Thu.Jul 25, 2024

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Dementia Risk Drops With Shingrix Vaccine

Med Page Today

(MedPage Today) -- The recombinant shingles vaccine (Shingrix) was associated with a larger reduction in dementia than the live shingles vaccine (Zostavax), an analysis of more than 200,000 U.S. older adults showed. Over a 6-year follow-up period.

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Patient Enrollment Commenced in Pivotal Phase 3 Trial of CardiAMP Cell Therapy for the Treatment of Ischemic Heart Failure

DAIC

mtaschetta-millane Thu, 07/25/2024 - 09:08 July 25, 2024 — BioCardia, Inc. , a global leader in cellular and cell-derived therapeutics for the treatment of cardiovascular and pulmonary diseases, announced today that the confirmatory Phase 3 trial of its autologous CardiAMP cell therapy product candidate for patients with ischemic heart failure of reduced ejection fraction (HFrEF) has commenced enrollment in the United States.

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FDA Accepts sNDA for Furosemide (Furoscix) in Chronic Kidney Disease

HCPLive

The sNDA for furosemide seeks to expand the indication to include the treatment of edema due to fluid overload in patients with CKD, with a PDUFA date of March 6, 2025.

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Innovative Data Featuring Nanox AI Cardiac Solution Showcased at SCCT 2024

DAIC

mtaschetta-millane Thu, 07/25/2024 - 08:55 July 25, 2024 — Nanox, an innovative medical imaging technology company, announced that the AI Cardiac Solution (HealthCCSng) of its subsidiary, Nanox.AI Ltd., was highlighted in multiple scientific presentations at the 2024 Society of Cardiovascular Computed Tomography (SCCT) Annual Meeting. “We are encouraged by the implementation of our AI cardiac solution at esteemed healthcare systems, along with the continued validation through real-world studies

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Resuscitated from ventricular fibrillation. Should the cath lab be activated?

Dr. Smith's ECG Blog

This patient was witnessed by bystanders to collapse. They started CPR. EMS arrived and found him in Ventricular Fibrillation (VF). He was defibrillated into VT. He then underwent dual sequential defibrillation into asystole. After 1 mg of epinephrine they achieved ROSC. Total prehospital meds were epinephrine 1 mg x 3, amiodarone 300 mg and 100 mL of 8.4% sodium bicarbonate.

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Positron Corporation Introduces New, Advanced Designed, Economically Priced PET-CT

DAIC

mtaschetta-millane Thu, 07/25/2024 - 08:36 July 25, 2024 — Positron Corporation , a leading molecular imaging medical device company offering PET & PET-CT imaging systems, presents its new NeuSight PET-CT 3D 64 slice scanner, available for US and North American Markets. The NeuSight PET-CT advanced technology sets a new standard in imaging and diagnostic precision, patient comfort, and operational efficiency for nuclear cardiology practices and hospitals.

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Artificial blood vessels could improve heart bypass outcomes

Science Daily - Heart Disease

3D-printed blood vessels, which closely mimic the properties of human veins, could transform the treatment of cardiovascular diseases. Strong, flexible, gel-like tubes -- created using a novel 3D printing technology -- could improve outcomes for heart bypass patients by replacing the human and synthetic veins currently used in surgery to re-route blood flow, experts say.

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Texas Heart Institute implants artificial heart

Becker's Hospital Review - Cardiology

"Discover the groundbreaking success of the first-in-human implantation of the BiVACOR Total Artificial Heart by the Texas Heart Institute, offering hope for he

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Tiny deletion in heart muscle protein linked to long-term effects on adult atrial fibrillation

Medical Xpress - Cardiology

Millions of adults have atrial fibrillation—an irregular beating of the upper chambers of the heart that yields increased risk of heart failure, stroke and death. Many genetic mutations in the developing fetus can lead to adult atrial fibrillation, including mutations that shorten the massive protein titin in cardiac muscle cells.

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The Cardiometabolic Event of the Year: What to Expect at the 19th Annual Cardiometabolic Health Congress (CMHC) 

Cardiometabolic Health Congress

For 19 years, the Cardiometabolic Health Congress (CMHC) has worked towards a vision of a better future for clinicians, patients, and the entire health sector. This fall, we come together for the largest and most innovative cardiometabolic event in honor of the legacy of Dr. George L. Bakris. His unwavering dedication and contributions to CMHC as a renowned expert, educator, and mentor in the cardiorenal metabolic space have left an indelible mark on our community.

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Role of coronary computed tomography angiography to optimise percutaneous coronary intervention outcomes

Heart BMJ

Learning objectives: To learn how to assess coronary CT angiography (CTA) relevant to percutaneous coronary intervention (PCI). To learn how coronary CTA can help to select patients for revascularisation, plan PCI and guide procedures in the catheterisation laboratory. To realise the benefit of CT-guided PCI. Introduction Coronary CT angiography (CTA) is recommended as the first-line diagnostic evaluation for patients presenting with chest pain. 1 As a result, a significant proportion of patient

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Artificial blood vessels could improve heart bypass outcomes

Medical Xpress - Cardiology

Strong, flexible, gel-like tubes—created using a novel 3D printing technology—could improve outcomes for heart bypass patients by replacing the human and synthetic veins currently used in surgery to re-route blood flow, experts say.

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Physical Activity Linked to Reducing Depression Symptoms, Mediated by Pain

HCPLive

A study found the association between physical activity engagement and reduction in depression symptoms is moderated by pain.

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Mathematical method enables fast, accurate estimates of cardiovascular state to inform blood pressure management

Medical Xpress - Cardiology

If patients receiving intensive care or undergoing major surgery develop excessively high or low blood pressures, they could suffer severe organ dysfunction. It's not enough for their care team to know that pressure is abnormal. To choose the correct drug to treat the problem, doctors must know why blood pressure has changed. A new MIT study presents the mathematical framework needed to derive that crucial information accurately and in real time.

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Habit-Based Interventions Increase Treatment Adherence in Gout

HCPLive

A predictable, structured routine was shown to promote consistent treatment adherence among a cohort of patients with gout.

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Method enables fast, accurate estimates of cardiovascular state to inform blood pressure management

Science Daily - Heart Disease

A new mathematical method, validated with experimental animal data, provides a fast, reliable and minimally invasive way of determining how to treat critical blood pressure changes during surgery or intensive care.

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High levels of a specific antibody may contribute to acute coronary syndrome, investigators say

Medical Xpress - Cardiology

How a person's immune system responds to a protein called LL-37 may increase the risk of developing acute coronary syndrome, but the response may also serve as a potential target for future treatments. These findings come from a research study led by investigators at the Smidt Heart Institute at Cedars-Sinai.

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Periodic Text Messages Can Improve Daily Activity During Cardiac Rehab

HCPLive

Personalized text messages can boost physical activity in cardiac rehab patients, especially in early stages, but effectiveness varies by time and device, study finds.

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Hyperbaric oxygen therapy improves physical performance in older adults

Medical Xpress - Cardiology

Intermittent hyperbaric oxygen therapy (HBOT) may improve physical performance in sedentary older adults, according to a study published online July 3 in BMC Geriatrics.

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Adventist Health heart center renamed

Becker's Hospital Review - Cardiology

"Discover the new name of Northwest Regional Heart and Vascular, now known as Adventist Health Northwest Heart Center, reflecting its affiliation with Adventist

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Revealing the hidden threat behind detectable cardiac troponin levels in the emergency department

Heart BMJ

Cardiac troponin (cTn) plays a key role in diagnosing acute coronary syndrome (ACS) in the emergency department (ED). 1 However, with the introduction of high-sensitivity (hs) assays for cTn and the need for biomarkers for cardiovascular risk stratification, their use has expanded beyond the diagnosis of ACS. A meta-analysis of 28 studies involving 154 052 participants showed that detectable high-sensitivity cardiac troponin (hs-cTn) levels below the 99th percentile were found in 60–80% of

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New Data Highlights Nemolizumab with TCS Versus Calcineurin Inhibitors for Eczema

HCPLive

These new phase 3 findings from ARCADIA 1 and 2 highlight the effects of nemolizumab in combination with either topical corticosteroids or topical calcineurin inhibitors.

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Sitting less, moving more helps stroke patients recover mobility, research shows

Medical Xpress - Cardiology

University of Alberta research is creating new recovery advice for stroke patients based on a precision health approach.

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FDA Approves Label Expansion for Maralixibat (Livmarli) in PFIC

HCPLive

The expanded label includes use in patients with PFIC 12 months of age and older as well as a higher concentration formulation.

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A retrospective analysis of transudative pleural effusion due to fibrosing mediastinitis

Journal of Cardiothoracic Surgery

Pleural effusion caused by fibrosing mediastinitis is rarely reported. This study aimed to summarize the clinical manifestations, diagnosis and treatment of transudative pleural effusion due to fibrosing media.

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Lebrikizumab Shown to Have Comparable Efficacy to Dupilumab for Eczema

HCPLive

This meta-analysis was conducted to compare the efficacy and safety of lebrikizumab to other systemic treatments for patients with atopic dermatitis.

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Absorbable metal stents for vascular use in pediatric cardiology: progress and outlook

Frontiers in Cardiovascular Medicine

The past five years have yielded impressive advancements in fully absorbable metal stent technology. The desired ultimate ability for such devices to treat a vascular stenosis without long-term device-related complications or impeding future treatment continues to evoke excitement in clinicians and engineers alike. Nowhere is the need for fully absorbable metal stents greater than in patients experiencing vascular anomalies associated with congenital heart disease (CHD).

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Sirolimus Balloons Show Promise in Treating Coronary In-Stent Restenosis

Med Page Today

(MedPage Today) -- For interventionalists hoping that a new generation of coronary balloons might improve treatment of in-stent restenosis (ISR), contemporary registry data were encouraging. In a propensity score-matched analysis of 335 pairs.

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Cardioneuroablation: the known and the unknown

Frontiers in Cardiovascular Medicine

Cardioneuroablation (CNA) is a novel interventional procedure for the treatment of recurrent vasovagal syncope (VVS) and advanced atrioventricular block secondary to hyperactivation of vagal tone in young patients. By damaging the cardiac parasympathetic ganglia, CNA seems to be able to mitigate and/or abolish the excessive vagal activity and improve patients’ outcome.

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Healthcare utilisation and quality of life according to atrial fibrillation burden, episode frequency and duration

Heart BMJ

Background We aimed to evaluate the association between atrial fibrillation (AF) burden, duration and number of episodes with healthcare utilisation and quality of life in patients with early paroxysmal AF without a history of AF. Methods In this observational cohort study, we included 417 patients with paroxysmal AF from the Reappraisal of Atrial Fibrillation: interaction between hyperCoagulability, Electrical remodelling and Vascular destabilisation in the progression of AF (RACE V) Study.

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Left bundle branch pacing in third-degree atrioventricular block following morrow surgery: a case report

Frontiers in Cardiovascular Medicine

Left bundle branch pacing (LBBP) has proven to be an alternative method for delivering physiological pacing to achieve electrical synchrony of the left ventricle (LV), especially in patients with atrioventricular block and left bundle branch block (LBBB). However, it is unclear whether it still achieved in patients whose left bundle branch (LBB) has had surgery-induced damage.

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Sudden cardiac arrest in patients with cancer in the general population: insights from the Paris-SDEC registry

Heart BMJ

Background Data on the management of patients with cancer presenting with sudden cardiac arrest (SCA) are scarce. We aimed to assess the characteristics and outcomes of SCA according to cancer history. Methods Prospective, population-based registry including every out-of-hospital SCA in adults in Paris and its suburbs, between 2011 and 2019, with a specific focus on patients with cancer.

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Arthritis Disease Severity Peaks in Spring and Fall, According to PROs

HCPLive

Higher PROs, which were indicative of worse disease activity, were more likely to be reported in the spring and fall months.

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Angiogram-derived physiology: will it change the game or miss the boat?

Heart BMJ

Ghobrial et al describe the impact that one coronary angiogram-derived physiology system, virtual fractional flow reserve (vFFR), has on diagnosis and decision-making of cardiologists when assessing patients undergoing diagnostic angiography for either chronic coronary syndrome or non-ST elevation (NSTE) myocardial infarction (MI), when compared with angiography alone. 1 In 320 patients, the availability of vFFR data led to a significant reduction in the number of vessels considered to have impo

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SPRING: CM-101, A CCL24-Neutralizing Antibody, Impresses in Phase 2 PSC Trial

HCPLive

Positive topline results from the phase 2 SPRING trial highlight CM-101’s anti-fibrotic, anti-inflammatory, and anti-cholestatic effects in primary sclerosing cholangitis.

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AFib Associated With Higher Mortality in Patients With CIEDs

American College of Cardiology

Device-recognized atrial fibrillation (AFib) may be associated with a higher risk of all-cause mortality in patients with cardiac implantable electronic devices (CIEDs), according to a study published in Circulation.

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Diagnostic Nomogram Enables Noninvasive Detection of HBV-Related Cirrhosis

HCPLive

The nomogram was constructed using independent risk factors for early cirrhosis and demonstrated greater diagnostic accuracy than current noninvasive fibrosis tests.