HCPLive
JANUARY 10, 2025
New research reveals that frequent social media use, especially active use of platforms such as TikTok and Facebook, is linked to greater irritability levels.
Medical Xpress - Cardiology
JANUARY 10, 2025
Stanford University School of Medicineled researchers have found that intensive blood pressure (BP) control produces cardiovascular benefits and increases the risk of adverse events in people with chronic kidney disease (CKD).
HCPLive
JANUARY 10, 2025
Submission of the supplemental NDA was based on positive findings from the FINEARTS-HF trial investigating finerenone for heart failure with an LVEF 40%.
Medical Xpress - Cardiology
JANUARY 10, 2025
Humans and mice exposed to long-wavelength red light had lower rates of blood clots that can cause heart attacks, lung damage and strokes, according to research led by University of Pittsburgh School of Medicine and UPMC surgeon-scientists and published today in the Journal of Thrombosis and Haemostasis.
HCPLive
JANUARY 10, 2025
SP-624, a SIRT6 activator, showed promise in a Phase 2b/3 study for treating depression and cognition in females with MDD. Positive EEG data suggests enhanced neural connectivity.
Medical Xpress - Cardiology
JANUARY 10, 2025
A study has revealed a significant link between a common pregnancy complication and early heart disease in women. The study is published in the Journal of the American College of Cardiology.
HCPLive
JANUARY 10, 2025
Small molecule drugs may help fill gaps in treatment with biologic therapies.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
HCPLive
JANUARY 10, 2025
Atumelnant rapidly lowered key biomarkers in congenital adrenal hyperplasia in positive topline results from the Phase 2 TouCAHn trial.
Medical Xpress - Cardiology
JANUARY 10, 2025
A research team in the Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), found that hip fractures not only result in both physical and psychological injuries, but may also induce adverse cardiovascular events. In particular, hip fracture patients with pre-existing cardiac conditions are associated with a significantly higher risk of cardiovascular events (CVEs) and mortality, poorer prognosis, and greater health service utilization.
HCPLive
JANUARY 10, 2025
As the number of metabolic components increased, so did the risk of adverse outcomes in patients with biopsy-proven IgAN.
Med Page Today
JANUARY 10, 2025
(MedPage Today) -- Repetitive transcranial magnetic stimulation (rTMS) added to tai chi chuan exercise improved sleep and cognition in older adults who had both sleep disorders and mild cognitive impairment, a randomized clinical trial showed.
HCPLive
JANUARY 10, 2025
This analysis highlights the transcriptomic patterns of chronic hand eczema, indicating the potential of novel drug targets.
Becker's Hospital Review - Cardiology
JANUARY 10, 2025
Greensboro, N.C.-based Cone Health will establish a heart and vascular center after receiving a $7.5 million gift from the Bell Foundation, the largest in the health system's history.
HCPLive
JANUARY 10, 2025
4D-150 shows promising efficacy and safety in DME as FDA greenlights Phase 3 trial for Biologics License Application submission.
Frontiers in Cardiovascular Medicine
JANUARY 10, 2025
BackgroundThe weight adjusted waist index (WWI) represents a novel indicator for assessing central obesity. The objective of this study is to investigate the association between WWI and coronary heart disease (CHD).MethodThe data of 44,528 participants in total were gathered from NHANES database from 1999 to 2020. WWI is calculated as the waist circumference (WC, cm) divided by the square root of the body weight (kg), and CHD was determined based on participants self-reports.
HCPLive
JANUARY 10, 2025
HCPLive spoke with John M. Kane, MD, about phase 2 LB-102 data for schizophrenia.
Med Page Today
JANUARY 10, 2025
(MedPage Today) -- Exposure to radon was linked to an increased risk for gestational diabetes, a population-based cohort study suggested. Among 9,107 mothers-to-be, those living in U.S. counties with the highest radon level (≥2 pCi/L) had.
HCPLive
JANUARY 10, 2025
This study looks into the relationship of caffeine intake among pregnant mothers with asthma development outcomes among their offspring.
HeartRhythm
JANUARY 10, 2025
Although drug interactions between clarithromycin/erythromycin/fluconazole and direct oral anticoagulants (DOACs) are mechanistically plausible, it is uncertain whether they are clinically relevant.
HCPLive
JANUARY 10, 2025
A new study found that depression prevalence among older adults was greater for those who were 65 69 years old.
European Journal of Heart Failure
JANUARY 10, 2025
Abstract Aims A cardiovascular magnetic resonance (CMR) approach to non-invasively estimate left ventricular (LV) filling pressure was recently developed and shown to correlate with invasively measured pulmonary capillary wedge pressure (PCWP). We examined the association between CMR-estimated PCWP (CMR-PCWP) and other imaging and biomarker measures of congestion, and the effect of empagliflozin on these, in the SUGAR-DM-HF trial (NCT03485092).
HCPLive
JANUARY 10, 2025
Tocilizumab and other biological drugs were particularly efficacious in lowering overall hemostatic potential, mitigating blood clot risks.
European Journal of Heart Failure
JANUARY 10, 2025
Changes in N-terminal pro-B-type natriuretic peptide and assessment of clinical endpoints according to prior exposure to reninangiotensin system inhibitors in the Pre-specified substudy of Prospective comparison of ARNI with ARB Given following stabiLization In DEcompensated HFpEF (PARAGLIDE-HF). ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; CI, confidence interval; CV, cardiovascular; EF, ejection fraction; HF, heart failure.
HCPLive
JANUARY 10, 2025
Non-Hispanic Black and Hispanic children were less likely to undergo preemptive KT and had longer wait times than non-Hispanic White children.
European Journal of Heart Failure
JANUARY 10, 2025
Abstract Aims In VERTIS CV, ertugliflozin was associated with a 30% risk reduction for adjudication-confirmed, first and total hospitalizations for heart failure (HHF) in participants with type 2 diabetes and atherosclerotic cardiovascular disease. We evaluated the impact of ertugliflozin on the broader spectrum of all reported heart failure (HF) events independent of adjudication confirmation.
Journal of the American Heart Association
JANUARY 10, 2025
Journal of the American Heart Association, Ahead of Print.
Stroke: Vascular and Interventional Neurology
JANUARY 10, 2025
Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDAlthough bypass surgery can reduce rebleeding risk in hemorrhagic moyamoya disease, the risk remaining after surgery is not negligible. We hypothesized that the postoperative persistence of periventricular anastomosis (PA), a fragile periventricular collateral manifestation, is associated with rebleeding.METHODSThis retrospective cohort study included patients with moyamoya disease who underwent direct bypass at 2 instituti
Journal of the American Heart Association
JANUARY 10, 2025
Journal of the American Heart Association, Ahead of Print.
American College of Cardiology
JANUARY 10, 2025
Among patients without diabetes or cardiovascular disease and with a BMI 27 kg/m2, those with coronary artery calcium (CAC) scoring 300 derive the largest benefit from a weight-loss-dose of semaglutide for the prevention of major adverse cardiovascular events (MACE).
Journal of the American Heart Association
JANUARY 10, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundCarotid intimamedia thickness (IMT) is a measure of atherosclerosis and a predictor of vascular diseases. Traditional vascular risk factors and genetic variants do not completely explain the variation in carotid IMT. We sought to identify epigenetic factors that may contribute to the remaining carotid IMT variability.Methods and ResultsAn epigenomewide association study was performed in 61 Dominican families with 769 individual
American College of Cardiology
JANUARY 10, 2025
The lifetime risk of developing heart failure with reduced ejection fraction (HFrEF) is greater in men, while women are at greater risk of developing HF with preserved EF (HFpEF), according to 25-year results from the PREVEND study published Dec. 30 in the European Heart Journal.
Journal of the American Heart Association
JANUARY 10, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundHypertension control and related cardiovascular outcomes among Americans remain suboptimal, and differ by race, ethnicity, and geography. Healthcare access is one of multiple critical factors in hypertension control. Understanding the degree to which healthcare access, versus other factors, produce these outcomes can inform policies and interventions to improve cardiovascular outcomes and reduce disparities.
American College of Cardiology
JANUARY 10, 2025
Assisted reproductive technology (ART) does not appear to be significantly associated with increased long-term risk of cardiovascular diseases in women, according to a meta-analysis of 10 studies comprised nearly 37 million participants.
Journal of the American Heart Association
JANUARY 10, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundHeart failure with preserved ejection fraction (HFpEF) is linked to prolonged endoplasmic reticulum (ER) stress. P21activated kinase 2 (Pak2) facilitates a protective ER stress response. This study explores the mechanism and role of Pak2 in HFpEF pathology.Methods and ResultsThe HFpEF mouse model was established using a highfat diet combined with the nitric oxide synthase inhibitor NNitrolarginine methyl ester (highfat diet+NNi
American College of Cardiology
JANUARY 10, 2025
Therapeutic- compared with prophylactic-dose anticoagulation was associated with reduced 28-day mortality in patients hospitalized for COVID-19, according to a prospective meta-analysis from the World Health Organization (WHO) Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group.
Journal of the American Heart Association
JANUARY 10, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundThe economic burden of nonvalvular atrial fibrillation (NVAF) is substantial. Many patients with NVAF are obese and manage other health conditions requiring multiple medications. This realworld study compared health care resource use (HRU) and costs for rivaroxaban and warfarin in patients with NVAF who had polypharmacy and obesity.Methods and ResultsWe used health care claims databases (Merative MarketScan commercial and Medic
Stroke: Vascular and Interventional Neurology
JANUARY 10, 2025
Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDEndovascular thrombectomy allows for detailed study of thrombus composition in acute ischemic stroke. Differences in thrombus composition can affect outcomes, and the impact of sex on coagulation physiology is recognized. This study investigates whether thrombus composition in acute ischemic stroke varies between sexes.METHODSRetrospective study on consecutive endovascular thrombectomytreated patients with acute ischemic st
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