysubstance abuse. Vitals were within normal limits except for tachypnea. Here are his EMS ECGs along with the Queen of Hearts interpretations below each one: EMS1 0650 EMS2 0707 Click here to sign up for Queen of Hearts Access The ECGs show RBBB and LAFB, with

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Electrocardiographic predictors of clinical outcomes in non-ischemic cardiomyopathy patients with left bundle branch area pacing cardiac resynchronization therapy

HeartRhythm

Paced QRS morphology may vary during left bundle branch area pacing (LBBAP) as per the pacing location. It remains unclear whether electrocardiographic changes observed during LBBAP can predict clinical outcomes.

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Substituting Medical Cannabis for Medications Improved Rheumatic Disease Symptom Management

HCPLive

Substitutors also reported fewer adverse events and greater social accetpance with MC.

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Foods with low Nutri-Scores associated with an increased risk of cardiovascular diseases, study finds

Science Daily - Stroke

In a new article, reesearchers report an increased risk of cardiovascular diseases associated with the consumption of foods that rank less favorably on the Nutri-Score scale (new 2024 version) within the European cohort EPIC.

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Introducing the APAC Recap, with Viet Le, DMSc, PA-C, and Erin Pardee, PA-C

HCPLive

The APAC Recap is a new multimedia series created through a partnership between APAC and HCPLive where members of the Academy of Physician Associates have peer-to-peer discussions centered around recent scientific congresses and meetings.

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Coronary Intravascular Imaging Optimum: IVUS, OCT & FFR, A Remarkable Learning Experience at Hisar Hospital

ADN Center of Excellence

We are pleased to announce the successful completion of the Coronary Intravascular Imaging Optimum: IVUS, OCT & FFR training, held in partnership with Hisar Intercontinental Hospital. This event brought together an exceptional group of medical professionals from around the world, facilitating advanced learning in coronary intravascular imaging techniques.

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Dupilumab for Chronic Prurigo Induces Remission Among Subset of Patients

HCPLive

These data highlighted dupilumab’s potential as a means to break the ‘itch–scratch cycle’ in those with chronic prurigo, with disease remission induced in a subset.

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Cautious Optimism for Surgical LAA Closure for People Without Afib

Med Page Today

(MedPage Today) -- Adding prophylactic left atrial appendage (LAA) closure to planned cardiac surgery was linked to lower stroke risk for patients without atrial fibrillation (Afib, or AF), based on a meta-analysis. Pooling six observational and.

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FDA Gives Authorization for First Over-the-Counter Hearing Aid Software Device

HCPLive

This marketing authorization by the FDA allows the Hearing Aid Feature to be implemented alongside compatible Apple AirPod Pro headphones.

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Cardiac groups standardized social determinants of health

Becker's Hospital Review - Cardiology

The American College of Cardiology and the American Heart Association's Committee on Clinical Data Standards has published guidance on the social determinants of health faced by cardiology patients. With clear definitions, these determinants can more easily be incorporated into clinical practice, the committee said in the report published Aug. 26 in the Journal of the American College of Cardiology.

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52-Week Data Support MYL-1701P as Aflibercept Biosimilar for DME

HCPLive

MYL-1701P showed equivalent efficacy, with comparable safety and immunogenicity, to reference aflibercept in the Phase 3 INSIGHT trial.

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Genotype-Guided P2Y12 Inhibitor De-Escalation Strategy in ACS Patients

American College of Cardiology

Is genotype-guided de-escalation of P2Y12 inhibitors safe and effective in a real-world acute coronary syndrome (ACS) population?

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FDA Grants Breakthrough Therapy Designation to Plozasiran for FCS

HCPLive

The agency's designation was granted to plozasiran as an adjunct to diet to reduce triglycerides in adults with familial chylomicronemia syndrome.

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Optimal Antiplatelet Therapy After PCI

American College of Cardiology

What is the evidence comparing dual antiplatelet therapy (DAPT) de-escalation to ticagrelor monotherapy versus continuing DAPT for 12 months after coronary drug-eluting stent implantation?

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Positive Airway Pressure Benefits Older Adults with Sleep Apnea

HCPLive

This analysis may help to inform research evaluating the value of obstructive sleep apnea treatments designed to minimize cardiovascular risk as well as related deaths among older patients.

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Peroxisome Proliferator-Activated Receptor Gamma Regulates Interleukin-6-Induced Lipoprotein (a) Gene Expression in Human HepG2 Cells

Journal of Cardiovascular Pharmacology

Lipoprotein(a) [Lp(a)] is a risk factor for coronary disease. Although levels are primarily genetically determined, data from patients with inflammatory diseases indicate that the inflammatory milieu is associated with increased Lp(a) levels. Lp(a) is synthesized in the liver and the LPA gene promoter contains an interleukin-6 (IL-6) responsive binding site, but the regulatory steps linking inflammation with hepatic Lp(a) synthesis are not well clarified.

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JAK Inhibitors vs TNF Inhibitors: Effects on Administration, Efficacy, and Safety

HCPLive

Panelists discuss how JAK inhibitors and TNF inhibitors differ in administration, efficacy, and safety due to their unique characteristics and mechanisms of action, with further variations in binding activities within the TNFi class impacting clinical outcomes.

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PDE8 Inhibition and Its Impact on ICa,L in Persistent Atrial Fibrillation: Evaluation of PDE8 as a Potential Drug Target

Journal of Cardiovascular Pharmacology

Atrial fibrillation (AF) poses a significant therapeutic challenge with drug interventions showing only limited success. Phosphodiesterases (PDE) regulate cardiac electrical stability and may represent an interesting target. Recently, PDE8 inhibition was proposed as an antiarrhythmic intervention by increasing L-type Ca2+ current (ICa,L) and action potential duration (APD).

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JAK Inhibitor Selectivity and Dose-Related Toxicity

HCPLive

Panelists discuss how the varying selectivity of JAK inhibitors—such as tofacitinib's broad inhibition of JAK1/JAK2/JAK3, baricitinib's inhibition of JAK1/JAK2, and upadacitinib's focus on JAK1—affects dose-related toxicity and overall treatment safety.

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Traumatic Brain Injury is Associated with the Subsequent Risk of Atrial Fibrillation or Atrial Flutter

HeartRhythm

Traumatic brain injury (TBI) is associated with a variety of adverse long-term outcomes and increases sympathetic nervous system activation which could increase the risk of arrhythmias including atrial fibrillation or atrial flutter (AF/AFL).

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The 5-Fold Psychosis, Mania Risk on High Dose Amphetamine with Lauren Moran, MD

HCPLive

In an interview, lead investigator Lauren Moran, MD, shared how the results inform clinical practice on safe amphetamine dosing.

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Eight Practice-Changing Trials Featured at ESC Congress 2024

American College of Cardiology

In this special edition of Eagle’s Eye View, Dr. Eagle summarizes the most important trials that were featured at the ESC Congress 2024, August 30 to September 2—eight trials that could have significant influence on your day-to-day practice.

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Managing Disorders of Gut-Brain Interaction, with Nicole Martinez de Andino, NP

HCPLive

Martinez de Andino reviews key considerations for the management of DGBI with brain-gut behavioral therapy and neuromodulators.

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Unlocking Success: Strategies for Preventing and Managing Complications in CTO PCI Procedures

The American Journal of Cardiology

Publication date: Available online 12 September 2024 Source: The American Journal of Cardiology Author(s): Reza Masoomi, Kathleen E Kearney, Rhian E.

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Patients on High Dose Amphetamine Face Over 5-Fold Psychosis, Mania Risk

HCPLive

A new study highlights the need for caution when prescribing high-dose amphetamines (≥ 30 mg) due to their psychosis and mania risk.

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Are We Nearing the End of 12-Month DAPT Following PCI?

NEJM Journal Watch - Cardiology

Short-term DAPT followed by ticagrelor monotherapy did not increase ischemic events and reduced bleeding risk in the first year after PCI.

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Lavinia Iordache, PA: Presentation, Diagnosis of Hepatobiliary Issues in Pregnancy

HCPLive

Iordache reviews complications of diagnosing hepatobiliary disease in pregnancy and explains how these patients typically present.

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More Data on Beta-Blockers After Myocardial Infarction

NEJM Journal Watch - Cardiology

In a randomized trial, stopping beta-blockers was judged as possibly inferior to continuing them for secondary prevention.

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Research Identifies Potential Markers for ASCVD Risk in People With Rheumatoid Arthritis

HCPLive

Hs-cTnT was found to be associated with a higher risk of MACE and all-cause mortality in a 10-year cohort study.

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Sub-intimal tracking and re-entry and investment procedures: current applications and future directions

The American Journal of Cardiology

Publication date: Available online 12 September 2024 Source: The American Journal of Cardiology Author(s): Jesse A.

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New Research from the ESC Congress 2024

NEJM Journal Watch - Cardiology

NEJM Journal Watch coverage of the meeting

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Editorial Board

The American Journal of Cardiology

Publication date: 15 October 2024 Source: The American Journal of Cardiology, Volume 229 Author(s):

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Trisomy 21 and Congenital Heart Disease: Impact on Health and Functional Outcomes From Birth Through Adolescence: A Scientific Statement From the American Heart Association

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. Due to improvements in recognition and management of their multisystem disease, the long‐term survival of infants, children, and adolescents with trisomy 21 and congenital heart disease now matches children with congenital heart disease and no genetic condition in many scenarios. Although this improved survival is a triumph, individuals with trisomy 21 and congenital heart disease have unique and complex care needs in the domains of phys

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Contents

The American Journal of Cardiology

Publication date: 15 October 2024 Source: The American Journal of Cardiology, Volume 229 Author(s):

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Single-branched stent-graft with on-table fenestration for the management of zone 2 landing TEVAR with an isolated left vertebral artery: a pilot study

Journal of Cardiothoracic Surgery

It is challenging to simultaneously conduct total endovascular repair and reconstruct the left subclavian artery (LSA) and isolated left vertebral artery (ILVA) in patients who had an ILVA and required zone 2.

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Atrial hiPSC-CM as a pharmacological model to evaluate anti-AF drugs: Some lessons from IKur

Journal of Cardiovascular Pharmacology

Human induced pluripotent stem cells (hiPSC) and atrial hiPSC-derived cardiomyocytes (hiPSC-CM) have entered the arena of preclinical AF research. A central question is whether they reproduce the physiological contribution of atrial selective potassium currents (such as the ultrarapid potassium current, IKur) to repolarization. Of note, two studies in single atrial hiPSC-CM reported prolongation of action potential duration by IKur block indicating that IKur might in fact represent a valuable ta