Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

C1q/TNF-related protein 4 (CTRP4) is generally thought to be released extracellularly and plays a critical role in energy metabolism and protecting against sepsis. However, its physiological functions in autoimmune diseases have not been thoroughly explored. In this study, we demonstrate that Th17 cell–associated experimental autoimmune encephalomyelitis was greatly exacerbated in Ctrp4–/– mice compared with WT mice due to increased Th17 cell infiltration.

Physiology 133

Physiology 133

Medical Xpress - Cardiology

FEBRUARY 15, 2024

More than 4,500 heart transplants were performed in the U.S. in 2023. While the lifesaving operation improves the quality of life and longevity for most recipients, organ rejection remains a risk, with acute rejection occurring in up to 32% of recipients within the first year.

Heart Transplant 128

Heart Transplant Transplant Quality of Life 128

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Skull development coincides with the onset of cerebrospinal fluid (CSF) circulation, brain-CSF perfusion, and meningeal lymphangiogenesis, processes essential for brain waste clearance. How these processes are affected by craniofacial disorders such as craniosynostosis are poorly understood. We report that raised intracranial pressure and diminished CSF flow in craniosynostosis mouse models associate with pathological changes to meningeal lymphatic vessels that affect their sprouting, expansion,

Plaque 131

Plaque Circulation 131

Med Page Today

FEBRUARY 15, 2024

(MedPage Today) -- History of migraine combined with persistent hot flashes was associated with higher risks for cardiovascular disease and stroke, according to an analysis of women in the Coronary Artery Risk Development in Young Adults (CARDIA.

Heart Disease 119

Heart Disease Stroke Strokes Cardiovascular Disease 119

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Blood vessels are continually exposed to circulating lipids, and elevation of ApoB-containing lipoproteins causes atherosclerosis. Lipoprotein metabolism is highly regulated by lipolysis, largely at the level of the capillary endothelium lining metabolically active tissues. How large blood vessels, the site of atherosclerotic vascular disease, regulate the flux of fatty acids (FAs) into triglyceride-rich (TG-rich) lipid droplets (LDs) is not known.

Atherosclerosis 128

Atherosclerosis Chronic Disease Physiology Circulation 128

HCPLive

FEBRUARY 15, 2024

Viral Shah, MD, of Indiana University, joins Diabetes Dialogue to discuss a recent proof-of-concept study examining use of tirzepatide in type 1 diabetes.

Diabetes 125

Diabetes 125

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Choline deficiency causes disorders including hepatic abnormalities and is associated with an increased risk of multiple types of cancer. Here, by choline-free diet–associated RNA-Seq analyses, we found that the tumor suppressor p53 drives the Kennedy pathway via PCYT1B to control the growth of lipid droplets (LDs) and their fueling role in tumorigenesis.

Diet 117

Diet Cancer 117

HCPLive

FEBRUARY 15, 2024

Marla Dubinsky, MD, discusses the use of off-label upadacitinib in pediatric IBD patients and the importance of this research due to delays in pediatric drug approvals.

Pediatrics 111

Pediatrics Research 111

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Altered tryptophan catabolism has been identified in inflammatory diseases like rheumatoid arthritis (RA) and spondyloarthritis (SpA), but the causal mechanisms linking tryptophan metabolites to disease are unknown. Using the collagen-induced arthritis (CIA) model, we identified alterations in tryptophan metabolism, and specifically indole, that correlated with disease.

Diet 107

Diet 107

DAIC

FEBRUARY 15, 2024

Dr. Anne Alexandrov. Image courtesy of the UT Health Science Center milla1cf Thu, 02/15/2024 - 13:16 February 15, 2024 — Research findings in a clinical trial led by a professor at the University of Tennessee Health Science Center ’s College of Nursing are likely to dramatically change care and improve outcomes for patients suffering from acute stroke.

Stroke 105

Stroke Strokes Nursing Blood Clot 105

HCPLive

FEBRUARY 15, 2024

This research also included results from a sub-analysis of non-responders with hand eczema to dupilumab and upadacitinib.

Research 128

Research 128

DAIC

FEBRUARY 15, 2024

milla1cf Thu, 02/15/2024 - 13:10 February 15, 2024 — Canary Medical , a medical data company focused on the development and commercialization of its patented implantable sensor technology and complementary data and analytics ecosystem, today announced the completion of the first-in-human limited feasibility trial of their Cardiac Auscultation (Acoustic) monitoring sensor device.

Heart Failure 105

Heart Failure Technology Bicuspid/Mitral Research 105

HCPLive

FEBRUARY 15, 2024

Test your knowledge with this clinician quiz! In this quiz, we test your knowledge on clinical assessment recommendations for patients with inherited retinal diseases based on 2022 guidelines from the American Academy of Ophthalmology.

104

104

DAIC

FEBRUARY 15, 2024

milla1cf Thu, 02/15/2024 - 12:15 February 15, 2024 — Abbott announced that the Circulatory System Devices Panel of the Medical Devices Advisory Committee for the U.S. Food and Drug Administration ( FDA ) confirmed 13 to 1, with 0 abstention that the benefits of Abbott's TriClip™ transcatheter edge-to-edge repair (TEER) system outweighed the risks for the treatment of people with tricuspid regurgitation (TR).

Tricuspid 102

Tricuspid Heart Valves Quality of Life Bicuspid/Mitral 102

Medical Xpress - Cardiology

FEBRUARY 15, 2024

Healthy gums are imperative to a healthy mouth, but what about your cardiovascular health? In honor of Heart Month, Dr. Frank Nichols, professor of periodontics at the UConn School of Dental Medicine, unravels the underlying connection between gum health and heart health.

100

100

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Mutations in the N-terminal WD40 domain of coatomer protein complex subunit α (COPA) cause a type I interferonopathy, typically characterized by alveolar hemorrhage, arthritis, and nephritis. We described 3 heterozygous mutations in the C-terminal domain (CTD) of COPA (p.C1013S, p.R1058C, and p.R1142X) in 6 children from 3 unrelated families with a similar syndrome of autoinflammation and autoimmunity.

Hemorrhage 106

Hemorrhage 106

Medical Xpress - Cardiology

FEBRUARY 15, 2024

A team of roboticists at Multi-Scale Robotics Lab, ETH Zurich, working with several hospitals in Switzerland, has developed a magnetically operated robot that could potentially be used to treat people after a stroke. Their paper is published in the journal Science Robotics.

Stroke 99

Stroke Strokes Hospital 99

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Effective immunity requires a large, diverse naive T cell repertoire circulating among lymphoid organs in search of antigen. Sphingosine 1-phosphate (S1P) and its receptor S1PR1 contribute by both directing T cell migration and supporting T cell survival. Here, we addressed how S1P enables T cell survival and the implications for patients treated with S1PR1 antagonists.

Circulation 98

Circulation 98

Frontiers in Cardiovascular Medicine

FEBRUARY 15, 2024

Background Inflammation is pivotal to the progression of atherosclerosis. Cholesterol crystals (CCs) that grow and enlarge within the plaque core can cause plaque rupture and trigger inflammation as they deposit into the atherosclerotic bed. Thus, agents that affect CC formation, expansion, and morphology may reduce cardiovascular (CV) risk independent of lipid-lowering and anti-inflammatory therapy.

Cholesterol 72

Cholesterol Atherosclerosis Plaque 72

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

The mechanisms behind a lack of efficient fear extinction in some individuals are unclear. Here, by employing a principal components analysis–based approach, we differentiated the mice into extinction-resistant and susceptible groups. We determined that elevated synapsin 2a (Syn2a) in the infralimbic cortex (IL) to basolateral amygdala (BLA) circuit disrupted presynaptic orchestration, leading to an excitatory/inhibitory imbalance in the BLA region and causing extinction resistance.

Electrophysiology 98

Electrophysiology 98

Medical Xpress - Cardiology

FEBRUARY 15, 2024

A new study published in Nature Cardiovascular Research has unveiled a remarkable discovery that may have far-reaching implications for the treatment of heart disease.

Heart Disease 80

Heart Disease Research 80

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Aplasia cutis congenita (ACC) is a congenital epidermal defect of the midline scalp and has been proposed to be due to a primary keratinocyte abnormality. Why it forms mainly at this anatomic site has remained a long-standing enigma. KCTD1 mutations cause ACC, ectodermal abnormalities, and kidney fibrosis, whereas KCTD15 mutations cause ACC and cardiac outflow tract abnormalities.

Congenital 98

Congenital 98

Frontiers in Cardiovascular Medicine

FEBRUARY 15, 2024

Background The clinical prognosis of mitral valve surgery at morning, afternoon, and evening is not yet clear. The aim of the study is to investigate the impact of different time periods of surgery in the morning, afternoon and evening on the short-term and long-term results of mitral valve surgery. Methods From January 2018 to December 2020, 947 patients with mitral valve surgery in our department were selected.

Bicuspid/Mitral 69

Bicuspid/Mitral Outcomes Aortic Hospital 69

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Nicotinamide adenine dinucleotide (NAD) is essential for embryonic development. To date, biallelic loss-of-function variants in 3 genes encoding nonredundant enzymes of the NAD de novo synthesis pathway — KYNU, HAAO, and NADSYN1 — have been identified in humans with congenital malformations defined as congenital NAD deficiency disorder (CNDD). Here, we identified 13 further individuals with biallelic NADSYN1 variants predicted to be damaging, and phenotypes ranging from multiple severe malformat

Congenital 97

Congenital Outcomes 97

Stroke: Vascular and Interventional Neurology

FEBRUARY 15, 2024

Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDEndovascular treatment of large ischemic cores is challenging. The severity of ischemic stress is assessed using the apparent diffusion coefficient (ADC). We aimed to evaluate the ADC in patients with a low Alberta Stroke Program Early CT [Computed Tomography] Score using diffusion‐weighted imaging and whether it correlates with clinical outcomes.METHODSThis study included consecutive patients with acute large ischemic stro

Outcomes 74

Outcomes Stroke Strokes 74

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Several canonical translocations produce oncofusion genes that can initiate acute myeloid leukemia (AML). Although each translocation is associated with unique features, the mechanisms responsible remain unclear. While proteins interacting with each oncofusion are known to be relevant for how they act, these interactions have not yet been systematically defined.

90

90

Frontiers in Cardiovascular Medicine

FEBRUARY 15, 2024

Background With the rapid development of technology, artificial intelligence (AI) has been widely used in the diagnosis and prognosis prediction of a variety of diseases, including cardiovascular disease. Facts have proved that AI has broad application prospects in rapid and accurate diagnosis. Objective This study mainly summarizes the research on the application of AI in the field of cardiovascular disease through bibliometric analysis and explores possible future research hotpots.

Cardiovascular Disease 64

Cardiovascular Disease Article Research Cardiovascular Imaging 64

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

The physiology of lipid droplets (LDs) has been most extensively characterized in adipocytes, but LDs also accumulate in endothelial cells lining blood vessels in response to changing levels of triglycerides. In recent issues of the JCI, two independent papers highlight a direct role of endothelial LDs in the genesis of hypertension and atherosclerosis in rodent models.

Cardiovascular Disease 90

Cardiovascular Disease Atherosclerosis Physiology Hypertension 90

HCPLive

FEBRUARY 15, 2024

This segment of Lungcast features a discussion with Spicer about the timing of lung cancer treatment, as well as evolution of adjuvant and neoadjuvant therapies.

Cancer 64

Cancer 64

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Chronic and elevated levels of the antiviral cytokine IFN-α in the brain are neurotoxic. This is best observed in patients with genetic cerebral interferonopathies such as Aicardi-Goutières syndrome. Cerebral interferonopathies typically manifest in early childhood and lead to debilitating disease and premature death. There is no cure for these diseases with existing treatments largely aimed at managing symptoms.

82

82

HCPLive

FEBRUARY 15, 2024

A new study found engaging the amygdala can help with memory recall for individuals with depression—and familiar scents helped more than word cues. Memories with odor cues were more arousing and vivid.

59

59

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Melanocortin 4 receptor (MC4R) mutations are the most common cause of human monogenic obesity and are associated with hyperphagia and increased linear growth. While MC4R is known to activate Gsα/cAMP signaling, a substantial proportion of obesity-associated MC4R mutations do not affect MC4R/Gsα signaling. To further explore the role of specific MC4R signaling pathways in the regulation of energy balance, we examined the signaling properties of one such mutant, MC4R (F51L), as well as the metabol

Obesity 75

Obesity 75

HCPLive

FEBRUARY 15, 2024

The review explored the global epidemiology of HCV in patients on dialysis, providing novel estimations of its prevalence and case fatality rate in this patient population.

59

59

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Next-generation sequencing (NGS) applications for the diagnostics of infectious diseases has demonstrated great potential with three distinct approaches: whole-genome sequencing (WGS), targeted NGS (tNGS), and metagenomic NGS (mNGS, also known as clinical metagenomics). These approaches provide several advantages over traditional microbiologic methods, though challenges still exist.

74

74

American College of Cardiology

FEBRUARY 15, 2024

The 2023 guideline provides an evidenced-based and patient-centered approach to management of patients with chronic coronary disease, considering social determinants of health and incorporating the principles of shared decision-making and team-based care.

Article 61

Article 61

Journal of Clinical Investigation - Cardiology

FEBRUARY 15, 2024

Ten percent of the population worldwide suffers from chronic kidney disease (CKD), but the mechanisms driving CKD pathology are incompletely understood. While dysregulated lipid metabolism is one hallmark of CKD, the pathogenesis of cellular lipid accumulation remains unclear. In this issue of the JCI, Mukhi et al. Identify acyl-CoA synthetase short-chain family 2 (ACSS2) as a disease risk gene and demonstrate a role for ACSS2 in de novo lipogenesis (DNL).

Kidney Disease 66

Kidney Disease Pharmacology 66

HCPLive

FEBRUARY 15, 2024

The study performed the first genome-wide cross-trait analysis to investigate the shared genetic basis underlying hypothyroidism and rheumatoid arthritis.

59

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