Med Page Today
APRIL 15, 2024
(MedPage Today) -- More than one in five older adults hospitalized for respiratory syncytial virus (RSV) infection experienced an acute cardiac event, an observational study found. Among 6,248 hospitalized patients 50 or older with laboratory.
Journal of Clinical Investigation - Cardiology
APRIL 15, 2024
RAD54 and BLM helicase play pivotal roles during homologous recombination repair (HRR) to ensure genome maintenance. BLM amino acids (aa 181–212) interact with RAD54 and enhance its chromatin remodeling activity. Functionally, this interaction heightens HRR, leading to a decrease in residual DNA damage in colon cancer cells. This contributes to chemoresistance in colon cancer cells against cisplatin, camptothecin, and oxaliplatin, eventually promoting tumorigenesis in preclinical colon cancer mo
Medical Xpress - Cardiology
APRIL 15, 2024
An analysis of the biomolecule substudy of the EAST–AFNET 4 trial has revealed that biomolecule concentrations in the blood of patients with atrial fibrillation can be used to identify patients at high and low cardiovascular risk. The findings were published in Cardiovascular Research.
Journal of Clinical Investigation - Cardiology
APRIL 15, 2024
SARS-CoV-2 infection of the upper airway and the subsequent immune response are early, critical factors in COVID-19 pathogenesis. By studying infection of human biopsies in vitro and in a hamster model in vivo, we demonstrated a transition in nasal tropism from olfactory to respiratory epithelium as the virus evolved. Analyzing each variant revealed that SARS-CoV-2 WA1 or Delta infect a proportion of olfactory neurons in addition to the primary target sustentacular cells.
DAIC
APRIL 15, 2024
Image courtesy of Abbott mtaschetta-millane Mon, 04/15/2024 - 09:54 April 15, 2024 — The U.S. Food and Drug Administration ( FDA ) announced A bbott/Thoratec Corp. is recalling HeartMate II and HeartMate 3 Left Ventricular Assist System (LVAS) due to an issue called Extrinsic Outflow Graft Obstruction , (EOGO). This occurs when biological material builds up between certain parts of the device, causing a blockage that makes it harder for the heart to pump blood.
Journal of Clinical Investigation - Cardiology
APRIL 15, 2024
Chromosomal instability is a prominent biological feature of myelodysplastic syndromes (MDS), with over 50% of patients with MDS harboring chromosomal abnormalities or a complex karyotype (CK). Despite this observation, the mechanisms underlying mitotic and chromosomal defects in MDS remain elusive. In this study, we identified ectopic expression of the transcription factor ONECUT3, which is associated with CKs and poorer survival outcomes in MDS.
Med Page Today
APRIL 15, 2024
(MedPage Today) -- Women who experienced major adverse pregnancy outcomes still had increased mortality risks decades later, a population-based cohort study of Swedish data found. Adverse pregnancy outcomes independently associated with increased.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
HCPLive
APRIL 15, 2024
A recent multi-center study identified risk factors linked to premature mortality in sickle cell disease, including male gender and hematologic and biochemical parameters.
Heart BMJ
APRIL 15, 2024
Objective To study the association between COVID-19 vaccination and the risk of post-COVID-19 cardiac and thromboembolic complications. Methods We conducted a staggered cohort study based on national vaccination campaigns using electronic health records from the UK, Spain and Estonia. Vaccine rollout was grouped into four stages with predefined enrolment periods.
Cardiology Update
APRIL 15, 2024
Dr. Chadi Alraies discusses the top impactful trials presented at the 2024 American College of Cardiology conference. Learn more about the highlights from ACC 2024. For more cardiology research news join our newsletter or follow us on Twitter , Facebook , LinkedIn or Instagram. The post ACC 2024 Highlights appeared first on Cardiology Update.
Journal of Clinical Investigation - Cardiology
APRIL 15, 2024
Loss of arterial smooth muscle cells (SMCs) and abnormal accumulation of the extracellular domain of the NOTCH3 receptor (Notch3ECD) are the 2 core features of CADASIL, a common cerebral small vessel disease caused by highly stereotyped dominant mutations in NOTCH3. Yet the relationship between NOTCH3 receptor activity, Notch3ECD accumulation, and arterial SMC loss has remained elusive, hampering the development of disease-modifying therapies.
Heart BMJ
APRIL 15, 2024
Inflammation has a direct role in the development of atherosclerotic vascular disease, and oral colchicine displays broad anti-inflammatory properties. Several large, randomised controlled trials (RCTs) have evaluated colchicine’s impact on cardiovascular outcomes. Results from a meta-analysis of these trials demonstrate that colchicine reduces the risk of recurrent major adverse cardiovascular events (MACEs) by 25%, leading to its recent approval by the Food and Drug Administration for th
Becker's Hospital Review - Cardiology
APRIL 15, 2024
Seventeen percent of cardiologists said their burnout was so severe that they may leave medicine, according to a Medscape report.
HCPLive
APRIL 15, 2024
Barratt discusses the potential of targeting the alternative pathway for controlling inflammation and the significance of the new APPLAUSE-IgAN data.
Journal of Clinical Investigation - Cardiology
APRIL 15, 2024
Staphylococcus aureus is a leading cause of biofilm-associated prosthetic joint infection (PJI). A primary contributor to infection chronicity is an expansion of granulocytic myeloid-derived suppressor cells (G-MDSCs), which are critical for orchestrating the antiinflammatory biofilm milieu. Single-cell sequencing and bioinformatic metabolic algorithms were used to explore the link between G-MDSC metabolism and S. aureus PJI outcome.
Med Page Today
APRIL 15, 2024
(MedPage Today) -- A multi-pronged electronic health record-based population health management intervention failed to move the needle for slowing chronic kidney disease (CKD) progression, a cluster randomized trial showed. Over a median follow.
Journal of Clinical Investigation - Cardiology
APRIL 15, 2024
Antitumor responses of CD8+ T cells are tightly regulated by distinct metabolic fitness. High levels of glutathione (GSH) are observed in the majority of tumors, contributing to cancer progression and treatment resistance in part by preventing glutathione peroxidase 4–dependent (GPX4-dependent) ferroptosis. Here, we show the necessity of adenosine A2A receptor (A2AR) signaling and the GSH/GPX4 axis in orchestrating metabolic fitness and survival of functionally competent CD8+ T cells.
HCPLive
APRIL 15, 2024
EULAR’s fibromyalgia guidelines provide comprehensive recommendations for managing active fibromyalgia to assist clinicians in making informed decisions. Test your knowledge with this quiz.
Journal of Clinical Investigation - Cardiology
APRIL 15, 2024
Merkel cell carcinoma (MCC) is a highly immunogenic skin cancer primarily induced by Merkel cell polyomavirus, which is driven by the expression of the oncogenic T antigens (T-Ags). Blockade of the programmed cell death protein-1 (PD-1) pathway has shown remarkable response rates, but evidence for therapy-associated T-Ag–specific immune response and therapeutic strategies for the nonresponding fraction are both limited.
American College of Cardiology
APRIL 15, 2024
Glucagon-like peptide-1 is an incretin (gut-derived hormone) that plays a crucial role in glucose homeostasis, linking nutrient absorption to pancreatic hormone secretion.
Journal of Clinical Investigation - Cardiology
APRIL 15, 2024
Adoptive transfer of T cell receptor–engineered T cells (TCR-T) is a promising strategy for immunotherapy against solid tumors. However, the potential of CD4+ T cells in mediating tumor regression has been neglected. Nasopharyngeal cancer is consistently associated with EBV. Here, to evaluate the therapeutic potential of CD4 TCR-T in nasopharyngeal cancer, we screened for CD4 TCRs recognizing EBV nuclear antigen 1 (EBNA1) presented by HLA-DP5.
HCPLive
APRIL 15, 2024
Although the intervention did not reduce risk of CKD progression versus standard care, it addressed barriers to care and increased patients’ exposure to ACEi/ARBs.
American College of Cardiology
APRIL 15, 2024
The following are key points to remember from a state-of-the-art review on the long-term safety of low-dose colchicine for atherosclerosis.
Becker's Hospital Review - Cardiology
APRIL 15, 2024
COVID-19 vaccination is not linked with sudden cardiac death among previously healthy young people, an April 11 CDC report found.
HeartRhythm
APRIL 15, 2024
Endocardial electrogram (EGM) characteristics in non-ischemic cardiomyopathy (NICM) have not been explored adequately for prognostication.
HCPLive
APRIL 15, 2024
Counting down the most impactful news at major medical meetings, it’s the HCPLive Five! This edition focuses on 5 updates from the American College of Cardiology 2024 (ACC.24) Annual Scientific Sessions.
Nature Reviews - Cardiology
APRIL 15, 2024
Nature Reviews Cardiology, Published online: 16 April 2024; doi:10.1038/s41569-024-01026-w A new study identifies a group of gut bacteria that can metabolize cholesterol and are associated with lower plasma cholesterol levels.
HCPLive
APRIL 15, 2024
This post-hoc analysis of phase 3 data, using GRAPPA-recognized PsA domains, highlighted disease improvements following treatment with guselkumab.
Journal of Cardiothoracic Surgery
APRIL 15, 2024
During a routine physical examination three years ago, a 47-year-old woman received a diagnosis of a nodule in her right upper lung. Since then, she has been regularly attending outpatient clinic appointments.
HCPLive
APRIL 15, 2024
Patients with a delayed appendicitis diagnosis had 1.23 times increased hospital care costs, and Black patients had a greater increased cost than White patients.
Journal of Cardiothoracic Surgery
APRIL 15, 2024
The ectopic superior parathyroid in the tracheoesophageal groove and paraesophageal region is rare. Hyperparathyroidism results when these glands become hyperfunctioning. That may necessitate surgical interven.
All About Cardiovascular System and Disorders
APRIL 15, 2024
High degree of awareness of heart attack symptoms in the community will go a long way in seeking early treatment. For life threatening diseases like heart attack, early recognition of symptoms and prompt reporting to the emergency department is highly desirable. But a study from United States showed that 47% were not able to recognize some heart attack symptoms while 6% were not able to recognize any heart attack symptoms.
Journal of Cardiothoracic Surgery
APRIL 15, 2024
An 80-year-old female was referred to our institution due to transient right upper limb weakness. Transthoracic and transesophageal echocardiography revealed a tumor in the left atrium. The tumor was attached.
Open Heart
APRIL 15, 2024
Background and aims Hypertension is a leading risk factor for cardiovascular disease. Electronic health records (EHRs) are routinely collected throughout a person’s care, recording all aspects of health status, including current and past conditions, prescriptions and test results. EHRs can be used for epidemiological research. However, there are nuances in the way conditions are recorded using clinical coding; it is important to understand the methods which have been applied to define expo
Journal of Cardiothoracic Surgery
APRIL 15, 2024
Cardiac herniation occurs when there is a residual pericardial defect post thoracic surgery and is recognised as a rare but fatal complication. It confers a high mortality and requires immediate surgical corre.
Heart BMJ
APRIL 15, 2024
Atrial fibrillation (AF) is the most common sustained cardiac dysrhythmia encountered in practice. It is currently estimated that AF affects approximately 2% of the general population; however, the true prevalence of AF is likely to be at least 3%–4% when asymptomatic AF is considered. For clinically apparent AF, the investigations and management are relatively well established.
Journal of Cardiothoracic Surgery
APRIL 15, 2024
Infective endocarditis of the aortic valve can result in a wide range of destructive pathology beyond the valve leaflets and annulus which require careful surgical planning to provide appropriate debridement a.
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