Tue.May 14, 2024

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New Treatment in Pipeline for Patients with Hypertrophic Cardiomyopathy

DAIC

Getty Images milla1cf Tue, 05/14/2024 - 13:00 May 14, 2024 — One of the most common genetic heart diseases worldwide, hypertrophic cardiomyopathy (HCM) causes the walls of the left ventricle to become thick and stiff. In about 70 percent of cases, patients with HCM experience obstruction to blood flow, which increases pressures in the heart and can lead to chest pain, shortness of breath and reduced exercise capacity.

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Therapeutic strategies targeting mechanisms of macrophages in diabetic heart disease

Cardiovascular Diabetology

Diabetic heart disease (DHD) is a serious complication in patients with diabetes. Despite numerous studies on the pathogenic mechanisms and therapeutic targets of DHD, effective means of prevention and treatme.

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GE HealthCare and Medis Medical Imaging Announce Collaboration Focused on Non-Invasive Coronary Assessments to Help Advance Precision Care in Treatment of Coronary Artery Disease

DAIC

milla1cf Tue, 05/14/2024 - 12:53 May 14, 2024 — GE HealthCare , a leading global medical technology, pharmaceutical diagnostics and digital solutions innovator, and Medis Medical Imaging , a leading cardiac imaging software company, announced their collaboration aimed at helping advance precision care in the diagnosis and treatment of coronary artery disease ( CAD ).

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Hidradenitits Suppurativa Linked to Increased Risk of Cardiovascular Diseases

HCPLive

Patients with hidradenitis suppurativa had the greatest risk of developing various CVS, with heart failure being the most common one.

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SHINE Trial Sheds Light on Deadly Stroke Complication

DAIC

UVA Health's Karen Johnston, MD, the SHINE trial leader, was pleased to see the new insights into best practices for stroke care. “These data from the SHINE trial continue to inform the national stroke community about potential approaches to treating hyperglycemic stroke patients to assure better outcomes,” she said. Dan Addison | UVA Communications milla1cf Tue, 05/14/2024 - 12:57 May 14, 2024 — An ambitious, nationwide clinical trial led by UVA Health ’s Karen Johnston , MD, has provided docto

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Artificial intelligence tool to improve heart failure care

Science Daily - Heart Disease

The powerful new AI tool can predict heart failure outcomes in specific patients, helping doctors improve care.

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Tildrakizumab Effective for Patients with Psoriasis Unresponsive to Anti-IL17

HCPLive

A study showed tildrakizumab treated difficult-to-treat psoriasis areas in patients who failed anti-IL17 treatment.

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Febuxostat Use Is Linked to Reduced Risk of Kidney Events for Patients with Gout

HCPLive

A new study found febuxostat can effectively delay the progression of kidney function deterioration in patients with gout.

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Have a heart – caregivers need care, too

American Heart News - Heart News

DALLAS, May 14, 2024 — Living with a chronic medical condition after surviving a heart attack or stroke may come with additional health and personal care needs. Often survivors must rely on a family member or close friend to help. However, there’s a.

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UPMC Harrisburg 1st to use new TAVR system

Becker's Hospital Review - Cardiology

UPMC Harrisburg pioneers new transcatheter aortic valve replacement system, providing improved lifetime management for patients with aortic valve stenosis.

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Early diagnosis & treatment of peripheral artery disease essential to improve outcomes, reduce amputation risk

American Heart News - Heart News

Guideline Highlights: The new joint guideline from the American Heart Association and the American College of Cardiology provides recommendations to guide clinicians in the treatment of patients with lower extremity peripheral artery disease (PAD) and.

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Efferocytosis in atherosclerosis

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 15 May 2024; doi:10.1038/s41569-024-01037-7 In this Review, Adkar and Leeper describe the mechanisms of programmed cell death and efferocytosis, discuss how efferocytosis becomes impaired in atherosclerosis and other cardiometabolic diseases, and suggest potential strategies to target these pathways for the treatment of atherosclerotic cardiovascular disease.

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FDA Issues CRL for HEPLISAV-B in Adults on Hemodialysis

HCPLive

The CRL for the sBLA cites a lack of sufficient data to support the full evaluation of the effectiveness and safety of a 4-dose regimen in this patient population.

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Osteosarcopenia and Mortality in Older Adults Undergoing Transcatheter Aortic Valve Replacement

JAMA Cardiology

This cohort study examines whether there is an association between osteosarcopenia and adverse outcomes, such as increased risk of mortality, in older adults following transcatheter aortic valve replacement (TAVR).

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Anti-IL-17A Biologics Superior in Treating Patients with Psoriasis, Concomitant Nail Psoriasis

HCPLive

These results may support clinical decision-making for psoriasis and nail psoriasis management and may allow future real-world studies to further understand the nature of this skin disease.

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Antihypertensive Medication Initiation and Fracture Risk in Nursing Home Residents

NEJM Journal Watch - Cardiology

Within 30 days of antihypertensive medication initiation, the rate of fracture was more than twice as high in initiators than in noninitiators.

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El diagnóstico y tratamiento tempranos de la enfermedad arterial periférica son esenciales para mejorar los resultados y reducir el riesgo de amputación

American Heart News - Heart News

Aspectos destacados de la guía: La nueva guía conjunta de la American Heart Association (la Asociación Americana del Corazón) y el American College of Cardiology ofrece recomendaciones para guiar a los médicos en el tratamiento de pacientes con.

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HCV Tops HBV as Leading Cause of Cirrhosis, Global Burden Projected to Increase

HCPLive

Study results highlight the role of HCV and alcohol use in the growing global disease burden posed by cirrhosis, which is projected to increase over the next 20 years.

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Tenga corazón: los cuidadores también necesitan de cuidados

American Heart News - Heart News

DALLAS, 14 de mayo de 2024 — Vivir con una afección médica crónica luego de sobrevivir a un ataque cardíaco o derrame cerebral puede acarrear muchas otras necesidades de cuidado personal y de salud, y con frecuencia los supervivientes deben recurrir a la.

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Anti-VEGF Improves Outcomes in Proliferative Sickle Cell Retinopathy

HCPLive

Within one month of treatment, anti-VEGF therapy improves anatomic and visual outcomes among eyes with stage 3 and 4 proliferative sickle cell retinopathy.

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Florida hospital establishes electrophysiology program after $10M donation

Becker's Hospital Review - Cardiology

Jupiter (Fla.) Medical Center established the Elliot Family Center for Cardiac Electrophysiology thanks to a $10 million donation, CBS12 reported May 13.

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Elevated Lp(a) Can Predict Premature ASCVD Risk

HCPLive

A systematic review and meta-analysis of 51 studies suggests elevated Lp(a) can help predict risk of premature atherosclerotic cardiovascular disease.

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Association between the triglyceride-glucose index and in-hospital major adverse cardiovascular events in patients with acute coronary syndrome: results from the Improving Care for Cardiovascular Disease in China (CCC)-Acute Coronary Syndrome project

Cardiovascular Diabetology

Although the TyG index is a reliable predictor of insulin resistance (IR) and cardiovascular disease, its effectiveness in predicting major adverse cardiac events in hospitalized acute coronary syndrome (ACS).

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FDA Extends Review for TransCon PTH in Hypoparathyroidism to August 2024

HCPLive

The FDA has extended the review period for palopegteriparatide in treatment of hyperparathyroidism in adult patients by 3 months to August 14, 2024.

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Non-neuronal cell-derived acetylcholine, a key modulator of the vascular endothelial function in health and disease

Frontiers in Cardiovascular Medicine

Vascular endothelial cells play an important role in regulating peripheral circulation by modulating arterial tone in the microvasculature. Elevated intracellular Ca2+ levels are required in endothelial cells to induce smooth muscle relaxation via endothelium-dependent mechanisms such as nitric oxide production, prostacyclin, and endothelial cell hyperpolarization.

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Andrew Alexis, MD, MPH: Findings on Trifarotene for Acne Sequelae in Skin of Color

HCPLive

This interview featured a discussion of Alexis’s team’s findings on the importance of treating patients with skin of color and acne-induced post-inflammatory hyperpigmentation.

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Interacting and joint effects of triglyceride-glucose index and hypertension on stroke risk in middle-aged and older Chinese adults: a population-based prospective cohort study

Frontiers in Cardiovascular Medicine

BackgroundTriglyceride-glucose (TyG) index and hypertension were well-established risk factors for stroke. And TyG index was associated with hypertension. However, no prior study has investigated the interactive effects of the TyG index and hypertension on stroke. This study examined whether hypertension mediates associations of TyG index with incident stroke and the extent of interaction or joint relations of TyG index and hypertension with stroke in middle-aged and older Chinese adults.Methods

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Transmasculine Hormone Therapy Could Carry Greater Cardiovascular Risk than Transfeminizing Therapy

HCPLive

Transmasculine patients undergoing GAHT may experience adverse lipid profile changes, unlike transfeminine counterparts, which investigators say is cause for closer monitoring.

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Stacking Invasive Tests for Chronic Coronary Syndrome: Good Results, Less Hassle

Med Page Today

(MedPage Today) -- PARIS -- Using a structured series of tests together, operators greatly improved the diagnostic accuracy of invasive coronary angiography (ICA) for people with chronic coronary syndrome (CCS), the prospective AID-ANGIO study.

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Improved Clinical Outcomes with Intravascular Imaging-Guided PCI: Impact of Standardized Optimization Protocols

Cardiology Update

Intravascular imaging (IVI), such as intravascular ultrasound (IVUS) and optical coherence tomography (OCT), play a crucial role in assessing lesion characteristics and optimizing stent placement during percutaneous coronary intervention (PCI). Studies have consistently shown that procedural optimization guided by IVUS leads to better clinical outcomes compared to angiography-guided PCI alone.

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Joined Cath Procedures Turn the Table on SAVR-CABG

Med Page Today

(MedPage Today) -- PARIS -- For patients with severe aortic stenosis (AS) and concomitant obstructive coronary artery disease (CAD), a percutaneous combined intervention worked surprisingly well relative to surgery, the TCW randomized trial found.

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1 in 12 Lupus Neprhitis Patients Experience Cardiovascular Events

HCPLive

Data presented at NKF Spring Clinical Meeting suggest events including myocardial infarction and stroke are more prevalent among patients with lupus in North America.

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The potential of artificial intelligence to revolutionize health care delivery, research, and education in cardiac electrophysiology

HeartRhythm

The field of electrophysiology (EP) has benefited from numerous seminal innovations and discoveries that have enabled clinicians to deliver therapies and interventions that save lives and promote quality of life. The rapid pace of innovation in EP may be hindered by several challenges including the aging population with increasing morbidity, the availability of multiple costly therapies that, in many instances, confer minor incremental benefit, the limitations of healthcare reimbursement, the la

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Study Details Cirrhosis-Related IgA Nephropathy Clinical Presentation, Mortality

HCPLive

The multicenter study examined the presentation and outcomes of patients with cirrhosis-related IgAN and compared clinicopathological profiles with primary IgAN.

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“Honey Pot”-Like Lesion Formation: Impact of Catheter Contact Angle on Lesion Formation by Novel Diamond-embedded Temperature-controlled Ablation Catheter in a Porcine Experimental Model

HeartRhythm

Novel diamond-embedded catheter enables precise temperature-controlled ablation. However, the effects of contact angle on lesion formation of this catheter are poorly understood.

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Sparsentan Limits eGFR Reduction Regardless of IgAN Patient Proteinuria Levels

HCPLive

Further analyses into the 2-year PROTECT trial further support the longevity of benefit with sparsentan in patients with IgAN.

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Eosinophilic Enigma: Deciphering Intriguing Symptomatology and Treatment Challenges in Atypical Lumbosacral Radiculopathy

BMH Medical Journal

Eosinophilic meningitis is a rare but fascinating neurological condition characterized by eosinophilic infiltration of the meninges. We present a compelling case of a woman with a history of dust allergy who presented with myalgia, low backache, and persistent headache, ultimately diagnosed with eosinophilic meningitis. Despite initial challenges in diagnosis and treatment, a multidisciplinary approach involving, neurology, and infectious disease specialists led to successful management and reso

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