Fri.Jan 10, 2025

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Hip fractures linked to fivefold increase in cardiovascular event risk in patients with heart failure

Medical Xpress - Cardiology

A research team in the Department of Pharmacology and Pharmacy, LKS Faculty of Medicine, the University of Hong Kong (HKUMed), found that hip fractures not only result in both physical and psychological injuries, but may also induce adverse cardiovascular events. In particular, hip fracture patients with pre-existing cardiac conditions are associated with a significantly higher risk of cardiovascular events (CVEs) and mortality, poorer prognosis, and greater health service utilization.

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Study Shows a Correlation Between Social Media Use and Irritability

HCPLive

New research reveals that frequent social media use, especially active use of platforms such as TikTok and Facebook, is linked to greater irritability levels.

Research 116
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Blood pressure trial intervention shows mixed outcomes in chronic kidney disease patients

Medical Xpress - Cardiology

Stanford University School of Medicineled researchers have found that intensive blood pressure (BP) control produces cardiovascular benefits and increases the risk of adverse events in people with chronic kidney disease (CKD).

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Racial, Ethnic Pediatric Kidney Transplant Disparities Suggest Inequities in ESRD Care

HCPLive

Non-Hispanic Black and Hispanic children were less likely to undergo preemptive KT and had longer wait times than non-Hispanic White children.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Red light linked to lowered risk of blood clots

Medical Xpress - Cardiology

Humans and mice exposed to long-wavelength red light had lower rates of blood clots that can cause heart attacks, lung damage and strokes, according to research led by University of Pittsburgh School of Medicine and UPMC surgeon-scientists and published today in the Journal of Thrombosis and Haemostasis.

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Metabolic Syndrome Components Influence IgA Nephropathy Prognosis, Study Finds

HCPLive

As the number of metabolic components increased, so did the risk of adverse outcomes in patients with biopsy-proven IgAN.

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4D-150 Reduces Injection Burden in DME, Paving Way for FDA-Backed Phase 3

HCPLive

4D-150 shows promising efficacy and safety in DME as FDA greenlights Phase 3 trial for Biologics License Application submission.

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Multi-disciplinary treatment of broncho-esophageal fistula in a high-risk single-lung patient

Journal of Cardiothoracic Surgery

A broncho-esophageal fistula (BEF) is a medical and surgical disaster. Treatment of BEF is often limited to palliative stent treatment that may migrate or cause erosions and tissue necrosis. Surgical repair of.

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Phase 2 LB-102 Data, Advancing Treatment Landscape in Schizophrenia, with John Kane, MD

HCPLive

HCPLive spoke with John M. Kane, MD, about phase 2 LB-102 data for schizophrenia.

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Transcranial Magnetic Stimulation After Tai Chi Improves Sleep in Older Adults

Med Page Today

(MedPage Today) -- Repetitive transcranial magnetic stimulation (rTMS) added to tai chi chuan exercise improved sleep and cognition in older adults who had both sleep disorders and mild cognitive impairment, a randomized clinical trial showed.

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Bayer Submits Finerenone Application to FDA for Treatment of Heart Failure

HCPLive

Submission of the supplemental NDA was based on positive findings from the FINEARTS-HF trial investigating finerenone for heart failure with an LVEF 40%.

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Sacubitril/valsartan versus valsartan initiation in patients naïve to renin–angiotensin system inhibitors: Insights from PARAGLIDE‐HF

European Journal of Heart Failure

Changes in N-terminal pro-B-type natriuretic peptide and assessment of clinical endpoints according to prior exposure to reninangiotensin system inhibitors in the Pre-specified substudy of Prospective comparison of ARNI with ARB Given following stabiLization In DEcompensated HFpEF (PARAGLIDE-HF). ACEi, angiotensin-converting enzyme inhibitor; ARB, angiotensin receptor blocker; CI, confidence interval; CV, cardiovascular; EF, ejection fraction; HF, heart failure.

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Meta-Analysis Confirms Efficacy of Small Molecules for Psoriatic Arthritis

HCPLive

Small molecule drugs may help fill gaps in treatment with biologic therapies.

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CAC Scoring Improves Allocation of Semaglutide, Potentially Mitigates MACE Risk

American College of Cardiology

Among patients without diabetes or cardiovascular disease and with a BMI 27 kg/m2, those with coronary artery calcium (CAC) scoring 300 derive the largest benefit from a weight-loss-dose of semaglutide for the prevention of major adverse cardiovascular events (MACE).

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Phase 2b/3 Study Shows Promise of SP-624 for Improving Depression, Cognition

HCPLive

SP-624, a SIRT6 activator, showed promise in a Phase 2b/3 study for treating depression and cognition in females with MDD. Positive EEG data suggests enhanced neural connectivity.

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Is Assisted Reproductive Technology Associated With CV Risk?

American College of Cardiology

Assisted reproductive technology (ART) does not appear to be significantly associated with increased long-term risk of cardiovascular diseases in women, according to a meta-analysis of 10 studies comprised nearly 37 million participants.

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Efficacy and safety of single-branched stent graft in the treatment of type B aortic dissection: a meta-analysis of cohort studies

Journal of Cardiothoracic Surgery

Thoracic aortic endovascular repair (TEVAR) is the most commonly employed method for treating type B aortic dissection (TBAD). One of the primary challenges in TEVAR is the reconstruction of the left subclavia.

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Men at Higher Lifetime Risk of Developing HFrEF While Women at Higher Risk of HFpEF

American College of Cardiology

The lifetime risk of developing heart failure with reduced ejection fraction (HFrEF) is greater in men, while women are at greater risk of developing HF with preserved EF (HFpEF), according to 25-year results from the PREVEND study published Dec. 30 in the European Heart Journal.

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Atumelnant Reduces Key CAH Biomarkers, Hits Primary Phase 2 Endpoint

HCPLive

Atumelnant rapidly lowered key biomarkers in congenital adrenal hyperplasia in positive topline results from the Phase 2 TouCAHn trial.

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ACC Practice Made Perfect: The Physician-AI Collaboration – Reimagining Roles

American College of Cardiology

In the first of a three-part series on artificial intelligence (AI) in cardiology, Dr. Effie Andrikopoulou is joined by two leading cardiologists, Drs. Ashley Beecy and Rohan Khera, to explore how AI is transforming the field.

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Study Highlights Findings on Chronic Hand Eczema from Skin Tape Stripping

HCPLive

This analysis highlights the transcriptomic patterns of chronic hand eczema, indicating the potential of novel drug targets.

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Therapeutic- vs. Prophylactic-Dose Anticoagulation Reduces Mortality in Patients Hospitalized For COVID-19

American College of Cardiology

Therapeutic- compared with prophylactic-dose anticoagulation was associated with reduced 28-day mortality in patients hospitalized for COVID-19, according to a prospective meta-analysis from the World Health Organization (WHO) Rapid Evidence Appraisal for COVID-19 Therapies (REACT) Working Group.

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A Data-Driven Approach to Optimizing Outcomes in Congenital Heart Surgery

Society of Thoracic Surgeons - Adult Cardiac

At STS 2025, a presentation was given on the role of procedure-specific factors on understanding mortality following congenital heart surgery.

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Effects of continuous positive airway pressure treatment on arterial stiffness and inflammatory factors in patients with coronary heart disease complicated with obstructive sleep apnea

Journal of Cardiothoracic Surgery

Continuous Positive Airway Pressure (CPAP) treatment brings more benefits than risks to most coronary heart disease (CHD) patients with obstructive sleep apnea (OSA). However, the pathophysiological mechanism.

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Cone Health to establish heart center with $7.5M donation

Becker's Hospital Review - Cardiology

Greensboro, N.C.-based Cone Health will establish a heart and vascular center after receiving a $7.5 million gift from the Bell Foundation, the largest in the health system's history.

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Study Highlights Effect of Caffeine Intake While Pregnant on Childhood Asthma

HCPLive

This study looks into the relationship of caffeine intake among pregnant mothers with asthma development outcomes among their offspring.

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High Levels of Radon Exposure: Risk Factor for Gestational Diabetes?

Med Page Today

(MedPage Today) -- Exposure to radon was linked to an increased risk for gestational diabetes, a population-based cohort study suggested. Among 9,107 mothers-to-be, those living in U.S. counties with the highest radon level (≥2 pCi/L) had.

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6.2% of Community-Dwelling Older Adults in a Multisite Sample Face Depression

HCPLive

A new study found that depression prevalence among older adults was greater for those who were 65 69 years old.

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Comparison of Continuous Milrinone Versus Dobutamine on Pulmonary Pressures in Patients With Advanced Heart Failure

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.

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Early Control of Rheumatoid Arthritis Improves Hemostatic Imbalance

HCPLive

Tocilizumab and other biological drugs were particularly efficacious in lowering overall hemostatic potential, mitigating blood clot risks.

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Variation in Hypertension Control by Race and Ethnicity, and Geography in US Veterans

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundHypertension control and related cardiovascular outcomes among Americans remain suboptimal, and differ by race, ethnicity, and geography. Healthcare access is one of multiple critical factors in hypertension control. Understanding the degree to which healthcare access, versus other factors, produce these outcomes can inform policies and interventions to improve cardiovascular outcomes and reduce disparities.

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Potential interactions between antimicrobials and direct oral anticoagulants: population-based cohort and case-crossover study

HeartRhythm

Although drug interactions between clarithromycin/erythromycin/fluconazole and direct oral anticoagulants (DOACs) are mechanistically plausible, it is uncertain whether they are clinically relevant.

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Targeting P21‐Activated Kinase 2 as a Novel Therapeutic Approach to Mitigate Endoplasmic Reticulum Stress in Heart Failure With Preserved Ejection Fraction

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundHeart failure with preserved ejection fraction (HFpEF) is linked to prolonged endoplasmic reticulum (ER) stress. P21activated kinase 2 (Pak2) facilitates a protective ER stress response. This study explores the mechanism and role of Pak2 in HFpEF pathology.Methods and ResultsThe HFpEF mouse model was established using a highfat diet combined with the nitric oxide synthase inhibitor NNitrolarginine methyl ester (highfat diet+NNi

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Cardiovascular magnetic resonance‐estimated pulmonary capillary wedge pressure, congestion markers, and effect of empagliflozin in patients with heart failure with reduced ejection fraction and dysglycaemia (SUGAR‐DM‐HF)

European Journal of Heart Failure

Abstract Aims A cardiovascular magnetic resonance (CMR) approach to non-invasively estimate left ventricular (LV) filling pressure was recently developed and shown to correlate with invasively measured pulmonary capillary wedge pressure (PCWP). We examined the association between CMR-estimated PCWP (CMR-PCWP) and other imaging and biomarker measures of congestion, and the effect of empagliflozin on these, in the SUGAR-DM-HF trial (NCT03485092).

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Contemporary Administrative Codes to Identify Pulmonary Vein Isolation Procedures for Atrial Fibrillation

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundUse of pulmonary vein isolation (PVI) to treat atrial fibrillation continues to increase. Despite great interest in leveraging administrative data for realworld analyses, contemporary procedural codes for identifying PVI have not been evaluated.Methods and ResultsIn this observational retrospective cohort study, inpatient PVIs were identified among US Medicare feeforservice beneficiaries using Current Procedural Terminology (CP

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Heart failure outcomes captured by adverse event reporting in participants with type 2 diabetes and atherosclerotic cardiovascular disease: Observations from the VERTIS CV trial

European Journal of Heart Failure

Abstract Aims In VERTIS CV, ertugliflozin was associated with a 30% risk reduction for adjudication-confirmed, first and total hospitalizations for heart failure (HHF) in participants with type 2 diabetes and atherosclerotic cardiovascular disease. We evaluated the impact of ertugliflozin on the broader spectrum of all reported heart failure (HF) events independent of adjudication confirmation.