iRythm Technologies

NOVEMBER 1, 2023

Research indicates that healthcare quality varies across racial and ethnic groups. This article offers examples of inequity in atrial fibrillation detection and management. Raising awareness could help advance the path toward health equity.

Atrial Fibrillation 52

Atrial Fibrillation Arrhythmia Article Research 52

Coronary Artery Disease Journal

NOVEMBER 1, 2023

Background Spontaneous coronary artery dissection (SCAD) and Takotsubo syndrome (TTS) constitute two common causes of nonatherosclerotic acute cardiac syndrome particularly frequent in women. Currently, there is no information comparing long-term clinical outcomes in unselected patients with these conditions. Methods We compared the baseline characteristics, in-hospital outcomes, and the 12-month and long-term clinical outcomes of two large prospective registries on SCAD and TTS.

SCAD 52

SCAD Outcomes Risk Factors Atrial Fibrillation 52

Stroke Journal

NOVEMBER 1, 2023

Stroke, Volume 54, Issue 12 , Page 3012-3020, December 1, 2023. BACKGROUND:Smoking is a well-established risk factor for subarachnoid hemorrhage (SAH), and current smokers have an increased risk of SAH. However, there are insufficient data on whether smoking cessation in current smokers reduces the risk of SAH.METHODS:A nested case-control study was conducted based on the National Health Insurance Service-National Health Screening Cohort, which comprises nationwide health claims data and a natio

Hemorrhage 40

Hemorrhage Blood Pressure Risk Factors Stroke 40

Science Daily - Heart Disease

NOVEMBER 1, 2023

Researchers have for the first time identified the genetic pathway between the heart and brain tied to fainting. They found that vagal sensory neurons trigger fainting, laying a foundation for addressing fainting-related disorders.

Research 40

Research 40

Stroke Journal

NOVEMBER 1, 2023

Stroke, Volume 54, Issue 12 , Page 3030-3037, December 1, 2023. BACKGROUND:Inflammation contributes to atherosclerosis but is incompletely characterized in intracranial large artery stenosis (ICAS). We hypothesized that immune markers would be associated with ICAS and modify the risk ICAS confers on future vascular events.METHODS:This study included a subsample of stroke-free participants in the prospective NOMAS (Northern Manhattan Study), who had blood samples analyzed with a 60-plex immunoass

Stenosis 40

Stenosis Atherosclerosis Stroke Strokes 40

Hypertension Journal

NOVEMBER 1, 2023

Hypertension, Ahead of Print. Background:After a large intracerebral hemorrhage (ICH), the hematoma and swelling cause intracranial pressure (ICP) to increase, sometimes causing brain herniation and death. This is partly countered by widespread tissue compliance, an acute decrease in tissue volume distal to the stroke, at least in young healthy animals.

Hypertension 40

Hypertension Hemorrhage Risk Factors Stroke 40

Stroke Journal

NOVEMBER 1, 2023

Stroke, Volume 54, Issue 12 , Page 3090-3096, December 1, 2023. BACKGROUND:Acute ischemic infarct identification on noncontrast computed tomography (NCCT) is highly variable between raters. A semiautomated method for segmentation of acute ischemic lesions on NCCT may improve interrater reliability.METHODS:Patients with successful endovascular reperfusion from the DEFUSE 3 trial (Endovascular Therapy Following Imaging Evaluation for Ischemic Stroke) were included.

Stroke 40

Stroke Strokes 40

Stroke Journal

NOVEMBER 1, 2023

Stroke, Volume 54, Issue 12 , Page 3097-3106, December 1, 2023. BACKGROUND:Stroke survivors are frequently physically inactive. However, evidence of the effectiveness of active physiotherapy on physical activity level in stroke survivors is scarce.METHODS:We conducted a systematic review and meta-analysis of randomized controlled trials according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement, covering electronic searches from inception to March 16, 2022.

Stroke 40

Stroke Strokes Exercise Outcomes 40

Hypertension Journal

NOVEMBER 1, 2023

Hypertension, Ahead of Print. Background:Kir4.2 and Kir4.1 play a role in regulating membrane transport in the proximal tubule (PT) and in the distal-convoluted-tubule (DCT), respectively.Methods:We generated kidney-tubule-specific-AT1aR-knockout (Ks-AT1aR-KO) mice to examine whether renal AT1aR regulates Kir4.2 and Kir4.1.Results:Ks-AT1aR-KO mice had a lower systolic blood pressure thanAgtr1aflox/flox(control) mice.

Blood Pressure 40

Blood Pressure Hypertension 40

Circulation: Heart Failure

NOVEMBER 1, 2023

Circulation: Heart Failure, Ahead of Print. BACKGROUND:The “I Need Help” markers have been proposed to identify patients with advanced heart failure (HF). We evaluated the prognostic impact of these markers on clinical outcomes in a real-world, contemporary, multicenter HF population.METHODS:We included consecutive patients with HF and at least 1 high-risk “I Need Help” marker from 4 centers.

Heart Failure 40

Heart Failure Blood Pressure Hospital Circulation 40

Circulation: Cardiovascular Quality & Outcomes

NOVEMBER 1, 2023

Circulation: Cardiovascular Quality and Outcomes, Volume 16, Issue 11 , Page e000123, November 1, 2023. Enhancing access to care using telehealth is a priority for improving outcomes among older adults with heart failure, increasing quality of care, and decreasing costs. Telehealth has the potential to increase access to care for patients who live in underresourced geographic regions, have physical disabilities or poor access to transportation, and may not otherwise have access to cardiologists

Heart Failure 40

Heart Failure COVID-19 Circulation Outcomes 40

Circulation: Cardiovascular Interventions

NOVEMBER 1, 2023

Circulation: Cardiovascular Interventions, Ahead of Print. Dual antiplatelet therapy (DAPT) is the standard approach to prevent thrombotic events in patients undergoing percutaneous coronary intervention and presenting with chronic or acute coronary syndromes. However, a sizeable proportion of patients presents with an impaired or unwarranted response to DAPT depending on genetic polymorphisms or variability in platelet response.

Cardiovascular Interventions 40

Cardiovascular Interventions Circulation Research 40

The New England Journal of Medicine

NOVEMBER 1, 2023

Findings from a study involving two siblings homozygous for a null variant in CORIN have implications for understanding the extent to which the BNP and ANP pathways overlap.

Arrhythmia 40

Arrhythmia Cardiomyopathy Hypertension 40

HeartRhythm

NOVEMBER 1, 2023

Over a hundred genetic loci have been associated with atrial fibrillation (AF). But the exact mechanism remains unclear and the treatment needs to be improved.

Atrial Fibrillation 40

Atrial Fibrillation 40

Coronary Artery Disease Journal

NOVEMBER 1, 2023

An abstract is unavailable.

Aneurysm 52

Aneurysm 52

Stroke Journal

NOVEMBER 1, 2023

Stroke, Volume 54, Issue 12 , Page e505-e507, December 1, 2023.

Stroke 40

Stroke Strokes 40

Hypertension Journal

NOVEMBER 1, 2023

Hypertension, Ahead of Print.

Kidney Disease 40

Kidney Disease Hypertension 40

Dr. Smith's ECG Blog

NOVEMBER 1, 2023

This ECG was texted to me by a colleague. I assumed it was from a patient with symptoms compatible with ACS/OMI. What do you think? There is sinus rhythm with RBBB and ST Elevation in V2 which is concordant with the QRS. The ST segment in RBBB should be ST depression , discordant to the positive R'-wave (i.e., opposite direction of the upright R'-wave).

Myocardial Infarction 119

Myocardial Infarction Heart Disease Hospital STEMI 119

Physiologically Speaking

NOVEMBER 1, 2023

Greetings. In this week's post, we take a deep dive into the latest study showing that red meat intake is associated with type 2 diabetes…one that caused quite a stir in the media. Whether you’re plant-based or full-on-carnivore, you’ll be interested in what this study does (and doesn’t) say about dietary intake and disease risk.

Diabetes 52

Diabetes BMI Nursing Diet 52

Coronary Artery Disease Journal

NOVEMBER 1, 2023

Background The Naples prognostic score (NPS) is an effective inflammatory and nutritional scoring system widely applied as a prognostic factor in various cancers. However, the prognostic significance of NPS is unknown in ST-segment elevation myocardial infarction (STEMI). We aimed to analyze the prognostic value of the NPS in-hospital mortality in patients with STEMI.

Myocardial Infarction 52

Myocardial Infarction Hospital STEMI Cancer 52

Hypertension Journal

NOVEMBER 1, 2023

Hypertension, Ahead of Print. Background:Complement may drive the pathology of hypertension through effects on innate and adaptive immune responses. Recently an injurious role for the anaphylatoxin receptors C3aR (complement component 3a receptor) and C5aR1 (complement component 5a receptor) in the development of hypertension was shown through downregulation of Foxp3+(forkhead box protein 3) regulatory T cells.

Hypertension 40

Hypertension Blood Pressure 40