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Researchers have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development. The breakthrough science focused on replicating heart tissues, bringing research closer to generating functional, bioprinted organs, which would have broad applications in disease modelling, drug screening and regenerative medicine.
Although GLP-1s have proven to significantly help with weight loss and cardiometabolic disorders, a new Nature Medicine study shed light on the drugs potential side-effects. GLP-1s have skyrocketed in popularity due to their weight loss impact, while their potential heart benefits could make GLP-1s a common cardiology drug. However, little is known about the long-term risks of this wonder drug class due to its relatively short time on the market and a lack of studies on the topic.
Arterial stiffness is strongly associated with vascular aging and pathology and can be assessed in many ways. Existing devices for measuring central arterial stiffness, such as carotid-femoral pulse wave velocity (PWV), are limited by high costs and the need for specialized expertise, limiting widespread clinical adoption. This study introduces a semi- and non-occlusive PWV measurement system using phonocardiography (PCG) and plethysmography (PPG) and a single femoral pressure cuff, aiming to ad
Nature Reviews Cardiology, Published online: 23 January 2025; doi:10.1038/s41569-025-01121-6 In this Review, Wu and colleagues discuss the evolution in cannabis regulation, the endocannabinoid system and cannabinoid receptors, the influence of cannabis on cardiovascular risk factors, and the effects of traditional and synthetic cannabinoids on cardiovascular health and disease.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
BackgroundHeart failure (HF) is a clinical syndrome resulting from structural damage or dysfunction of the heart. Previous investigations have highlighted the critical involvement of immune cells in the progression of heart failure, with distinct roles attributed to different types of immune cells. The objective of the current research was to explore the potential connections between immune characteristics and the development of HF, as well as to ascertain the nature of the causality between the
Researchers evaluated a drug that represents a new class of anticoagulants known as Factor XI inhibitors for treating patients with atrial fibrillation as part of the AZALEA-TIMI 71 Study. The trial was stopped early by the recommendation of the Data Monitoring Committee due to an overwhelming reduction in bleeding compared to standard-of-care treatment.
PurposeWe aimed to investigate the correlation between CT-derived fractional flow reserve (CTFFR) and myocardial strain in patients with single coronary artery stenosis and to investigate the diagnostic value of CTFFR in identifying impaired myocardial strain.MethodsWe selected 89 patients, categorized into three groups based on the affected coronary artery: 36 with left anterior descending (LAD), 23 with left circumflex (LCX), and 30 with right coronary artery (RCA) stenosis, along with 25 heal
PurposeWe aimed to investigate the correlation between CT-derived fractional flow reserve (CTFFR) and myocardial strain in patients with single coronary artery stenosis and to investigate the diagnostic value of CTFFR in identifying impaired myocardial strain.MethodsWe selected 89 patients, categorized into three groups based on the affected coronary artery: 36 with left anterior descending (LAD), 23 with left circumflex (LCX), and 30 with right coronary artery (RCA) stenosis, along with 25 heal
IntroductionThe objective of this study was to examine the impact of ventricular assist device support as a bridge to heart transplantation in children with end-stage heart failure. In light of the limited availability of donor organs, particularly in Europe, the number of children requiring ventricular assist device support is rising at an unavoidable rate.MethodsWe performed a retrospective cohort study of patients who underwent a single and primary pediatric heart transplantation.
A recent study by researchers from the University of Toronto, Tyndale University and the University of Texas at Arlington found that older adults are at greater risk of having a stroke if they experienced their parents divorcing during childhood.
Researchers at University of Galway have developed a way of bioprinting tissues that change shape as a result of cell-generated forces, in the same way that it happens in biological tissues during organ development.
"Cincinnati Children's and Akron Children's partner for comprehensive cardiovascular care, expanding treatment options for children with complex heart condition
Publication date: Available online 20 January 2025 Source: The American Journal of Cardiology Author(s): Robert C. Stoler, Minseob Jeong, Talha Akram, Alec Monhollen, David Fernandez Vazquez, Mufaddal Mamawala, Trenton A. Witt, Blake Bruneman, Sarah Weideman, Kennedy S. Adelman, Shalini Sharma, Yumna Furqan, Zachary P. Rosol, Ronak Rengarajan, Jeffrey M.
This randomized trial showed no significant difference in return of spontaneous circulation between initial intraosseous and intravenous vascular access in adults with out-of-hospital cardiac arrest.
Panelists discuss how the CLEAR-outcomes trial demonstrated bempedoic acids efficacy in primary prevention of cardiovascular events, informing its clinical implementation for patients with statin intolerance or inadequate LDL-C control.
In a trial involving adults with out-of-hospital cardiac arrest, an intraosseous-first strategy for vascular access did not result in a higher incidence of 30-day survival than an intravenous-first strategy.
Circulation: Cardiovascular Interventions, Ahead of Print. Some patients with aortic stenosis may require multiple valve interventions in their lifetime, and choosing transcatheter aortic valve replacement (TAVR) as the initial intervention may be appealing to many. If their transcatheter heart valve degenerates later in life, most will hope to undergo redo-TAVR.
In patients with atrial fibrillation and moderate-to-high risk of stroke, abelacimab, a monoclonal antibody that inhibits activation of factor XI, led to fewer bleeding events than rivaroxaban.
(MedPage Today) -- Individual SGLT2 inhibitors showed roughly comparable cardiovascular effectiveness and safety in an observational study of real-world claims data. Compared with people who had type 2 diabetes treated with empagliflozin (Jardiance.
A 54-year-old male athlete was evaluated at this hospital because of exertional dyspnea and chest pain. Physical examination revealed jugular venous distention and Kussmauls sign. A diagnosis was made.
In this observational cross-sectional study, investigators highlighted the challenges associated with tapering cortisone creams for patients with atopic dermatitis.
This editorial describes the science behind a clinical trial reported by Ruff et al. in which a monoclonal antibody targeting factors XI and XIa was evaluated for its effects on bleeding events in patients with atrial fibrillation.
This interactive feature describes a woman who received a diagnosis of hypertension and preeclampsia at 27 years of age. After giving birth, her blood pressure remained elevated. Test your diagnostic and therapeutic skills at NEJM.org.
Circulation, Ahead of Print. BACKGROUND:Plasma NT-proBNP (N-terminal pro-B-type natriuretic peptide) is commonly used to diagnose heart failure with preserved ejection fraction (HFpEF), but its diagnostic performance in the ambulatory/outpatient setting is unknown because previous studies lacked objective reference standards.METHODS:Among patients with chronic dyspnea, diagnosis of HFpEF or noncardiac dyspnea was determined conclusively by exercise catheterization in a derivation cohort (n=414),
A new molecular imaging technique -- 18F-FAPI PET -- can detect the first signs of tissue remodeling in patients with pulmonary arterial hypertension (PAH), providing physicians with an early marker for disease progression. This approach has the potential to pave the way for more personalized management of PAH, offering more timely interventions to improve patient prognosis.
A new molecular imaging technique18F-FAPI PETcan detect the first signs of tissue remodeling in patients with pulmonary arterial hypertension (PAH), providing physicians with an early marker for disease progression. This approach has the potential to pave the way for more personalized management of PAH, offering more timely interventions to improve patient prognosis.
Mitral and aortic annular calcification is an age-related degenerative process that can result in severe mitral and/or aortic stenosis and/or regurgitation. Annular calcification not only increases the surgica.
Manchester, N.H.-based Elliot Health System has tapped Gerald Sardella, MD, to lead the cardiac surgery program at the system's new heart and vascular center.
Solitary fibrous tumors (SFTs) of the pleura are usually benign. We present a case of SFT of the pleura which grew rapidly after slow long-term progression.
HCPLive spoke with Mattingly about esketamines recent FDA approval as a monotherapy for treatment-resistant depression which works within hours or 1 2 days.
Baseline systemic inflammation is associated with worse long-term outcomes after coronary artery bypass grafting [CABG], but the mechanisms of this association are unclear. This study aims to explore the assoc.
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