Thu.Dec 12, 2024

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FDA Finds Obeticholic Acid (Ocaliva) Linked to Serious Liver Injury in Noncirrhotic PBC

HCPLive

An FDA review of postmarket clinical trial data revealed an increased risk of liver injury with obeticholic acid in patients with PBC without cirrhosis.

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Mediterranean plants show promise in heart disease prevention

Medical Xpress - Cardiology

Cardiovascular problems are the leading cause of disease and mortality worldwide. Plant extracts, rich in bioactive compounds, have contributed significantly to the development of drugs, as they offer therapeutic potential for several of these diseases. However, their use is limited by possible side effects, drugdrug interactions and the lack of scientific evidence from quality preclinical and clinical studies.

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Micro-Factors May Explain the Connection Between COVID-19, Schizophrenia

HCPLive

Patients with schizophrenia and COVID-19 both present dysregulated energy metabolism, explaining the high COVID-19 rates among those with schizophrenia.

COVID-19 105
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Study likely to change standard of care for deadly strokes

Medical Xpress - Cardiology

Endovascular therapy, or EVT, a minimally invasive surgery performed inside the blood vesselsis 2 times more likely than standard medical management to achieve a positive outcome after vertebrobasilar stroke that affects the back of the brain, including the brain stem.

Stroke 79
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Dupilumab Treatment of Atopic Dermatitis Safe for Up to 5 Years in Children, Adults

HCPLive

This assessment of dupilumab for pediatric and adult patients with moderate-to severe eczema treated for up to 5 years confirms the drug efficacy and safety across age groups.

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Investigation raises new concerns over landmark trial for top selling anti-platelet drug

Medical Xpress - Cardiology

An investigation published in The BMJ raises new concerns over the landmark clinical trial (PLATO) that was used to gain worldwide approval for the anti-platelet drug ticagrelor (Brilinta in the US and Brilique in Europe), manufactured by AstraZeneca.

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Lebrikizumab for Atopic Dermatitis Results in Long-Term Improvements Over 152 Weeks

HCPLive

These long-term results from the ADjoin trial show that long-term lebrikizumab therapy may improve sleep disturbances, pruritus, and skin symptoms, using POEM as an assessment tool.

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Where is the Mental Health Crisis Heading in 2025? Hear from Experts

HCPLive

America's mental health crisis continues to escalatewhat drives it, and what lies ahead in 2025? Hear insight from psychiatry and psychology experts.

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Prediction of postoperative stroke in patients experienced coronary artery bypass grafting surgery: a machine learning approach

Frontiers in Cardiovascular Medicine

BackgroundCoronary artery bypass grafting (CABG) surgery has been a widely accepted method for treating coronary artery disease. However, its postoperative complications can have a significant effect on long-term patient outcomes. A retrospective study was conducted to identify before and after surgery that contribute to postoperative stroke in patients undergoing CABG, and to develop predictive models and recommendations for single-factor thresholds.Materials and methodsWe utilized data from 1,

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Tobevibart, Elebsiran Receive FDA Breakthrough Therapy Designation for Chronic HDV

HCPLive

The FDA awarded Breakthrough Therapy Designation to Vir Biotechnologys tobevibart and elebsiran for the treatment of chronic hepatitis delta.

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Association between “Life's Essential 8” cardiovascular health and apparent treatment-resistant hypertension among US adults from the NHANES, 2005 to 2018

Frontiers in Cardiovascular Medicine

BackgroundThe association between healthy lifestyle and American Heart Association (AHA) Life's Essential 8 (LE8) score and apparent treatment-resistant hypertension(aTRH)remains uncertain. We aimed to explore the association between healthy lifestyle and higher LE8 score and apparent treatment-resistant hypertension in the general population.MethodsUsing NHANES data from 2005 to 2018, we included and analyzed information on 7,474 participants eligible for this study.

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Mifepristone Notably Reduces HbA1c in Treatment Phase of CATALYST Trial

HCPLive

Patients with hypercortisolism and difficult-to-control type 2 diabetes who received mifepristone exhibited a significant HbA1c improvement in the Phase 4 trial.

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How an Intermountain community hospital earned vascular verification

Becker's Hospital Review - Cardiology

Salt Lake City-based Intermountain Health's St. Mary's Regional Hospital in Grand Junction, Colo., recently became the first community hospital in the nation to receive vascular verification from the American College of Surgeons and the Society for Vascular Surgery.

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Study Discovers Constipation Has a Causal Relationship with Schizophrenia, MDD

HCPLive

A study shows constipation has a causal relationship with schizophrenia and MDD, but the relationship with schizophrenia may have limited clinical implications.

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NYU Langone expands cardiac services

Becker's Hospital Review - Cardiology

New York City-based NYU Langone has expanded cardiology services at the NYU Langone HospitalBrooklyn. Previously, NYU Langone patients living in Brooklyn were travelling to Manhattan to receive advanced cardiac care.

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Insulin Resistance Amplifies Risk of Colorectal Cancer Development

HCPLive

Elevated blood insulin levels and insulin resistance each contributed to an elevated risk of colorectal cancer, a new study finds.

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'We cannot continue doing this': Cardiologists react to 2025 fee schedule

Becker's Hospital Review - Cardiology

After CMS released its finalized 2025 physician fee schedule, which will reduce reimbursements by 2.83%, some cardiologists are raising concerns over what they call an unstable healthcare system, according to a Dec. 9 TCTMD report.

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Diabetes Dialogue: Celebrating 25 Years of CGM, with Irl Hirsch, MD

HCPLive

To celebrate surpassing 100 episodes, Diabetes Dialogue sits down with Irl Hirsch, MD, to discuss the 25-year anniversary of continuous glucose monitoring in 2024.

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Salary disparities in cardiothoracic surgery: 4 study notes

Becker's Hospital Review - Cardiology

Women in academic cardiothoracic surgery earn 80% to 87% of the salary men with equal academic rank earn, according to a study published Dec. 2 in The Annals of Thoracic Surgery.

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A New Era for NMIBC: How a Decade of Progress is Reshaping Treatment

HCPLive

The BCG-unresponsive non-muscle invasive bladder cancer space has gone from a dearth of options to a wave of new treatments.

Cancer 52
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Trial to Evaluate Cardiovascular Outcomes in Patients Treated With the Tricuspid Valve Repair System Pivotal

American College of Cardiology

The goal of the TRILUMINATE Pivotal trial was to evaluate percutaneous tricuspid valve transcatheter edge-to-edge repair (TEER) compared with medical therapy among patients with symptomatic severe tricuspid regurgitation.

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Lower Diet Diversity, Quality Linked to More Severe IBS Symptoms

HCPLive

Patients with IBS had different dietary patterns than matched general population controls, with poor diet diversity and quality linked to symptom severity.

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Why do some VTs are non-sustained ?

Dr. S. Venkatesan MD

Ventricular tachycardia can be a killer arrhythmia that can arrest the heart within seconds or behave like your pet, gently cuddling the heart and terminating spontaneously. The latter phenomenon we call it casually as benign non-sustained VT. Such VTs are more common in the out flows, fascicles or in HCMs. Most of us do not have time, to wonder why some of these blessed arrhythmias are not able to sustain.

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Long-term exposure to air pollution linked to blood clots in veins that bring blood to the heart

Medical Xpress - Cardiology

A large study found that greater exposure to long-term air pollution was linked with increased risks for blood clots that can occur in deep veins, which, if untreated, can block blood flow and cause serious complications, even death.

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Value-Based Care in Cardiology Forum Explores CV Contributions to High-Value Care

American College of Cardiology

Presenting and learning from real-world accountable care cardiovascular arrangements was the focus of ACCs sixth annual Value-Based Care in Cardiology Forum, held Dec. 5 in Washington, DC.

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Optimization of vascular closure techniques in TAVI procedures: Study shows advantages of the combined procedure

Medical Xpress - Cardiology

The randomized ACCESS-TAVI study led by PD Dr. Tobias Rheude and DZHK-Prof. Michael Joner from the German Heart Center Munich and the German Center for Cardiovascular Research shows that a combined method of suture and plug technique achieves the best results in percutaneous closure of the vascular access routes after minimally invasive transcatheter aortic valve implantation (TAVI).

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ACC Priority Legislation to Fund Cardiomyopathy Awareness, AEDs in Schools Passes Senate

American College of Cardiology

The U.S. Senate passed the Cardiomyopathy Health Education, Awareness, Research, and Training in the Schools (HEARTS) Act (H.R. 6829), a major ACC Advocacy priority, on Dec. 10. The bill secures funding for cardiomyopathy awareness initiatives and supporting the placement of AEDs in schools, along with CPR and AED training.

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Caregiving stress linked to high blood pressure in younger Black women

Medical Xpress - Cardiology

A new analysis finds that the stress of being a caregiver is associated with an increased risk of developing hypertension in 21 to 44-year-old Black women, a group known to have a higher prevalence of the condition compared to women of other racial and ethnic groups. Caregiving has been linked by past studies to high blood pressure in middle-aged and older black women, but this relationship has been understudied in this younger group.

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ACCEL Lite: Top Takeaways from 2024: Heart Failure with Clyde W. Yancy, MD, MACC

American College of Cardiology

In this interview, Clyde W. Yancy, MD, MACC, and Alison L. Bailey, MD FACC, discuss the Top Heart Failure Takeaways from 2024. Dr. Yancy discusses the FINEARTS-HF trial, the PREVENT calculator, the multisociety Heart Failure Guidelines, and more.

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Model including polygenic risk, polysocial score improves CHD risk prediction

Medical Xpress - Cardiology

A prediction model incorporating a polygenic risk score (PRS) and polysocial score (PSS), including social determinants of health and lifestyle-psychological factors, improves performance of clinical risk calculators for coronary heart disease (CHD), according to a study published online Dec. 10 in the Annals of Internal Medicine.

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Davide Matino, MD, MSc: Bringing Marstacimab Treatment to Hemophilia A and B

HCPLive

Matino discussed data from the phase 3 BASIS study evaluating the recently approved Hympavzi.

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Genetic Testing for Cardiomyopathies: Key Points

American College of Cardiology

The following are key points to remember from a European Society of Cardiology (ESC) clinical consensus statement on integration of genetic testing into diagnostic pathways for cardiomyopathies.

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Case Report: The unrelenting journey—successful resolution of catecholaminergic polymorphic ventricular tachycardia (CPVT) through right cardiac sympathetic denervation in a teenager after left cardiac sympathetic denervation

Frontiers in Cardiovascular Medicine

BackgroundCatecholaminergic polymorphic ventricular tachycardia (CPVT) is a rare inherited arrhythmia disorder characterized by ventricular arrhythmia triggered by adrenergic stimulation.Case presentationA 9-year-old boy presented with convulsions following physical exertion. Bidirectional ventricular tachycardia (VT) during a treadmill test led to the diagnosis of catecholaminergic polymorphic ventricular tachycardia (CPVT).

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Erin Michos, MD: HFpEF in Women and Sex-Specific Therapeutic Approaches

HCPLive

Erin Michos, MD examines unique HFpEF mechanisms for women and implications for sex-specific treatment.

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End‐organ protective effect of serelaxin in patients hospitalized for heart failure: Results of the biomarker substudy of Relaxin in Acute Heart Failure‐2 (RELAX‐AHF‐2)

European Journal of Heart Failure

End-organ protective effect of serelaxin in patients with acute heart failure. CV, cardiovascular; HF, heart failure; NT-proBNP, N-terminal pro-B-type natriuretic peptide. Abstract Aims Serelaxin is recombinant human relaxin-2, a hormone responsible for haemodynamic adaptations and organ protection in pregnancy. In the RELAX-AHF trial, serelaxin demonstrated reductions in cardiac, renal and hepatic damage.