Fri.Dec 22, 2023

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Beware of Fake Ozempic, FDA Warns

Med Page Today

(MedPage Today) -- The FDA continues its investigation into counterfeit semaglutide (Ozempic) products -- which may still be available for purchase -- and has already seized thousands of units, the agency announced Thursday. In its warning.

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Parents Pass Down Psychiatric Conditions Due to a General Psychopathology Factor

HCPLive

In a new study, children had 8 - 40% higher odds of a psychiatric condition if their parents scored 1 SD above the mean on the general psychopathology. This demonstrates how parents with psychiatric disorders have a higher likelihood of passing it down to their children.

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HeartBeam Unveils AI Program Designed to Deliver Unprecedented Personalized Cardiac Insights

DAIC

milla1cf Fri, 12/22/2023 - 08:21 December 22, 2023 — HeartBeam, Inc., a medical technology company focused on transforming cardiac care through the power of personalized insights, announced significant developments for the use of artificial intelligence (AI) applied to its proprietary vectorelectrocardiography (VECG) technology, including the addition of new leadership and advisory roles.

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Is there OMI on this ECG?

Dr. Smith's ECG Blog

This is a case I had quite a while back. The patient with no prior cardiac history presented in the middle of the night with acute chest pain, and had this ECG recorded during active pain: I did not see any ischemia on this electrocardiogram. It does not look entirely normal, since there are some nonspecific STT abnormalities, such as flattening of the T waves in aVL.

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Ease up on drinking to cut your risk for 'holiday heart syndrome,' doctors warn

Medical Xpress - Cardiology

Rum-laced eggnog, mulled wine, or a hot toddy all sound good around the holidays, but too much imbibing can increase your risk of "holiday heart syndrome," doctors warn.

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Poet as Patient

The New England Journal of Medicine

A hospitalized poet writes a series of poems that seem possible only when one is near death. Grasping his condition through metaphor, he shares with his doctors an evolving understanding of life’s mysteries.

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Epidemiology, Pathophysiology, Diagnosis and Management of Chronic Right?Sided Heart Failure and Tricuspid Regurgitation. A clinical consensus statement of the Heart Failure Association (HFA) and the European Association of Percutaneous Cardiovascular Interventions (EAPCI) of the ESC

European Journal of Heart Failure

Abstract Right-sided heart failure and tricuspid regurgitation are common and strongly associated with poor quality of life and an increased risk of heart failure hospitalizations and death. While medical therapy for right-sided heart failure is limited, treatment options for tricuspid regurgitation include surgery and, based on recent developments, several transcatheter interventions.

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Natriuretic Peptides, Body Mass Index and Heart Failure Risk: Pooled Analyses of SAVOR?TIMI 53, DECLARE?TIMI 58 and CAMELLIA?TIMI 61

European Journal of Heart Failure

Abstract Background N-terminal pro-B-type natriuretic peptide (NT-proBNP) concentrations are lower in patients with obesity. The interaction between body mass index (BMI) and NT-proBNP with respect to heart failure (HF) risk remains incompletely defined. Methods Data were pooled across three randomized clinical trials enrolling predominantly patients who were overweight or obese with established cardiometabolic disease: SAVOR-TIMI 53, DECLARE-TIMI 58 and CAMELLIA-TIMI 61.

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Andrew Miller, PhD: Inventor of KarXT Discusses Pivotal EMERGENT-2 Data

HCPLive

Miller discusses the EMERGENT-2 trial and the benefits of xanomeline-trospium for treating adults with schizophrenia, for which the treatment is currently awaiting FDA decision.

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Fractional Flow Reserve Versus Angiography for Multivessel Evaluation 3

American College of Cardiology

The goal of the FAME 3 trial was to demonstrate the noninferiority of fractional flow reserve (FFR)-guided percutaneous coronary intervention (PCI) to coronary artery bypass grafting (CABG) for patients with three-vessel disease.

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Endocrine Case Report: Epigastric Pain in T2D and Hypothyroidism

HCPLive

This endocrine case report from Brady Pregerson, MD, features a woman in her early 50s with a history of type 2 diabetes and hypothyroidism presenting with 5 days of epigastric pain. Can you determine the correct diagnosis?

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TRiCares Announces Successful Implantation of Minimally Invasive Topaz Tricuspid Heart Valve Replacement System in Patient with a Pacemaker

DAIC

milla1cf Fri, 12/22/2023 - 08:03 December 22, 2023 — TRiCares SAS (“TRiCares”), a privately held pioneer in the field of minimally invasive treatment of tricuspid regurgitation , announced the successful implantation of its Topaz transfemoral tricuspid heart valve replacement system (“Topaz”) in a patient with a pacemaker at the University Medical Center of Mainz, Germany.

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Multidrug Resistant Infections: Is the Clinical Infection Treatment Pathway Outdated?

HCPLive

The current treatment paradigm might need to evolve to adjust to rapid diagnostics and narrowing down the antibiotics to aid in optimal outcomes for sicker patients with gram-negative infections.

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Short and Optimal Duration of Dual Antiplatelet Therapy After Everolimus-Eluting Cobalt-Chromium Stent-3

American College of Cardiology

The goal of the STOPDAPT-3 trial was to compare the safety and efficacy of an aspirin-free strategy among patients undergoing percutaneous coronary intervention (PCI) or at high bleeding risk.

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The Treacherous Journey Toward Immunity for Patients with Food Allergies: Past to Present

HCPLive

The seismic shifts in mentality for allergy management and the strides made in immunotherapy have kept parents of children with allergies hopeful, but changes are still needed.

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Prognostic Impact of Repeated NT-proBNP for HFrEF

American College of Cardiology

What is the prognostic impact of serial N-terminal pro–B-type natriuretic peptide (NT-proBNP) levels in stable patients with chronic heart failure (HF)?

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Direct-Acting Antivirals Improve HCC-Free Survival, Liver Function in Patients with HCV Decompensated Cirrhosis

HCPLive

Results from the systematic review and meta-analysis demonstrated the positive effect of DAA therapy on overall survival, HCC-free survival, and liver function among patients with HCV decompensated cirrhosis compared to a non-DAA control group.

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Physiology Friday #197: Do Morning Workouts Maximize the Cardiometabolic Benefits of Exercise?

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. This newsletter is brought to you by Examine.com — the best place on the internet for health and nutrition information — and my new eBook, “VO2 Max Essentials.” Details can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Highlighting Dermatologic Treatments Approved This Decade

HCPLive

This research letter highlights opportunities for researchers to develop more innovative treatments for skin disease, especially for conditions that have unmet therapeutic needs.

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Physiology Friday #197: Do Morning Workouts Maximize the Cardiometabolic Benefits of Exercise?

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. This newsletter is brought to you by Examine.com — the best place on the internet for health and nutrition information — and my new eBook, “VO2 Max Essentials.” Details can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Long Term Survival and Quality of Life Following Transcatheter Aortic Valve Replacement in Nonagenarians

The American Journal of Cardiology

Publication date: Available online 21 December 2023 Source: The American Journal of Cardiology Author(s): Luai Madanat, Mohamed Allam, Houman Khalili, Andrew Rabah, Rehan Tariq, Mazen Zamzam, Josep Rodés-Cabau, Thomas Pilgrim, Taishi Okuno, Sammy Elmariah, Philippe Pibarot, Amr E.

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Stacie Bell, PhD: Differences in Perceived Executive Function Between Parents, Children with SLE

HCPLive

Stacie Bell, PhD, discusses the disagreement between adolescents and parents regarding how lupus impacts daily life.

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Individualized Studies of Triggers of Paroxysmal Atrial Fibrillation

American College of Cardiology

The goal of the I-STOP-AFIB trial was to assess the efficacy of trigger-based testing for atrial fibrillation (AF) versus routine tracking alone among patients with AF.

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Study Demonstrates Efficacy, Safety of Topical PF-07038124 for Eczema, Psoriasis

HCPLive

These new data highlight the importance of larger trials to evaluate the persistence of this treatment’s efficacy and safety seen here.

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Eagle’s Eye View: The Year in Cardiology: 2023 in Review

American College of Cardiology

In this week’s View, Dr. Eagle explores the breakthroughs, trends, and major developments in cardiology over the last twelve months.

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Effect of left bundle branch pacing on right ventricular function: A three-dimensional echocardiography study

HeartRhythm

The effect of left bundle branch pacing (LBBP) on right ventricular (RV) function is not well known, and there is conflicting evidence regarding whether cardiac resynchronization therapy improves RV function.

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Using Genetics to Inform Interventions Related to Sodium and Potassium in Hypertension

Circulation

Circulation, Ahead of Print. BACKGROUND:Hypertension is a key risk factor for major adverse cardiovascular events but remains difficult to treat in many individuals. Dietary interventions are an effective approach to lower blood pressure (BP) but are not equally effective across all individuals. BP is heritable, and genetics may be a useful tool to overcome treatment response heterogeneity.

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The role of multimorbidity in patients with heart failure across the left ventricular ejection fraction spectrum: data from the Swedish Heart Failure Registry

European Journal of Heart Failure

ABSTRACT Aims The aim of this analysis was to provide data on the overall comorbidity burden, both cardiovascular (CV) and non-CV, in a large real-world heart failure (HF) population across the ejection fraction (EF). Methods and Results Patients with HF from the Swedish HF Registry between 2000-2021 were included. Of 91,463 patients (median age 76 years [IQR 67–82]), 98% had at least one among the 17 explored comorbidities (94% at least one CV and 85% at least one non-CV comorbidity).

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Mortality benefit with AF ablation: Impact of normal sinus rhythm seen in CABANA and EAST AFnet

Journal of Cardiovascular Electrophysiology

Abstract Atrial fibrillation (AF) is significantly associated with morbidity and mortality and erodes the quality and quantity of life. It is standard of care to treat patients with AF and an increased risk of stroke with oral anticoagulation therapy, but the more daunting question many clinicians face is whether to pursue a “rate-only” or “rhythm” control strategy.

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Real?world candidacy to mavacamten in a contemporary hypertrophic obstructive cardiomyopathy population

European Journal of Heart Failure

Abstract Background and aims In the EXPLORER-HCM trial, mavacamten reduced left ventricular outflow tract obstruction (LVOTO) and improved functional capacity of symptomatic hypertrophic obstructive cardiomyopathy (HOCM) patients. We sought to define the potential use of mavacamten by comparing real-world (RW) HOCM patients with those enrolled in EXPLORER-HCM and assessing their eligibility to treatment.

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Biosense Webster Begins Enrollment of SmartPulse Study in the U.S. to Evaluate RF and PFA Dual Energy Catheter to Treat Atrial Fibrillation

DAIC

milla1cf Fri, 12/22/2023 - 08:11 December 22, 2023 — Biosense Webster, Inc. , a global leader in cardiac arrhythmia treatment and part of Johnson & Johnson MedTech , announced the first patient cases with the investigational Dual Energy Thermocool SmartTouch SF Catheter took place as part of the SmartPulse pivotal study for treatment of paroxysmal atrial fibrillation (AFib).

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Study Explores Sex-Based Differences in Safety, Efficacy of DAAs in Clinical Trials

HCPLive

Although no differences were observed in the safety and efficacy of FDA-approved combination DAA therapies, female participants reported numerically more adverse events than male participants.

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CANHEART Population-Based Lab Prediction Models for ASCVD

American College of Cardiology

Can sex-specific prediction models for atherosclerotic cardiovascular disease (ASCVD) using age and routine laboratory tests be developed and validated?