Sat.Aug 31, 2024

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Women's 30-Year Heart Risk Can Be Predicted by Just Three Factors

Med Page Today

(MedPage Today) -- LONDON -- A combination of three factors -- high-sensitivity C-reactive protein (hsCRP), LDL cholesterol, and lipoprotein(a), or lp(a) -- independently predicted cardiovascular disease over 30 years in women who were initially.

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FLOW: Semgalutide Provides Consistent CV Benefit Across Spectrum of Kidney Disease

HCPLive

Kenneth Mahaffey, MD, discusses FLOW trial data showing semaglutide improves cardiovascular outcomes in patients with type 2 diabetes, regardless of CKD severity.

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Potassium Strategy After Cardiac Bypass Grafting Doesn't Impact Afib Risk

Med Page Today

(MedPage Today) -- LONDON -- Keeping potassium levels high after cardiac surgery in hopes of preventing post-surgical atrial fibrillation (Afib) didn't work, a randomized clinical trial showed. New-onset Afib after isolated coronary artery bypass.

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M-TEER Reduces Cardiovascular Risk, Improves Quality of Life in HF with Mitral Regurgitation

HCPLive

RESHAPE-HF2 shows mitral transcatheter edge-to-edge repair (M-TEER) reduces heart failure hospitalizations and improves quality of life vs optimal medical therapy alone.

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Predicting COVID Outbreaks Via Wastewater; New Medicine for Menopause

Med Page Today

(MedPage Today) -- TTHealthWatch is a weekly podcast from Texas Tech. In it, Elizabeth Tracey, director of electronic media for Johns Hopkins Medicine in Baltimore, and Rick Lange, MD, president of the Texas Tech University Health Sciences Center.

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Rahul Aggarwal, MD: Sotagliflozin Benefit Grows with Increasing Diabetes Duration

HCPLive

Rahul Aggarwal, MD, discusses the findings of a SCORED analysis examining sotagliflozin's effects based on diabetes duration.

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Pause or Keep RAS Inhibitors Before Surgery? Take Your Pick.

Med Page Today

(MedPage Today) -- LONDON -- No blanket statement could be made regarding whether patients undergoing noncardiac surgery should continue or withdraw their renin-angiotensin system (RAS) inhibitor therapy based on the Stop-or-Not Trial. Death.

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Another Trial Sides With MitraClip for Functional Mitral Regurgitation

Med Page Today

(MedPage Today) -- LONDON -- Despite another positive trial, controversy rages on over transcatheter edge-to-edge repair (TEER or M-TEER) in people with symptomatic heart failure (HF) and functional mitral regurgitation (MR). All three primary.

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Burden of Atherosclerotic Disease Risk Factors in patients with vs without Rheumatologic Disease: A Retrospective cohort study of US patients from the Houston Methodist Cardiovascular Disease Learning Health System Registry

The American Journal of Cardiology

Publication date: Available online 30 August 2024 Source: The American Journal of Cardiology Author(s): Helene DiGregorio, Eleonora Avenatti, Rakesh Gullapelli, Kenneth Williams, Elia El Hajj, Charles Foster, Siddharth Das, Izza Shahid, Aayush Shah, Juan Nicolas, Budhaditya Bose, Kobina Hagan, Shubham Lahan, Nwabunie Nwana, Sara Butt, Zulqarnain Javed, Lily Romero Karam, Kanika Monga, Myriam Guevara, Brittany Weber

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TriClip's 'Soft' Benefits Affirmed in Severe Tricuspid Regurgitation

Med Page Today

(MedPage Today) -- LONDON -- Tricuspid transcatheter edge-to-edge repair (T-TEER) improved how well patients functioned and felt without major cardiovascular events in the first academic randomized trial to affirm the pivotal trial findings.

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RESHAPE-HF2: Impact of M-TEER on Patients With FMR and Symptomatic HF

American College of Cardiology

In patients with symptomatic heart failure (HF) and moderate to severe functional mitral regurgitation (FMR), mitral transcatheter edge-to-edge repair (M-TEER) reduced cardiovascular death and heart failure (HF)-related hospitalizations with improved health status, based on results of the RESHAPE-HF2 trial presented at ESC Congress 2024 in London and simultaneously published in the New England Journal of Medicine.

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ID: 4116520 Integration of Cloud-enabled AI Analyses of Ventricular Tachycardia Isthmuses with Electroanatomic Mapping Systems

HeartRhythm

Invasive mapping of ventricular tachycardia (VT) can be time consuming and difficult to perform. A novel cloud- enabled, AI-based analysis was developed to colocalize electrical and scar VT substrate by combining computational source mapping of 12-lead ECG and wall thickness analysis using machine learning models to segment the left ventricular myocardium from CTs.

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Third Nordic Aortic Valve Intervention

American College of Cardiology

The goal of the NOTION-3 trial was to evaluate percutaneous coronary intervention (PCI) compared with conservative therapy among patients with obstructive coronary artery disease undergoing transcatheter aortic valve implantation (TAVI).

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ID: 4120594 Detection Of Structural Heart Disease Using The 12-Lead ECG: Comparative Performance Of Cardiologists And The Echonext Ai Model With Analysis Of Optimal Strategies Of Human-Computer Interaction

HeartRhythm

Early detection of structural heart disease (SHD) is paramount in cardiology. AI-based analysis of 12-lead ECGs has shown promise for detecting SHD, but further study of accuracy compared to cardiologists is needed.

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ASSURE DES: Continuing vs. Interrupting Aspirin Therapy Before Noncardiac Surgery in Patients With DES

American College of Cardiology

Continuing aspirin monotherapy for patients with previous drug-eluting stents (DES) who are undergoing low-to-intermediate risk noncardiac surgery did not significantly reduce ischemic events compared with temporarily holding all antiplatelet therapy before the surgery, according to findings from the ASSURE DES trial presented at ESC Congress 2024 in London and simultaneously published in JACC.

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ID: 4120879 Deep Learning Approaches For Prediction of Ventricular Arrhythmias Using Upstream Electrograms From Intracardiac Devices

HeartRhythm

Implantable cardioverter defibrillators (ICD) are effective at terminating ventricular arrhythmias (VA), though have significant drawbacks. The opportunity to predict the onset of arrhythmia holds promise for insight into VA initiation and the opportunity to deliver therapy prior to an event. We hypothesize that novel features of intracardiac electrogram (EGM) prior to an event could be identified by deep learning to predict the onset of VA.

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SWEDEGRAFT: 'No-Touch' vs. Conventional Vein Harvesting For CABG

American College of Cardiology

Findings from the SWEDEGRAFT trial presented at ESC Congress 2024 in London showed no benefits to using a "no-touch" technique to harvest the saphenous vein graft during CABG compared with the conventional technique that involves stripping the vein of surrounding tissue prior to grafting.

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ID: 4121926 Validation of a Deep Learning Ventricular Tachycardia Substrate Model

HeartRhythm

Myocardial wall thickness analysis of the cardiac CT is an emerging technique to identify arrhythmogenic tissue underlying ventricular tachycardia (VT). AI algorithms can be used to segment cardiac structures, but it is unclear how they perform in a clinical setting.

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Periprocedural Continuation Versus Interruption of Oral Anticoagulant Drugs During Transcatheter Aortic Valve Implantation

American College of Cardiology

The goal of the POPular PAUSE TAVI trial was to determine whether, in patients undergoing transcatheter aortic valve implantation (TAVI) who also take oral anticoagulation for a comorbid condition, continuation of anticoagulant therapy is noninferior to periprocedural interruption of anticoagulation with respect to major adverse cardiovascular and bleeding events.

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ID: 4118529 Initial Experience with a Novel Augmented Reality System for use During Catheter Ablation

HeartRhythm

The CommandEP system (Sentiar, Inc) is a FDA-cleared novel augmented reality system that can display a real-time, 3-dimensional (3D) electroanatomic images along with catheter locations. The system provides the user with a hands-free interface and multiple ways to interact with the 3D model. A clipping plane allows for a customizable 3D endocardial view of the cardiac chamber of interest.

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Randomized Investigation of the MitraClip Device in Heart Failure: Second Trial in Patients With Clinically Significant Functional Mitral Regurgitation

American College of Cardiology

The goal of the RESHAPE-HF2 trial was to assess the safety and efficacy of mitral transcatheter edge-to-edge repair (M-TEER) using MitraClip among symptomatic heart failure (HF) patients with secondary mitral regurgitation (MR).

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ID: 4121570 Atrial Extent Comparison of Spatiotemporal Electrogram Dispersion and Low-Voltage in Persistent Atrial Fibrillation Patients

HeartRhythm

Multiple reports suggest that atrial regions exhibiting either spatio-temporal dispersion (STD) or low voltage (LV) during persistent atrial fibrillation (AF) may represent driver regions.

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Transcatheter Versus Surgical Mitral Valve Repair in Patients With Heart Failure and Secondary Mitral Regurgitation

American College of Cardiology

The goal of the MATTERHORN trial was to evaluate mitral transcatheter edge-to-edge repair (M-TEER) compared with surgical mitral valve repair among patients with secondary mitral regurgitation (MR).

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ID: 4120624 Building Patient Archetypes to Analyze Willingness to Change using New Technologies: Generative Artificial Intelligence with the Goal of More Optimally Influencing Change in Patient Behaviors with Atrial Fibrillation

HeartRhythm

Influence on patient behavior— namely changing ingrained, maladaptive behaviors for those with Atrial Fibrillation (AF)— lends itself to varied methodology due to evidence-based research. Patient behavioral archetypes describe patterns exhibited by individuals in healthcare grounded on factors including socioeconomic status and attitudes surrounding change.

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Tri.fr Shows Benefits of T-TEER in Secondary TR

American College of Cardiology

Tricuspid transcatheter edge-to-edge repair (T-TEER) significantly reduced the severity of secondary tricuspid regurgitation (TR) and improved quality of life after one year, based on findings from the Tri.fr trial presented at ESC Congress 2024 in London.

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ID: 4121334 Perceptions Regarding CIED Patient Management Performance Reported In An International Survey

HeartRhythm

Management of patients with cardiac implantable electronic devices (CIEDs) is challenging with many organizational aspects to consider, including for remote monitoring (RM) which is now standard of care. The 2023 HRS/EHRA/APHRS/LAHRS consensus on management of remote device clinics provided guidance, but state of current practices and performance remains unexplored.

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Women’s Health Study: hs-CRP, LDL-C, Lp(a), and 30-Year CV Outcomes

American College of Cardiology

How do high-sensitivity C-reactive protein (hs-CRP), low-density lipoprotein cholesterol (LDL-C), and lipoprotein(a) [Lp(a)] levels predict cardiovascular (CV) risk over decades of time in women?

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ID: 4121467 Two-Lead ECGs Providing Enough Information for AI Models: Insights into Age Prediction

HeartRhythm

Biological age, which reflects the underlying senescence of cells, differs from chronological age. We hypothesize that an AI model can predict the heart's biological age by analyzing electrophysiological changes, particularly in the presence of arrhythmias, using fewer than 12 leads. This predicted age can then be juxtaposed against the patient’s chronological age to understand early cardiac aging.

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Excess Morbidity and Mortality Associated With Flu in HF

American College of Cardiology

What is the excess burden of morbidity and mortality, as determined by annual excess number of deaths and hospitalizations associated with influenza infection in patients with heart failure (HF) in Denmark?

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ID: 4117031 Reducing Ambulatory ECG Review Burden Through the Integration of Automated Signal Quality Indicators

HeartRhythm

Ambulatory ECGs are frequently corrupted with noise, prolonging review times as clinicians must differentiate between actionable and poor-quality data. Despite their potential to reduce review burden, signal quality assessment algorithms are underutilized in clinical workflows.

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A Clinical Trial on No-Touch Vein Graft in Coronary Surgery

American College of Cardiology

The goal of the SWEDEGRAFT trial was to determine whether harvesting a saphenous vein graft (SVG) for use in coronary artery bypass grafting (CABG) using a no-touch (NT) technique is associated with improved graft patency compared with conventional open skeletonized (COS) SVG harvesting.

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ID: 4121951 Adoption Of Remote Monitoring-Supporting Technologies And Their Association With In-Person Visit Frequency

HeartRhythm

The 2023 HRS/EHRA/APHRS/LAHRS consensus statement on remote monitoring (RM) supports limiting scheduled in-person visits to every 24 months for patients with pacemakers and ICDs if consistent and continuous RM can be achieved. While this guidance represents an opportunity to streamline efficiency in device clinics, achieving consistent connectivity in RM remains a barrier.

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Multicentric Randomized Evaluation of Tricuspid Valve Percutaneous Repair System (Clip for the Tricuspid Valve) in the Treatment of Severe Secondary Tricuspid Disorders

American College of Cardiology

The goal of the TRI.Fr trial was to assess the efficacy and safety of tricuspid transcatheter edge-to-edge repair (T-TEER) + guideline-directed medical therapy (GDMT) compared with GDMT alone among patients with symptomatic ≥ severe tricuspid regurgitation (TR).

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ID: 4121476 Digital Pipeline for Extraction and Processing of Implantable Cardioverter Defibrillator Electrograms for Machine Learning Analysis

HeartRhythm

Machine learning (ML) based technologies have transformed the landscape of digital health by providing improvement in diagnosis, novel insight into disease diagnosis and treatment selection. However, supervised machine learning training requires access to high-quality labeled datasets. We have developed a digital pipeline to extract, process, and annotate intracardiac electrograms (EGM) from implantable cardioverter defibrillators (ICD).

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Atrial Fibrillation and Stable Coronary Artery Disease

The New England Journal of Medicine

Patients with atrial fibrillation are at high risk for stroke, and international guidelines recommend oral anticoagulant therapy. In patients with stable vascular disease without atrial fibrillation, antiplatelet therapy is recommended. However, atrial fibrillation commonly coexists with vascular diseases, such as coronary artery disease. When patients with both conditions present with.

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ID: 4115909 Clinical and Administrative Burden of High-Intensity Remote Monitoring

HeartRhythm

Remote monitoring (RM) of cardiac implantable electronic devices (CIED) is considered standard of care; however, the resulting data stream necessitates a robust organizational model capable of rapidly identifying clinically relevant events that require immediate attention.

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New Science From NOTION-3, POPular PAUSE TAVI, RHEIA Add to Growing Evidence Surrounding TAVI

American College of Cardiology

The benefit of PCI in patients with stable coronary artery disease and severe aortic stenosis who are undergoing transcatheter aortic valve implantation (TAVI) was the focus of the NOTION-3 trial presented at ESC Congress 2024 in London. Two other trials – POPular PAUSE TAVI and RHEIA – also addressed aspects of TAVI, including continuation vs. disruption of anticoagulants during the procedure, as well a comparison with surgical aortic valve implantation (SAVI) in women.