Fri.Oct 11, 2024

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Loneliness Tied to Alzheimer's and Dementia Risk

Med Page Today

(MedPage Today) -- Loneliness increased the risk for all-cause dementia, a meta-analysis that included more than 600,000 people showed. Feeling lonely was tied to a 31% higher risk of overall dementia (HR 1.306, 95% CI 1.197-1.426), according.

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FASCINATE-2: Denifanstat Improves Disease Activity, MASH Resolution, Fibrosis

HCPLive

New phase 2b data highlight denifanstat’s impact on histological features of MASH, meeting both fibrosis improvement and MASH resolution primary endpoints.

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Safety Data Favor Diuretic Strategy Triggered by Cardiac Monitoring Alerts in HF

Med Page Today

(MedPage Today) -- For a range of hospitalized patients at risk of worsening heart failure (HF), tying medical interventions to cardiac monitoring seemed safe thus far according to the small ALLEVIATE-HF trial. There were no serious adverse events.

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CGRP Monoclonal Antibodies Not More Effective Than Topiramate or Botox for Treating Migraine

HCPLive

A study finds CGRP monoclonal antibodies are not clinically superior to topiramate or Botox in treating chronic migraines, raising cost-effectiveness concerns.

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Early Treatment of Atrial Fibrillation for Stroke Prevention Trial

American College of Cardiology

The goal of the EAST-AFNET 4 trial was to compare a rhythm-control strategy vs. usual care (rate control in the majority of cases) among patients with a recent diagnosis of atrial fibrillation (AF).

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Age at Onset Predicts Longevity in Long-Term Care of Schizophrenia

HCPLive

Factors, including older age at onset and longer length of stay, may predict longevity for schizophrenia in psychiatric long-term care settings.

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ACC CardiaCast: 2024 Update to the AHA/ACC HCM Guideline: Focus on Early Diagnosis and New and Emerging Treatments

American College of Cardiology

In this episode of CardiaCast, hypertrophic cardiomyopathy (HCM) expert Dr. Matthew Martinez will discuss with Dr. Michelle Kittleson recommendations for early diagnosis in the 2024 HCM guideline and review the latest clinical and real-world trial data for new (mavacamten) and emerging (aficamten) cardiac myosin inhibitors.

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Perioperative Cardiovascular Management for Patients Undergoing Noncardiac Surgery

NEJM Journal Watch - Cardiology

New recommendations in these updated American College of Cardiology/American Heart Association guidelines include selective measurement of cardiac biomarkers.

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FDA Approves Marstacimab-hncq (Hympavzi) for Hemophilia A or B Without Inhibitors

HCPLive

The anti-TFPI significantly reduced ABR compared to routine prophylaxis treatment in the phase 3 BASIS trial.

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The titanium heart keeping transplant patients alive

Becker's Hospital Review - Cardiology

Banner-University Medical Center Phoenix has become the third U.S. hospital to perform a BiVACOR Total Artificial Heart implantation as part of the FDA's early feasibility study.

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Topiramate, Pregabalin Reduce Headache Frequency, Intensity in Pediatric Migraine

HCPLive

A meta-analysis revealed taking pregabalin with supplement vitamin D reduced migraine frequency in children by 88%

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Spatial multiomics atlas reveals smooth muscle phenotypic transformation and metabolic reprogramming in diabetic macroangiopathy

Cardiovascular Diabetology

Diabetic macroangiopathy has been the main cause of death and disability in diabetic patients. The mechanisms underlying smooth muscle cell transformation and metabolic reprogramming other than abnormal glucos.

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Is Cardiology Overtreating Aortic Stenosis? with Linda Gillam, MD, MPH

HCPLive

Linda Gillam, MD, MPH, discusses the idea that the cardiology community may. be overtreating aortic stenosis.

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Perioperative outcomes of thoracoscopic versus non-thoracoscopic minimally invasive repair of pectus excavatum: a systematic review and meta-analysis

Journal of Cardiothoracic Surgery

Pectus excavatum is the most common chest wall deformity, with the Nuss procedure being the preferred surgical approach for correction. However, the decision to use thoracoscopic assistance remains challenging.

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Uncovering the Role of COVID-19 in Rheumatic Disease, with Leonard Calabrese, DO

HCPLive

Calabrese discussed considerations for patients with rheumatic disease diagnosed with COVID-19 and the virus’s role in promoting inflammation.

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Have We Turned The Tide On Obesity?

Dr. Paddy Barrett

Obesity is one of the world’s biggest health crisis and only seems to be getting worse. Or is it? Maybe we have turned the tide on one of the most pressing health issues of the century. For over 50 years, the rates of obesity have continued to rise worldwide 1. That is until now. The most recent data on obesity has shown a decline for the first time in a very long time.

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Graded Oral Challenge Safe, Effective for Pediatric Macrolide Allergy

HCPLive

This research letter suggests that direct GOC may be considered efficacious for pediatric patients reporting non-severe symptoms which are skin-limited during a macrolide treatment.

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What is new in Heart failure management ? Ultrasonic cardiac re-synchronization : The WiSE -CRT device

Dr. S. Venkatesan MD

Cardiac resynchronisation (CRT )as a modality for severe or refractory cardiac failure is practiced for nearly two decades. It works on the principle of aggregating mechanically wasted and disorganized myocardial contractile force into a coherent forward pushing activity. In the process, improving the ejection fraction and possibly reducing mitral regurgitation.

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Debunking Myths about Heart Disease

AMS Cardiology

Heart disease remains a leading cause of death worldwide despite advancements in medical science and healthcare. Unfortunately, many misconceptions surround this condition, leading to delayed diagnosis, inappropriate treatment and preventable health risks. Below, we aim to debunk common myths about cardiovascular disease, providing accurate information and emphasizing the importance of treatment for heart disease with timely interventions.

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Elamipretide for Barth Syndrome Survives FDA Advisory Vote

Med Page Today

(MedPage Today) -- FDA advisors indicated a possible path forward for elamipretide as a treatment for Barth syndrome despite the lack of definitive evidence. On Thursday, the Cardiovascular and Renal Drugs Advisory Committee voted 10-6 that elamipretide.

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Point-of-Care HCV RNA Test Could Expedite Diagnosis, Treatment in High-Risk Settings

HCPLive

Findings support the feasibility and clinical performance of Xpert HCV, the first FDA-approved point-of-care test for diagnosing HCV, in a nonclinical justice setting.

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Assessment of Primary Prevention Patients Receiving an ICD–Systematic Evaluation of ATP

American College of Cardiology

The goal of the APPRAISE ATP trial was to determine the efficacy of antitachycardia pacing (ATP) in terminating ventricular tachycardia (VT) compared with a shock-only strategy in patients with a primary prevention implantable cardioverter-defibrillator (ICD).

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Alnylam Submits sNDA for Vutrisiran for Treatment of ATTR-CM

HCPLive

The sNDA submission to the FDA included a Priority Review Voucher, which commits the regulatory agency to an accelerated review timeline.

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Recurrent Rejection in Pediatric Heart Transplantation

American College of Cardiology

What is the prevalence and impact of recurrent rejection (RR) on cardiac allograft vasculopathy (CAV) and graft loss after pediatric heart transplant?

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AHA Scientific Statement Promotes Expanded Use of Lipoprotein Apheresis

HCPLive

A new AHA statement highlights the benefits of lipoprotein apheresis for familial hypercholesterolemia and urges broader access to the underutilized therapy.

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Class I Recalls of Cardiovascular Devices

American College of Cardiology

What are Class I Food and Drug Administration (FDA) recalls of cardiovascular devices and what is the clinical evidence supporting authorization?

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Association Between Cerebral Microbleeds and Neurological Outcomes in Patients Who Underwent Extracorporeal Membrane Oxygenation

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundCerebral microbleeds (CMBs) are common and varied in patients receiving extracorporeal membrane oxygenation (ECMO). Here, the authors describe CMB findings in patients receiving ECMO and their association with clinical factors.Methods and ResultsA total of 138 patients receiving ECMO were enrolled and categorized as venovenous and venoarterial.

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Implementation of a Cardiovascular Implantable Electronic Device Heart Failure Prediction Tool-Guided Management Pathway: CIED-Guided Heart Failure Management

The American Journal of Cardiology

Publication date: Available online 11 October 2024 Source: The American Journal of Cardiology Author(s): Allison Kratka, Gregory Rohrbach, Carrie Puckett, Thomas L. Rotering, Merritt H. Raitt, Mary A. Whooley, Sanket S.

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Unraveling the Complexities for Antiplatelet Strategies Among Patients With Acute Coronary Syndromes Undergoing Percutaneous Coronary Intervention

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.

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Gender Disparities on the Use and Outcomes of Mechanical Circulatory Support in Patients with Cardiogenic Shock Complicating Acute Myocardial Infarction

The American Journal of Cardiology

Publication date: Available online 11 October 2024 Source: The American Journal of Cardiology Author(s): Carlos Diaz-Arocutipa, Norma Nicole Gamarra-Valverde, Rafael Salguero, Roberto Martín-Asenjo, Lourdes Vicent

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Correction to: Proteomic Correlates and Prognostic Significance of Kidney Injury in Heart Failure With Preserved Ejection Fraction

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print.

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Physiology Friday #239: Can Exercise Prevent the Blood-Pressure-Elevating Effects of Sleep Deprivation?

Physiologically Speaking

Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.

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Synthetic Antiangiogenic Vascular Endothelial Growth Factor—A Splice Variant Revascularizes Ischemic Muscle in Peripheral Artery Disease

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundAlternative splicing in the eighth exon C‐terminus of VEGF‐A (vascular endothelial growth factor‐A) results in the formation of proangiogenic VEGF165a and antiangiogenic VEGF165b isoforms. The only known difference between these 2 isoform families is a 6‐amino acid switch from CDKPRR (in VEGF165a) to SLTRKD (in VEGF165b).