Fri.Feb 14, 2025

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You Are Being Lied To About Cholesterol & Heart Disease.

Dr. Paddy Barrett

“Cholesterol does not cause heart disease.“ “Statins do not prevent heart attacks.” These are two statements you will hear repeatedly on social media. Usually made by those who really don’t understand what they are saying but increasingly by doctors who really should know better. In the middle of this hurricane of noise are people who just want to know what to do so they don’t have a heart attack at a young age.

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Physiology Friday #257: Does Training Frequency Matter for Fitness Gains?

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. If you’re looking for a new (mess-free) way to fuel your workouts, you should check out Intra Chew—it’s a workout gummy bear made by one of my friends that has carbohydrates and electrolytes. I’ve been using them during all of my long bike rides and before runs. At the very least, it’s something you should try once, and you can get 20% off using the code BRADY20 on the site.

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Research shows sotagliflozin is the first medication of its kind to significantly reduce both heart attacks and strokes

Medical Xpress - Cardiology

Sotagliflozin, a drug recently approved by the Food and Drug Administration to treat type 2 diabetes and kidney disease with additional cardiovascular risk factors, can significantly reduce heart attack and stroke among these patients, according to results from an international clinical trial led by a Mount Sinai researcher.

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Data Demonstrates Favorable Impact of AVIM Therapy on Diastolic Dysfunction

DAIC

tim.hodson Fri, 02/14/2025 - 14:32 Feb. 12, 2025 Orchestra BioMed Holdings, a biomedical company accelerating high-impact technologies to patients through risk-reward sharing partnerships, recently made anoral presentation of data on the benefits of atrioventricular interval modulation (AVIM) therapy on patients with diastolic dysfunction at the Technology and Heart Failure Therapeutics (THT) 2025 Conference in Boston, Mass.

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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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A diabetes, heart failure, and kidney disease medication is the first of its kind to significantly reduce both heart attacks and strokes

Science Daily - Heart Disease

New research shows sotagliflozin is the only drug in its class to demonstrate these results.

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New Dodero Center at UH will Revolutionize Limb Salvage

DAIC

Lorraine and Bill Dodero tim.hodson Fri, 02/14/2025 - 15:33 Feb. 10, 2025 A generous gift of $5 million from Lorraine and Bill Dodero will establish the Lorraine and Bill Dodero Limb Preservation Center at University Hospitals Harrington Heart & Vascular Institute in Cleveland, Ohio. Led by Mehdi Shishehbor DO, MPH, PhD, interventional cardiologist and a pioneer in the field of limb preservation, the Dodero Center will revolutionize care for patients at risk of losing a leg due to peripheral ar

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FDA OKs First Rapid-Acting Insulin Biosimilar for Diabetes

Med Page Today

(MedPage Today) -- The FDA approved insulin-aspart-szjj (Merilog) as the first rapid-acting insulin biosimilar product to treat adults and children with diabetes, the agency announced Friday. Like its reference counterpart, insulin aspart (Novolog.

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Patient Enrollment Low in Cardiovascular Clinical Trials in the US

HCPLive

Cardiovascular clinical outcome trials require a large number of sites to meet enrollment targets, but patient-per-site ratios were often low.

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SGLT1/2 Inhibitor Cut Stroke, Heart Attack Risk in Diabetic Kidney Disease

Med Page Today

(MedPage Today) -- The dual SGLT1/2 inhibitor sotagliflozin (Inpefa) reduced the risk for myocardial infarction (MI) and stroke in high-risk patients with type 2 diabetes (T2D), chronic kidney disease (CKD), and cardiovascular risk factors, a prespecified.

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Anticoagulation in Atrial Fibrillation With Valvular Heart Disease

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.

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Predicting major adverse cardiac events in diabetes and chronic kidney disease: a machine learning study from the Silesia Diabetes-Heart Project

Cardiovascular Diabetology

People living with diabetes mellitus (DM) and chronic kidney disease (CKD) are at significantly high risk of cardiovascular events (CVEs), however the predictive performance of traditional risk prediction meth.

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The Death of an Unlikable Man

The New England Journal of Medicine

Mr. M. was notorious, and hed managed to antagonize nearly everyone who cared for him each time he appeared at the hospital. How was a clinician supposed to find the requisite empathy in cases like his?

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Advancing the CV Care of the Oncology Patient: Atherosclerosis, CV Risk Factors Common at Lung Cancer Diagnosis

American College of Cardiology

Nearly 80% of patients with lung cancer had detectable atherosclerosis on their cancer staging CT scans and other cardiovascular risk factors were common, offering an opportunity for earlier cardiac testing and risk factor modification, according to a new study.

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Understanding Angioedema in Urticaria, with Jonathan Bernstein, MD

HCPLive

Bernstein discussed recent and upcoming research and management of angioedema in patients with urticaria.

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Stress hyperglycemia ratio and machine learning model for prediction of all-cause mortality in patients undergoing cardiac surgery

Cardiovascular Diabetology

The stress hyperglycemia ratio (SHR) was developed to reduce the effects of long-term chronic glycemic factors on stress hyperglycemia levels, which was associated with adverse clinical outcomes. This study ai.

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Deucravacitinib Effective for Psoriasis Regardless of Prior Biologic, Apremilast Use

HCPLive

These data highlight deucravacitinibs impact among patients with psoriasis who are biologic- and apremilast-naive and those with prior histories with these treatments.

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The strategy that propelled Northwestern's heart institute to a top program

Becker's Hospital Review - Cardiology

Discover the incredible success and growth of Northwestern Health's Bluhm Cardiovascular Institute, ranked among the top 10 cardiology programs in the nation

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Dupilumab May Improve Growth in Children with Severe Atopic Dermatitis by 16 Weeks

HCPLive

Children with severe atopic dermatitis saw > 5 percentile height gains after 16 weeks of dupilumab, per a study to be presented at AAAAI 2025.

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University Hospitals Receives Grant for New Limb Preservation Center

DAIC

Lorraine and Bill Dodero tim.hodson Fri, 02/14/2025 - 15:33 Feb. 10, 2025 A generous gift of $5 million from Lorraine and Bill Dodero will establish the Lorraine and Bill Dodero Limb Preservation Center at University Hospitals Harrington Heart & Vascular Institute in Cleveland, Ohio. Led by Mehdi Shishehbor DO, MPH, PhD, interventional cardiologist and a pioneer in the field of limb preservation, the Dodero Center will revolutionize care for patients at risk of losing a leg due to peripheral ar

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FDA Approves Merilog, Biosimilar Product of Insulin Aspart (Novolog) for Diabetes

HCPLive

On February 14, 2025, the FDA approved the first rapid-acting biosimilar insulin product called nsulin-aspart-szjj (Merilog).

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Clinical outcomes after surgical resection in asymptomatic and symptomatic children with congenital lung malformations

Journal of Cardiothoracic Surgery

Purpose Our study aims to evaluate the outcomes of children with congenital lung malformation (CLM) who have undergone surgical resection. Methods A retrospective analysis was conducted among children under 18 who were diagnosed with CLM and underwent surgery at Srinagarind Hospital, Khon Kaen University between January 2007 and December 2023. We collected data on surgical outcomes, including operative time, postoperative complications, and mortality rate.

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Solar Urticaria More Prevalent in Women, UV and Visible Light Both Triggers

HCPLive

Around half of participants had insufficient vitamin D levels.

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The evaluation of patient blood management in lung resection under thoracotomy

Journal of Cardiothoracic Surgery

Unnecessary blood preparation by surgeons adversely affects blood bank stocks and the healthcare system in many ways. In this study, it is aimed to evaluate the patient blood management strategy in patients in.

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Association between the systemic immune-inflammation index and metabolic syndrome and its components: results from the multi-ethnic study of atherosclerosis (MESA)

Cardiovascular Diabetology

The Systemic Immune-Inflammation Index (SII) is a novel biomarker of systemic inflammation. We explored the association between the SII and metabolic syndrome (MetS) and its components in middle-aged and older.

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Surgical treatment of delayed partial bronchial rupture under venovenous extracorporeal membrane oxygenation support: a case report

Journal of Cardiothoracic Surgery

Chest trauma may precipitate a spectrum of injuries, among which tracheal laceration represents an uncommon but critical sequela. The occurrence of tracheal laceration could significantly impair respiratory an.

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Blood thinner side effects diminish over time, research suggests

Medical Xpress - Cardiology

Blood thinners prescribed after blood clots in the leg or lung initially increase the risk of bleeding, especially in women and the elderly. But over time, this risk decreases and gender and age differences fade, a University of Gothenburg study shows.

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Impact of the COVID-19 pandemic on patients with coronary artery disease requiring cardiac surgery at a German university hospital

Journal of Cardiothoracic Surgery

Studies show conflicting results regarding the impact of the COVID-19 pandemic on the treatment of patients with coronary artery disease requiring cardiac surgery and data from Germany are lacking. In this stu.

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Comprehensive CT scans may help identify atherosclerosis among lung cancer patients

Medical Xpress - Cardiology

Several cardiovascular risk factors, such as advanced age and smoking history, are prevalent among lung cancer patients at the time of the diagnosis and increase their risk of future heart disease, according to a new study being presented at ACC's Advancing the Cardiovascular Care of the Oncology Patient course. Comprehensive assessments are needed in this vulnerable group to improve survival outcomes and quality of care for cancer patients.

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Encouraging DOAC Data for Afib With Various Valvular Heart Diseases

Med Page Today

(MedPage Today) -- For some patients with atrial fibrillation (Afib, AF) and valvular heart disease (VHD), direct oral anticoagulants (DOACs) appeared to offer better prevention of stroke and thromboembolic events compared with warfarin, without.

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Clinical Quiz: Anaphylaxis Risk Factors and Community Preparedness

HCPLive

In this quiz, we test your knowledge of anaphylaxis risk assessment, prevention strategies, and best practices for enhancing preparedness.

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Direct Oral Anticoagulants Compared With Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease Without Mechanical Valves

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundDespite proven efficacy and safety of direct oral anticoagulants (DOACs) over warfarin in patients with atrial fibrillation (AF), data on patients with AF and valvular heart disease remain scarce. We aimed to evaluate the DOACs compared with warfarin among patients with AF and valvular heart disease.Methods and ResultsWe conducted a retrospective cohort study of patients 18 years of age, who had AF and valvular heart disease, a

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Ensifentrine (ENHANCE Trials) in COPD

HCPLive

Panelists discuss how the ENHANCE trials assessed ensifentrine in patients with chronic obstructive pulmonary disease (COPD) with moderate-to-severe airflow obstruction and a history of exacerbations. Outcomes showed improved lung function and reduced exacerbations. Clinically, ensifentrine may be used as monotherapy or an add-on, addressing diverse patient needs.

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From Spoke to Hub: The “Golden Hours” in Cardiogenic Shock

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.

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Maintenance Therapy and Adherence to COPD Treatment

HCPLive

Panelists discuss how individualized chronic obstructive pulmonary disease (COPD) maintenance therapy considers symptom severity, exacerbation risk, and eosinophil levels. Dupilumab and ensifentrine require adherence to prescribed dosing for efficacy and safety.

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Low Adherence to High Blood Pressure Treatments: Innovative Solutions Are Needed

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.

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Identifying B-cell Depleting Agents for Lupus Nephritis, with Richard Furie, MD

HCPLive

Furie discussed his experiences in evaluating therapies such as rituximab and now obinutuzumab for lupus nephritis.

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