Tue.Aug 20, 2024

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Gut microbial pathway identified as target for improved heart disease treatment

Medical Xpress - Cardiology

Cleveland Clinic researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease. The study published in Nature Communications found that phenylacetylglutamine (PAG), produced by gut bacteria as a waste product, then absorbed and formed in the liver, interacts with previously undiscovered locations on beta-2 adrenergic receptors on heart cells once it enters the circulation.

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Semaglutide Has Disproportionate Suicidality Signal, Analysis Finds

Med Page Today

(MedPage Today) -- A disproportionality analysis based on reports in a World Health Organization (WHO) database suggested a suicidal ideation signal with the GLP-1 receptor agonist semaglutide (Ozempic, Rybelsus, Wegovy). Between 2000 and 2023.

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AI tools help uncover connections between radiotherapy for lung cancer and heart complications

Medical Xpress - Cardiology

Researchers from Brigham and Women's Hospital have used artificial intelligence tools to accelerate the understanding of the risk of specific cardiac arrhythmias when various parts of the heart are exposed to different thresholds of radiation as part of a treatment plan for lung cancer.

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More Than 15 Million US Adults Use Herbal, Dietary Supplements with Hepatotoxic Botanicals

HCPLive

Estimates based on NHANES data suggest 15.6 million US adults have used a potentially hepatotoxic botanical herbal and dietary supplement product within the past 30 days.

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Tiny killers: How autoantibodies attack the heart in lupus patients

Medical Xpress - Cardiology

Cardiovascular disease is the leading cause of death in patients suffering from lupus, an autoimmune disease in which our immune system attacks our own tissues and organs, the heart, blood, lung, joints, brain, and skin. Lupus myocarditis—inflammation of the heart muscle—can be very serious because the inflammation alters the regularity of the rhythm and strength of the heartbeat.

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JAK Inhibitor Improves Autoimmune Conditions in Down Syndrome

HCPLive

A phase 2 trial shows tofacitinib improves autoimmune conditions in Down syndrome, with notable skin health benefits and a good safety profile.

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Blood platelet score detects previously unmeasured risk of heart attack and stroke

Medical Xpress - Cardiology

Platelets are circulating cell fragments known to clump up and form blood clots that stop bleeding in injured vessels. Cardiologists have long known that platelets can become "hyperreactive" to cause abnormal clotting that blocks arteries and contributes to heart attack, stroke, and poor blood flow (peripheral artery disease) in the legs of millions of Americans.

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Redefining Cardiac Involvement in Systemic Immunoglobulin AL Amyloidosis

JAMA Cardiology

This cohort study analyzes data for 560 patients newly diagnosed with systemic AL amyloidosis to assess the differences between biomarkers, echocardiography, and cardiovascular magnetic resonance with extracellular volume mapping in characterizing cardiac amyloid infiltration.

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Researchers use AI tools to uncover connections between radiotherapy for lung cancer and heart complications

Science Daily - Heart Disease

Researchers have used artificial intelligence tools to accelerate the understanding of the risk of specific cardiac arrhythmias when various parts of the heart are exposed to different thresholds of radiation as part of a treatment plan for lung cancer.

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Tombstone Pattern Electrocardiogram in a Young Woman

JAMA Cardiology

A woman in her mid-20s presented with acute fever, chest pain, and exertional dyspnea. Electrocardiogram results showed sinus tachycardia, QRS widening, low-voltage complexes, and ST-segment elevation. What would you do next?

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The FDA calls them 'recalls,' yet the targeted medical devices often remain in use

Medical Xpress - Cardiology

In 2016, medical device giant Abbott issued a recall for its MitraClip cardiac device—"a Class I recall, the most serious type," the FDA said.

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Gut microbial pathway identified as target for improved heart disease treatment

Science Daily - Heart Disease

Researchers have made a significant discovery about how the gut microbiome interacts with cells to cause cardiovascular disease. The study found phenylacetylglutamine (PAG), produced by gut bacteria as a waste product, then absorbed and formed in the liver, interacts with previously undiscovered locations on beta-2 adrenergic receptors on heart cells once it enters the circulation.

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Cardiologist’s Date Rape Verdict; Feds Come Down on DOAC Price; POC Test for HF?

Med Page Today

(MedPage Today) -- In a highly publicized case, a former Denver cardiologist was found guilty of 35 out of 38 counts of sexual assault related to women he met on dating apps, continuing as recently as 2023. Google announced that Loss of Pulse.

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Researchers uncover genetic link between heart disease, Alzheimer's

Becker's Hospital Review - Cardiology

Researchers have uncovered a genetic link between heart disease and Alzheimer's, according to a study published Aug. 13 in the International Journal of Molecular Sciences.

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Mid LAD Occlusion

EMS 12-Lead

A 50 y/o Male presented to the ED with new-onset chest discomfort. He reported no pertinent history (eg, HTN, HLD, DM, Smoking, etc). The initial Trop I returned <0.012 ng/mL. Here is the time-zero ECG. The critical features that immediately caught my attention were both the hyperacute T-wave in aVL, and the reciprocal down-up T-wave in III.

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Tiny killers: How autoantibodies attack the heart in lupus patients

Science Daily - Heart Disease

A team of researchers report that autoantibodies alone directly affect heart function in lupus patients.

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USPSTF: Iron Deficiency Screening, Supplementation in Pregnancy Lacks Evidence

HCPLive

A new recommendation statement cites a lack of current evidence to assess the benefits of iron deficiency screening and supplementation in pregnant individuals.

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'Heart-in-a-box' better than cooler for heart transplants

Science Daily - Heart Disease

The risk of early heart failure after heart transplantation is lower if the donor heart is stored in a so-called heart-in-a-box instead of in the usual cooler with ice.

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Paternal HBV Infection Linked to Higher Risk of Congenital Heart Defect in Offspring

HCPLive

Results suggest paternal hepatitis B virus infection prior to pregnancy is associated with a 40% increased risk of congenital heart diseases in their children.

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ECG changes following balloon pulmonary angioplasty in patients with chronic thromboembolic pulmonary hypertension: a retrospective study

Journal of Cardiothoracic Surgery

This research evaluates the effect of balloon pulmonary angioplasty (BPA) on cardiac electrophysiological changes in patients with chronic thromboembolic pulmonary hypertension (CTEPH).

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Allergies and Asthma During the School Year, with S. Christy Sadeameli, MD, and Juanita Mora, MD

HCPLive

In this Lungcast episode, Mora and Sadeameli highlight Asthma Action Plans as well as Asthma Peak Weak considerations for children in the new school year.

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iSN04: A novel nucleic acid drug for the treatment of vascular diseases

Medical Xpress - Cardiology

Atherosclerosis, a major cause of mortality worldwide, involves an overgrowth of vascular smooth muscle cells in the blood vessels, constraining blood flow and potentially causing cardiovascular diseases.

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Stretching, Meditation Reduces Cramp Severity and Improves Sleep Quality

HCPLive

Stretching and meditation both reduced cramp severity and improved sleep quality with no significant differences. However, patients preferred stretching.

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Investigators automate mitral regurgitation detection and diagnosis

Medical Xpress - Cardiology

Investigators with the Smidt Heart Institute at Cedars-Sinai have developed an artificial intelligence (AI) program to detect the presence and severity of mitral valve regurgitation, the most common heart valve disorder.

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What cardiologists make of new heart guidelines

Becker's Hospital Review - Cardiology

Guidelines in cardiology continue to evolve as technology and research advance. Cardiologists from two leading health systems in the U.S. spoke to Becker's about their reactions to recent guideline updates.

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Study shows naloxone benefits in both drug-related and non-drug-related cardiac arrests

Medical Xpress - Cardiology

Patients who overdose on opioids and have a pulse are often given naloxone (Narcan) by first responders, a common life-saving measure.

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Bimekizumab Effective Among Patients with Nail, Genital, Scalp Psoriasis

HCPLive

These data on the efficacy of bimekizumab suggest positive therapeutic effects on nail, scalp, and genital lesions as well as quality of life.

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Point-of-Care Troponin at 0 and 2 Hours in Suspected AMI

American College of Cardiology

Can a 2-hour (0 and 2 hours) point-of-care (POC) high-sensitivity cardiac troponin I (hs-cTnI) strategy be safely applied in emergency patients with suspected acute myocardial infarction (AMI)?

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10 hospitals with the highest, lowest payments for heart failure

Becker's Hospital Review - Cardiology

Becker's has compiled a list of the hospitals with the highest and lowest payments for heart failure cases, as based on CMS's payment provider database.

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Blood platelet score detects previously unmeasured risk of heart attack and stroke

Science Daily - Heart Disease

A new study created a score to identify patients with platelet hyperreactivity and risk of related, future cardiovascular disease.

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Risankizumab Confirms Long-Term Safety in Treating Psoriatic Disease

HCPLive

Rates of adverse events leading to discontinuation were similar between populations of moderate-to-severe psoriasis and psoriatic arthritis.

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A 69 year old with acute chest pain

Dr. Smith's ECG Blog

This ECG was emailed to me by Sam Ghali. (@EM_RESUS) "What do you think, Steve? 69 year old woman with chest pain.” What do you think? I responded: " Suggestion of inferior OMI, but not quite diagnostic." There is an incomplete RBBB. There is minimal STE in lead III with an inverted T-wave, suggesting acute MI with some degree of reperfusion. Same in aVF.

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What Should I Do About an Elevated Lp(a) Based on Current Evidence and Available Treatments?

American College of Cardiology

In this interview, Raul Santos MD, PhD, and Sun Moon Kim MD, FACC discuss strategies to lowering an elevated Lp(a) based on current evidence and available treatments.

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OCEAN(a)-DOSE: Olpasiran Expresses Prolonged Reduction in Lp(a) Levels

HCPLive

Higher olpasiran doses sustained a ~50% placebo-adjusted mean reduction in Lp(a) levels nearly 1 year after the final dose.

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Erectile dysfunction risk among patients with diabetes mellitus using sodium–glucose cotransporter 2 inhibitors

Journal of Cardiovascular Pharmacology

To explore the incidence of new-onset erectile dysfunction (ED) in diabetes mellitus (DM) patients with sodium–glucose cotransporter 2 inhibitors (SGLT2I) use compared to a control group of non-SGLT2I use by propensity matching (PS) matching approach. Cox proportion hazards regression models were used to examine the effect of SGLT2I and risk factors on the risk of developing ED, presented as a hazard ratio (HR) with a 95% confidence interval (CI). 159773 DM patients using SGLT2I and 159773 PS-ma

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Research Identifies Risk Factors for Long-Term Opioid Use in Patients With PsA, AxSpA

HCPLive

Higher risk associations also included being a current smoker and socioeconomic deprivation.

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Exceptionally rare MINOCA: a case of acute myocardial infarction following surgery for Stanford type A aortic dissection

Journal of Cardiothoracic Surgery

Aortic dissection is a severe cardiovascular condition associated with high mortality rates, particularly in cases of Stanford type A aortic dissection (TAAD). Myocardial infarction with non-obstructive corona.