Thu.Apr 04, 2024

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Oral-gut microbial transmission promotes diabetic coronary heart disease

Cardiovascular Diabetology

Diabetes is a predominant driver of coronary artery disease worldwide. This study aims to unravel the distinct characteristics of oral and gut microbiota in diabetic coronary heart disease (DCHD). Simultaneous.

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Review identifies disrupted mitochondrial metabolism as a trigger for diabetic cardiomyopathy

Medical Xpress - Cardiology

Diabetes is a global health burden. A whopping 536 million people worldwide struggle with diabetes. Diabetic cardiomyopathy (DC) is a serious condition characterized by impaired heart function due to diabetes-related metabolic abnormalities.

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Osso VR Expands Cardiology Training through ACC Collaboration

DAIC

milla1cf Thu, 04/04/2024 - 12:14 April 4, 2024 — Osso VR , a leader in immersive procedural training, announces the release of a co-developed curriculum with the American College of Cardiology ( ACC ). This collaboration expands Osso VR’s presence in the cardiovascular sector. With the integration of Osso VR's immersive technology and the expertise of the ACC, interventionalists will gain access to a state-of-the-art training simulation of the workflow and skills required to successfully perf

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Association between triglyceride–glucose index trajectories and radiofrequency ablation outcomes in patients with stage 3D atrial fibrillation

Cardiovascular Diabetology

This study investigates the relationship between triglyceride-glucose (TyG) index trajectories and the results of ablation in patients with stage 3D atrial fibrillation (AF).

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Top 10: What Viewers Were Reading in March

DAIC

Here is a Top 10 look at the content that was trending during the month of March on dicardiology.com: 1. CLS Health Cardiologists Achieve Historic First with Transcarotid TAVR in Southeast Houston 2. FDA Announces Abiomed Recall of the Instructions for Use for the Impella Left Sided Blood Pumps due to Perforation Risks 3. Boston Scientific Receives FDA Approval for the AGENT Drug-Coated Balloon 4.

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Oral nitrate-reducing bacteria as potential probiotics for blood pressure homeostasis

Frontiers in Cardiovascular Medicine

Hypertension is a leading cause of morbidity and mortality worldwide and poses a major risk factor for cardiovascular diseases and chronic kidney disease. Research has shown that nitric oxide (NO) is a vasodilator that regulates vascular tension and the decrease of NO bioactivity is considered one of the potential pathogenesis of essential hypertension.

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Researchers say around 10% of deaths from coronary stenting, balloon angioplasty are preventable

Medical Xpress - Cardiology

Each year more than 500,000 Americans undergo percutaneous coronary intervention, or PCI, a minimally invasive procedure to unclog the arteries that feed the heart.

More Trending

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Treatment with anti-inflammatory proteins following heart attack shows promise to reduce the risk of further heart damage

Science Daily - Heart Disease

Research into the protective effects of two anti-inflammatory molecules, transforming growth factor-beta1 (TGF 1) and Heligmosomoides polygyrus TGM (HpTGM), following heart attack found that both proteins reduced the inflammatory response within the injured heart and reduced mature scarring. Anti-inflammatory therapy to treat patients following acute myocardial infarction is an exciting prospect that deserves further translational studies, report investigators.

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Early coronary disease, impaired heart function found in asymptomatic people with HIV

Medical Xpress - Cardiology

A new study has found that increased coronary vessel wall thickness is significantly associated with impaired diastolic function in asymptomatic, middle-aged individuals living with HIV. The study is published in Radiology: Cardiothoracic Imaging.

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FDA Announces Medos International Sàrl Recall of Cerenovus CEREBASE DA Guide Sheath due to Cracking of the Distal Catheter Shaft

DAIC

milla1cf Thu, 04/04/2024 - 10:09 April 4, 2024 — The U.S. Food and Drug Administration ( FDA ) announced that Medos International Sàrl is recalling Cerenovus CEREBASE DA Guide Sheath due to a crack found in the far end of the catheter, where different parts of the catheter are joined together. The FDA has identified this as a Class I recall , the most serious type of recall.

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Low-Dose Corticosteroids, Leflunomide More Safe, Effective Than Full-Dose for IgA Nephropathy

HCPLive

Results suggest low-dose corticosteroids in combination with leflunomide are more efficacious for improving urine protein excretion with better safety than full-dose corticosteroids.

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Who to Select For Treatment With Semaglutide: A Look at the SELECT Trial

American College of Cardiology

At the American Heart Association's (AHA) Scientific Sessions 2023, the Semaglutide Effects on Cardiovascular Outcomes in People With Overweight or Obesity (SELECT) trial was presented demonstrating that 2.4mg once weekly subcutaneous semaglutide.

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International Working Group Releases First Guideline for Osteoporosis in Men

HCPLive

The first guideline for the management of osteoporosis in men provides recommendations for diagnosis, monitoring, and treatment.

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Dapagliflozin and Timing of Prior HF Hospitalization

American College of Cardiology

How does efficacy of dapagliflozin correlate with recency of heart failure hospitalization (HFH) across the range of left ventricular ejection fraction (LVEF)?

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Can Routine Chest X-Ray Predict Risk for Adverse Cardiac Events?

NEJM Journal Watch - Cardiology

A single chest x-ray predicted 10-year major adverse cardiac events as effectively as a traditional risk-prediction score.

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Verve Therapeutics’ PCSK9 Pivot

CardiacWire

Verve Therapeutics’ stock price and gene editing momentum both took major dips last week, after the company announced that it paused its Heart-1 trial evaluating its VERVE-101 PCSK9 gene therapy, and revealed that it will now prioritize the development of its VERVE-102 therapy. Verve is developing investigational CRISPR-based gene editing therapies intended to allow long-term LDL-C reductions by permanently altering the PCSK9 gene.

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Increasing Legislative Changes May Mark Turning Point in US Biosimilar Adoption

HCPLive

Clinicians advocate for an at-parity approach to biosimilars, in which they, their patients, and the local market would have the freedom to choose the product that best suits their needs.

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Fontan circulation link to changes in the genetic code may lead to new treatment for heart conditions

Medical Xpress - Cardiology

Patients who have had surgery to create a Fontan circulation show changes in their genetic code, which may provide a new treatment opportunity to reduce premature aging.

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Ophthalmology Month in Review: March 2024

HCPLive

Each month, our editorial staff compiles a recap of the top news in ophthalmology. Our March 2024 ophthalmology month in review features a recap of the latest news from the ophthalmic pipeline.

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Oldest Man Dies; Fentanyl Easter Eggs; Lauren Boebert's Blood Clot

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. The world's oldest man died at the age of 114 in Venezuela, the Guinness World Records announced. He would have turned 115 next month. "We beat Big Pharma," said.

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Increasing Access to HCV Treatment Through Facilitated Telemedicine, with Andrew Talal, MD

HCPLive

Talal discusses the integration of a facilitated telemedicine approach into opioid treatment centers in New York, giving people with opioid use disorder easier access to HCV treatment.

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TAVI in Patients With High-Risk Symptomatic Native AR

American College of Cardiology

What are the outcomes with transfemoral transcatheter aortic valve implantation (TAVI) in patients with pure aortic regurgitation (AR) using the Trilogy transcatheter heart valve?

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Repressive H3K27me3 drives hyperglycemia-induced oxidative and inflammatory transcriptional programs in human endothelium

Cardiovascular Diabetology

Histone modifications play a critical role in chromatin remodelling and regulate gene expression in health and disease. Histone methyltransferases EZH1, EZH2, and demethylases UTX, JMJD3, and UTY catalyse trim.

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ACC.24 Consumer Research: Effects of E-Cigarettes, Eggs, Greenspace and More on Heart Health

American College of Cardiology

During ACC.24 in Atlanta, GA, researchers will be presenting the latest studies on a wide variety of topics, including the cardiovascular effects of e-cigarette use, fortified egg consumption, greenspace environments and more. Here’s a brief overview of the consumer research highlights.

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Right ventricular myocardial edema leading to severe heart failure after open heart surgery – possible effect of high-dose corticosteroid therapy

Journal of Cardiothoracic Surgery

Cardiopulmonary bypass induces a systemic inflammatory response and alterations in fluid homeostasis, resulting in generalized tissue edema. Additionally, ischemia-reperfusion injury following cardioplegic arr.

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Transcatheter Myotomy to Reduce LVOT Obstruction

American College of Cardiology

How safe and effective is the novel transcatheter electrosurgical procedure SESAME (SEptal Scoring Along Midline Endocardium) to reduce left ventricular outflow tract (LVOT) obstruction?

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Comparison of laser guidance and freehand hook-wire for CT-guided preoperative localization of pulmonary nodules

Journal of Cardiothoracic Surgery

In VATS surgery, precise preoperative localization is particularly crucial when dealing with small-diameter pulmonary nodules located deep within the lung parenchyma. The purpose of this study was to compare t.

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Self-Expanding Pulmonary Valve Replacement Registry Outcomes

American College of Cardiology

What are the short-term outcomes for patients with native or surgically repaired right ventricular outflow tract (RVOT) undergoing transcatheter pulmonary valve replacement (TPVR) with a self-expanding valve?

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Real-world Evidence at the American College of Cardiology Scientific Session ACC.24 to Demonstrate Positive Impact of Viz.ai on Suspected Disease Detection and Patient Triage for Improved Care

DAIC

Viz.ai will be announced new clinical data supporting advancements in cardiology care during the American College of Cardiology Scientific Sessions, ACC.24. Image courtesy: VizAI milla1cf Thu, 04/04/2024 - 12:16 April 4, 2024 — Viz.ai , a leader in AI-powered disease detection and intelligent care coordination, announced new clinical data supporting advancements in cardiology care.

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Biomechanics-mediated endocytosis in atherosclerosis

Frontiers in Cardiovascular Medicine

Biomechanical forces, including vascular shear stress, cyclic stretching, and extracellular matrix stiffness, which influence mechanosensitive channels in the plasma membrane, determine cell function in atherosclerosis. Being highly associated with the formation of atherosclerotic plaques, endocytosis is the key point in molecule and macromolecule trafficking, which plays an important role in lipid transportation.

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FDA Acceptance Announced of sBLA for Bimekizumab HS Treatment, 2mL Administration Devices

HCPLive

The FDA announcement on bimekizumab’s supplemental Biologics License Application followed the phase 3 BE HEARD I and II studies’ conclusion.

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A novel approach for denoising electrocardiogram signals to detect cardiovascular diseases using an efficient hybrid scheme

Frontiers in Cardiovascular Medicine

BackgroundElectrocardiogram (ECG) signals are inevitably contaminated with various kinds of noises during acquisition and transmission. The presence of noises may produce the inappropriate information on cardiac health, thereby preventing specialists from making correct analysis.MethodsIn this paper, an efficient strategy is proposed to denoise ECG signals, which employs a time-frequency framework based on S-transform (ST) and combines bi-dimensional empirical mode decomposition (BEMD) and non-l

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FDA Update: Abiomed Recalls Instructions For Use For Impella Left Sided Blood Pumps Due to Perforation Risks

American College of Cardiology

The U.S. Food and Drug Administration (FDA) has announced that Abiomed is recalling the instructions for use for its Impella Left Sided Blood Pumps due to risk that the pump catheter may perforate the wall of the left ventricle in the heart.

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Hereditary Angioedema: Spotlighting Disease Burden Insights

HCPLive

This analysis was conducted to evaluate the burden and disease characteristics of all 3 types of HAE among a set of Canadian patients.

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COGNITO Survey: How Can CIED Infection Patient Outcomes Be Improved?

American College of Cardiology

Infection from cardiac implantable devices (CIEDs) is a serious complication, and addressing discrepancies such as guideline education and streamlining care or referral pathways are key to bridging the gaps and improving patient outcomes, according to results from the COGNITO survey published Feb. 3 in JACC: Advances.

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Clinical application of virtual reality in patients with cardiovascular disease: state of the art

Frontiers in Cardiovascular Medicine

Virtual reality offers a multisensory experience to patients, allowing them to hear, watch, and interact in a virtual environment. Immersive virtual reality is particularly suitable for the purpose of completely isolating patients from the external environment to transport them away from the suffering related to the disease. On this state of the art, we summarize the available literature on the effectiveness of virtual reality on various physical and psychological outcomes in patients with ather

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HF Collaboratory Study Finds Increased Clinical Trial Diversity Could Help Close Gaps in Who Receives Newly Approved Treatments

American College of Cardiology

Increasing diversity in clinical trial enrollment may impact who receives early application of recently approved innovations, based on findings from a study conducted on behalf of the Heart Failure Collaboratory and being presented at ACC.24 in Atlanta, GA.