Wed.Oct 23, 2024

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Risk of cardiovascular disease linked to long-term exposure to arsenic in community water supplies

Science Daily - Heart Disease

Long-term exposure to arsenic in water may increase cardiovascular risk and especially heart disease risk even at exposure levels below the federal regulatory limit, according to new research. A study describes exposure-response relationships at concentrations below the current regulatory limit and substantiates that prolonged exposure to arsenic in water contributes to the development of ischemic heart disease.

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50 top hospitals for cardiac surgery: Healthgrades

Becker's Hospital Review - Cardiology

Healthgrades published its 2025 Specialty Excellence Awards recipients Oct. 22. Of those recipients, 50 hospitals were recognized for delivering superior clinical outcomes in cardiac surgery.

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Looking Ahead: Previewing IgAN at ASN Kidney Week 2024, with Jonathan Barratt, PhD

HCPLive

Jonathan Barratt, PhD, discusses his excitement surrounding data and programming at the American Society of Nephrology's Kidney Week 2024, with a focus on IgAN.

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Poor Sleep at Age 40 Linked to Accelerated Brain Aging

Med Page Today

(MedPage Today) -- Poor sleep at age 40 was associated with accelerated brain aging patterns at age 55, longitudinal data showed. A dose-response relationship emerged between the number of poor sleep characteristics early in midlife and brain.

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Schizophrenia Tied to 4-Fold Increase in Sudden Cardiac Death Risk

HCPLive

A study found people with schizophrenia have a 4-fold higher risk of sudden cardiac death compared to the general population, underscoring the need for cardiometabolic care.

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Live well, think well: Research shows healthy habits tied to brain health

Science Daily - Heart Disease

In middle-aged people, having risk factors like blood pressure, blood sugar and cholesterol that are not well-controlled combined with not following certain healthy habits including exercise, diet and sleep, are linked to a higher risk of stroke, dementia or depression later in life, according to a new study. These results do not prove that not having healthy habits increases the risk of these conditions, they only show an association.

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Incident Migraine is Linked to Healthy Cardiovascular System

HCPLive

A new study found that individuals with healthier cardiovascular systems are more likely to develop migraines, linking incident migraine to lower cardiovascular risk.

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Christine N. Kay, MD: Interim Data on ATSN-201 Shows Promise for XLRS

HCPLive

At AAO 2024, Kay describes encouraging interim safety and efficacy results from the ATSN-201 gene therapy trial in patients with X-linked retinoschisis.

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Scripts for GLP-1, SGLT2 Drugs on the Rise in Type 1 Diabetes Patients

Med Page Today

(MedPage Today) -- GLP-1 receptor agonist or SGLT2 inhibitor prescribing became more common for people with type 1 diabetes in recent years, a nationwide cross-sectional analysis found. From 2010 to 2023, the percentage of type 1 diabetes patients.

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Rapid Cardiovascular Response to Belzutifan in HIF2A-Mediated Paraganglioma

The New England Journal of Medicine

Many patients with pheochromocytoma and paraganglioma have hypertension from tumor-derived catecholamines. The HIF-2α inhibitor belzutifan rapidly reduced blood pressure and excess catecholamine levels.

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Efficacy of atorvastatin on renal function in patients with contrast-induced nephropathy after percutaneous coronary intervention

Journal of Cardiothoracic Surgery

At present, the clinical methods for preventing and treating contrast-induced nephropathy (CIN) are limited, and statins can play a better role during this process. So, we aimed to assess the atorvastatin on r.

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Updated stroke prevention guidelines: 8 things to know

Becker's Hospital Review - Cardiology

The American Heart Association and American Stroke Association have updated the organizations' stroke prevention guidelines to include gender-focused insights and GLP-1 recommendations. The new guidelines were published Oct. 21 in Stroke.

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The triglyceride glucose: high-density lipoprotein cholesterol ratio is associated with coronary artery calcification evaluated via non-gated chest CT

Cardiovascular Diabetology

Coronary artery calcification (CAC) is a common risk factor of cardiovascular disease. Although triglyceride glucose (TYG) index and high-density lipoprotein cholesterol (HDL-c) are both associated with CAC, n.

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RWJBarnabas names heart and vascular services leader

Becker's Hospital Review - Cardiology

West Orange, N.J.-based RWJBarnabas Health has appointed Conor Barrett, MD, senior vice president and chief clinical officer of heart and vascular services.

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Prognostic impact of switching to the 2021 chronic kidney disease epidemiology collaboration creatinine-based equation in Caucasian patients with type 2 diabetes: the Renal Insufficiency and Cardiovascular events (RIACE) Italian Multicenter Study

Cardiovascular Diabetology

A Chronic Kidney Disease (CKD) Epidemiology Collaboration (EPI) formula not including a Black race coefficient has been recently developed and is now recommended in the US. The new (2021) equation was shown to.

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Inflammatory Back Pain in Malignancy Mimics Spondyloarthritis

HCPLive

Malignancy-related IBP has distinct features: shorter diagnosis time, higher ESR/CRP/LDH, lower hemoglobin, and often involves metastasis or paraneoplastic causes.

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Obesity cardiomyopathy could contribute to sudden cardiac death: a Japanese epidemiological morphological study

Cardiovascular Diabetology

Background We aimed to clarify the existence and pathological features of obesity cardiomyopathy (OCM) in Japan using our series of autopsy cases. Methods In this retrospective autopsy study, OCM was defined as cardiac hypertrophy (≥ 400 g in men, ≥ 320 g in women) of unknown aetiology in individuals with obesity (body mass index [BMI] ≥ 25 kg/m2 according to the Japanese definition of obesity).

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FINEARTS-HF — The Latest Masterpiece for MRAs in Heart Failure

The New England Journal of Medicine

Mineralocorticoid receptor antagonists (MRAs) are a cornerstone of treatment for patients with chronic heart failure and reduced ejection fraction.

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Validation of AHA PREVENT CVD Risk Equations

American College of Cardiology

What are the prognostic capabilities, calibration, and discrimination of the American Heart Association’s (AHA) Predicting Risk of Cardiovascular Disease Events (PREVENT) equations in a cohort representative of the US population when compared to the Pooled Cohort Equations (PCEs)?

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FDA Issues CRL for Ketamine to Treat Pain, Mental Health, and More

HCPLive

In the complete response letter, the FDA classified deficiencies in the Abbreviated New Drug Application for ketamine as MINOR.

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Impact of Ablation on AF Burden and Symptoms in HCM

American College of Cardiology

What is the impact of atrial fibrillation (AF) catheter ablation in patients with hypertrophic cardiomyopathy (HCM) on reduction in AF burden and symptoms?

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Upadacitinib Effective Long-Term for Adolescents with Atopic Dermatitis

HCPLive

The drug’s favorable risk-benefit profile and sustained efficacy through 76 weeks was highlighted in this analysis’s findings.

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Impact of Race on Sacubitril/Valsartan Use in HF

American College of Cardiology

What is the association between self-reported race and the safety and efficacy of sacubitril/valsartan use in patients with heart failure (HF)?

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Multimorbidity Screening Reduced Hospitalizations in Patients With Rheumatic Diseases

HCPLive

Patients exposed to screening were also more likely to receive vaccinations and consult a cardiologist and/or a pneumologist.

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Clinical outcomes of Asian patients with newly diagnosed atrial fibrillation and previously diagnosed atrial fibrillation: Insights from the CODE-AF registry

HeartRhythm

Atrial fibrillation (AF) may have different clinical features in its early phase. Objective: This study compared the characteristics and clinical outcomes of early-phase AF with later-phase AF using a large multicenter prospective registry (COmparison study of Drugs for symptom control and complication prEvention of Atrial Fibrillation [CODE-AF]).

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Alto Neuroscience’s ALTO-100 Fails to Beat Placebo in Improving Depressive Symptoms

HCPLive

Alto Neuroscience's ALTO-100 failed to beat placebo in a phase 2b trial for depression, leading to a 60% stock drop.

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Validation and Predictive Performance of the PAT Score

HeartRhythm

In regard to the Predicting Arrhythmic Event (PAT) score in Brugada syndrome patients derived from the Japan Idiopathic Ventricular Fibrillation Study (J-IVFS) (1), the study presents important findings but a few points may benefit from further discussion and clarification.

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Clinical Quiz: ACG Guidelines on Acute Pancreatitis Management

HCPLive

Test your knowledge of the 2024 American College of Gastroenterology acute pancreatitis diagnosis and management guidelines with this clinical quiz!

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Authors’ Reply to Validation and Predictive Performance of the PAT score

HeartRhythm

We appreciate the interest shown by Rattanawong et al.1 in our manuscript. In their letter, they state that (1) our study should be viewed as an internal validation rather than a true external validation. (2) the small number of events, especially in the first event cohort, could impact the interpretation of our results. (3) the Kaplan–Meier curve in Figure 4A does not represent the total cohort.

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Arshad Khanani, MD: First Results from Fellow Eye Dosing of RGX-314 in nAMD

HCPLive

At AAO 2024, Khanani discussed data showing a 97% reduction in annualized injection needs at 9 months with RGX-314 gene therapy.

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Increased TRPV4 Channel Expression Enhances and Impairs Blood Vessel Function in Hypertension

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Endothelial cell TRPV4 (transient receptor potential vanilloid 4) channels provide a control point that is pivotal in regulating blood vessel diameter by mediating the Ca2+-dependent release of endothelial-derived vasoactive factors. In hypertension, TRPV4-mediated control of vascular function is disrupted, but the underlying mechanisms and precise physiological consequences remain controversial.METHODS:Here, using a comprehensive array of methodologies,

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Sibeprenlimab Meaningfully Reduces uPCR in Adults With IgA Nephropathy

HCPLive

The data, which will be presented at a later time, may enable regulatory submission for accelerated approval to the FDA.

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Society for Vascular Surgery Launches Campaign to Help People Maintain Vascular Health

DAIC

tim.hodson Wed, 10/23/2024 - 13:54 Oct. 23, 2024 – The Society for Vascular Surgery (SVS) is launching a three-year patient education campaign, Highway to Health, to empower Americans to learn their SVS Strong Vessel Score and start a conversation with their doctor to see if a vascular surgeon could be a good addition to their overall care team. According to a recent survey released today by the Society, nearly one in three Americans at the highest risk for developing blood vessel (vascular) dis

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Outcomes Following Arteriovenous Fistula Creation Among Medicare Beneficiaries with End Stage Kidney Disease

The American Journal of Cardiology

Publication date: Available online 22 October 2024 Source: The American Journal of Cardiology Author(s): Nathan W. Kong, Joseph M. Kim, Anna K. Krawisz, Patrick Heindel, Archana Tale, Yang Song, Jeffrey L. Weinstein, Mohamad A. Hussain, Eric A.

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Anthracycline Cardiotoxicity in Cancer Patients; Arrhythmias, Autonomic Dysfunction and COVID-19; Lowering Non–HDL Cholesterol After MI

American College of Cardiology

In this week’s View, Dr. Eagle looks at anthracycline cardiotoxicity in treatment of cancer patients.

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Clinical Outcomes After Percutaneous Coronary Intervention for Left Main Coronary Artery Disease in Patients of Diverse Race/Ethnicity

The American Journal of Cardiology

Publication date: Available online 22 October 2024 Source: The American Journal of Cardiology Author(s): Pier Pasquale Leone, Samantha Sartori, Jonathan Murphy, Kenneth Smith, Angelo Oliva, Mauro Gitto, Benjamin Bay, Anastasios Roumeliotis, Birgit Vogel, David Power, Anton Camaj, Francesca Maria Di Muro, Annapoorna Kini, Samin Sharma, Roxana Mehran, George Dangas

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AN INTERNATIONAL PHYSICIAN SURVEY OF CURRENT ABLATION PRACTICES IN ATRIAL FIBRILLATION: AN AIM-AF SUBSTUDY

HeartRhythm

Practice guidelines recommend Ablation (ABL) in atrial fibrillation (AF) for rhythm control; guidance for antiarrhythmic drugs (AADs) post-ablation is limited.