Dr. Smith's ECG Blog

NOVEMBER 27, 2024

Pendell and I and the geniuses at Powerful Medical (Producers of the PMCardio Queen of Hearts OMI AI app ) are working on an objective, mathematical definition of hyperacute T-waves , based on real OMI outcomes and hyperacute T-wave annotation that has excellent interrater agreement (between me and Pendell), and it will end up being a logistic regression using these 3 variables: 1) area under the curve (AUC) relative to the QRS size 2) increased symmetry , as defined by time from T-wave onset to

Blog 103

Blog STEMI Research Outcomes 103

Med Page Today

NOVEMBER 27, 2024

(MedPage Today) -- The relationship between air pollution and cardiovascular harm was supported by another study, this time down to the level of specific types of pollution that appeared to have varying effects according to geographical region.

88

88

Becker's Hospital Review - Cardiology

NOVEMBER 27, 2024

A recent study using data from the UK BioBank highlighted the extended risk of major adverse cardiac events in individuals who have recovered from COVID-19.

COVID-19 97

COVID-19 97

HCPLive

NOVEMBER 27, 2024

In this analysis, egg consumption among pregnant mothers was found to be insufficient for the development of oral tolerance to eggs among infants at 1 year of age.

59

59

Open Heart

NOVEMBER 27, 2024

The optimal timing for initiating direct oral anticoagulants (DOACs) for secondary stroke prevention in patients with atrial fibrillation and acute ischaemic stroke remains controversial due to concerns about haemorrhagic transformation. This study aimed to analyse the efficacy and safety of early versus late DOAC initiation. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic review was conducted, searching major databases (PubMed, Embase, C

Atrial Fibrillation 52

Atrial Fibrillation Stroke Strokes Embolism 52

Dr. Paddy Barrett

NOVEMBER 27, 2024

The Heart Health Formula is the process I use to: Understand a person’s risk of heart disease using the best science available. Maximally reduce a person’s risk. With the ultimate goal that all of my patients (Myself included) live a long and healthy life and die with, not from, heart disease. The steps to implementing this process result from over a decade of research.

Heart Disease 52

Heart Disease Cholesterol Blood Pressure Coronary Angiogram 52

Open Heart

NOVEMBER 27, 2024

Introduction Atrial fibrillation (AF)-induced cardiomyopathy (AIC) is retrospectively defined after normalisation of left ventricular ejection fraction (LVEF) in sinus rhythm. It is unclear why some patients develop AIC. Hypothesis Patients with AIC have a subtle cardiomyopathic process that precedes their AF-mediated LVEF reduction. Detailed assessment of cardiac function after successful catheter ablation will reveal this.

Atrial Fibrillation 52

Atrial Fibrillation Cardiomyopathy Ablation Cardiac Function 52

Open Heart

NOVEMBER 27, 2024

Introduction Cardiac implantable electronic devices (CIED) can transfer data to the healthcare team, remotely. National and international cardiac organisations recommend all patients use this technology, however patient engagement is suboptimal. Previously, in cardiovascular patients, SMS messaging services have shown improvements in patient engagement and subsequent health outcomes.

Defibrillator 52

Defibrillator Quality of Life Education Risk Factors 52

CardiacWire

NOVEMBER 27, 2024

Stunning topline results from Merck Winrevair’s Phase 3 ZENITH trial found that the drug significantly reduced morbidity and mortality risks in patients with pulmonary arterial hypertension, paving the way for stronger commercialization and further functional trials. PAH is a rare, progressive disease that increases blood pressure in the lungs, forcing the heart to pump harder.

Blood Pressure 52

Blood Pressure Pulmonary Transplant Hypertension 52

HCPLive

NOVEMBER 27, 2024

Panelists discuss how cardiovascular disease remains a leading health concern in the United States, examining its rising prevalence, risk factors such as dyslipidemia, and management strategies aligned with AHA guidelines to reduce patient mortality.

Cardiovascular Disease 52

Cardiovascular Disease Risk Factors 52

Med Page Today

NOVEMBER 27, 2024

(MedPage Today) -- MedPage Today spoke with experts during an Instagram Live 2 years ago about the growing buzz around GLP-1 receptor agonists and their role in transforming diabetes and obesity care. Since then, the use of medications like semaglutide.

Obesity 52

Obesity Diabetes 52

HCPLive

NOVEMBER 27, 2024

Panelists discuss how effective management of dyslipidemia through adherence to AHA guidelines is crucial for reducing cardiovascular mortality rates and improving patient outcomes.

Outcomes 52

Outcomes 52

HeartRhythm

NOVEMBER 27, 2024

Endomyocardial biopsy (EMB) remains the reference method for diagnosing a range of cardiac conditions. Owing to its invasive nature, the risk of complications may be as high as 3%. Therefore, EMB tends to be performed when non-invasive methods are unable to reach a definitive diagnosis, guide clinical management or when histology is necessary. In such patients, the “last-resort” use of EMB may also incur diagnostic delay.

40

40

HCPLive

NOVEMBER 27, 2024

Panelists discuss how familial chylomicronemia syndrome (FCS) and persistent chylomicronemia are diagnosed either genetically or clinically, outlining the prevalence and disease burden of FCS in the US, as well as its signs, symptoms, and diagnostic criteria, and how to differentiate FCS from other forms of hyperlipidemia.

52

52

HeartRhythm

NOVEMBER 27, 2024

Despite an elevated risk of sudden cardiac death among dialysis patients, implantable cardioverter defibrillators (ICDs) have not been shown to improve mortality and are associated with high complication rates. Subcutaneous (S-)ICDs may reduce the risk of complications for eligible dialysis patients, but safety and benefits versus transvenous (TV-)ICDs are unknown.

Defibrillator 40

Defibrillator Sudden Cardiac Death Outcomes 40

HCPLive

NOVEMBER 27, 2024

Panelists discuss how Familial Chylomicronemia Syndrome (FCS) fits into the context of severe hypertriglyceridemia, highlighting its distinct characteristics and the associated risks of acute pancreatitis.

52

52

HeartRhythm

NOVEMBER 27, 2024

Technical success left bundle branch area pacing (LBBAP) is predicated upon deep septal penetration to capture left ventricular (LV) conduction system. Potential barriers include non-complaint interventricular septum (IVS) either due to fibrosis/scar, hypertrophy, or abnormal geometry in structurally abnormal/dilated hearts. Lead entanglement also hinders septal penetration, increases procedural/fluoroscopic times, necessitates repositioning, and usage of more hardware.

Heart Failure 40

Heart Failure 40

HCPLive

NOVEMBER 27, 2024

The panel of experts outline the primary treatment goals for patients with primary biliary cholangitis (PBC), detailing how goals adjust based on disease severity, the role of ursodeoxycholic acid (UDCA) as first-line therapy, and the challenges that may require therapy modifications based on biochemical response.

52

52

American College of Cardiology

NOVEMBER 27, 2024

What is the association between changes in maximum daily atrial fibrillation duration (MDAFD) and stroke or mortality in patients with cardiac implantable electronic devices (CIEDs)?

Stroke 40

Stroke Strokes Atrial Fibrillation Article 40

HCPLive

NOVEMBER 27, 2024

The panel of experts cover second-line treatment options for primary biliary cholangitis (PBC), focusing on the use of obeticholic acid (OCA), its mechanism of action, management of adverse effects like pruritus and fatigue, the role of off-label fibrates, and strategies for assessing and adjusting therapy based on patient response and adverse effects.

52

52

American College of Cardiology

NOVEMBER 27, 2024

The goal of the pCAD-POAF trial was to determine the efficacy and safety of partial cardiac denervation to reduce the risk of postoperative atrial fibrillation (POAF) following coronary artery bypass grafting (CABG).

Coronary Artery Bypass Graft 40

Coronary Artery Bypass Graft Atrial Fibrillation Article 40

HCPLive

NOVEMBER 27, 2024

Fromme describes the importance of risk stratification in AATD and explains the potential utility of noninvasive fibrosis measures for predicting outcomes.

Outcomes 52

Outcomes 52

American College of Cardiology

NOVEMBER 27, 2024

The goal of the Amulet IDE trial was to evaluate left atrial appendage (LAA) occlusion with the Amulet device compared with the Watchman device among patients with nonvalvular atrial fibrillation (AF).

Atrial Fibrillation 40

Atrial Fibrillation Article 40

HCPLive

NOVEMBER 27, 2024

David G. Armstrong, DPM, PhD, and Michael S. Conte, MD discuss Phase 2 results on anatomically directed lower extremity gene therapy for ulcer healing.

52

52

The American Journal of Cardiology

NOVEMBER 27, 2024

Publication date: Available online 26 November 2024 Source: The American Journal of Cardiology Author(s): Luca Fazzini, Matteo Casula, Riccardo Cau, Marta Figueiral, Matteo Castrichini, Giulio Binaghi, Marco Corda, Naveen L.

40

40

HCPLive

NOVEMBER 27, 2024

These findings indicate that incorporating educational video materials for psoriasis improved engagement in the shared decision-making process.

Education 52

Education 52

HeartRhythm

NOVEMBER 27, 2024

The ventricular conduction system (VCS) is essential for highly synchronous myocardial excitation and contraction. Developmental and acquired diseases affecting VCS structure and function are responsible for a substantial burden of rhythm disturbances. We highlight 5 recently published studies that advance our understanding of VCS formation, function, pathophysiology, and therapeutics.

Physiology 40

Physiology 40

HCPLive

NOVEMBER 27, 2024

ONS-5010 missed the pre-specified non-inferiority endpoint set with the FDA, but Outlook Therapeutics plans to resubmit the BLA in Q1 of 2025.

52

52

HeartRhythm

NOVEMBER 27, 2024

Although he is widely believed to have stated “and still it moves,” there is no documentary evidence that Galileo Galilei uttered these words subsequent to his forced retraction of his notion that the earth moved round the sun. His alleged statement, nonetheless, stated an obvious fact, which was eventually supported by evidence. Nowadays, we allegedly practice evidence-based medicine.

Electrophysiology 40

Electrophysiology Document 40

HCPLive

NOVEMBER 27, 2024

Stone discussed the phase 3 MITIGATE study, other potential treatment strategies, and top research priorities moving forward for IgG4.

Research 52

Research 52

HeartRhythm

NOVEMBER 27, 2024

In a case report published in 1984 in the New England Journal of Medicine, Figure 1 was an electrocardiogram that showed sinus bradycardia with a short PR interval and prominent delta waves, with a pattern of preexcitation typical of a posteroseptal accessory pathway (PSAP).1 The patient was a young man with Wolff-Parkinson-White syndrome who had experienced 2 episodes of atrial fibrillation with very rapid ventricular rates and near-syncope, terminated by transthoracic cardioversion.

Electrocardiogram 40

Electrocardiogram Atrial Fibrillation Bradycardia Ablation 40

HCPLive

NOVEMBER 27, 2024

A new study supports mindfulness-based interventions as a complementary treatment for patients with schizophrenia spectrum disorders.

52

52

HeartRhythm

NOVEMBER 27, 2024

Beginning in January 2025, Heart Rhythm will adopt the correct anatomic nomenclature, as described by Anderson et al1 and as endorsed by Richardson et al2 on behalf of the journal editors.

Anatomy 40

Anatomy Heart Rhythm 40

HCPLive

NOVEMBER 27, 2024

Test your knowledge of the AASLD NAFLD Practice Guidance and its clinical application in light of the new MASLD nomenclature.

52

52

HeartRhythm

NOVEMBER 27, 2024

The goals of the current scientific research on ventricular tachycardia (VT) ablation included studies to prove the benefit of early ablation on heart failure progression and mortality and the need to better characterize and treat heterogeneous deep VT substrates. In the last 2 years, 5 studies have taken steps to turn the tide.

Tachycardia 40

Tachycardia Ablation Heart Failure Research 40

HCPLive

NOVEMBER 27, 2024

At the highest dose levels, mean plasma urate levels remained below 6.0 mg/dL for up to 12 weeks.

52

52

HeartRhythm

NOVEMBER 27, 2024

Atrial fibrillation (AF) is rare in children and young adults, but the last several years have expanded our understanding of genetic causes in young people with structurally normal hearts and brought new tools to treat AF in all patients.

Atrial Fibrillation 40

Atrial Fibrillation 40