Journal of Clinical Investigation - Cardiology

OCTOBER 15, 2024

Tissue regeneration is orchestrated by macrophages that clear damaged cells and promote regenerative inflammation. How macrophages spatially adapt and diversify their functions to support the architectural requirements of actively regenerating tissue remains unknown. In this study, we reconstructed the dynamic trajectories of myeloid cells isolated from acutely injured and early stage dystrophic muscles.

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Dr. Smith's ECG Blog

OCTOBER 15, 2024

This was sent to me by an undergraduate name Hans Helseth, who is an EKG tech, but who is an expert OMI ECG reader. He wrote most of it and I (Smith) edited. A prehospital “STEMI” activation was called on a 75 year old male ( Patient 1 ) with a history of hyperlipidemia and LAD and Cx OMI with stent placement. He arrived to the ED by helicopter at 1507, about three hours after the start of his chest pain while chopping wood around noon.

Chest Pain 100

Chest Pain STEMI Echocardiogram Stent 100

HCPLive

OCTOBER 15, 2024

Study findings showed children with both obesity and MASLD have a greater risk of youth-onset type 2 diabetes than those with obesity alone.

Obesity 97

Obesity Diabetes 97

Journal of Clinical Investigation - Cardiology

OCTOBER 15, 2024

Immunological self-tolerance is established in the thymus by the expression of virtually all self-antigens, including tissue-restricted antigens (TRAs) and cell-type–restricted antigens (CRAs). Despite a wealth of knowledge about the transcriptional regulation of TRA genes, posttranscriptional regulation remains poorly understood. Here, we show that protein arginine methylation plays an essential role in central immune tolerance by maximizing the self-antigen repertoire in medullary thymic epith

Cancer 79

Cancer 79

Med Page Today

OCTOBER 15, 2024

(MedPage Today) -- Sociologist Elena Portacolone, PhD, was taken aback. Many of the older adults in San Francisco she visited at home for a research project were confused when she came to the door. They'd forgotten the appointment or couldn't remember.

Dementia 77

Dementia Research 77

Becker's Hospital Review - Cardiology

OCTOBER 15, 2024

From preparing for the effects of AI to bracing for the "silver tsunami," here is what cardiology leaders who shared their insights with Becker's said should be prominent topics of conversation in the industry.

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Journal of Clinical Investigation - Cardiology

OCTOBER 15, 2024

Cannabis has been legalized for medical and recreational purposes in multiple countries. A large number of people are using cannabis and some will develop cannabis use disorder (CUD). There is a growing recognition that CUD requires specific interventions. This Review will cover this topic from a variety of perspectives, with a particular emphasis on neurobiological findings and innovative treatment approaches that are being pursued.

Pharmacology 99

Pharmacology Innovation Risk Factors 99

Medical Xpress - Cardiology

OCTOBER 15, 2024

In a first-ever trial, researchers from Edith Cowan University (ECU) have provided abdominal aortic calcification (AAC) imaging results to attempt to elicit behavioral changes to improve diet, physical activity, and other cardiovascular disease risk factors in older men and women.

Diet 59

Diet Risk Factors Cardiovascular Disease Aortic 59

HCPLive

OCTOBER 15, 2024

Brian Hansen, president of CGM at Ascensia Diabetes Care, joins the podcast to discuss the FDA clearance of the Eversense 365 CGM.

Diabetes 72

Diabetes 72

Med Page Today

OCTOBER 15, 2024

(MedPage Today) -- Severe COVID-19 infection was associated with major cardiac events as much as -- and in some cases more than -- having a history of heart disease, U.K. Biobank data showed. (Arteriosclerosis, Thrombosis, and Vascular Biology.

COVID-19 55

COVID-19 Thrombosis Heart Disease 55

HCPLive

OCTOBER 15, 2024

The study found that, following gradual policy changes, children with acute liver failure requiring a transplant now face a reduced risk of both mortality and graft failure from 1989.

Transplant 59

Transplant Pediatrics 59

Journal of Clinical Investigation - Cardiology

OCTOBER 15, 2024

The precise conditions by which cytokines drive cancer is relevant to improving immune checkpoint inhibition (ICI) responses while decreasing toxicity. In this issue of the JCI, Kao et al. investigated T helper cell pathways in patients with solid tumors receiving ICI. The authors evaluated T cell populations, cytokine signatures, immune related adverse events (irAEs), and survival outcomes.

Cancer 75

Cancer Outcomes 75

HCPLive

OCTOBER 15, 2024

These data on metabolic dysfunction-associated steatotic liver disease provide information on the economic burden among high-risk patients.

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Society of Thoracic Surgeons - Surgeon

OCTOBER 15, 2024

Resource Esophagectomy for Cancer Risk Calculator kchalko Tue, 10/15/2024 - 15:08 Engineered using contemporary data from the STS General Thoracic Surgery Database, the new esophagectomy for cancer risk calculator allows surgeons and multidisciplinary medical providers to estimate a patient’s individualized risk in real-time, based on specific factors such as tumor characteristics, comorbidities, and procedures performed.

Cancer 52

Cancer Risk Factors Hospital Research 52

Journal of Cardiothoracic Surgery

OCTOBER 15, 2024

A 41 year old female with stage 5 chronic kidney disease undergoing hemodialysis was admitted to the hospital. Chest CT scan revealed a large mass lesion of approximately 6.0 × 3.5x4.9 cm in size in the anteri.

Kidney Disease 52

Kidney Disease Cancer Hospital 52

Medical Xpress - Cardiology

OCTOBER 15, 2024

Obesity is a widespread public health challenge in the Middle East, maintaining prevalence in 54.2% of women and 31.4% of men in this region. Overweight and obese women have a higher risk of hypertension and cardiovascular risk factors than women with a standard BMI, according to an analysis of the ANCORS-YW STUDY presented at ACC Middle East 2024.

Obesity 52

Obesity Hypertension BMI Public Health 52

Journal of Cardiothoracic Surgery

OCTOBER 15, 2024

Patients undergoing dialysis treatment have long been recognized as having an elevated risk of developing coronary artery disease necessitating coronary artery bypass grafting (CABG). However, the prognostic i.

Coronary Artery Bypass Graft 52

Coronary Artery Bypass Graft Coronary Artery Disease Research 52

DAIC

OCTOBER 15, 2024

tim.hodson Tue, 10/15/2024 - 13:49 Oct. 14, 2024 – The Institute for AI Governance in Healthcare (IAIGH) has published the draft Healthcare AI Governance Standard (HAIGS) for public comment. The comment period opened Oct. 14, 2024, and closes Nov. 14, 2024. The draft standard is available for review and feedback at AiHealthcareGovernance.org. "As AI continues to transform healthcare, there is a pressing need for governance practices that ensure these technologies operate transparently and safel

Technology 52

Technology 52

Journal of Cardiothoracic Surgery

OCTOBER 15, 2024

Hereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disorder characterized by epistaxis, gastrointestinal bleeding, iron deficiency anemia, and arteriovenous malformations (AVMs) affecting the.

Hemorrhage 52

Hemorrhage Myocardial Infarction 52

DAIC

OCTOBER 15, 2024

tim.hodson Tue, 10/15/2024 - 12:12 Oct. 15, 2024 – Elucid has announced that four of the seven Medicare Administrative Contractors (MACs) will extend coverage for AI-enabled quantitative coronary plaque analysis, including its FDA-cleared PlaqueIQ image analysis software, beginning Nov. 24, 2024. The updated policy will allow for Medicare patients whose claims are administered within the four MACs who present with acute or stable chest pain and no known history of cardiovascular disease to be as

Medicare 52

Medicare Plaque Coronary Artery Disease Chest Pain 52

Society of Thoracic Surgeons - Surgeon

OCTOBER 15, 2024

Webinar The Evolving Role of Radiation Therapy in Resectable Lung Cancer gmckinney Tue, 10/15/2024 - 10:15 October 24, 2024 In the past five years, immunotherapy has transformed the approach to treating resectable lung cancer in both neoadjuvant and adjuvant settings. During this webinar, experts will explore the continued importance of radiation therapy in managing resectable lung cancer and highlight essential insights that thoracic surgeons need for daily practice.

Cancer 52

Cancer Webinar Hospital 52

Dr. S. Venkatesan MD

OCTOBER 15, 2024

A new Intelligent thrombo-suction catheter system , is being introduced for treatment of acute pulmonary embolism.This device regulates the force with which thrombus is sucked , with less injury and bleeding and better outcomes. Human studies & Evidence The experience from this device was presented in ESC 2024 London. Intelligent CT vacuum aspiration thrombectomy system : ALEKSANDER A. et al from Poznan University Of Medical Sciences, Pozna POLAND What to know more about this device ?

Technology 52

Technology Pulmonary Embolism Innovation 52

Frontiers in Cardiovascular Medicine

OCTOBER 15, 2024

BackgroundHypertension (HTN) currently affects over 120 million Americans, in the United States (US). Thus, the implementation of evidence-based interventions (EBI) for blood pressure (BP) reduction is pivotal in minimizing this burden. We sought to evaluate evidence from published literature on the effectiveness of musical interventions for BP reduction within the US.MethodsA systematic review of studies that utilize music interventions to manage BP was conducted in October of 2022.

Blood Pressure 52

Blood Pressure Pharmacology Article Outcomes 52

HCPLive

OCTOBER 15, 2024

Lauren Miller, MPAS, PA-C; Jayme M. Heim, MSN FNP-BC, and Kirk Gautier, PA-C, discuss recent advancements in plaque psoriasis treatment, focusing on novel oral systemic therapies like the TYK-2 inhibitor deucravacitinib and its clinical trial data, to inform therapeutic decisions for this systemic disease.

Plaque 52

Plaque 52

MIBHS

OCTOBER 15, 2024

The heart is the powerhouse of the human body, working tirelessly to ensure that oxygenated blood reaches every organ and tissue. But like any hardworking organ, it also needs its own blood supply to function effectively. This is where coronary circulation comes into play. Coronary circulation refers to the movement of blood through the network of coronary arteries and veins that supply the heart muscle (myocardium) itself.

Circulation 52

Circulation Heart Attack Heart attacks Coronary Artery Disease 52

Cardiology Update

OCTOBER 15, 2024

Dr. Chadi Alraies and Dr. Mark Schuuring discuss the results of the ADMINISTER2 trial ( NCT05413447 ) which investigated whether the use of digital consults (DCs) could enhance the adoption of guideline-directed medical therapy (GDMT) in patients with heart failure and reduced ejection fraction (HFrEF). A total of 150 patients were randomized to either receive standard care or participate in DCs.

Heart Failure 52

Heart Failure Research Outcomes General Cardiology 52

HCPLive

OCTOBER 15, 2024

SGLT2 inhibitors appeared effective in improving hepatic inflammation and fibrosis indices in patients with type 2 diabetes and suspected MASLD.

Diabetes 59

Diabetes 59

American College of Cardiology

OCTOBER 15, 2024

A 19-year-old collegiate volleyball player with no significant medical history was referred for evaluation after she was found to have remarkable electrocardiographic (ECG) findings during a preparticipation screening.

Article 56

Article 56

HCPLive

OCTOBER 15, 2024

This analysis may help identify at-risk patients of liver enzyme elevation following sustained virologic response among individuals with hepatitis C virus infection.

Risk Factors 52

Risk Factors 52

Journal of Clinical Investigation - Cardiology

OCTOBER 15, 2024

Expression of tissue-restricted antigens (TRAs) within the thymus is critical for the establishment of self-tolerance; however, exact mechanisms regulating the expression of TRAs has proven more complex than previously appreciated. In this issue of the JCI, Muro et al. identify a central role for protein arginine methyltransferase 5 (PRMT5) in posttranscriptional regulation of TRAs and thereby central tolerance.

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68

HCPLive

OCTOBER 15, 2024

A new study highlights suboptimal HDV screening rates in HBV-infected individuals, suggesting that treating HBV may improve survival for those with HDV coinfection.

Outcomes 52

Outcomes 52

Journal of Clinical Investigation - Cardiology

OCTOBER 15, 2024

Kidney transplantation from donors with HIV to recipients with HIV (HIV D+/R+) is an emerging practice that has shown substantial clinical benefit. Sustained HIV superinfection, whereby a transplant recipient acquires a new strain of HIV from their organ donor, is a theoretical risk, which might increase chances of viral failure. In this issue of the JCI, Travieso, Stadtler, and colleagues present phylogenetic analysis of HIV from kidney tissue, urine, plasma, and cells from 12 HIV D+/R+ kidney

Transplant 68

Transplant 68

HCPLive

OCTOBER 15, 2024

Findings highlight the potential utility of the FAST score for ruling out fibrotic MASH, pointing to the need for a sequential testing approach to rule it in.

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American College of Cardiology

OCTOBER 15, 2024

The goal of the REMAIN-1 trial was to assess the lipid-lowering efficacy and safety of recaticimab, a long-acting monoclonal antibody targeting proprotein convertase subtilisin/kexin type 9 (PCSK9).

Article 53

Article 53

Journal of Clinical Investigation - Cardiology

OCTOBER 15, 2024

BACKGROUND The HIV Organ Policy Equity (HOPE) Act allows individuals living with HIV to accept organs from donors with HIV. This practice widens the pool of available organs, but also presents important virological issues, including the potential for HIV superinfection of the recipient, viral persistence in the kidney, and loss of virological control.METHODS We addressed these issues by performing in-depth longitudinal viral sequence analyses on urine, blood, and urine-derived renal epithelial c

Transplant 50

Transplant Kidney Disease Diabetes 50

American College of Cardiology

OCTOBER 15, 2024

Women with a higher BMI may have a higher prevalence of cardiovascular risk factors, according to an analysis of the ANCORS-YW study presented during ACC Middle East 2024.

BMI 53

BMI Risk Factors Article 53

HCPLive

OCTOBER 15, 2024

Increased serum TBA levels at baseline significantly raised the risk of HCC development in patients with multi-etiology cirrhosis.

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