Wed.Dec 18, 2024

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Cardiovascular Protection Tracks With Wine Intake, Now Provable With Urinary Marker

Med Page Today

(MedPage Today) -- Moderate wine consumption maintained its association with cardiovascular benefit when self-reports were taken out of the equation, the large PREDIMED trial showed. Using urinary tartaric acid as an objective biomarker measuring.

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New evidence on the relationship between moderate wine consumption and cardiovascular health

Science Daily - Stroke

Light and moderate consumption of wine is associated with a lower risk of cardiovascular complications, according to a multicenter study. The study is based on the analysis of a biomarker of wine intake -- specifically, tartaric acid, present in grapes. It was carried out in 1,232 participants in the PREDIMED project, a major scientific epidemiological study in nutrition on the effects of the Mediterranean diet on cardiovascular health.

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Pediatric Food Allergies Linked to Uncontrolled Atopic Dermatitis, Long-Term Prognosis

HCPLive

Findings suggest an association between food allergies and atopic dermatitis control and persistence.

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Coronary Subclavian Steal Syndrome

The New England Journal of Medicine

A 63-year-old man with a history of CABG presented with a 2-month history of angina during exertion of the left arm. Angiography revealed retrograde flow in the left internal thoracic artery graft (shown in a video).

Angina 68
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Coughing won't save you if you're having a heart attack, despite what people claim on social media

Medical Xpress - Cardiology

A recent trend on social media has revived a curious technique from the late 1970s called cough CPR. A post claims that this method can help people, if they are alone, to survive a heart attack by coughing rhythmically to keep their heart beating. The idea is striking and dramatic, often framed as a life-saving hack, but it's not without controversy.

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Overactive cells linked to type 2 diabetes

Science Daily - Heart Disease

Researchers studied oxygen treatment as a potential therapy to target specific cells linked to the development of cardiovascular and metabolic disorders like high blood pressure and type 2 diabetes and found no significant improvement in function in patients with type 2 diabetes.

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Study pinpoints pivotal period for improving cardiovascular health in children

Medical Xpress - Cardiology

Cardiovascular disease (CVD) is a critical public health concern, with risk factors such as high blood pressure, abnormal blood sugar levels, elevated cholesterol, and obesity beginning in childhood. A new study pinpoints the age when cardiovascular health (CVH) trajectories begin to decline, revealing a crucial window for targeted interventions to improve CVH into adolescence and adulthood.

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Tralokinumab Effectively Treats Moderate-to-Severe Atopic Dermatitis: Real-World Data

HCPLive

In a recent study, tralokinumab demonstrates effectiveness and safety for treating moderate-to-severe atopic dermatitis in adults who are dupilumab nave and non-nave.

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Engineering extracellular vesicles for targeted therapeutics in cardiovascular disease

Frontiers in Cardiovascular Medicine

Extracellular vesicles (EVs) are nanosized particles secreted by cells that play crucial roles in intercellular communication, especially in the context of cardiovascular diseases (CVDs). These vesicles carry complex cargo, including proteins, lipids, and nucleic acids, that reflects the physiological or pathological state of their cells of origin. Multiomics analysis of cell-derived EVs has provided valuable insights into the molecular mechanisms underlying CVDs by identifying specific proteins

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Current Therapeutic Guidelines for Managing Resistant Hypertension

HCPLive

Panelists discuss how resistant hypertension management requires a structured approach combining lifestyle modifications, optimal doses of multiple drug classes, and the identification of underlying causes such as sleep apnea.

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Prognostic potential of inflammatory markers in chronic kidney disease patients combined with acute myocardial infarction

Frontiers in Cardiovascular Medicine

BackgroundInflammation significantly impacts chronic kidney disease (CKD) and acute myocardial infarction (AMI). This study investigates the prognostic value of inflammatory markers in predicting outcomes for CKD patients with AMI.MethodsWe enrolled patients diagnosed with CKD concomitant with AMI, choosing five inflammatory markers related to both diseases.

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Challenging the CHAGASICS Trial

CardiacWire

Exposing the failures of peer review, Dr. Anis Rassi Jr. MD, PhD, recently published his letter to JAMA Cardiology in Sensible Medicine about glaring issues with the CHAGASICS trial. Dr. Rassi was one of the primary authors and designers of CHAGASICS, but resigned his authorship prior to publishing due to concerns about the study. CHAGASICS aimed to uncover if ICDs were more effective than amiodarone therapy for Chagas cardiomyopathy, finding that ICDs did show some benefits but didnt reduce all

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FDA Expands Indication for Impella Heart Pumps for Pediatric Patients

DAIC

Impella 5.5 with SmartAssist tim.hodson Wed, 12/18/2024 - 14:06 Dec. 12, 2024 Physicians have a new treatment option for many of the sickest pediatric patients with heart failure andcardiogenic shock. Johnson & Johnson MedTech has announcedthat the U.S. Food and Drug Administration (FDA) has expanded the indications for the Impella 5.5 with SmartAssist and Impella CP with SmartAssist heart pumps, granting premarket approval (PMA) for use in specific pediatric patients with symptomatic acute deco

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Construction and validation of a readmission risk prediction model for elderly patients with coronary heart disease

Frontiers in Cardiovascular Medicine

BackgroundTo investigate the risk factors for readmission of elderly patients with coronary artery disease, and to construct and validate a predictive model for readmission risk of elderly patients with coronary artery disease within 3 years by applying machine learning method.MethodsWe selected 575 elderly patients with CHD admitted to the Affiliated Luan Hospital of Anhui Medical University from January 2020 to January 2023.

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Dr. McGuire, Dr. Yastreboff, and Dr. C. Michael Gibson discuss new oral semaglutide and the SOUL trial which lowered death, MI and stroke rates by 14% in patients with diabetes.

Clinical Trial Results

Disclosures: TBD

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Reoperative minimal invasive off-pump coronary artery bypass graft in early left main stem stenosis following Modified Bentall procedure

Journal of Cardiothoracic Surgery

Six months following modified Bentall procedure a patient presented with angina and acute ST depression. CT coronary angiogram revealed severe narrowing of the left main coronary artery. Minimal invasive off p.

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Hope on the Horizon: 2 Food Allergy Breakthroughs in 2024

HCPLive

Kim, Sindher, Huffaker spoke with HCPLive about some of the years most important developments in the food allergy space, namely the approvals of omalizumab and neffy.

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A massive cardiac lipoma in the right atrium with multimodality imaging

Journal of Cardiothoracic Surgery

We report the noninvasive imaging diagnosis of a massive right atrial lipoma in a young male patient. Echocardiography and myocardial contrast echocardiography were used to assess echo intensity, tumor size, a.

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Julia Weisinger, MD: Obinutuzumab a Promising Option for Intolerant/Refractory iTTP

HCPLive

Weisinger discussed findings from the largest cohort of patients with iTTP treated with Obinutuzumab.

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A case of posterior mediastinal Müllerian cyst characterized by morphology of serous papillary cystadenoma

Journal of Cardiothoracic Surgery

Background Müllerian cysts of the posterior mediastinum are rare, benign lesions typically discovered incidentally via routine medical exams. Case presentation We present a distinctive case of a 49-year-old asymptomatic woman, illustrating a rare Müllerian cyst located in the posterior mediastinum with serous papillary cystadenoma-like features, a novel finding in the medical literature.

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Virtual cardiac rehab cuts costs, improves outcomes: 5 study notes

Becker's Hospital Review - Cardiology

When compared to virtual cardiac rehabilitation, center-based cardiac rehabilitation was associated with a 38.4% higher hospital readmission rate, according to a study published Dec. 14 in the Journal of the American Heart Association.

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A simplified approach to managing a complex infected left ventricular pseudoaneurysm

Journal of Cardiothoracic Surgery

Left ventricular pseudoaneurysm (LVP) is a rare but life-threatening condition resulting from acute myocardial infarction, trauma, bacterial infection, or previous cardiac operations. Diagnosis can be challeng.

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Treatment Response to PPAR Agonists and Other Therapies in PBC

HCPLive

The panel of experts discuss how to determine the effectiveness of treatment in primary biliary cholangitis (PBC), focusing on key clinical markers, biochemical responses, and patient outcomes.

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Rotarex®S rotational atherectomy combined with drug-coated balloon angioplasty for treating femoropopliteal artery in-stent restenosis

Journal of Cardiothoracic Surgery

This study aimed to analyze the safety and mid-term outcomes of a hybrid treatment method combining rotational atherectomy (RA) with drug-coated balloon (DCB) angioplasty in patients with femoropopliteal arter.

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Parents of Children with Atopic Dermatitis Often Sleep Less Than 7 Hours

HCPLive

A study showed parents of children with atopic dermatitis have an increased odds of taking medication to aid sleep.

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The association between blood metals and cardiovascular diseases: findings from National Health and Nutrition Examination Survey 2011–2020

Frontiers in Cardiovascular Medicine

ObjectivesPrevious studies have examined the relationship between cardiovascular diseases (CVDs) and blood metal levels. However, fewer studies have investigated the role of the combinations of blood metals on CVDs. In the current study, our aim is to explore the roles of specific blood metals and further develop a model to differentiate between healthy participants and CVD patients using database from the National Health and Nutrition Examination Survey (NHANES).MethodsData from the National He

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J&J Submits sBLA for Golimumab (Simponi) for Pediatric Ulcerative Colitis

HCPLive

The sBLA seeks to expand golimumabs approval for UC to include pediatric patients 2 years of age and is supported by data from the PURSUIT program.

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Cardiac deceleration capacity and acceleration capacity have diagnostic value in patients with vasovagal syncope regardless of age

Frontiers in Cardiovascular Medicine

BackgroundDeceleration capacity (DC) and acceleration capacity (AC) are used to characterize autonomic regulation. The purpose of this study was to evaluate the autonomic nervous function in patients with vasovagal syncope (VVS) and to evaluate the diagnostic value of DC and AC for VVS.MethodsA total of 94 consecutive patients with VVS [51.0 (38.060.0) years; 48 males] and 76 healthy subjects [53.0 (44.362.8) years; 46 males] were recruited as controls.

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The Slow-Moving Antimicrobial Resistance Train is Picking-up Morbidity and Mortality Steam

HCPLive

Resistance is expected to worsen significantly, but can a combination of both ground-level clinician stewardship actions as well as systemic reforms such as the Pasteur Act at least slow down the train?

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The expanding role of 16s ribosomal RNA PCR in the management of patients with infective endocarditis undergoing cardiac surgery

Frontiers in Cardiovascular Medicine

BackgroundAetiological diagnosis and targeted antibiotic therapy are essential to improve the prognosis of patients with infective endocarditis. Molecular tests on blood have been reported to be effective in identifying the causative organism and are recommended when blood cultures are negative. The role of molecular tests on the surgically excised valve is still unclear and needs further investigation.Materials and methodsIn this prospective, observational, single center study, we enrolled 100

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FDA Approves Seventh Ustekinumab Biosimilar

HCPLive

Celltrions CT-P43/ustekinumab-stba has been approved under the name Steqeyma and is expected to launch in February 2025.

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Cardiovascular risk profile with SCORE2 and SCORE2-OP: comparing Portugal, Spain, Italy, and France using the new European predictive models

Frontiers in Cardiovascular Medicine

IntroductionThis study aims to characterize the cardiovascular risk profile in countries with low-to-moderate cardiovascular mortality risk (Italy, Portugal, France, and Spain) using the SCORE2 and SCORE2-OP models. It also examines regional variations and the involvement of healthcare professionals in performing risk assessments.MethodsA retrospective observational study was conducted using data from 24,434 cardiovascular risk assessments performed between December 2022 and July 2023 through a

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FCS’ Affect on Quality of Life

HCPLive

Panelists discuss how familial chylomicronemia syndrome (FCS) affects patients quality of life, particularly in terms of their emotional well-being, employment burden, and social isolation due to recurrent acute pancreatitis, and explore the significant economic burden it places on patients and their families.

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Body mass index mediates the association between plasma lipid concentrations and the prevalence of obstructive sleep apnea among US adults: a cross-sectional study

Frontiers in Cardiovascular Medicine

BackgroundThe association between obstructive sleep apnea (OSA) and plasma lipid concentrations is not consistent. This study aimed to investigate the association of plasma lipid concentrations with the prevalence of OSA among US adults, with an additional examination of the mediating effect of body mass index (BMI).MethodsThis cross-sectional study included 8,086 individuals who participated in the National Health and Nutrition Examination Survey (NHANES), conducted from 2005 to 2008 and 201520

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Integration of PPAR Agonists in Treatment Landscape of PBC

HCPLive

The panel of experts explore the potential integration of peroxisome proliferator-activated receptor (PPAR) agonists into the current treatment landscape for primary biliary cholangitis (PBC) and provides recommendations for patients currently taking fibrates for managing the disease.

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Analyzing the non-linear relationship between fasting blood glucose levels and Gensini score in patients with STEMI

Frontiers in Cardiovascular Medicine

BackgroundAcute myocardial infarction (AMI), particularly ST-segment elevation myocardial infarction (STEMI), significantly impacts global health, exacerbated by risk factors such as diabetes mellitus (DM). While the Gensini score effectively quantifies coronary artery lesions, its correlation with fasting blood glucose (FBG) levels, particularly in a non-linear fashion, has not been thoroughly explored in STEMI patients.MethodsThis study analyzed data from 464 STEMI patients treated with percut

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Endothelin Pathway

HCPLive

Panelists discuss how the endothelin pathway critically regulates blood pressure and vascular health through the interplay between vasodilators and vasoconstrictors such as endothelin-1, representing a key mechanism in hypertension pathophysiology.