ECG Weekly Workout

JANUARY 7, 2024

HPI: A young woman presents to the ED after a syncopal episode. She hit her chest after falling and has reproducible chest wall tenderness on exam. She is also noted to be febrile at triage, with reported malaise, vomiting, and unilateral back ache. The following ECG is obtained on arrival before the patient is hospitalized for pyelonephritis, chest pain, and syncope: Case ECG Before watching this week’s video.

Chest Pain 125

Chest Pain Hospital 125

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Background Redo sternotomy aortic root surgery is technically demanding, and the evidence on outcomes is mostly from retrospective, small sample, single-centre studies. We report the trend, early clinical results and outcome predictors of redo aortic root replacement over 20 years in the United Kingdom. Methods We retrospectively analysed collected data from the UK National Adult Cardiac Surgery Audit (NACSA) on all redo sternotomy aortic root replacements performed between 30th January 1998 and

Coronary Artery Bypass Graft 69

Coronary Artery Bypass Graft Aortic Hospital Outcomes 69

HCPLive

JANUARY 7, 2024

Eyes with DED showed a correlation between the severity of ocular symptoms, obtained using dry eye and pain questionnaires, and all aspects of sleep quality.

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Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Introduction The use of contemporary drug-eluting stents (DES) has significantly improved outcomes of patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). However, concerns exist regarding the long-term proinflammatory effects of durable polymer coatings used in most DES, potentially leading to long-term adverse events.

Stent 64

Stent Stents Cardiogenic Shock Coronary Artery Disease 64

CardiacWire

JANUARY 7, 2024

Applied Therapeutics saw its shares fall 40% late last week after revealing that its diabetic cardiomyopathy drug candidate AT-001 (caficrestat) didn’t meet its phase 3 trial’s primary endpoint. However, the trial did show enough “encouraging results” for Applied to assert that AT-001 could still become the first diabetic cardiomyopathy treatment. Diabetic cardiomyopathy (DbCM) describes diabetes-associated changes in the structure and function of the heart’s myocardium, often leading to heart f

Cardiomyopathy 59

Cardiomyopathy Diabetes Cardiac Function Heart Failure 59

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Background The no-reflow phenomenon affects about one out of five patients undergoing Primary Percutaneous Coronary Intervention (PPCI). As the prolonged no-reflow phenomenon is linked with unfavorable outcomes, making early recognition is crucial for effective management and improved clinical outcomes in these patients. Our review study aimed to determine whether electrocardiogram (ECG) findings before PCI could serve as predictors for the occurrence of the no-reflow phenomenon.

Electrocardiogram 64

Electrocardiogram Article Outcomes 64

Heart Sisters

JANUARY 7, 2024

A New Year can be a discouraging time for those living with chronic illness – and I blame those damned resolutions!

Heart Disease 74

Heart Disease 74

HCPLive

JANUARY 7, 2024

Applied Therapeutics announced topline results from ARISE-HF on January 04, 2023 and plans to present full results at an upcoming medical conference.

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Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Background High-altitude pulmonary hypertension (HAPH) is a common disease in regions of high altitude where performing right heart catheterization (RHC) is challenging. The development of a diagnostic scoring system is crucial for effective disease screening. Methods A total of 148 individuals were included in a retrospective analysis, and an additional 42 residents were prospectively enrolled.

Pulmonary 59

Pulmonary Hypertension Laboratory Risk Factors 59

HCPLive

JANUARY 7, 2024

These findings may require further evaluation using classification of age range as well as severity of disease, allowing for more precise results.

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Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Objective Mercury sphygmomanometer (MS) has now been less and less used and no new devices have been manufactured (according to Minamata convention 2013). The application of the electronic sphygmomanometer (ES) in clinical practice has become increasingly common. However, reliable evidence for the use of the ES in high-altitude areas remains scarce.

Blood Pressure 59

Blood Pressure Hypertension 59

Circulation

JANUARY 7, 2024

Circulation, Volume 149, Issue 2 , Page 78-79, January 9, 2024.

Circulation 81

Circulation 81

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Myocardial damage caused, for example, by cardiac ischemia leads to ventricular volume overload resulting in increased stretch of the remaining myocardium. In adult mammals, these changes trigger an adaptive cardiomyocyte hypertrophic response which, if the damage is extensive, will ultimately lead to pathological hypertrophy and heart failure. Conversely, in response to extensive myocardial damage, cardiomyocytes in the adult zebrafish heart and neonatal mice proliferate and completely regenera

Ischemia 59

Ischemia Heart Failure 59

HCPLive

JANUARY 7, 2024

Results indicated patients with GERD are at a 69% increased risk of developing RA.

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Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Objectives In dyspneic patients with atrial fibrillation (AF) or obesity, the diagnostic performance of NT-proBNP for acute heart failure is reduced. We evaluated the erythroblast derived protein erythroferrone (ERFE) as an ancillary biomarker for the diagnosis of acute decompensated heart failure (ADHF) in these comorbid subgroups in both Western and Asian populations.

Heart Failure 59

Heart Failure Circulation Obesity Atrial Fibrillation 59

HeartRhythm

JANUARY 7, 2024

Randomized clinical trials have proven the survival benefit of implantable cardioverter defibrillators (ICDs) in different patient populations.1-3 Evidence generated by these trials has informed professional guidelines on ICDs for many years.4-6 The most recent AHA/ACC/HRS guideline document on the prevention of sudden cardiac death (SCD) clearly acknowledged that while the guideline is intended to define practices that prioritize the needs of patients, it does so for most, but not all, situatio

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Sudden Cardiac Death Defibrillator Document 45

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Introduction Differences in pathophysiology, clinical presentation, and natural course of ST-elevation myocardial infarction in female patients due to either spontaneous dissection (SCAD-STEMI) or atherothrombotic occlusion (type 1 STEMI) have been discussed. Current knowledge on differences in left ventricular myocardial function and infarct size is limited.

Myocardial Infarction 59

Myocardial Infarction SCAD STEMI Thrombolysis 59

HeartRhythm

JANUARY 7, 2024

PVC response Atrial-Pace (PVC-A-Pace) is a programmable algorithm developed by Abbott to prevent pacemaker mediated tachycardia after premature ventricular contractions (PVC) in all dual chamber cardiac implantable electronic devices (CIED) (1). The algorithm automatically extends post-ventricular atrial refractory period (PVARP) after PVC and initiates atrial pacing with a 330 ms delay when atrial sensed event occurs during extended PVARP.

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Pacemaker Tachycardia 40

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Background Different ST-segment elevation myocardial infarction (STEMI) localizations go along with dissimilarities in the size of the affected myocardium, the causing coronary vessel occlusion, and the right ventricular participation. Therefore, this study aims to clarify if there is any difference in long-term survival between anterior- and non-anterior-wall STEMI.

Myocardial Infarction 59

Myocardial Infarction STEMI 59

Journal of Cardiovascular Electrophysiology

JANUARY 7, 2024

Abstract Background The mechanism of typical slow-fast atrioventricular nodal re-entrant tachycardia (AVNRT) and its anatomical and electrophysiological circuit inside the right atrium (RA) and Koch's Triangle (KT) are not well known. Objective To identify the potentials of the compact AV node and inferior extensions and to perform accurate mapping of the RA and KT in sinus rhythm (SR) and during AVNRT, to define the tachycardia circuit.

Tachycardia 40

Tachycardia Ablation Electrophysiology Arrhythmia 40

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Background The number of models developed for predicting major adverse cardiovascular events (MACE) in patients undergoing percutaneous coronary intervention (PCI) is increasing, but the performance of these models is unknown. The purpose of this systematic review is to evaluate, describe, and compare existing models and analyze the factors that can predict outcomes.

Myocardial Infarction 59

Myocardial Infarction STEMI Article Diabetes 59

Journal of Cardiovascular Electrophysiology

JANUARY 7, 2024

Abstract New-onset atrial fibrillation (NOAF) in COVID-19 raises significant clinical and public health issues. This systematic review and meta-analysis aims to compile and analyze the current literature on NOAF in COVID-19 and give a more comprehensive understanding of the prevalence and outcomes of NOAF in COVID-19. A comprehensive literature search was carried out using several databases.

COVID-19 40

COVID-19 Atrial Fibrillation Public Health Article 40

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Takotsubo syndrome (TTS) is characterized by a transient left ventricular systolic dysfunction, burdened by significant acute and long-term mortality and morbidity. The prognosis of TTS, especially in the long-term, is influenced by both non-cardiovascular (non-CV) and CV comorbidities, among which cancer is one of the most common. The presence of a malignancy is proven to be associated with higher mortality in TTS.

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Cancer 59

Circulation

JANUARY 7, 2024

Circulation, Volume 149, Issue 2 , Page 160-163, January 9, 2024.

Circulation 49

Circulation 49

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Background Secretoneurin (SN) is a neuropeptide with potential utility as a biomarker of cardiovascular episodes. The main effect of SN is mediated through its inhibition of calmodulin-dependent kinase II (CaMKII), which influences calcium handling. We aimed to associate the levels of SN in plasma with different causes of heart failure. Methods We prospectively enrolled consecutive patients with ischaemic (ICM) and dilated (DCM) cardiomyopathy from the outpatient heart failure clinic and healthy

Cardiomyopathy 59

Cardiomyopathy Heart Failure Outpatient Biomarkers 59

Circulation

JANUARY 7, 2024

Circulation, Volume 149, Issue 2 , Page 77-77, January 9, 2024.

Circulation 49

Circulation 49

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Background A metabolic shift from fatty acid (FAO) to glucose oxidation (GO) occurs during cardiac hypertrophy (LVH) and heart failure with reduced ejection fraction (HFrEF), which is mediated by PGC-1α and PPARα. While the transcription factor EB (TFEB) regulates the expression of both PPARGC1A /PGC-1α and PPARA /PPARα, its contribution to metabolic remodeling is uncertain.

Heart Failure 59

Heart Failure Cardiac Function Aortic 59

Circulation

JANUARY 7, 2024

Circulation, Volume 149, Issue 2 , Page 155-159, January 9, 2024.

Circulation 45

Circulation 45

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Aims To develop a model-informed methodology for the optimization of the Major Adverse Cardiac Events (MACE) composite endpoint, based on a model-based meta-analysis across anti-hypercholesterolemia trials of statin and anti-PCSK9 drugs. Methods and results Mixed-effects meta-regression modeling of stand-alone MACE outcomes was performed, with therapy type, population demographics, baseline and change over time in lipid biomarkers as predictors.

Cholesterol 59

Cholesterol Biomarkers Outcomes 59

Circulation

JANUARY 7, 2024

Circulation, Volume 149, Issue 2 , Page 168-169, January 9, 2024.

Myocardial Infarction 45

Myocardial Infarction Article Circulation 45

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Heart failure with preserved ejection fraction (HFpEF) is the largest unmet clinical need in cardiovascular medicine. Despite decades of research, the treatment option for HFpEF is still limited, indicating our ongoing incomplete understanding on the underlying molecular mechanisms. Non-coding RNAs, comprising of microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs), are non-protein coding RNA transcripts, which are implicated in various cardiovascular diseases.

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Preserved Ejection Fraction Heart Failure Biomarkers Cardiovascular Disease 59

Circulation

JANUARY 7, 2024

Circulation, Volume 149, Issue 2 , Page 167-167, January 9, 2024.

Myocardial Infarction 45

Myocardial Infarction Article Circulation 45

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

A 14-year-old male with no significant medical history presented with intermittent palpitations for 2–3 months that occurred at rest and were associated with light-headedness. Electrocardiogram in clinic showed sinus arrhythmia with early repolarization and no ischemic changes. The echocardiogram showed normal cardiac structure and function, however, there was a concern for possible anomalous origin of the left coronary artery.

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Chest Pain Exercise Electrocardiogram Echocardiogram 59

Circulation

JANUARY 7, 2024

Circulation, Volume 149, Issue 2 , Page 164-166, January 9, 2024.

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Circulation 45

Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

The most frequent haematological malignancy associated with acquired hypo/dysfibrinogenemia is multiple myeloma. We present an unusual case of severe haemorrhagic diathesis due to acquired hypofibrinogenemia in a patient with early T-cell precursor acute lymphoblastic leukaemia/lymphoma (ETP-ALL/LBL). A 57-year-old male was admitted to the General Internal Medicine Department of Padova University Hospital for acute massive haematomas of the left lower extremity associated with macrohaematuria.

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Circulation Hospital 52

Coronary Artery Disease Journal

JANUARY 7, 2024

No abstract available

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Frontiers in Cardiovascular Medicine

JANUARY 7, 2024

Background Percutaneous pulmonary valve implantation (PPVI) has emerged as a less invasive alternative for treating severe pulmonary regurgitation after tetralogy of Fallot (TOF) repair in patients with a native right ventricular outflow tract (RVOT). However, the success of PPVI depends on precise patient-specific valve sizing, the avoidance of oversizing complications, and optimal valve performance.

Pulmonary 49

Pulmonary Heart Valves Innovation Technology 49