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(MedPage Today) -- Loneliness increased the risk for all-cause dementia, a meta-analysis that included more than 600,000 people showed. Feeling lonely was tied to a 31% higher risk of overall dementia (HR 1.306, 95% CI 1.197-1.426), according.
Researchers at the Heart Research Institute (HRI) have made a new discovery, finding an existing drug used to kill tumor cells in cancer patients could also be used to save the limbs of patients with blocked arteries in their legs.
New phase 2b data highlight denifanstat’s impact on histological features of MASH, meeting both fibrosis improvement and MASH resolution primary endpoints.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
(MedPage Today) -- For a range of hospitalized patients at risk of worsening heart failure (HF), tying medical interventions to cardiac monitoring seemed safe thus far according to the small ALLEVIATE-HF trial. There were no serious adverse events.
Banner-University Medical Center Phoenix has become the third U.S. hospital to perform a BiVACOR Total Artificial Heart implantation as part of the FDA's early feasibility study.
Banner-University Medical Center Phoenix has become the third U.S. hospital to perform a BiVACOR Total Artificial Heart implantation as part of the FDA's early feasibility study.
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post! Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber.
A study finds CGRP monoclonal antibodies are not clinically superior to topiramate or Botox in treating chronic migraines, raising cost-effectiveness concerns.
New recommendations in these updated American College of Cardiology/American Heart Association guidelines include selective measurement of cardiac biomarkers.
These data highlight barriers to pediatric treatments for eczema, providing potential strategies for caregivers and patients for adherence improvement.
Obesity is one of the world’s biggest health crisis and only seems to be getting worse. Or is it? Maybe we have turned the tide on one of the most pressing health issues of the century. For over 50 years, the rates of obesity have continued to rise worldwide 1. That is until now. The most recent data on obesity has shown a decline for the first time in a very long time.
For patients undergoing nonemergent cardiopulmonary bypass (CPB), use of an extracorporeal blood purification (EBP) device is associated with a lower rate of cardiac surgery-associated acute kidney injury (CSA-AKI), according to a study published online Oct. 9 in the Journal of the American Medical Association to coincide with the annual congress of the European Society of Intensive Care Medicine, held from Oct. 5 to 9 in Barcelona, Spain.
The goal of the EAST-AFNET 4 trial was to compare a rhythm-control strategy vs. usual care (rate control in the majority of cases) among patients with a recent diagnosis of atrial fibrillation (AF).
Cardiac resynchronisation (CRT )as a modality for severe or refractory cardiac failure is practiced for nearly two decades. It works on the principle of aggregating mechanically wasted and disorganized myocardial contractile force into a coherent forward pushing activity. In the process, improving the ejection fraction and possibly reducing mitral regurgitation.
In this episode of CardiaCast, hypertrophic cardiomyopathy (HCM) expert Dr. Matthew Martinez will discuss with Dr. Michelle Kittleson recommendations for early diagnosis in the 2024 HCM guideline and review the latest clinical and real-world trial data for new (mavacamten) and emerging (aficamten) cardiac myosin inhibitors.
(MedPage Today) -- FDA advisors indicated a possible path forward for elamipretide as a treatment for Barth syndrome despite the lack of definitive evidence. On Thursday, the Cardiovascular and Renal Drugs Advisory Committee voted 10-6 that elamipretide.
This research letter suggests that direct GOC may be considered efficacious for pediatric patients reporting non-severe symptoms which are skin-limited during a macrolide treatment.
The goal of the APPRAISE ATP trial was to determine the efficacy of antitachycardia pacing (ATP) in terminating ventricular tachycardia (VT) compared with a shock-only strategy in patients with a primary prevention implantable cardioverter-defibrillator (ICD).
Diabetic macroangiopathy has been the main cause of death and disability in diabetic patients. The mechanisms underlying smooth muscle cell transformation and metabolic reprogramming other than abnormal glucos.
Pectus excavatum is the most common chest wall deformity, with the Nuss procedure being the preferred surgical approach for correction. However, the decision to use thoracoscopic assistance remains challenging.
A new AHA statement highlights the benefits of lipoprotein apheresis for familial hypercholesterolemia and urges broader access to the underutilized therapy.
Heart disease remains a leading cause of death worldwide despite advancements in medical science and healthcare. Unfortunately, many misconceptions surround this condition, leading to delayed diagnosis, inappropriate treatment and preventable health risks. Below, we aim to debunk common myths about cardiovascular disease, providing accurate information and emphasizing the importance of treatment for heart disease with timely interventions.
Findings support the feasibility and clinical performance of Xpert HCV, the first FDA-approved point-of-care test for diagnosing HCV, in a nonclinical justice setting.
Circulation, Volume 151, Issue 1 , Page 76-93, January 7, 2025. BACKGROUND:Many specialized cells in adult organs acquire a state of cell cycle arrest and quiescence through unknown mechanisms. Our limited understanding of mammalian cell cycle arrest is derived primarily from cell culture models. Adult mammalian cardiomyocytes, a classic example of cell cycle arrested cells, exit the cell cycle postnatally and remain in an arrested state for the life of the organism.
The Society for Cardiovascular Angiography & Interventions (SCAI) is pleased to announce the publication of the Expert Consensus Statement on the Management of Patients with STEMI Referred for Primary PCI.
Publication date: Available online 11 October 2024 Source: The American Journal of Cardiology Author(s): Allison Kratka, Gregory Rohrbach, Carrie Puckett, Thomas L. Rotering, Merritt H. Raitt, Mary A. Whooley, Sanket S.
Publication date: Available online 11 October 2024 Source: The American Journal of Cardiology Author(s): Carlos Diaz-Arocutipa, Norma Nicole Gamarra-Valverde, Rafael Salguero, Roberto Martín-Asenjo, Lourdes Vicent
Journal of the American Heart Association, Ahead of Print. BackgroundAlternative splicing in the eighth exon C‐terminus of VEGF‐A (vascular endothelial growth factor‐A) results in the formation of proangiogenic VEGF165a and antiangiogenic VEGF165b isoforms. The only known difference between these 2 isoform families is a 6‐amino acid switch from CDKPRR (in VEGF165a) to SLTRKD (in VEGF165b).
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