Wed.Nov 27, 2024

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Men at high risk of cardiovascular disease face brain health decline 10 years earlier than women, study finds

Medical Xpress - Cardiology

Men with cardiovascular disease risk factors, including obesity, face brain health decline a decade earlier—from their mid 50s to mid 70s—than similarly affected women who are most susceptible from their mid 60s to mid 70s, suggest the findings of a long term study, published online in the Journal of Neurology Neurosurgery & Psychiatry.

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What makes a T-wave Hyperacute? And: 30 Examples of Hyperacute T-waves, 10 in each of 3 myocardial territories.

Dr. Smith's ECG Blog

Pendell and I and the geniuses at Powerful Medical (Producers of the PMCardio Queen of Hearts OMI AI app ) are working on an objective, mathematical definition of hyperacute T-waves , based on real OMI outcomes and hyperacute T-wave annotation that has excellent interrater agreement (between me and Pendell), and it will end up being a logistic regression using these 3 variables: 1) area under the curve (AUC) relative to the QRS size 2) increased symmetry , as defined by time from T-wave onset to

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Irregular sleep-wake cycle linked to heightened risk of major cardiovascular events

Medical Xpress - Cardiology

An irregular sleep-wake cycle is associated with a heightened risk of major cardiovascular events, such as heart attack and stroke, even for those who clock up the recommended nightly hours of shut-eye, finds research published online in the Journal of Epidemiology & Community Health.

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ASCVD Mortality Linked to Specific Air Pollution Sources

Med Page Today

(MedPage Today) -- The relationship between air pollution and cardiovascular harm was supported by another study, this time down to the level of specific types of pollution that appeared to have varying effects according to geographical region.

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Risk of heart problems persists years after COVID infection: 4 study findings

Becker's Hospital Review - Cardiology

A recent study using data from the UK BioBank highlighted the extended risk of major adverse cardiac events in individuals who have recovered from COVID-19.

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Certain hormone replacement therapy tablets linked to increased heart disease and blood clot risk

Medical Xpress - Cardiology

Certain hormone replacement therapy (HRT) tablets containing both estrogen and progestogen are associated with a higher risk of heart disease and rare but serious blood clots known as venous thromboembolism (VTE) in women around the age of menopause, finds a study from Sweden published in The BMJ today.

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Different menopausal hormone treatments pose different risks

Science Daily - Heart Disease

Researchers have analysed the effects of seven different hormone treatments for menopausal symptoms on the risk of blood clots, stroke and heart attack. The study, which involved around one million women aged between 50 and 58, is the largest and most comprehensive study of currently prescribed hormonal substances in the world. The results show that the risks differ depending on the active substance and how the medicine is taken.

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How best to describe the location of the substrates for abnormal cardiac rhythms

HeartRhythm

Although he is widely believed to have stated “and still it moves,” there is no documentary evidence that Galileo Galilei uttered these words subsequent to his forced retraction of his notion that the earth moved round the sun. His alleged statement, nonetheless, stated an obvious fact, which was eventually supported by evidence. Nowadays, we allegedly practice evidence-based medicine.

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Research shows death rates linked to obesity-related heart disease are up, especially among men

Medical Xpress - Cardiology

The rate of deaths from ischemic heart disease related to obesity nearly tripled in the U.S. over a two-decade span, according to new research. The rate for men more than tripled.

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Changes in Maximum Daily AF Duration, Stroke, and Mortality

American College of Cardiology

What is the association between changes in maximum daily atrial fibrillation duration (MDAFD) and stroke or mortality in patients with cardiac implantable electronic devices (CIEDs)?

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Educational Video Use in Shared Decision-Making Improves Literacy About Psoriasis

HCPLive

These findings indicate that incorporating educational video materials for psoriasis improved engagement in the shared decision-making process.

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Do You Want The Formula For Preventing Heart Disease?

Dr. Paddy Barrett

The Heart Health Formula is the process I use to: Understand a person’s risk of heart disease using the best science available. Maximally reduce a person’s risk. With the ultimate goal that all of my patients (Myself included) live a long and healthy life and die with, not from, heart disease. The steps to implementing this process result from over a decade of research.

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Egg Consumption Through Breast Milk Insufficient for Allergy Prevention in Infants at 12 Months

HCPLive

In this analysis, egg consumption among pregnant mothers was found to be insufficient for the development of oral tolerance to eggs among infants at 1 year of age.

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Congenital heart defects caused by problems with the placenta

Medical Xpress - Cardiology

Congenital heart defects are the most common form of human birth defect, but we still don't fully understand what causes them. Previous research had suggested that some heart defects could be triggered by problems with the placenta, the organ that provides oxygen and nutrients to the developing embryo.

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Partnering RemoTe monitoring of Implanted Cardiac devices with Intelligent PATient Engagement - PARTICIPATE trial: a protocol for a randomised controlled trial

Open Heart

Introduction Cardiac implantable electronic devices (CIED) can transfer data to the healthcare team, remotely. National and international cardiac organisations recommend all patients use this technology, however patient engagement is suboptimal. Previously, in cardiovascular patients, SMS messaging services have shown improvements in patient engagement and subsequent health outcomes.

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PEGylated Uricase Well-Tolerated, Demonstrates Dose-Dependent Urate-Lowering

HCPLive

At the highest dose levels, mean plasma urate levels remained below 6.0 mg/dL for up to 12 weeks.

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IG Live December 2: The Weight of Wegovy

Med Page Today

(MedPage Today) -- MedPage Today spoke with experts during an Instagram Live 2 years ago about the growing buzz around GLP-1 receptor agonists and their role in transforming diabetes and obesity care. Since then, the use of medications like semaglutide.

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AMG0001 Advances Healing in CLTI with David G. Armstrong, DPM, PhD, and Michael S. Conte, MD

HCPLive

David G. Armstrong, DPM, PhD, and Michael S. Conte, MD discuss Phase 2 results on anatomically directed lower extremity gene therapy for ulcer healing.

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Winrevair’s Big PAH Win

CardiacWire

Stunning topline results from Merck Winrevair’s Phase 3 ZENITH trial found that the drug significantly reduced morbidity and mortality risks in patients with pulmonary arterial hypertension, paving the way for stronger commercialization and further functional trials. PAH is a rare, progressive disease that increases blood pressure in the lungs, forcing the heart to pump harder.

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Clinical Quiz: Impact of New MASLD Nomenclature on 2023 AASLD NAFLD Guidance

HCPLive

Test your knowledge of the AASLD NAFLD Practice Guidance and its clinical application in light of the new MASLD nomenclature.

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Diagnosis of Hypertrophic Cardiomyopathy: Video

All About Cardiovascular System and Disorders

Though echocardiography is the sheet anchor of diagnosis of hypertrophic cardiomyopathy, clinical evaluation is equally important while deciding management and ruling out differential diagnoses. Role of cardiac cath is now mostly limited to septal ablation. Magnetic resonance imaging and bone scan to rule out transthyretin amyloidosis may be considered when clinically indicated.

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Prevalence of Cardiovascular Disease

HCPLive

Panelists discuss how cardiovascular disease remains a leading health concern in the United States, examining its rising prevalence, risk factors such as dyslipidemia, and management strategies aligned with AHA guidelines to reduce patient mortality.

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Amplatzer Amulet Left Atrial Appendage Occluder IDE

American College of Cardiology

The goal of the Amulet IDE trial was to evaluate left atrial appendage (LAA) occlusion with the Amulet device compared with the Watchman device among patients with nonvalvular atrial fibrillation (AF).

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AHA Guidelines and Patient Mortality

HCPLive

Panelists discuss how effective management of dyslipidemia through adherence to AHA guidelines is crucial for reducing cardiovascular mortality rates and improving patient outcomes.

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Prevalence of U.S. Overweight and Obesity, Consensus on CPR, Bleeding Risk Using NSAIDs With Anticoagulants

American College of Cardiology

In this week’s View, Dr. Eagle looks at the prevalence of overweight and obesity among children, adolescents, and adults in the U.S., with forecasts up to 2050.

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John Stone, MD, MPH: Continuing Progress With IgG4-Related Disease Research

HCPLive

Stone discussed the phase 3 MITIGATE study, other potential treatment strategies, and top research priorities moving forward for IgG4.

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Top stories on advances in understanding ventricular conduction system development, physiology, arrhythmogenesis, and therapeutics

HeartRhythm

The ventricular conduction system (VCS) is essential for highly synchronous myocardial excitation and contraction. Developmental and acquired diseases affecting VCS structure and function are responsible for a substantial burden of rhythm disturbances. We highlight 5 recently published studies that advance our understanding of VCS formation, function, pathophysiology, and therapeutics.

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ONS-5010 for Wet AMD Fails to Meet Noninferiority in NORSE EIGHT Trial

HCPLive

ONS-5010 missed the pre-specified non-inferiority endpoint set with the FDA, but Outlook Therapeutics plans to resubmit the BLA in Q1 of 2025.

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Pace and Biopsy

HeartRhythm

Endomyocardial biopsy (EMB) remains the reference method for diagnosing a range of cardiac conditions. Owing to its invasive nature, the risk of complications may be as high as 3%. Therefore, EMB tends to be performed when non-invasive methods are unable to reach a definitive diagnosis, guide clinical management or when histology is necessary. In such patients, the “last-resort” use of EMB may also incur diagnostic delay.

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Overview of FCS

HCPLive

Panelists discuss how familial chylomicronemia syndrome (FCS) and persistent chylomicronemia are diagnosed either genetically or clinically, outlining the prevalence and disease burden of FCS in the US, as well as its signs, symptoms, and diagnostic criteria, and how to differentiate FCS from other forms of hyperlipidemia.

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Long-Term Outcomes of Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Use Among Patients on Maintenance Dialysis

HeartRhythm

Despite an elevated risk of sudden cardiac death among dialysis patients, implantable cardioverter defibrillators (ICDs) have not been shown to improve mortality and are associated with high complication rates. Subcutaneous (S-)ICDs may reduce the risk of complications for eligible dialysis patients, but safety and benefits versus transvenous (TV-)ICDs are unknown.

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Severe Hypertriglyceridemia

HCPLive

Panelists discuss how Familial Chylomicronemia Syndrome (FCS) fits into the context of severe hypertriglyceridemia, highlighting its distinct characteristics and the associated risks of acute pancreatitis.

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Salvaged by the Stylet: Procedural Insights from Difficult Cases of Left Bundle Branch Area Pacing

HeartRhythm

Technical success left bundle branch area pacing (LBBAP) is predicated upon deep septal penetration to capture left ventricular (LV) conduction system. Potential barriers include non-complaint interventricular septum (IVS) either due to fibrosis/scar, hypertrophy, or abnormal geometry in structurally abnormal/dilated hearts. Lead entanglement also hinders septal penetration, increases procedural/fluoroscopic times, necessitates repositioning, and usage of more hardware.

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Malin Fromme, MD: Lung, Liver Risk Stratification in Alpha-1 Antitrypsin Deficiency

HCPLive

Fromme describes the importance of risk stratification in AATD and explains the potential utility of noninvasive fibrosis measures for predicting outcomes.

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Hemolysis After Pulsed Field Ablation: The Role of Dose and Contact in an Acute Porcine Model

Circulation: Arrhythmia and Electrophysiology

Circulation: Arrhythmia and Electrophysiology, Ahead of Print.

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Treatment Goals and First-Line Therapy in PBC

HCPLive

The panel of experts outline the primary treatment goals for patients with primary biliary cholangitis (PBC), detailing how goals adjust based on disease severity, the role of ursodeoxycholic acid (UDCA) as first-line therapy, and the challenges that may require therapy modifications based on biochemical response.

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Partial Cardiac Denervation to Prevent Postoperative Atrial Fibrillation After Coronary Artery Bypass Grafting

American College of Cardiology

The goal of the pCAD-POAF trial was to determine the efficacy and safety of partial cardiac denervation to reduce the risk of postoperative atrial fibrillation (POAF) following coronary artery bypass grafting (CABG).