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Nature Reviews Cardiology, Published online: 04 April 2025; doi:10.1038/s41569-025-01146-x Heart transplantation remains the optimal long-term treatment for appropriate patients with advanced heart failure. However, the donor heart shortage is a limiting factor, and the risk profile of transplant candidates is worsening. In this landscape, the utility of conventional cold static storage for donor hearts is increasingly limited.
IntroductionManaging acute coronary syndrome (ACS) remains a major global healthcare concern. Identifying novel biomarkers is crucial to improving early detection and patient classification. Traditional markers such as cardiac troponins have limitations, including delayed detectability in blood samples, necessitating the search for better alternatives.
In 2025, the world of healthcare is changing daily, and nowhere is this more apparent than in cardiology. As patient expectations rise and technology advances, engaging patients effectively has never been more crucial to delivering top-tier care. For cardiology practices, choosing the right patient engagement platform is vital for improving outcomes, optimizing workflow, and maintaining a competitive edge.
IntroductionZero-fluoroscopy, exclusively ultrasound-guided atrial septal defect (ASD) catheter closure has been reported. However, data on the effectiveness of this technique in complex cases remains limited.ObjectivesThis study aims to evaluate the safety, efficacy, and outcomes of ASD catheter closure using exclusive ultrasound guidance, with a particular focus on complex cases.MethodsWe conducted a retrospective review of clinical data from patients who underwent attempted ASD catheter closu
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Parkinson's doesn't just affect movement and the brain -- it may also impact the heart, according to new research. Scientists suggest that targeting a key protein outside of the brain could help manage Parkinson's-related heart issues.
BackgroundNon-valvular atrial fibrillation (NVAF) significantly increases ischemic stroke and systemic embolism (SE) risks. Despite the proven efficacy of oral anticoagulants (OAC) in reducing these risks, their underutilization highlights a gap in clinical practice. This study examined OAC utilization patterns within the first year after NVAF diagnosis in patients without prior OAC use and the association between the timing of OAC initiation and the risk of all-cause and stroke/SE-specific hosp
In recent years, the incidence of cardiovascular disease (CVD) has risen steadily, significantly impacting public health. Subclinical hypothyroidism (SCH) remains a controversial risk factor for CVD. This review examines the associations between SCH and dyslipidemia, carotid intima-media thickness (C-IMT), cardiac dysfunction, and cardiovascular event risk.
BackgroundThe next-generation closure device for interventional treatment of patent foramen ovale (PFO) is regarded as biodegradable, yet the corresponding biomaterial technique is still challenging. Herein, we report the clinical application of a novel biodegradable PFO occluder [made of the biodegradable material polydioxanone (PDO)] that is finally coming into clinical use.ObjectivesThis study aimed to assess the safety and efficacy of the biodegradable Pansy occluder (Mallow Medical, Shangha
In a new extensive systematic review, researchers identified 17 modifiable risk factors that are shared by stroke, dementia, and late-life depression. Modifying any one of them can reduce your risk of all three conditions. The findings provide evidence to inform novel tools such as the Brain Care Score.
This case report describes a 58-year-old woman who sought treatment in the dermatology department after experiencing a three-day episode of widespread rash and itching, along with fever, chills, abdominal distress, and increased urinary frequency and urgency. Upon examination, she exhibited numerous erythematous patches and wheals on her face and body, devoid of blisters or erosions.
There are over six million Americans with heart failure who are at greater risk of losing their cognitive abilities earlier in life, a study suggests. Global cognition and executive functioning declined more rapidly over the years after heart failure diagnosis, as people with the condition mentally aged the equivalent of 10 years within just seven years of a heart failure diagnosis.
Vertebrojugular arteriovenous fistula (VJAVF) and vertebral artery pseudoaneurysm (VAPA) are usually caused by iatrogenic and penetrating traumas. The concurrence of these two entities originating from different ostia of the vertebral artery (VA) is extremely rare. The history of repeated open-heart surgery and the application of central venous catheterization during anesthesia increased the risk of VA injuries and its complications of the VJAVF and VAPA.
The increasing frequency and intensity of extreme weather events and wildfires, driven by climate change, pose a growing threat to cardiovascular health.
Circadian rhythm, or the biological clock, is an intrinsic timing system present in organisms that operates on a cycle of approximately 24h. Nearly every cell in the human body adheres to a specific circadian rhythm, governing various biological processes essential for overall health. REV-ERB, a key circadian clock-regulating gene, plays a crucial role in maintaining the precision of these rhythms.
BackgroundRecent data suggest that the true incidence of atrial fibrillation (AF) after patent foramen ovale (PFO) closure has probably been underestimated, and may differ according to the type of closing device used.ObjectivesOn the basis of continuous rhythm monitoring with an implantable device, this study aims to assess the incidence of supraventricular arrhythmia following PFO closure with the Occlutech PFO device.MethodsThis is a multicentric analysis of consecutive PFO closure patients tr
A global study establishes long-term risk of stroke. Findings shows one in five people who experience a minor stroke or TIA will have another stroke within 10 years.
Cardiovascular diseases (CVDs) are the leading global cause of mortality, with South America reflecting similar trends. Among congenital heart diseases (CHDs), atrioventricular (AV) block is included. AV block is a condition defined by abnormal electrical signal transmission between the atria and ventricles. Advances in Next-Generation Sequencing (NGS) have facilitated the identification of genetic variants associated with cardiac disorders, such as AV block.
You may be familiar with the common signs and symptoms of a stroke: loss of vision, drooping face, weak limbs, and slurred speech. But what happens during the recovery phase, once a patient has spent time in the hospital and their brain has begun to recover?
These findings, while reassuring for JAK inhibitor prescription, nonetheless suggest that VTE-related recommendations for prescriptions should be maintained.
Pulmonary surgery can significantly impact patients respiratory function and reduce their quality of life. Previous studies have shown that perioperative breathing exercises (BE) can facilitate the recovery o.
Heart failure with preserved ejection fraction (HFpEF) represents a significant and growing clinical challenge. Initially, for an extended period, HFpEF was simply considered as a subset of heart failure, mani.
Q1 2025 allergy updates: FDA approved the first omalizumab biosimilar, and experts shared insights on peanut immunotherapy and food allergy treatments.
A New Acute Coronary Syndromes Guideline From ACC, AHA and a Scientific Statement Addresses Competitive Sports Participation For Athletes With CV Abnormalities.
The March 2025 month in review spotlights an RX Review about USMSTF guidance on bowel prep for colonoscopy, an FDA approval, and clinical trial updates.
Delays in care and treatment in the hospital emergency department (ED) and other departments have long contributed to poor patient outcomes and medical malpractice litigation. The Doctors Company's medical malpractice data show continued claims stemming from delays in care.
Training to become a cardiologist is a demanding journey, reaching far beyond the mastery of clinical skills to include building community, advancing quality and cultivating leadership.
Low neighborhood walkability is associated with increased risk of cardiovascular disease (CVD), according to research presented April 3 at ESC Preventive Cardiology 2025, a scientific congress of the European Society of Cardiology. The findings are also published in the journal Environmental Research.
Journal of the American Heart Association, Ahead of Print. BackgroundIschemic stroke incidence in young adults is increasing globally, with return to work (RTW) a key rehabilitation goal. We aimed to assess the overall proportions of and factors associated with RTW following young adult ischemic stroke.Methods and ResultsWe performed a retrospective cohort study of all patients with ischemic stroke aged 18 to 50 years at 2 tertiary hospitals in Singapore from 2020 to 2022.
Journal of the American Heart Association, Ahead of Print. BackgroundMyocardial fibrosis is a pathological hallmark of heart failure post infarction, emphasizing the need for innovative treatment strategies. This research assesses the antifibrotic potential of a sodium alginate (SA) hydrogel loaded with extracellular vesicles (EVs) from bone marrow mesenchymal stem cells and PAP (p38 antagonistic peptides), aiming to interfere with fibrosisinducing pathways in myocardial tissue after infarction.
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