Thu.Jan 25, 2024

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Analysis finds biomarkers that improve prediction accuracy of cardiovascular disease risk in people with type 2 diabetes

Medical Xpress - Cardiology

An international academic consortium has identified 13 biomarkers that significantly improve the ability to accurately predict cardiovascular disease risk in people with type 2 diabetes. The analysis, conducted by 23 experts from 11 countries, was led by The Johns Hopkins University in the United States, the Chinese University of Hong Kong in Hong Kong, and Lund University in Sweden.

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National retailers support heart and stroke health through annual Life is Why™ campaign

American Heart News - Heart News

DALLAS, Jan. 25, 2024 — This February, during American Heart Month and the American Heart Association’s Centennial year, the Association is devoted to a world of healthier lives for all by teaming up with retailers and brands around the country for Life.

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Central Obesity Potentially Linked to Hyperuricemia, Gout

HCPLive

After adjusting for confounders, data revealed higher levels of obesity indices were linked with a gradual and dose-dependent increase in urate levels.

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Graded exercise therapy should not be recommended for patients with post-exertional malaise

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 26 January 2024; doi:10.

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Iron, Vitamin D Status Predict Maternal Mental Health During Pregnancy

HCPLive

Iron and vitamin D status during the second trimester predicted maternal depression symptoms during the third trimester.

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Potassium-enriched salt is the missing ingredient in hypertension guidelines, say experts

Medical Xpress - Cardiology

A call to include recommendations on low-sodium potassium-enriched salt in hypertension treatment guidelines has been made by an international group of experts in the journal Hypertension.

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Agepha Pharma and Caristo Diagnostics Team Up to Fight Coronary Inflammation

DAIC

Getty Images milla1cf Thu, 01/25/2024 - 20:44 January 25, 2024 — Agepha Pharma , a leading multinational pharmaceutical company with the first FDA-approved anti-inflammatory cardiovascular treatment ( LODOCO – colchicine, 0.5 mg tablets), together with Caristo Diagnostics , a leading cardiac disease diagnostics company with the novel CaRi-Heart technology to visualize and quantify coronary inflammation, announced today their collaboration to improve awareness and clinical education about the

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ACC Cardiovascular Summit Equips CV Team to Transform Care, Address Emerging Trends

DAIC

Getty Images milla1cf Thu, 01/25/2024 - 20:37 January 25, 2024 — The American College of Cardiology ’s Cardiovascular Summit (CV Summit) will take place on February 1-3 in Washington, DC. Bringing together all members of the CV team, the educational event highlights best practices for creating a more efficient, effective and equitable health care system.

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Clinician Quiz: Role of Adjunctive Tests in Diagnosing Iron Deficiency Anemia

HCPLive

Test your knowledge with this clinician quiz! In this quiz, we test your knowledge of adjunctive tests in the diagnosis of iron deficiency anemia based on recommendations from the 2020 American Gastroenterological Association's clinical practice guidelines on gastrointestinal evaluation of iron deficiency anemia.

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Immune checkpoints in cardiac physiology and pathology: therapeutic targets for heart failure

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 26 January 2024; doi:10.1038/s41569-023-00986-9 In this Review, Varga and colleagues provide an overview of the evidence on immune checkpoint inhibitor-induced heart failure and cardiac dysfunction that is unrelated to myocarditis, and discuss how pharmacological targeting of immune checkpoints might be a potential strategy to treat heart failure.

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Selenium Deficiency Linked to Anemia in Heart Failure Patients

HCPLive

Lower levels of selenoprotein P were associated with reduced hemoglobin, greater transferrin receptor 1, and an increased prevalence of anemia in a cohort of hospitalized heart failure patients.

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Acute chest pain in a patient with LVH and known coronary disease. What does the ECG show?

Dr. Smith's ECG Blog

A 40-something with severe diabetes on dialysis and with known coronary disease presented with acute crushing chest pain. Here is his ED ECG: What do you think? There is a flat and downsloping ST segment in V2 and V3. This could be due to posterior OMI. Is there an old ECG for comparison? Here is the most recent previous ECG: Indeed, there was some normal ST elevation in V2 and V3 , discordant to a relatively deep S-wave which could be due to some LVH.

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Reply to ‘Graded exercise therapy should not be recommended for patients with post-exertional malaise’

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 26 January 2024; doi:10.

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Iron Deficiency May Elevate the Risk of Celiac Disease Development

HCPLive

A Mendelian randomization study suggests a link between genetically lower iron levels and the risk of subsequently developing celiac disease.

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Local V-A Index For the Differential Diagnosis of Supraventricular Tachycardia

HeartRhythm

Differentiating between atypical atrioventricular node re-entrant tachycardia (aAVNRT) and orthodromic reciprocating tachycardia (ORT) utilizing a septal accessory pathway is a complex challenge.

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Venoarterial extracorporeal membrane oxygenation for vasoplegic shock after treprostinil refill of an implanted intravenous pump: a case report

Frontiers in Cardiovascular Medicine

Introduction Venoarterial extracorporeal membrane oxygenation (ECMO) is a rescue therapy that can stabilize patients with hemodynamic compromise. Indications continue to evolve, including drug overdose. However, the indication merely for vasoplegic shock following drug overdose is controversial. Case summary We report a case of a 57-year-old male with high-risk idiopathic pulmonary arterial hypertension treated with upfront triple combination therapy (sildenafil, bosentan, and intravenous trepro

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Dupilumab's Role in Managing Pediatric EoE, with Evan Dellon, MD, MPH

HCPLive

We sat down with Evan Dellon, MD, MPH, to discuss the use of dupilumab in pediatric EoE patients, with the agent gaining FDA approval as the first and only indication for this patient population on January 25, 2024.

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Revisiting percutaneous balloon mitral valvotomy technique and safety in various population: an evidence-based case report and literature review

Frontiers in Cardiovascular Medicine

Percutaneous balloon mitral valvotomy (PBMV) is a good and preferred therapy choice over surgical commissurotomy for patients with rheumatic mitral stenosis (MS). However, interventional cardiologists must recognize that treating patients with rheumatic MS poses unique challenges for each patient, especially in special populations such as pregnant patients or patients with arrhythmias like atrial fibrillation (AF), which can complicate procedures.

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72-Week Phase 2B ORIGIN Data Highlight Potential Benefit of Atacicept in IgA Nephropathy

HCPLive

The 72-week open-label extension of the phase 2b ORIGIN trial reveals atacicept's potential as a disease-modifying treatment for IgA nephropathy, showing eGFR stabilization and improvements in key indicators

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Left ventricular assist device and transcatheter edge-to-edge mitral valve repair in advanced heart failure: allies or enemies?

Frontiers in Cardiovascular Medicine

The implantation of left ventricular assist devices (LVADs) has been increasing, with good long-term results, in parallel with a growing population with advanced heart failure (HF). However, in some European countries, LVADs are still underused, with one of the main issues being the patient's late referral. On the contrary, the use of transcatheter edge-to-edge mitral valve repair (TEER) has exponentially increased over the past decade, expanding its potential use even in patients on the heart t

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Liquidia Corporation: FDA Still Reviewing NDA to Add PH-ILD Indication for Treprostinil Inhalation Powder

HCPLive

On January 25, 2024, the day following the proposed PDUFA goal date, Liquidia Corporation announced the FDA was still reviewing the NDA for pulmonary hypertension with interstitial lung disease for treprostinil inhalation powder (Yutrepia).

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The role of structured inpatient lipid protocols in optimizing non-statin lipid lowering therapy: a review and single-center experience

Frontiers in Cardiovascular Medicine

Dyslipidemia is a leading contributor to atherosclerotic cardiovascular disease (ASCVD). There has been a significant improvement in the treatment of dyslipidemia in the past 10 years with the development of new pharmacotherapies. The intent of this review is help enhance clinicians understanding of non-statin lipid lowering therapies in accordance with the 2022 American College of Cardiology Expert Consensus Clinical Decision Pathway on the Role of Non-statin Therapies for LDL-Cholesterol Lower

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Integration of implantable device therapy in patients with heart failure. A clinical consensus statement from the Heart Failure Association (HFA) and European Heart Rhythm Association (EHRA) of the European Society of Cardiology (ESC)

European Journal of Heart Failure

Implantable devices form an integral part of the management of patients with heart failure (HF) and provide adjunctive therapies in addition to cornerstone drug treatment. Although the number of these devices is growing, only few are supported by robust evidence. Current devices aim to improve haemodynamics, improve reverse remodelling, or provide electrical therapy.

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The role of stress echocardiography in identifying cardiotoxicity: an in-depth exploration

Frontiers in Cardiovascular Medicine

Cancer treatment might cause heart failure and deteriorate the patients’ quality of life. Despite the wide use of conventional echocardiography, it often fails to detect cardiotoxicity until advanced cardiac dysfunction at potentially irreversible stages. Advanced techniques, such as three-dimensional imaging and strain analysis in stress echocardiography, have shown promise in identifying cardiotoxicity at subclinical stages, even when traditional measures remain within normal ranges.

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Lower Maternal Hemoglobin Concentration Linked to Faster Fetal Growth, Larger Birth Weight

HCPLive

In this analysis, it is suggested that fetal growth trajectories require levels of oxygen promoted by the intake of maternal iron and hemoglobin.

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Perioperative myocardial injury and infarction after noncardiac surgery: a review of pathophysiology, diagnosis, and management

Frontiers in Cardiovascular Medicine

Perioperative myocardial injury is a relatively common complication after noncardiac surgery associated with significant morbidity and mortality. It is frequently driven by physiologic factors such as hypotension, tachycardia, and anemia. Diagnosis of perioperative myocardial injury after noncardiac surgery is based on elevated cardiac troponin levels, greater than the 99th percentile of the assay's upper reference limit within 30 days of surgery.

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Esophagus Deviation During AF Ablation: EASY AF Trial

American College of Cardiology

What is the incidence of esophageal injury in patients undergoing ablation of atrial fibrillation (AF) with and without an esophageal deviating device?

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Current barriers and recommendations on the diagnosis of transthyretin amyloid cardiomyopathy: a Delphi study

Frontiers in Cardiovascular Medicine

Objectives This study has been conducted to investigate the non-invasive diagnostic journey of patients with a transthyretin amyloid cardiomyopathy (aTTR-CM) in Turkey, identify the challenges and uncertainties encountered on the path to diagnosis from the perspectives of expert physicians, and develop recommendations that can be applied in such cases.

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Navigating the Future: How Medical Education is Evolving with Technology

ADN Center of Excellence

In the fast-paced world of medicine, staying ahead of the curve is not just a goal – it's a necessity. In today's blog, we'll explore the transformative impact of technology on medical education and why continuous learning is crucial for every doctor's success. The Technological Renaissance in Medicine: The realm of medicine is experiencing a renaissance, with cutting-edge technologies reshaping the way healthcare is delivered.

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Anemia Not Associated with Early Neurological Deficit After Ischemic Stroke

HCPLive

Anemia showed an association with disability and suboptimal functional outcomes, but no association with neurological deficit or mortality, at 90 days post-stroke.

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Focal Contrast Enhancement in Acute Type B Intramural Hematoma

American College of Cardiology

What are the prognostic implications of focal contrast enhancement (FCE) on computed tomographic angiography (CTA) in acute type B intramural hematoma (IMH)?

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Hemoglobin in Early Pregnancy Predicts Anemia During Third Trimester

HCPLive

In a new study, 7.9% of pregnant women without anemia during the first trimester developed anemia during the third trimester.

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Major research papers from NEJM in 2023

Dr. S. Venkatesan MD

Here is a pleasant surprise, a collectors issue of NEJM year book 2023, is made available free (even for a non subscribers in its website).It is fascinating to know how fast the Internal medicine has grown. For the busy cardiologists, this will a be refreshing reminder, that there are other important organs and specialties do exist in medicine , with equal breakthroughs and Innovations.

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Ferrokinetics Impacts Physical Therapy Responses in HFpEF

HCPLive

Compared to the usual care, patients with HFpEF in the active arms demonstrated less improvement in peakVO2 when they had iron deficiency and lower values of ferritin and transferrin saturation, according to a new study.

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What cardiology programs are eyeing in 2024

Becker's Hospital Review - Cardiology

Discover the top priorities for cardiology programs in 2024, including expanding services and improving operations, according to a recent Becker's poll.

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Long-Term, Sustained Remission of Pemphigus Observed in Patients Treated with Rituximab

HCPLive

These data were the results of the secondary analysis of the Ritux 3 study, as the treatment’s short-term efficacy and safety had been confirmed previously.

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The “fender” technique for redo-TAVR in a degenerated supra-annular valve with high-risk of coronary obstruction

The American Journal of Cardiology

Publication date: Available online 24 January 2024 Source: The American Journal of Cardiology Author(s): Giuseppe Tarantini, Tommaso Fabris, Subhash Banerjee, Luca Nai Fovino

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