Wed.Sep 18, 2024

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Metals in the body from pollutants associated with progression of harmful plaque buildup in the arteries

Medical Xpress - Cardiology

Metal exposure from environmental pollution is associated with increased buildup of calcium in the coronary arteries at a level that is comparable to traditional risk factors like smoking and diabetes, according to a study by Columbia University Mailman School of Public Health.

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Researchers use machine learning to improve cardiovascular risk assessment

Science Daily - Heart Disease

Researchers used advanced machine learning to increase the accuracy of a national cardiovascular risk calculator while preserving its interpretability and original risk associations.

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A transparent AI approach helps provide a more tailored cardiovascular risk assessment

Medical Xpress - Cardiology

Risk calculators are used to evaluate disease risk for millions of patients, making their accuracy crucial. But when national models are adapted for local populations, they often deteriorate, losing accuracy and interpretability.

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Metal exposure can increase cardiovascular disease risk

Science Daily - Heart Disease

Metal exposure from environmental pollution is associated with increased calcium buildup in the coronary arteries at a level comparable to traditional risk factors, according to a new study. The findings support that metals in the body are associated with the progression of plaque buildup in the arteries and potentially provide a new strategy for managing and preventing atherosclerosis.

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Happy with your life? Research links contentment with fewer heart attacks and strokes

Medical Xpress - Cardiology

People who are content with their lives or feel a sense of well-being may be less likely to develop heart disease and/or stroke compared to those with a lower sense of well-being, according to a new analysis published today (Sept. 18) in the Journal of the American Heart Association.

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New Report Estimates Potential Demand of Psilocybin-Assisted Therapy for MDD

HCPLive

A report shows only 24%, 56%, and 62% of patients meet the criteria PSIL-AT for depression according to low-bound, mid-range, and upper-bound estimates, respectively.

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Metal Exposure Also Linked to More Coronary Artery Calcium

Med Page Today

(MedPage Today) -- Exposure to metals, essential or not, was associated with the progression of subclinical atherosclerosis, according to longitudinal data from a geographically diverse cohort. Study participants with the highest urinary metal.

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Coffee and Heart, Metabolic Risks; What Drives Doctors Away; Ozempic for $100?

Med Page Today

(MedPage Today) -- Note that some links may require registration or subscription. Habitual moderate coffee consumption -- 200-300 mg of caffeine/day -- was tied to a lower risk of cardiometabolic multimorbidity, a U.K. Biobank analysis found.

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Happy with your life? Research links contentment with fewer heart attacks and strokes

American Heart News - Heart News

Research Highlights: People who are satisfied with their lives or feel contentment or well-being may be less likely to develop heart disease and stroke than their unsatisfied counterparts. The analysis of health records for more than 120,000 adults.

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FDA Approves Benralizumab for Eosinophilic Granulomatosis with Polyangiitis

HCPLive

Announced on September 18, 2024, the approval of benralizumab for adults with EGPA, which is based on the MANDARA trial, marks the second FDA approval for EGPA.

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Finerenone improves outcomes in HFmrEF and HFpEF

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 September 2024; doi:10.1038/s41569-024-01087-x The non-steroidal mineralocorticoid receptor antagonist finerenone reduces the risk of adverse outcomes in patients with heart failure with mildly reduced ejection fraction or with preserved ejection fraction, according to findings presented at the ESC Congress 2024.

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Updates to the Treatment of Rosacea, with Hilary Baldwin, MD

HCPLive

In her Maui Derm NP+PA Fall conference presentation, Baldwin highlighted the latest information on approaches to treating rosacea.

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TEER is non-inferior to surgery in patients with secondary mitral regurgitation

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 September 2024; doi:10.1038/s41569-024-01089-9 In patients with heart failure and secondary mitral valve regurgitation, transcatheter edge-to-edge repair is non-inferior to mitral valve surgery with respect to a composite of death, hospitalization for heart failure, reintervention, implantation of an assist device or stroke at 1 year after the procedure, according to findings from the MATTERHORN trial.

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Iron metabolism indexes as predictors of the incidence of cardiac surgery-associated acute kidney surgery

Journal of Cardiothoracic Surgery

Acute kidney injury (AKI) is a major complication following cardiac surgery. We explored the clinical utility of iron metabolism indexes for identification of patients at risk for AKI after cardiac surgery.

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Recovery rate from conduction disorders in patients with permanent pacemaker implantation after transcatheter aortic valve implantation

Open Heart

Backgrounds Permanent pacemaker implantation (PPMI) is one of the greatest disadvantages of transcatheter aortic valve implantation (TAVI). To seek the predictors and clinical impacts of PPMI and investigate the recovery rate from conduction disorders. Methods We retrospectively analysed data from 745 consecutive patients who underwent TAVI for severe aortic stenosis from November 2013 to July 2022.

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Uniportal left middle lobectomy in a patient with situs inversus totalis: a case report

Journal of Cardiothoracic Surgery

Situs inversus totalis (SIT), a rare recessive autosomal disease, involves the complete transposition of the thoracic and abdominal viscera in the left-right axis. Patients with SIT combined with lung cancer a.

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Appropriate use of wearable defibrillators with multiparametric evaluation to avoid unnecessary defibrillator implantation

Open Heart

Introduction Wearable cardioverter-defibrillators (WCD) have emerged as a valuable tool in the management of patients at risk for life-threatening arrhythmias. These devices offer a non-invasive and temporary solution, providing continuous monitoring and the potential for prompt defibrillation when needed. In this study, we explore the use of WCD and evaluate arrhythmic events through comprehensive monitoring.

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Questioning PCI’s Left Ventricular Dysfunction Effect

CardiacWire

New analysis of the REVIVED-BCIS2 trial adds more evidence that PCI has limited impact in patients with left ventricular dysfunction, even when you include quality of life and overall health status. The secondary analysis of the REVIVED-BCIS2 trial examined outcomes from 700 patients with severe ischemic left ventricular systolic dysfunction (median age: 70yrs; mean LVEF: 27) who were randomized to receive PCI and optimal medical therapy or only optimal medical therapy.

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Use of Existing Treatment and Ongoing Research in Treatment of Fibromyalgia

HCPLive

A key opinion leader discusses off-label treatments for fibromyalgia symptom management and promising ongoing studies, as well as mobile applications that can aid in monitoring and managing fibromyalgia symptoms.

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Study identifies link between congenital heart disease prevalence and high-altitude environments

Medical Xpress - Cardiology

The global prevalence of congenital heart disease is higher among women who live at high altitudes, according to a new study presented at ACC Latin America 2024 in Punta Cana, Dominican Republic. However, congenital heart disease in these regions is underestimated and underdiagnosed because of poor access to health care and health systems that lack essential tools.

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What Causes Respiratory Problems in Osteogenesis Imperfecta?

HCPLive

Roy Morello, MD, discusses his team's research into the causes of poor pulmonary function among patients with osteogenesis imperfecta—better known as "brittle bone disease.

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Meta-analysis of Physiology-guided Complete or Culprit lesion-only Percutaneous Coronary Interventions in Myocardial Infarction

The American Journal of Cardiology

Publication date: Available online 18 September 2024 Source: The American Journal of Cardiology Author(s): Sahib Singh, Udaya S Tantry, Kevin Bliden, Marwan Saad, Paul A Gurbel, J.

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Adding Brief CBT to Inpatient’s Usual Treatment Reduces Suicide Reattempts

HCPLive

Inpatients receiving brief cognitive behavioral therapy had a 60% reduced likelihood of suicide attempts and a 71% reduced rate of psychiatric readmissions post-discharge.

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Combining TAVI with PCI in patients with aortic stenosis and CAD

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 September 2024; doi:10.1038/s41569-024-01080-4 In the NOTION-3 trial, percutaneous coronary intervention reduced the occurrence of major adverse cardiac events compared with conservative treatment in patients who were undergoing transcatheter aortic valve implantation for severe aortic stenosis and who had stable coronary artery disease.

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Ustekinumab Reduces Uveitis Risk in Patients with Psoriasis

HCPLive

The IL-23 inhibitor lowered the risk of uveitis more than TNF-α inhibitors in patients with moderate to severe psoriasis.

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Benefit of vutrisiran in transthyretin amyloidosis with cardiomyopathy

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 19 September 2024; doi:10.1038/s41569-024-01086-y Data from the HELIOS-B trial show that RNA interference with vutrisiran reduces the risk of death and recurrent cardiovascular events in patients with transthyretin amyloidosis with cardiomyopathy.

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Using Microbiomes to Diagnose Ventilator-Associated Pneumonia

HCPLive

Georgios Kitsios, MD, PhD, discusses his team's interim results an analysis that is providing insights into the microbiome dynamics of critically ill patients with VAP.

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Exercise Alleviates Cardiovascular Diseases by Improving Mitochondrial Homeostasis

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. Engaging in regular exercise and physical activity contributes to delaying the onset of cardiovascular diseases (CVDs). However, the physiological mechanisms underlying the benefits of regular exercise or physical activity in CVDs remain unclear. The disruption of mitochondrial homeostasis is implicated in the pathological process of CVDs.

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Most Exciting New Therapies in Atopic Dermatitis, with Matthew Zirwas, MD

HCPLive

Zirwas described several highlights from his presentation on updates in managing atopic dermatitis, describing examples such as lebrikizumab and nemolizumab.

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American and European Guideline Comparison for Ischemic Stroke and TIA: Key Points

American College of Cardiology

The following are key points to remember from a review article comparing American and European guideline recommendations for diagnostic workup and secondary prevention of ischemic stroke and transient ischemic attack (TIA).

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What Do Patients Need to Learn About their Hypersensitivity Pneumonitis?

HCPLive

Kerri Aronson, MD, MS, describes her team's research efforts to create educational resources that address the profound lack of patient knowledge around HP.

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Congenital Heart Disease More Prevalent in High-Altitude Populations

American College of Cardiology

The prevalence of congenital heart disease (CHD) is higher among those who live at higher altitudes, and more prevalent among females, according to a new study presented at ACC Latin America 2024.

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Discussing Unmet Needs Among Patients in Dermatology, with Matthew Zirwas, MD

HCPLive

After his review on recent literature, Zirwas’s Maui Derm NP+PA Fall interview featured a discussion about the biggest unmet needs among patients.

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New Research Shows Potential of GHATI to Improve STEMI Care in Low-, Middle-Income Countries

American College of Cardiology

STEMI remains a major cause of morbidity, mortality, disability, and high health care costs in Latin America and the rest of the world. New data assessing the impact of ACC's Global Heart Attack Initiative (GHATI) on patient care outcomes at the CEDIMAT Cardiovascular Center in Santo Domingo, Dominican Republic.

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Subjective Tolerability Drives PsA Treatment Decisions in Cohort Study

HCPLive

There were also no significant differences in clinical parameters at baseline for patients initiating first-line or not first-line therapy.

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Urinary Levels of Non-Essential Metals Associated With Increased CV Risk

American College of Cardiology

Urinary levels of non-essential (i.e., cadmium, tungsten, uranium) and essential metals (i.e., cobalt, copper, zinc) are associated with increased coronary artery calcification (CAC) and are comparable to traditional cardiovascular disease risk factors like smoking and diabetes, according to results from the Multi-Ethnic Study of Atherosclerosis (MESA) published in JACC.

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FDA Clears Eversense 365, Marking First 1-Year CGM Option in Diabetes

HCPLive

The FDA has approved the Eversense 365, the world’s first 1-year continuous glucose monitor, with US availability expected in late 2024.