Wed.Dec 13, 2023

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Cardiac imaging in athlete’s heart: current status and future prospects

Cardiovascular Ultrasound

Physical activity contributes to changes in cardiac morphology, which are known as “athlete’s heart”. Therefore, these modifications can be characterized using different imaging modalities such as echocardiogr.

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Increased risk of heart rhythm disruption after COVID-19

Science Daily - Heart Disease

Individuals infected with COVID-19 are also at an increased risk of suffering from heart rhythm disturbances, such as atrial fibrillation, according to a new study.

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1 in 6 Patients with Gout Experience Second Flare within 1 Year

HCPLive

Patients with gout who did not experience recurrent flares had a shorter mean time between diagnosis and the start of urate-lowering therapy compared with those who had ≥1 flare.

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Deaths from heart valve infections drop across U.S. overall, but surged among young adults

American Heart News - Heart News

Research Highlights: An analysis of death certificate data from 1999 to 2020 showed a decline in deaths related to infective endocarditis throughout most of the United States yet found an alarming increase of 2%-5% among adults ages 25-44. There was.

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Stopping Tirzepatide Led to Weight Gain, Trial Shows

Med Page Today

(MedPage Today) -- After discontinuing the weight-management injectable tirzepatide (Zepbound), most patients had a hard time keeping the weight off during the phase III SURMOUNT-4 trial. People on a maximum tolerated dose of tirzepatide (10 or.

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Engineered hydrogel reveals contribution of matrix mechanics to esophageal adenocarcinoma and identifies matrix-activated therapeutic targets

Journal of Clinical Investigation - Cardiology

Increased extracellular matrix (ECM) stiffness has been implicated in esophageal adenocarcinoma (EAC) progression, metastasis, and resistance to therapy. However, the underlying protumorigenic pathways are yet to be defined. Additional work is needed to develop physiologically relevant in vitro 3D culture models that better recapitulate the human tumor microenvironment and can be used to dissect the contributions of matrix stiffness to EAC pathogenesis.

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Proportionality is a major element in the ECG Diagnosis of OMI.

Dr. Smith's ECG Blog

This middle aged patient presented with chest pain: What do you think? There is VERY low voltage. There is some ST Elevation, but it is MINIMAL. But look how small the QRS is!! Let's stretch out the QRS vertically so it is not so tiny: On upper left is the original. On the right are the precordial leads stretched vertically, so that the QRS is not tiny.

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sUA Achievement Linked to Treatment Adherence, Antihypertensive Medications in Patients with Gout

HCPLive

Patients with gout achieving target serum uric acid levels showed good adherence to urate-lowering therapy, used antihypertensive agents, and lacked a family history of gout.

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Hepatitis B virus infection disrupts homologous recombination in hepatocellular carcinoma by stabilizing resection inhibitor ADRM1

Journal of Clinical Investigation - Cardiology

Many cancers harbor homologous recombination defects (HRDs). A HRD is a therapeutic target that is being successfully utilized in treatment of breast/ovarian cancer via synthetic lethality. However, canonical HRD caused by BRCAness mutations do not prevail in liver cancer. Here we report a subtype of HRD caused by the perturbation of a proteasome variant (CDW19S) in hepatitis B virus–bearing (HBV-bearing) cells.

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BE GONE Trial: Dietary Bean Intervention Enhances Gut Microbiome

HCPLive

Adding navy beans to one’s usual diet may be a viable dietary strategy for modulating the gut microbiome and regulating host markers associated with metabolic obesity and colorectal cancer.

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Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses

Journal of Clinical Investigation - Cardiology

Intranasal vaccines are anticipated to be powerful tools for combating many infectious diseases, including SARS-CoV-2, because they induce not only systemic immunity but also mucosal immunity at the site of initial infection. However, they are generally inefficient in inducing an antigen-specific immune response without adjuvants. Here, we developed an adjuvant-free intranasal vaccine platform that utilizes the preexisting immunity induced by previous infection or vaccination to enhance vaccine

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Patients with Hemophilia A Without Inhibitors Have Low Physical Activity

HCPLive

Presented at ASH 2023, a new study demonstrated physical activity does not increase bleeding for patients with hemophilia A as patients with low physical activity still experienced frequent bleeding.

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Las muertes por ataques cardíacos aumentan durante la temporada de Fiestas en invierno

American Heart News - Heart News

La American Heart Association informa que la alta tasa de enfermedades cardíacas entre los hispanos significa que es posible que sea necesaria una mayor conciencia y precaución para evitar sufrir un “ataque cardíaco durante las Fiestas”.

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New 'Atherosclerosis Atlas' Sheds Light on Heart Attacks, Strokes

DAIC

THE UNIVERSITY OF VIRGINIA SCHOOL OF MEDICINE'S CLINT L. MILLER, PHD, LED THE DEVELOPMENT OF A NEW "ATHEROSCLEROSIS ATLAS" THAT DETAILS, AT THE LEVEL OF INDIVIDUAL CELLS, CRITICAL PROCESSES RESPONSIBLE FOR FORMING THE HARMFUL PLAQUE BUILDUP THAT CAUSES HEART ATTACKS, STROKES AND CORONARY ARTERY DISEASE. Credit: DAN ADDISON | UNIVERSITY COMMUNICATIONS milla1cf Wed, 12/13/2023 - 10:15 December 13, 2023 — University of Virginia School of Medicine researchers have created an “atlas of atheroscleros

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Claudin-2 protects against colitis-associated cancer by promoting colitis-associated mucosal healing

Journal of Clinical Investigation - Cardiology

Patients with inflammatory bowel disease (IBD) are susceptible to colitis-associated cancer (CAC). Chronic inflammation promotes the risk for CAC. In contrast, mucosal healing predicts improved prognosis in IBD and reduced risk of CAC. However, the molecular integration among colitis, mucosal healing, and CAC remains poorly understood. Claudin-2 (CLDN2) expression is upregulated in IBD; however, its role in CAC is not known.

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Unique Cell-based Approach for Pulmonary Arterial Hypertension Shown to Be Safe

DAIC

Pulmonary arterial hypertension, a form of high blood pressure that occurs in the lungs, is a target of research by Cedars-Sinai investigators. Image by Getty Images milla1cf Wed, 12/13/2023 - 10:38 December 13, 2023 —Infusions of potentially therapeutic cells derived from the heart are safe for people with pulmonary arterial hypertension , a form of high blood pressure that occurs in the blood vessels of the lungs and typically affects middle-aged women, according to a study led by Cedars-Sinai

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Mitral Annular Early Diastolic Velocity Has Good Accuracy in the Detection of Low Exercise Tolerance in Patients With Heart Failure

The American Journal of Cardiology

Publication date: 15 January 2024 Source: The American Journal of Cardiology, Volume 211 Author(s): Esther Munerato Figueira da Silva, Raquel Martins Loureiro, Renan Shida Marinho, Júlia Marioti, Samuel Sá, Gabriela Pereira Gil Castilho, Guilherme Casale, Audrey Borghi Silva, Carlos Henrique de Freitas Lima, Meliza Goi Roscani

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Activation of the pentose phosphate pathway in macrophages is crucial for granuloma formation in sarcoidosis

Journal of Clinical Investigation - Cardiology

Sarcoidosis is a disease of unknown etiology in which granulomas form throughout the body and is typically treated with glucocorticoids, but there are no approved steroid-sparing alternatives. Here, we investigated the mechanism of granuloma formation using single-cell RNA-Seq in sarcoidosis patients. We observed that the percentages of triggering receptor expressed on myeloid cells 2–positive (TREM2-positive) macrophages expressing angiotensin-converting enzyme (ACE) and lysozyme, diagnostic ma

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Large-scale study finds increased risk of heart rhythm disruption after COVID-19

Medical Xpress - Cardiology

Individuals infected with COVID-19 are also at an increased risk of suffering from heart rhythm disturbances, such as atrial fibrillation. This is shown in a new study published in European Heart Journal Open by researchers from Umeå University, Sweden, in one of the largest studies of its kind in the world.

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Stigma in Epilepsy in 2023: How Far Have We Come?

HCPLive

In recent conversations with experts in epilepsy, the impact of stigmatization remains high for patients and ongoing efforts by clinicians to address this issue in the clinical setting has been underscored, despite the global lack of awareness about new treatments and other resources.

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Unique cell-based approach for pulmonary arterial hypertension shown to be safe

Science Daily - Heart Disease

Infusions of potentially therapeutic cells derived from the heart are safe for people with pulmonary arterial hypertension, a form of high blood pressure that occurs in the blood vessels of the lungs and typically affects middle-aged women, according to a new study.

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Global Estimates Reveal Significant Variability in Type 1 Diabetes Among Youth

HCPLive

Global incidence of T1D among children and adolescents <20 years old is substantial, but these rates exhibited significant variability by country, region, and age group.

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Memory CD8 T cells promote pathogenic plaque buildup of the arteries in aged mice: Study

Medical Xpress - Cardiology

Aging is known to be a risk factor for the biological changes that create the dangerous buildup of plaque in arteries called atherosclerosis, and aging also induces a buildup of memory CD8 T cells, a type of immune cell, in mice and humans.

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Clinical Trial Results From Emerging Therapies in IgA Nephropathy

HCPLive

Jonathan Barratt, PhD, FRCP, and Brad Rovin, MD, review clinical trials for new and emerging treatments for IgAN, highlighting atacicept and telitacicept.

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Electrovectorcardiographic study of left ventricular aneurysm in ischemic heart disease

Frontiers in Cardiovascular Medicine

The aim was to characterize the electrovectorcardiographic pattern of ventricular aneurysms in ischemic cardiopathy by analyzing the cardiac ventricular repolarization. The medical records of 2,670 individuals were analyzed in this cross-sectional study. A test phase included 33 patients who underwent transthoracic echocardiogram with ultrasonic enhancing agent, electrocardiogram, and vectorcardiogram (aneurysm group - n  = 22, and akinesia group - n  = 11).

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Increased Prurigo Nodularis Severity Linked to Increased Disease Burden

HCPLive

This web-based research is the first conducted to assess the burden of disease and treatment satisfaction among those in Japan with PN.

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Understanding the risks of cell therapy for heart repair

Medical Xpress - Cardiology

A type of cell that plays a crucial role in tissue repair after a heart attack may also inadvertently be why cutting-edge cell therapies cause an increased risk of rhythm disorders, according to a new study from the Universities of Surrey and Oxford. Researchers hope the findings could open up new pathways to safe regenerative treatments for people who have suffered a heart attack.

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Prevalence of Diabetic Retinopathy Linked to Duration, Age in Type 1 Diabetes

HCPLive

Patients with T1D diabetic retinopathy showed a longer duration of diabetes and increased age, compared to those without retinopathy.

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Smartwatches can pick up abnormal heart rhythms in kids, study finds

Medical Xpress - Cardiology

Smartwatches can help physicians detect and diagnose irregular heart rhythms in children, according to a new study from the Stanford School of Medicine.

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Understanding the risk of cell therapy for heart repair

Science Daily - Heart Disease

A type of cell that plays a crucial role in tissue repair after a heart attack may also inadvertently be why cutting-edge cell therapies cause an increased risk of rhythm disorders, according to a new study. Researchers hope the findings could open up new pathways to safe regenerative treatments for people who have suffered a heart attack.

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Dual Inhibition of BlyS and APRIL in IgA Nephropathy

HCPLive

Nephrology experts explore the role of dual inhibition of BlyS and APRIL in the treatment of IgAN, and how this can impact disease pathogenesis.

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Hypertriglyceridemia in Apoa5–/– mice results from reduced amounts of lipoprotein lipase in the capillary lumen

Journal of Clinical Investigation - Cardiology

Why apolipoprotein AV (APOA5) deficiency causes hypertriglyceridemia has remained unclear, but we have suspected that the underlying cause is reduced amounts of lipoprotein lipase (LPL) in capillaries. By routine immunohistochemistry, we observed reduced LPL staining of heart and brown adipose tissue (BAT) capillaries in Apoa5–/– mice. Also, after an intravenous injection of LPL-, CD31-, and GPIHBP1-specific mAbs, the binding of LPL Abs to heart and BAT capillaries (relative to CD31 or GPIHBP1 A

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National cardiogenic shock initiative study results show significant increase in heart attack survival

Medical Xpress - Cardiology

Published results of a large, national heart attack study show that patients with a life-threatening complication known as cardiogenic shock survived at a significantly higher rate when treated with a protocol developed by cardiologists at Henry Ford Health, in collaboration with 80 hospitals nationwide.

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Recruitment of naive CD4+ T cells by the recombinant zoster vaccine correlates with persistent immunity

Journal of Clinical Investigation - Cardiology

Herpes zoster (HZ) is a substantial problem for people with decreased cell-mediated immunity, including older adults. The first vaccine approved for HZ prevention, the zoster vaccine live (ZVL), which provided limited and short-lived protection, has been supplanted by the superior recombinant zoster vaccine (RZV), which provides robust and durable protection.

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A heart valve that grows with a pediatric patient

Medical Xpress - Cardiology

A prototype of an expanding artificial heart valve could make a big dent in the number of surgeries that many kids born with congenital heart disease need.

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Case Report: Kommerell's diverticulum and left aberrant subclavian artery stenosis hybrid treatment with branched aortic stent-graft

Frontiers in Cardiovascular Medicine

Kommerell's diverticulum in association with left or right aberrant subclavian arteries is a rare finding and is challenging to treat. Contemporary surgical and endovascular techniques provide a broad arsenal of possible treatments. Imaging techniques and modeling technology allow a more personalized strategy for each patient. In this case, we present a symptomatic patient with a Kommerell's diverticulum and a left aberrant subclavian artery complicated by proximal stenosis and poststenotic aneu

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Unique cell-based approach for pulmonary arterial hypertension shown to be safe

Medical Xpress - Cardiology

Infusions of potentially therapeutic cells derived from the heart are safe for people with pulmonary arterial hypertension, a form of high blood pressure that occurs in the blood vessels of the lungs and typically affects middle-aged women, according to a study led by Cedars-Sinai investigators.