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An FDA review of postmarket clinical trial data revealed an increased risk of liver injury with obeticholic acid in patients with PBC without cirrhosis.
(MedPage Today) -- The non-small cell lung cancer (NSCLC) drug osimertinib (Tagrisso) was associated with an increased risk of therapy-related cardiovascular (CV) events compared with older EGFR inhibitors, a retrospective cohort study from Taiwan.
Patients with schizophrenia and COVID-19 both present dysregulated energy metabolism, explaining the high COVID-19 rates among those with schizophrenia.
(MedPage Today) -- Actor, comedian, and singer Jamie Foxx revealed that his mystery ailment last year was a brain bleed and stroke. In his new comedy special "Jamie Foxx: What Had Happened Was," filmed in the fall in Atlanta and now streaming.
Cardiovascular problems are the leading cause of disease and mortality worldwide. Plant extracts, rich in bioactive compounds, have contributed significantly to the development of drugs, as they offer therapeutic potential for several of these diseases. However, their use is limited by possible side effects, drugdrug interactions and the lack of scientific evidence from quality preclinical and clinical studies.
I was sent the ECG in Figure-1 initially told only that it was obtained from an older man with palpitations. The cardiology team thought the rhythm was an SVT ( S upra V entricular T achycardia ) with QRS widening as a result of aberrant conduction. QUESTION: Do YOU agree that the rhythm is consistent with an SVT , in which there is QRS widening because of aberrancy?
Endovascular therapy, or EVT, a minimally invasive surgery performed inside the blood vesselsis 2 times more likely than standard medical management to achieve a positive outcome after vertebrobasilar stroke that affects the back of the brain, including the brain stem.
Some patients with diabetes develop a serious condition known as diabetic cardiomyopathy, which is slow and cannot be directly attributed to hypertension or other cardiovascular disorders. This often under-diagnosed heart function impairment is one of the leading causes of death in diabetic patients and it affects both type 1 and type 2 diabetes. There is no current specific drug treatment or clinical protocol approved to address this disease.
Some patients with diabetes develop a serious condition known as diabetic cardiomyopathy, which is slow and cannot be directly attributed to hypertension or other cardiovascular disorders. This often under-diagnosed heart function impairment is one of the leading causes of death in diabetic patients and it affects both type 1 and type 2 diabetes. There is no current specific drug treatment or clinical protocol approved to address this disease.
This assessment of dupilumab for pediatric and adult patients with moderate-to severe eczema treated for up to 5 years confirms the drug efficacy and safety across age groups.
Endovascular therapy, a minimally invasive surgery performed inside the blood vessels, is preferred to alternative approaches for vessel obstructions in life-sustaining areas of the brain, analysis suggests.
These long-term results from the ADjoin trial show that long-term lebrikizumab therapy may improve sleep disturbances, pruritus, and skin symptoms, using POEM as an assessment tool.
An investigation published in The BMJ raises new concerns over the landmark clinical trial (PLATO) that was used to gain worldwide approval for the anti-platelet drug ticagrelor (Brilinta in the US and Brilique in Europe), manufactured by AstraZeneca.
It is unusual for young patients without any underlying diseases to experience sudden cerebral infarction and heart failure. Here, we report a rare case of a 28-year-old female patient who presented with chest tightness and dizziness. Left ventricular thrombus formation and cardiac insufficiency were evident on echocardiogram, while multiple acute or subacute cerebral infarctions were visible on brain magnetic resonance imaging.
BackgroundCoronary artery bypass grafting (CABG) surgery has been a widely accepted method for treating coronary artery disease. However, its postoperative complications can have a significant effect on long-term patient outcomes. A retrospective study was conducted to identify before and after surgery that contribute to postoperative stroke in patients undergoing CABG, and to develop predictive models and recommendations for single-factor thresholds.Materials and methodsWe utilized data from 1,
(MedPage Today) -- NEW ORLEANS -- Tenecteplase in recent years outpaced alteplase as the stroke thrombolytic of choice at one large hospital system, despite shrinking cost savings, a researcher reported here. In 2021, clinicians at Cardinal.
BackgroundThe association between healthy lifestyle and American Heart Association (AHA) Life's Essential 8 (LE8) score and apparent treatment-resistant hypertension(aTRH)remains uncertain. We aimed to explore the association between healthy lifestyle and higher LE8 score and apparent treatment-resistant hypertension in the general population.MethodsUsing NHANES data from 2005 to 2018, we included and analyzed information on 7,474 participants eligible for this study.
Salt Lake City-based Intermountain Health's St. Mary's Regional Hospital in Grand Junction, Colo., recently became the first community hospital in the nation to receive vascular verification from the American College of Surgeons and the Society for Vascular Surgery.
Patients with hypercortisolism and difficult-to-control type 2 diabetes who received mifepristone exhibited a significant HbA1c improvement in the Phase 4 trial.
New York City-based NYU Langone has expanded cardiology services at the NYU Langone HospitalBrooklyn. Previously, NYU Langone patients living in Brooklyn were travelling to Manhattan to receive advanced cardiac care.
A study shows constipation has a causal relationship with schizophrenia and MDD, but the relationship with schizophrenia may have limited clinical implications.
After CMS released its finalized 2025 physician fee schedule, which will reduce reimbursements by 2.83%, some cardiologists are raising concerns over what they call an unstable healthcare system, according to a Dec. 9 TCTMD report.
Women in academic cardiothoracic surgery earn 80% to 87% of the salary men with equal academic rank earn, according to a study published Dec. 2 in The Annals of Thoracic Surgery.
To celebrate surpassing 100 episodes, Diabetes Dialogue sits down with Irl Hirsch, MD, to discuss the 25-year anniversary of continuous glucose monitoring in 2024.
The goal of the TRILUMINATE Pivotal trial was to evaluate percutaneous tricuspid valve transcatheter edge-to-edge repair (TEER) compared with medical therapy among patients with symptomatic severe tricuspid regurgitation.
Ventricular tachycardia can be a killer arrhythmia that can arrest the heart within seconds or behave like your pet, gently cuddling the heart and terminating spontaneously. The latter phenomenon we call it casually as benign non-sustained VT. Such VTs are more common in the out flows, fascicles or in HCMs. Most of us do not have time, to wonder why some of these blessed arrhythmias are not able to sustain.
Patients with IBS had different dietary patterns than matched general population controls, with poor diet diversity and quality linked to symptom severity.
A large study found that greater exposure to long-term air pollution was linked with increased risks for blood clots that can occur in deep veins, which, if untreated, can block blood flow and cause serious complications, even death.
Presenting and learning from real-world accountable care cardiovascular arrangements was the focus of ACCs sixth annual Value-Based Care in Cardiology Forum, held Dec. 5 in Washington, DC.
The randomized ACCESS-TAVI study led by PD Dr. Tobias Rheude and DZHK-Prof. Michael Joner from the German Heart Center Munich and the German Center for Cardiovascular Research shows that a combined method of suture and plug technique achieves the best results in percutaneous closure of the vascular access routes after minimally invasive transcatheter aortic valve implantation (TAVI).
The U.S. Senate passed the Cardiomyopathy Health Education, Awareness, Research, and Training in the Schools (HEARTS) Act (H.R. 6829), a major ACC Advocacy priority, on Dec. 10. The bill secures funding for cardiomyopathy awareness initiatives and supporting the placement of AEDs in schools, along with CPR and AED training.
A new analysis finds that the stress of being a caregiver is associated with an increased risk of developing hypertension in 21 to 44-year-old Black women, a group known to have a higher prevalence of the condition compared to women of other racial and ethnic groups. Caregiving has been linked by past studies to high blood pressure in middle-aged and older black women, but this relationship has been understudied in this younger group.
Hydroquinidine reduces arrhythmic events in patients with Brugada syndrome (BrS). The mechanism by which it exerts antiarrhythmic benefit and its electrophysiological effects on BrS substrate remain incompletely understood.
A prediction model incorporating a polygenic risk score (PRS) and polysocial score (PSS), including social determinants of health and lifestyle-psychological factors, improves performance of clinical risk calculators for coronary heart disease (CHD), according to a study published online Dec. 10 in the Annals of Internal Medicine.
The Adaptive cardiac resynchronization therapy (CRT) algorithm (aCRT) provides important clinical benefit. However, a significant number of patients are nonresponders.
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