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Tissue regeneration is orchestrated by macrophages that clear damaged cells and promote regenerative inflammation. How macrophages spatially adapt and diversify their functions to support the architectural requirements of actively regenerating tissue remains unknown. In this study, we reconstructed the dynamic trajectories of myeloid cells isolated from acutely injured and early stage dystrophic muscles.
A new study highlights suboptimal HDV screening rates in HBV-infected individuals, suggesting that treating HBV may improve survival for those with HDV coinfection.
(MedPage Today) -- Sociologist Elena Portacolone, PhD, was taken aback. Many of the older adults in San Francisco she visited at home for a research project were confused when she came to the door. They'd forgotten the appointment or couldn't remember.
The study found that, following gradual policy changes, children with acute liver failure requiring a transplant now face a reduced risk of both mortality and graft failure from 1989.
This was sent to me by an undergraduate name Hans Helseth, who is an EKG tech, but who is an expert OMI ECG reader. He wrote most of it and I (Smith) edited. A prehospital “STEMI” activation was called on a 75 year old male ( Patient 1 ) with a history of hyperlipidemia and LAD and Cx OMI with stent placement. He arrived to the ED by helicopter at 1507, about three hours after the start of his chest pain while chopping wood around noon.
The blood-retina barrier (BRB), which is disrupted in diabetic retinopathy (DR) and uveitis, is an important anatomical characteristic of the retina, regulating nutrient, waste, water, protein, and immune cell flux. The BRB is composed of endothelial cell tight junctions, pericytes, astrocyte end feet, a collagen basement membrane, and perivascular macrophages.
Cannabis has been legalized for medical and recreational purposes in multiple countries. A large number of people are using cannabis and some will develop cannabis use disorder (CUD). There is a growing recognition that CUD requires specific interventions. This Review will cover this topic from a variety of perspectives, with a particular emphasis on neurobiological findings and innovative treatment approaches that are being pursued.
The precise conditions by which cytokines drive cancer is relevant to improving immune checkpoint inhibition (ICI) responses while decreasing toxicity. In this issue of the JCI, Kao et al. investigated T helper cell pathways in patients with solid tumors receiving ICI. The authors evaluated T cell populations, cytokine signatures, immune related adverse events (irAEs), and survival outcomes.
In a first-ever trial, researchers from Edith Cowan University (ECU) have provided abdominal aortic calcification (AAC) imaging results to attempt to elicit behavioral changes to improve diet, physical activity, and other cardiovascular disease risk factors in older men and women.
BACKGROUND The HIV Organ Policy Equity (HOPE) Act allows individuals living with HIV to accept organs from donors with HIV. This practice widens the pool of available organs, but also presents important virological issues, including the potential for HIV superinfection of the recipient, viral persistence in the kidney, and loss of virological control.METHODS We addressed these issues by performing in-depth longitudinal viral sequence analyses on urine, blood, and urine-derived renal epithelial c
(MedPage Today) -- Severe COVID-19 infection was associated with major cardiac events as much as -- and in some cases more than -- having a history of heart disease, U.K. Biobank data showed. (Arteriosclerosis, Thrombosis, and Vascular Biology.
Immunological self-tolerance is established in the thymus by the expression of virtually all self-antigens, including tissue-restricted antigens (TRAs) and cell-type–restricted antigens (CRAs). Despite a wealth of knowledge about the transcriptional regulation of TRA genes, posttranscriptional regulation remains poorly understood. Here, we show that protein arginine methylation plays an essential role in central immune tolerance by maximizing the self-antigen repertoire in medullary thymic epith
From preparing for the effects of AI to bracing for the "silver tsunami," here is what cardiology leaders who shared their insights with Becker's said should be prominent topics of conversation in the industry.
The following are key points to remember from a state-of-the-art review on antithrombotic therapy in patients at high bleeding risk (HBR) from the Working Group of Thrombosis of the Italian Society of Cardiology.
A 19-year-old collegiate volleyball player with no significant medical history was referred for evaluation after she was found to have remarkable electrocardiographic (ECG) findings during a preparticipation screening.
Dr. Chadi Alraies and Dr. Mark Schuuring discuss the results of the ADMINISTER2 trial ( NCT05413447 ) which investigated whether the use of digital consults (DCs) could enhance the adoption of guideline-directed medical therapy (GDMT) in patients with heart failure and reduced ejection fraction (HFrEF). A total of 150 patients were randomized to either receive standard care or participate in DCs.
Expression of tissue-restricted antigens (TRAs) within the thymus is critical for the establishment of self-tolerance; however, exact mechanisms regulating the expression of TRAs has proven more complex than previously appreciated. In this issue of the JCI, Muro et al. identify a central role for protein arginine methyltransferase 5 (PRMT5) in posttranscriptional regulation of TRAs and thereby central tolerance.
Women with a higher BMI may have a higher prevalence of cardiovascular risk factors, according to an analysis of the ANCORS-YW study presented during ACC Middle East 2024.
Kidney transplantation from donors with HIV to recipients with HIV (HIV D+/R+) is an emerging practice that has shown substantial clinical benefit. Sustained HIV superinfection, whereby a transplant recipient acquires a new strain of HIV from their organ donor, is a theoretical risk, which might increase chances of viral failure. In this issue of the JCI, Travieso, Stadtler, and colleagues present phylogenetic analysis of HIV from kidney tissue, urine, plasma, and cells from 12 HIV D+/R+ kidney
The goal of the REMAIN-1 trial was to assess the lipid-lowering efficacy and safety of recaticimab, a long-acting monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9 (PCSK9).
As epigenetic therapies continue to gain ground as potential treatment strategies for cancer and other diseases, compounds that target histone lysine methylation and the enzyme complexes represent a major frontier for therapeutic development. Clinically viable therapies targeting the activities of histone lysine methyltransferases (HKMT) and demethylases (HKDMs) have only recently begun to emerge following FDA approval of the EZH2 inhibitor tazemetostat in 2020 and remain limited to compounds ta
Background The benefit of patent foramen ovale closure (PFOC) ≤9 months after a cryptogenic stroke has been demonstrated in several randomised clinical trials. There is, however, insufficient data to support PFOC in non-recent cryptogenic strokes. Aims The objective of the study was to evaluate the effectiveness of PFOC in relation to the time since the patient’s most recent cryptogenic cerebrovascular event (CVE) or systemic embolism (SE).
Webinar Latin Thoracic Rounds: Rounds on a Patient with Locally Advanced Stage Lung Cancer gmckinney Tue, 10/15/2024 - 11:07 November 15, 2024 Image An international panel of experts from the United Arab Emirates, Chile, Colombia, Uruguay, Brazil, Spain, and the US will discuss up-to-date management of a patient with stage IIIA lung cancer. Panelists will discuss diagnosis, neoadjuvant and adjuvant treatments, restaging, and surgical approach and complications.
Webinar Early Career Journey: Student Loan Management for Early Career Physicians gmckinney Tue, 10/15/2024 - 10:27 November 7, 2024 Early career surgeons should plan to attend this webinar on effective financial management of student loans, presented by an expert speaker from the White Coat Investor. The presentation will examine a variety of student loan considerations: loan repayment plans (IBR, SAVE, PAYE), loan forgiveness (Public Service Loan Forgiveness), refinancing, and making a persona
Webinar Latin Thoracic Rounds Series: Rounds on Patient with Locally Advanced Stage Lung Cancer gmckinney Tue, 10/15/2024 - 11:07 November 15, 2024 Image An international panel of experts from the United Arab Emirates, Chile, Colombia, Uruguay, Brazil, Spain, and the US will discuss up-to-date management of a patient with stage IIIA lung cancer. Panelists will discuss diagnosis, neoadjuvant and adjuvant treatments, restaging, and surgical approach and complications.
Webinar Student Loan Management for Early Career Physicians gmckinney Tue, 10/15/2024 - 10:27 November 7, 2024 Early career surgeons should plan to attend this webinar on effective financial management of student loans, presented by an expert speaker from the White Coat Investor. The presentation will examine a variety of student loan considerations: loan repayment plans (IBR, SAVE, PAYE), loan forgiveness (Public Service Loan Forgiveness), refinancing, and making a personal loan management plan
Resource Esophagectomy for Cancer Risk Calculator kchalko Tue, 10/15/2024 - 15:08 Engineered using contemporary data from the STS General Thoracic Surgery Database, the new esophagectomy for cancer risk calculator allows surgeons and multidisciplinary medical providers to estimate a patient’s individualized risk in real-time, based on specific factors such as tumor characteristics, comorbidities, and procedures performed.
A 41 year old female with stage 5 chronic kidney disease undergoing hemodialysis was admitted to the hospital. Chest CT scan revealed a large mass lesion of approximately 6.0 × 3.5x4.9 cm in size in the anteri.
Obesity is a widespread public health challenge in the Middle East, maintaining prevalence in 54.2% of women and 31.4% of men in this region. Overweight and obese women have a higher risk of hypertension and cardiovascular risk factors than women with a standard BMI, according to an analysis of the ANCORS-YW STUDY presented at ACC Middle East 2024.
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